WO2015053629A1 - Dispersions colloïdales aqueuses de particules inorganiques stabilisées - Google Patents

Dispersions colloïdales aqueuses de particules inorganiques stabilisées Download PDF

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Publication number
WO2015053629A1
WO2015053629A1 PCT/NL2014/050703 NL2014050703W WO2015053629A1 WO 2015053629 A1 WO2015053629 A1 WO 2015053629A1 NL 2014050703 W NL2014050703 W NL 2014050703W WO 2015053629 A1 WO2015053629 A1 WO 2015053629A1
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Prior art keywords
nanoparticles
particles
collagen
inorganic particles
composition according
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PCT/NL2014/050703
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English (en)
Inventor
Sebastiaan Antonius Martinus Waltherus VAN DEN BROEK
Luuk Joseph Antonius WILDERS
Jasper Johannes Franciscus VAN GOOL
Kaspar Koch
Pieter Jos Nieuwland
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Future Chemistry Holding B.V.
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Publication of WO2015053629A1 publication Critical patent/WO2015053629A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/20—Compounding polymers with additives, e.g. colouring
    • C08J3/205—Compounding polymers with additives, e.g. colouring in the presence of a continuous liquid phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B01J13/0008—Sols of inorganic materials in water
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B01J13/0034—Additives, e.g. in view of promoting stabilisation or peptisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B01J13/0039—Post treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B01J13/0043—Preparation of sols containing elemental metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B01J13/0047—Preparation of sols containing a metal oxide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/124—Treatment for improving the free-flowing characteristics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/20—Compounding polymers with additives, e.g. colouring
    • C08J3/205—Compounding polymers with additives, e.g. colouring in the presence of a continuous liquid phase
    • C08J3/2053—Compounding polymers with additives, e.g. colouring in the presence of a continuous liquid phase the additives only being premixed with a liquid phase
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/20—Compounding polymers with additives, e.g. colouring
    • C08J3/205—Compounding polymers with additives, e.g. colouring in the presence of a continuous liquid phase
    • C08J3/21—Compounding polymers with additives, e.g. colouring in the presence of a continuous liquid phase the polymer being premixed with a liquid phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/65—Characterized by the composition of the particulate/core
    • A61K2800/654—The particulate/core comprising macromolecular material
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2389/00—Characterised by the use of proteins; Derivatives thereof

Definitions

  • This disclosure generally relates to a stabilized colloidal dispersion of inorganic particles in water and to a method for stabilizing a colloidal dispersion of inorganic particles in water.
  • colloidal dispersions contain suspended micro or nano- scale particles and serve a wide variety of purposes.
  • Colloidal dispersions can be raw materials for nanomaterials, composites, and other materials. They are used in inks, paints, and other emulsions, pharmaceutical products, and are found naturally in clays, biological fluids such as blood, natural organic matter colloids, and petroleum and geological processes.
  • the stability of colloidal dispersions during transport through porous media is important in separation processes and the spread of contaminants, nutrients, and bio- solids through soil. In all applications it is necessary to be able to maintain the particles in a colloidal dispersion, wherein the particles are suspended as individual particles and with minimal amounts of flocculation, agglomeration, coagulation and/or sedimentation.
  • silica particles A particular class of inorganic particles for which stable colloidal dispersions are desired is the class of silica particles.
  • silica particles There are several different types of silica particles, for example mesoporous silica, fumed silica particles and silica gel. When one or more of these silica particles are dispersed in liquid, colloidal silica (a colloidal dispersion or sol) is formed.
  • colloidal silica a colloidal dispersion or sol
  • Fumed silica which is a very fine particulate form of silicon dioxide, is prepared by burning tetrachlorosilane in an oxygen rich hydrocarbon flame to produce a "smoke" of silicon dioxide.
  • Fumed silica particles and/or their colloids find applications as anticaking agent, as a desiccant, and in cosmetics for its light-diffusing properties. In addition, they are used as abrasives, fillers in paints, coatings and adhesives, and in the production of cat box filler. Applications are also found in medical areas, including drug delivery.
  • Silica particles in aqueous media form a colloidal dispersion which becomes unstable and therefore unusable at high temperatures and high salt concentrations.
  • This disclosure is directed to a colloidal dispersion of inorganic particles in water that is stabilized with soy particles, whey particles, collagen nanoparticles and/or collagen-derived nanoparticles. It is further directed to the use of soy particles, whey particles, collagen nanoparticles and/or collagen-derived nanoparticles for increasing the stability of a colloidal dispersion of inorganic particles in water.
  • the present invention is related to a composition
  • a composition comprising inorganic particles, in particular silica nanoparticles, and protein nanoparticles selected from the group of soy nanoparticles, whey nanoparticles, collagen nanoparticles and collagen-derived nanoparticles.
  • the composition is in particular a colloidal dispersion in an aqueous medium ⁇ i.e. water), wherein at least the inorganic particles form an aqueous colloidal dispersion.
  • the nanoparticles of soy, whey, collagen and collagen-derived material are usually also present as an aqueous colloidal dispersion.
  • the inorganic particles may in principle be any inorganic particle.
  • they are selected from the group of silica particles, sand particles, mineral particles including calcium phosphate and calcium apatite, titanium dioxide particles, aluminum trioxide particles, ceramic particles, metal particles including gold and silver particles, and particles of semi-conductor material.
  • the inorganic particles are silica particles
  • the silica the silica
  • nanoparticles are selected from the group of mesoporous silica particles, fumed silica particles and silica gel.
  • nanoparticles are meant particles with a size in the range of 1 -1000 nm.
  • size is in particular meant the mean cross-section of the particles.
  • the mean particle size of the particles used in the invention is measured by dynamic light scattering (DLS) according to Z-average.
  • the inorganic particles may have a size of 100 ⁇ or less, 50 ⁇ or less, 20 ⁇ or less, 10 ⁇ or less or 1 ⁇ or less.
  • the inorganic particles are nanoparticles. More in particular, their size is in the range of 1 -900 nm, even more in particular 5-800 nm. Usually, their size is
  • Their size may be 1 nm or more, 2 nm or more, 4 nm or more, 7 nm or more, 10 nm or more, 20 nm or more, 40 or more, 70 nm or more or 100 nm or more.
  • nanoparticles selected from the group of soy nanoparticles, whey nanoparticles, collagen nanoparticles and collagen-derived
  • nanoparticles usually have a size in the range of 1 -900 nm, in particular in the range of 5-800 nm, more in particular in the range of 40-600 nm, and even more in particular in the range of 80-500 nm.
  • their size is 750 nm or less, 600 nm or less, 550 nm or less, 450 nm or less, 400 nm or less, 350 nm or less, 300 nm or less, 250 nm or less, 200 nm or less, 150 nm or less, 100 nm or less, 50 nm or less, 25 nm or less or 10 nm or less.
  • Their size may be 1 nm or more, 2 nm or more, 4 nm or more, 7 nm or more, 10 nm or more, 20 nm or more, 40 or more, 70 nm or more or 100 nm or more.
  • collagen nanoparticles are meant nanoparticles that consist of collagen or that contain a certain component of collagen.
  • the collagen may for example be present in amount of at least 20 wt%, at least 35 wt%, at least 50 wt%, at least 60 wt%, at least 70 wt%, at least 80 wt%, at least 90 wt%, at least 95 wt%, at least 98 wt% or at least 99 wt%.
  • collagen-derived nanoparticles are meant nanoparticles that consist of collagen-derived material or that contain a certain component of collagen-derived material.
  • the collagen-derived material may for example be present in amount of at least 20 wt%, at least 35 wt%, at least 50 wt%, at least 60 wt%, at least 70 wt%, at least 80 wt%, at least 90 wt%, at least 95 wt%, at least 98 wt% or at least 99 wt%.
  • collagen (as in collagen nanoparticles) is meant the natural collagen as it can be obtained from an organism without substantial modification, as well as recombinant collagen that can be obtained by genetically modifying the collagen-producing organism.
  • collagen- derived is meant to include material that is derived from the naturally obtained collagen by modifying it, for example by hydrolyzing it. Collagen- derived material for example includes gelatin or gelatin hydrolysates. It also includes material derived from recombinant collagen, such as recombinant gelatin.
  • the collagen and the collagen-derived material are usually obtained from an animal source, for example from pig, bovine, poultry and fish.
  • the whey is usually obtained from bovine milk.
  • nanoparticles selected from the group of soy nanoparticles, whey nanoparticles, collagen nanoparticles and collagen-derived
  • nanoparticles (such as gelatin nanoparticles) can be readily produced using methods disclosed in WO2013004370.
  • the soy nanoparticles, whey nanoparticles, collagen nanoparticles and collagen-derived nanoparticles may be stabilized by a cross linking agent, for example selected from the group of dialdehydes, formaldehyde, isocyanates, diisocyanates, carbodiimides, alkyl dihalides and glutaraldehyde.
  • a cross linking agent for example selected from the group of dialdehydes, formaldehyde, isocyanates, diisocyanates, carbodiimides, alkyl dihalides and glutaraldehyde.
  • the gel strength of the collagen or collagen-derived raw material that is used for preparing the corresponding nanoparticles may be in the range of 50-350 g Bloom, preferably it is in the range of 200-300 g Bloom.
  • the content of inorganic particles may be in the range of 0.05 to 50 wt%, usually it is in the range of 0.1 to 25 wt%.
  • the solids content may in particular be 0.05 wt% or more, 0.07 wt% or more, 0.1 wt% or more, 0.2 wt% or more, 0.5 wt% or more, 0.7 wt% or more, 1 wt% or more, 2 wt% or more, 5 wt% or more, 7 wt% or more, 10 wt% or more, 15 wt% or more, 20 wt% or more, 25 wt% or more, 30 wt% or more, 35 wt% or more, 40 wt% or more or 50 wt% or more.
  • the inorganic particles (a) and the nanoparticles (b) selected from the group of soy nanoparticles, whey nanoparticles, collagen nanoparticles and collagen-derived nanoparticles are usually present in a mass ratio (a) : (b) that lies in the range of 0.1 : 10 to 10 : 0.1 .
  • the mass ratio is in the range of 0.5 : 1 to 5 : 1 .
  • the mass ratio is 1 : 1 or more, 1 : 1 .5 or more, 1 : 2 or more, 1 : 3 or more, 1 : 4 or more or 1 : 6 or more.
  • the invention in particular relies on the surprising effect that nanoparticles of soy, whey, collagen or collagen-derived material are capable of stabilizing an aqueous colloidal dispersion of inorganic particles, in particular of silica nanoparticles.
  • nanoparticles prevent or delay precipitation, flocculation and/or aggregation of the inorganic nanoparticles.
  • a known aqueous colloidal dispersion of inorganic particles is exposed to a change in an environmental condition ⁇ e.g. a change in pH, a change in temperature, contacted with a higher salt concentration
  • precipitation, flocculation and/or aggregation may occur.
  • the protein nanoparticles in the claimed composition nanoparticles of soy, whey, collagen or collagen-derived material
  • the aqueous colloidal dispersion of inorganic particles remains stable when exposed to the same change in an environmental condition.
  • aqueous colloidal dispersions according to the invention remain stable at 60 °C during a certain amount of time, while in aqueous colloidal dispersions that lack the protein nanoparticles that are exposed to the same conditions, a precipitate is formed during the same amount of time.
  • composition of the invention are present as a colloidal dispersion in water.
  • the invention also relates to a stabilized aqueous colloidal dispersion of inorganic particles, the dispersion comprising inorganic particles and nanoparticles selected from the group of soy nanoparticles, whey nanoparticles, collagen nanoparticles and collagen-derived nanoparticles.
  • the collagen-derived nanoparticles in the stabilized aqueous colloidal dispersion are gelatin nanoparticles.
  • the inorganic particles are silica particles, in particular silica nanoparticles. It appeared that an aqueous colloidal dispersion of silica particles, especially silica nanoparticles, is particularly well stabilized by gelatin nanoparticles.
  • soy nanoparticles, whey nanoparticles and collagen nanoparticles are capable of stabilizing aqueous colloidal dispersions of inorganic particles, in particular silica particles, more in particular silica nanoparticles.
  • the stabilized aqueous colloidal dispersion has a content of inorganic particles of at least 0.05 wt%.
  • the stabilized aqueous colloidal dispersion has a pH in the range of 3.0-14.0, in particular of 3.0-9.0, more in particular in the range of 8.0-9.0. It may also have a pH in the range of 5.0- 12.0 or of 6.0-10.0.
  • An effect of the invention is that the shelf-life of the dispersion is increased. Another effect is that the dispersion remains stable ⁇ i.e. it remains a colloidal dispersion) when it is applied for a particular purpose, for example in an environment with a higher temperature, a high salt concentration and/or an extreme pH. Such environment may be found in geological formations such as underground oil and/or gas reservoirs.
  • the invention further relates to the use of a composition as described herein (and in particular to the use of a stabilized aqueous colloidal dispersion of inorganic particles as described herein) as a mobile phase in the recovery of oil and/or gas from underground oil and/or gas reservoirs.
  • a stabilized aqueous colloidal dispersion of inorganic particles according to the invention may also be used for increased rheology control, suspension and stability behavior, adsorbent, free-flow of powders, anti- settling, anti-sagging, anti-blocking, reinforcement, pigment stabilization & dispersion, print definition, anti-setoff, mechanical/optical properties improvement, thixotropy, thickening, hydrophobicity control, and improved processability.
  • a stabilized aqueous colloidal dispersion of inorganic particles according to the invention may in particular be applied in adhesives, sealants, plastics, inks, paints, coatings, defoamers, greases, toner, silicone rubber, agriculture, cable gels, food, fire extinguishers, polyester resins and cosmetics.
  • the invention is in particular suitable for stabilizing an aqueous colloidal dispersion of silica.
  • a stabilized dispersion of the invention may be prepared in several ways. It can be prepared by mixing water with a dry composition of the inorganic particles and the nanoparticles selected from the group of soy nanoparticles, whey nanoparticles, collagen nanoparticles and collagen- derived nanoparticles. It can also be prepared by mixing an aqueous colloidal dispersion of the inorganic particles with the dry nanoparticles selected from the group of soy nanoparticles, whey nanoparticles, collagen nanoparticles and collagen-derived nanoparticles.
  • It can also be prepared by mixing an aqueous colloidal dispersion of the nanoparticles selected from the group of soy nanoparticles, whey nanoparticles, collagen nanoparticles and collagen- derived nanoparticles with the dry inorganic particles. It can also be prepared by mixing an aqueous colloidal dispersion of the nanoparticles selected from the group of soy nanoparticles, whey nanoparticles, collagen nanoparticles and collagen-derived nanoparticles with an aqueous colloidal dispersion of the inorganic particles.
  • the colloidal dispersion containing silica and gelatin particles is usually formed by mixing a silica solution and a gelatin particle solution. Surprisingly, it was found that when gelatin nanoparticles were added to a silica solution, flocculation and sedimentation of the silica was prevented, which is different from the addition of dissolved bulk gelatin, which results in a slow precipitation of the silica. In addition, this effect was observed when a composition of the inorganic particles and the nanoparticles was kept at an increased temperature and/or an increased salt concentration.
  • Gelatin particles may be added to the colloidal dispersion of inorganic particles.
  • the gelatin particles are added as a powder.
  • the gelatin particles are added as a colloidal dispersion.
  • a composition of the invention wherein the inorganic particles are present as a colloidal dispersion in water, has a pH in the range of 3.0-14.0, in particular of 3.0-9.0, more in particular in the range of 8.0-9.0. It may also have a pH in the range of 5.0-12.0 or of 6.0-10.0.
  • the whey, collagen or collagen- derived material may be charged or have a net neutral charge.
  • the type of protein particles is chosen and prepared such that the net charge is positive, negative or neutral at the pH dictated by the application.
  • the invention further relates to a stabilized dispersion obtainable by a method as given hereinabove.
  • the invention further relates to a composition comprising inorganic particles and protein nanoparticles wherein the protein is selected from the group of soy protein, zein protein, whey protein and recombinant protein.
  • the invention is in particular based on the realization that the formulation of a mixture of an inorganic particles dispersion (such as a silica dispersion) with a dispersion of particular nanoparticles (nanoparticles of soy, whey, collagen and collagen-derived material such as gelatin) in an aqueous medium results in a stable colloidal dispersion in which the concentration of the nanoparticles ⁇ e.g. gelatin particles) is high enough to prevent the inorganic particles ⁇ e.g. silica) to flocculate and sediment.
  • an inorganic particles dispersion such as a silica dispersion
  • nanoparticles nanoparticles of soy, whey, collagen and collagen-derived material such as gelatin
  • the colloidal dispersion remains stable at elevated temperatures and increased salt concentration.
  • the stability is tested by subjecting a sample of a dispersion with a certain composition to a stable temperature during at least 15 minutes followed by evaluating the sample by eye. If the sample is still a
  • the specific dispersion is deemed to be stable at the specific temperature. If there is a precipitation at the bottom, if flocks are visible or if any other inhomogeneity is observed by eye, the dispersion is deemed to be unstable.
  • Figures 1 a-1 c shows a graphic result of a particle size distribution after 5, 10 and 15 minutes.
  • Figure 1 a shows the particle size distribution of silicon dioxide particles in aqueous medium (mixture B of the Examples);
  • Figure 1 b shows the particle size distribution of gelatin
  • FIG. 1 c shows the particle size distribution of the mixture of 1 ) mixture B and 2) the FCPGP-RD450 in aqueous medium.
  • the dotted line shows the average hydrodynamic particle size of gelatin nanoparticles in aqueous medium (FCPGP-RD450 of the Examples); the dashed line shows the average hydrodynamic particle size of the mixture of 1 ) mixture B and 2) the FCPGP-RD450 in aqueous medium.
  • the invention further relates to a method for stabilizing a colloidal dispersion of inorganic particles in water, comprising mixing the colloidal dispersion with nanoparticles selected from the group of soy nanoparticles, whey nanoparticles, collagen nanoparticles and collagen-derived
  • the invention further relates to the use of nanoparticles selected from the group of soy nanoparticles, whey nanoparticles, collagen nanoparticles and collagen-derived nanoparticles for improving the stability of a colloidal dispersion of inorganic particles in water.
  • 0.2 wt% Solution 1 .6 mL AI2O3 (Aerosdisp® W925, 1 10 nm, pH 3.0-5.0, 25 %wt) in 198.4 mL demineralized water.
  • AI2O3 Align® W925, 1 10 nm, pH 3.0-5.0, 25 %wt
  • H 0.2 wt% Solution: 4.0 mL CeO2 (Cerium(IV) oxide, ⁇ 25 nm, 10.0 %wt) in 0.5 mL Artificial Ocean Water (ASTM) and diluted with 195.5 mL demineralized water.
  • ASTM Artificial Ocean Water
  • Protein dispersions are prepared according to the technology described in: EP2726068 (A1 ) - CONTINUOUS FLOW PRODUCTION OF GELATIN NANOPARTICLES
  • Stock solutions in an aqueous solution are prepared for the different protein particle dispersions.
  • Mean particle size of the protein particles is measured by DLS according to Z-average.
  • Proteins used for protein nanoparticle formation are Proteins used for protein nanoparticle formation:
  • Whey Whey Davisco - JE 063-4-420
  • Soy protein isolate krachtshop.nl, soy protein isolate neutral
  • Example Inorganic Protein particle Temperature Stable particle type (°C) dispersion at dispersion t 24 h, 60 °C
  • Table 1 1 lists the stabilization of S1O2 dispersions by different protein particles, which is depicted as + in Table 1 1 .

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Colloid Chemistry (AREA)
  • Cosmetics (AREA)

Abstract

Cette invention concerne une composition comprenant des particules inorganiques, en particulier des nanoparticules de silice, et des nanoparticules de protéines choisies dans le groupe des nanoparticules de soja, des nanoparticules de petit-lait, des nanoparticules de collagène et des nanoparticules dérivées du collagène. On a découvert qu'une dispersion colloïdale aqueuse des particules inorganiques de la composition est stabilisée par la présence des nanoparticules de protéines.
PCT/NL2014/050703 2013-10-09 2014-10-09 Dispersions colloïdales aqueuses de particules inorganiques stabilisées WO2015053629A1 (fr)

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Cited By (1)

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WO2007116954A2 (fr) * 2006-03-30 2007-10-18 Fujifilm Corporation Nanoparticule
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WO2013004370A1 (fr) 2011-07-01 2013-01-10 Futurechemistry Production en flux continu de nanoparticules de gélatine
EP2726068A1 (fr) 2011-07-01 2014-05-07 FutureChemistry Holding B.V. Production en flux continu de nanoparticules de gélatine

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CIGDEM O. METIN ET AL.: "Stability of aqueous silica nanoparticle dispersions", J NANOPART RES, vol. 13, September 2010 (2010-09-01), pages 839 - 850
NHU Y THI LE ET AL.: "Design and screening of synergistic blends of silicon dioxide nanoparticles and surfactants for enhanced oil recovery in high-temperature reservoirs", ADV. NAT. SCI.: NANOSCI. NANOTECHNOL., vol. 2, 2011, pages 035013

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3033697A1 (fr) * 2015-03-17 2016-09-23 Univ Pierre Et Marie Curie (Paris 6) Suspensions de collagene injectables, leur procede de preparation et leurs utilisations, notamment pour la formation de matrices denses de collagene
US11654212B2 (en) 2015-03-17 2023-05-23 Universite Pierre Et Marie Curie (Paris 6) Injectable collagen suspensions, the preparation method thereof, and the uses thereof, particularly for forming dense collagen matrices
EP3270882B1 (fr) * 2015-03-17 2023-06-07 Sorbonne Université Suspensions de collagene injectables, leur procede de preparation et leurs utilisations, notamment pour la formation de matrices denses de collagene

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