WO2015048339A4 - Compositions and formulations for non-human nutrition and methods of production and use thereof - Google Patents

Compositions and formulations for non-human nutrition and methods of production and use thereof Download PDF

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Publication number
WO2015048339A4
WO2015048339A4 PCT/US2014/057533 US2014057533W WO2015048339A4 WO 2015048339 A4 WO2015048339 A4 WO 2015048339A4 US 2014057533 W US2014057533 W US 2014057533W WO 2015048339 A4 WO2015048339 A4 WO 2015048339A4
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WO
WIPO (PCT)
Prior art keywords
formulation
nutritive polypeptide
human animal
nutritive
polypeptide
Prior art date
Application number
PCT/US2014/057533
Other languages
French (fr)
Other versions
WO2015048339A2 (en
WO2015048339A9 (en
WO2015048339A3 (en
Inventor
Kathryn HEARD
Michael J. HAMILL
Ying-Ja CHEN
Nathaniel W. SILVER
David A. Berry
Original Assignee
Pronutria, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pronutria, Inc. filed Critical Pronutria, Inc.
Publication of WO2015048339A2 publication Critical patent/WO2015048339A2/en
Publication of WO2015048339A9 publication Critical patent/WO2015048339A9/en
Publication of WO2015048339A3 publication Critical patent/WO2015048339A3/en
Publication of WO2015048339A4 publication Critical patent/WO2015048339A4/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/30—Oligoelements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Pediatric Medicine (AREA)
  • Insects & Arthropods (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.

Claims

AMENDED CLAIMS
received by the International Bureau on 1 1 Septemer 2015 (1 1 .09.2015)
1. A formulation comprising an isolated nutritive polypeptide, wherein the nutritive polypeptide comprises an amino acid ratio capable of providing nutrition for a non-human animal at an efficiency greater than the proteins present in the diet of the non-human animal, wherein the formulation contains the nutritive polypeptide in an amount sufficient to deliver at least 10% of the daily protein nutritional need of the non-human animal when administered thereto, and wherein the formulation is substantially free of non-comestible products;
wherein the nutritive polypeptide is at least 90% identical to a polypeptide selected from the group consisting of SEQ1D 00001-03909; wherein the solubility of the nutritive polypeptide exceeds about lOg l and wherein the nutritive polypeptide has a simulated gastric digestion half-life of less than sixty minutes.
2. The formulation of claim I . wherein the nutritive peptide is present in the formulation in an amount equal to at least 250 milligrams per kilogram of body weight of the non-human animal for whom the formulation is suitable for administration.
3. The formulation of claim 2, wherein the non-human animal is a mammal, such as a companion animal or a livestock animal.
4. The formulation of claim 2, wherein the non-human animal is a bird or a fish.
5. The formulation of any one of the preceding claims, wherein the nutritive polypeptide comprises at least one amino acid essential to the non-human animal.
6. The formulation of any one of the preceding claims, wherein the nutritive polypeptide comprises at least one essential amino acid selected from the group consisting of arginine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan and valine, and wherein the non-human animal is a member of the Canis genus; optionally wherein the formulation further comprises an effective amount of carnitine, calcium, iron, magnesium, or a combination thereof.
359
7. The formulation of any one of claims 1 to 5, wherein the nutritive polypeptide comprises at least one essential amino acid selected from the group consisting of arginine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine, and taurine and wherein the non-human animal is a member of the Felis genus; optionally wherein the formulation further comprises an effective amount of calcium, iron, magnesium, or a combination thereof.
8. The formulation of claim 6 or claim 7, comprising at least 5% nutritive polypeptide on a mass basis.
9. The formulation of any one of the preceding claims, formulated for enteral or parenteral administration.
10. The formulation of any one of claims 1 to 8, formulated as a liquid, solid, or gel.
1 1. The formulation of any one of claims 1 to 8, wherein the formulation is formulated for consumption as a food or beverage.
12. The formulation of any one of claims I to 8, further comprising an agriculturally- derived food product.
13. The formulation of any one of the preceding claims, wherein the nutritive polypeptide comprises an enzyme or enzyme-class polypeptide; optionally wherein the nutritive polypeptide comprises an enzyme having a detectable enzymatic activity, e.g. a phytase.
1 . The formulation of any one of the preceding claims, wherein the nutritive polypeptide is non-allergenic.
15. The formulation of any one of the preceding claims, wherein the nutritive polypeptide has a calculated solvation score of -20 or less; and/or wherein the nutritive polypeptide has a calculated aggregation score of 0.75 or less.
16. The formulation of any one of the preceding claims, further comprising an agent, wherein the agent comprises a carbohydrate, lipid, fatty acid, protein, vitamin, mineral, or combination thereof; or wherein the agent comprises indium, taurine, phytic acid, or selenium; or wherein the agent comprises a camallite salt; or wherein the agent comprises a 2-methylthioethyl-substituted heterocycle or an N-phenylphosphoric acid triamide, a chromium(lH) 1 :3 complex of amino acids in an amount effective to prevent or treat glucose intolerance, an isoflavone in an amount effective to prevent or treat sarcopenia or muscle atrophy, or lactic acid in an amount effective to prevent or treat a bacterial infection.
17. The formulation of any one of the preceding claims, further comprising a preservative.
PCT/US2014/057533 2013-09-25 2014-09-25 Compositions and formulations for non-human nutrition and methods of production and use thereof WO2015048339A2 (en)

Applications Claiming Priority (60)

Application Number Priority Date Filing Date Title
US201361882234P 2013-09-25 2013-09-25
US201361882232P 2013-09-25 2013-09-25
US201361882222P 2013-09-25 2013-09-25
US201361882267P 2013-09-25 2013-09-25
US201361882212P 2013-09-25 2013-09-25
US201361882219P 2013-09-25 2013-09-25
US201361882271P 2013-09-25 2013-09-25
US201361882229P 2013-09-25 2013-09-25
US201361882214P 2013-09-25 2013-09-25
US201361882243P 2013-09-25 2013-09-25
US201361882246P 2013-09-25 2013-09-25
US201361882180P 2013-09-25 2013-09-25
US201361882129P 2013-09-25 2013-09-25
US201361882235P 2013-09-25 2013-09-25
US201361882254P 2013-09-25 2013-09-25
US201361882225P 2013-09-25 2013-09-25
US201361882211P 2013-09-25 2013-09-25
US201361882220P 2013-09-25 2013-09-25
US201361882295P 2013-09-25 2013-09-25
US201361882233P 2013-09-25 2013-09-25
US201361882274P 2013-09-25 2013-09-25
US201361882198P 2013-09-25 2013-09-25
US201361882250P 2013-09-25 2013-09-25
US201361882300P 2013-09-25 2013-09-25
US201361882264P 2013-09-25 2013-09-25
US201361882260P 2013-09-25 2013-09-25
US201361882240P 2013-09-25 2013-09-25
US201361882189P 2013-09-25 2013-09-25
US201361882305P 2013-09-25 2013-09-25
US61/882,246 2013-09-25
US61/882,250 2013-09-25
US61/882,234 2013-09-25
US61/882,233 2013-09-25
US61/882,222 2013-09-25
US61/882,225 2013-09-25
US61/882,129 2013-09-25
US61/882,235 2013-09-25
US61/882,300 2013-09-25
US61/882,198 2013-09-25
US61/882,271 2013-09-25
US61/882,243 2013-09-25
US61/882,274 2013-09-25
US61/882,219 2013-09-25
US61/882,264 2013-09-25
US61/882,212 2013-09-25
US61/882,211 2013-09-25
US61/882,220 2013-09-25
US61/882,267 2013-09-25
US61/882,189 2013-09-25
US61/882,232 2013-09-25
US61/882,214 2013-09-25
US61/882,229 2013-09-25
US61/882,254 2013-09-25
US61/882,295 2013-09-25
US61/882,240 2013-09-25
US61/882,260 2013-09-25
US61/882,305 2013-09-25
US61/882,180 2013-09-25
US201361906862P 2013-11-20 2013-11-20
US61/906,862 2013-11-20

Publications (4)

Publication Number Publication Date
WO2015048339A2 WO2015048339A2 (en) 2015-04-02
WO2015048339A9 WO2015048339A9 (en) 2015-07-02
WO2015048339A3 WO2015048339A3 (en) 2015-08-27
WO2015048339A4 true WO2015048339A4 (en) 2015-11-12

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WO2015048339A9 (en) 2015-07-02
WO2015048339A3 (en) 2015-08-27

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