WO2015042679A1

WO2015042679A1 - Nanosalt, cryogenic grinding process, aerosol and use of said aerosol

Info

Publication number: WO2015042679A1
Application number: PCT/BR2014/000350
Authority: WO
Inventors: Eduardo CARITÀ; José Luiz de Paula JÚNIOR; Antal Gyorgy ALMÁSY
Original assignee: Ultrapan Ind. E Com. Ltda
Priority date: 2013-09-26
Filing date: 2014-09-26
Publication date: 2015-04-02

Abstract

The present invention patent application relates to: a) a sodium chloride (NaCl) nanoparticulate material having particles of less than 500 nm; b) a cryogenic grinding process for refined, iodized salt, or other substances such as soluble and insoluble salts, oxides or complex bioactive substances, such as caffeine, coenzymes, metals, dietary elements, vitamins, essential oils, pure or combined; and c) an aerosol comprised of 1-99% by weight gas propellants and 1-99% nanoparticles. Due to the reduced size of the particles in the sodium chloride nanoparticulate material, there is greater distribution thereof on taste buds and greater salty taste perception, wherein said nanoparticulate material can be used in a smaller amount than conventional salt to obtain the same salty taste perception. The cryogenic grinding process consists of the steps of drying and cryogenic grinding in a micronizer containing liquid nitrogen or other cooling liquid, at temperatures of -10 to -150°C. The aerosol preferably comprises 10-20% by weight sodium chloride and 80-90% gas propellants, wherein said propellants can be compressed air, butane, dimethyl ether, carbon dioxide, isobutane, isopentane, hydrofluorocarbon 134a, hydrofluorocarbon 152a, hydrofluorocarbon 227, nitrogen, nitrous oxide, pentane and propane, alone or in any proportion.

Description

NANOSAL, CROMOMOTION PROCESS, AEROSOL AND USE OF

AEROSOL

Field of the invention:

[1] This invention is in the field of nanotechnology and nanomaterials, more specifically in the field of food and pharmaceuticals, cosmetics, cosmeceuticals, nutraceuticals and herbal medicines; and describes a nanosal which has altered organoleptic properties and a higher salting power.

[2] Nanosal is obtained by the process of cryomolysis and is provided in aerosol form which comprises nanoparticulate material (ie nanosal) and a propellant gas solution.

[3] In addition, the present invention provides for the use of nanosal aerosol to reduce sodium content in the most diverse areas.

Background of the invention:

[4] Salt, also known as table salt or rock salt (halite), is a white, light gray or pale pink crystalline mineral usually obtained from seawater or rocky deposits. It is composed mainly of sodium chloride (NaCl), which belongs to the class of ionic salts.

[5] Sodium and chloride, the two main components of salt, are needed by all living things, even in small quantities: 40% sodium and 60% chlorine salt is involved in regulating the body's water content. (fluid balance) and the transmission of nerve impulses of electrical conduction throughout the body.

[6] It is worth mentioning that all salt sold for human consumption in Brazil and in many countries, whether from land or sea, is necessarily added iodine as a prophylactic measure to endemic goiter. Therefore, the name cooking salt is equivalent to iodized refined salt.

[7] Excess salt causes the body to retain more water, which It increases the pressure within the arteries and, in turn, the risk of cardiovascular disease.

Cryomoagem:

[8] Cryogenic crushing or milling is the use of a cryogenic liquid for the grinding of various materials, in which the heat generated by friction during operation is rapidly absorbed by the cryogenic liquid, avoiding thermal decomposition of the product and emission of elements. volatile in the atmosphere.

[9] The low process temperature (around -190 ° C) favors the disruption of the sodium chloride crystal and at this level! minimum power, any shock (mechanical energy) added to the system is sufficient to break it down.

[10] Cryoaming processes are typical for obtaining ultra-fine electronics inputs, as well as nano composites, nano sintered metals and molecular filters, among others, generating a particle size between 2 and 10 nm.

Gustation Physiology and Objectives of the Invention:

[1 1] In light of new knowledge about the physiology of smell and taste, it is understood that the distribution of taste buds in the oral cavity and their physicochemical and biological interaction with sodium chloride particles are responsible for stimulating papillary recognized as "salt taste".

[12] When in contact with nanosal, taste buds are stimulated by smaller but numerous salt particles, which together convey the same intensity of salt as the refined iodized salt.

[13] With time and continued repetition comes the typical saturation of chemical sensors that, once triggered, take some time to be able to re-stimulate, always

requiring a slight elevation of the stimulus by raising the excitation threshold with each new cycle. [14] Thus, the aim of the present invention is to provide an alternative to reducing salt consumption by providing a nanosal. Its altered organoleptic properties, with higher salting power, are due to its higher reactivity or dissolution rate in liquid medium, which results in a lower amount of salt to stimulate the taste buds.

[15] The invention proposes a new technological pathway for reducing sodium content, completely unconnected with the usual substitution routes.

[16] With more than half of the crystals in sub-micron condition, nanosal density is about four times lower and has increased speed and dissociation coefficient relative to iodized refined salt.

Advantages of the Invention:

[17] The proposed invention makes it possible to control sodium content by reducing daily nanosal intake over conventional salt. The reduction of consumption leads,

consequently, a reduction in sodium intake.

[18] Nanosal is especially recommended for hyposodic diets and prevention of the cascade of hypertensive events that culminate in chronic seizures of

arterial hypertension.

[19] The recommendation of nanosal is also elective in cases of Benign Essential Hypertension, whose control may lead to a statistical reduction in stroke and coronary hypertension, among others.

[20] Nanosal is still an adjunct to the arsenal.

chronic heart disease in all clinical stages, without the need to abandon the hyposodic diet.

[21] Nanosal is supplied as an aerosol which

comprises nanoparticulate material (i.e. nanosal) and a propellant gas solution. In this way, the stability of the nanoparticulate and avoids contact with the environment.

[22] Also, nanosal does not use preservatives: not only sa! It has intrinsic preservative properties, as well as the aerosol system, being closed under high pressure, is free and immune to microbiological contamination.

State of the art:

[23] Some prior art documents describe salts on a smaller scale and the use of cryomion to obtain

nanoparticles.

[24] Prior document US 7923047 describes a seasoning to decrease sodium intake, wherein the particles have an average size of less than or equal to 20 microns.

[25] In contrast, the nanosal dimensional scale of the present invention has a nanometric particle size distribution, which requires controlled technical requirements (much lower temperature, from -10 to -150 ° C) and differentiated equipment. For the reduction of refined salt below 20 microns, classical micronization at room temperature using regular equipment is sufficient.

[26] Yet, once on this scale, nanosal acquires exacerbated hygroscopicity due to the brutal increase in its surface area. Thus, a medium which completely isolates it from the relative humidity of the air such as the aerosol proposed in the present invention is required.

[27] Additionally, nanosal exhibits increased dissociation velocity and consequently much higher sensory impact using a drastically lower mass of sodium chloride.

[28] "Combined Cryo and Room-Temperature Ball Milling to Produce Ultrafine Halide Crystallites" reports the use of cryoproming followed by room temperature milling, where milling processes are performed with spheres.

[29] The cryomion process of the present invention utilizes a single temperature for a short time. Still, there is no use of spheres: the particles themselves shear themselves when accelerated in the grinding chamber.

[30] Smaller particles accelerate faster, colliding with larger ones in frontal and tangential shocks. Tangential shocks thin the surface profile of the larger crystals, reducing their initial size.

[31] In WO 2008005231, 20 micron salt particles are used as a flavor enhancing adjunct to other food flavorings.

[32] The nanosal proposed here is capable of salting a portion of food in small quantities and alone, acting on the salty taste specific taste buds in a specialized and non-diffused manner.

[33] In US 2011/003037, salt particles in the range 2 to 2000 nm are obtained by flame spray pyrolysis, which provides for the dissociation of salt into liquid for further flame spraying followed by grinding.

[34] Unlike the present invention, the process described is a physicochemical process in which there is prior saline solvation followed by explosive flame drying.

[35] The cryomorphic process of the present invention is purely physical, one-step, and occurs at very low temperatures without further drying.

[36] The nanosal obtained promotes the reduction of the ingestion of contents by increase of contact surface and by increase of dissociation coefficient, promoting nervous stimulation with smaller amount of salt.

[37] WO 2007010405 refers to the use of nanoscale particles (less than 500 nm) to modify taste sensation, which are obtained by grinding, ball milling, electro-spraying, flame pyrolysis methods. cycle evaporation / condensation, among others.

[38] The cryomion process of the present invention takes place at very low temperatures and the salt remains in its solid state throughout the process. In contrast, the salt described in WO 2007010405 is sublimated by laser ablation to then return to solid state by condensation.

[39] Condensed particles are necessarily spherical, with sub-stoichiometric atomic distribution, and part of their performance is attributed to this feature. In contrast, nanosal particles are fractal and stoichiometric.

[40] Also, in the salt described in WO 2007010405, Mg, Ca, K atoms may replace sodium in the vacant spaces of the condensed '¾ crystalline structure, and there are also vacant vacant spaces. The nanosal of this invention comprises only Na ⁺ and Cl ^" , without substitution or vacancy.

[41] Thus, the subject matter described in this invention is novel and inventive in view of the documents and teachings described in the prior art.

Brief Description of the Invention:

[42] This invention describes a nanosal, which presents

altered organoleptic properties and greater salting power,

compared to the same mass of iodized refined salt.

[43] Nanosal is obtained by the cryocoupling process and is

provided in aerosol form comprising the material

nanoparticulate (ie nanosal) and a gas solution

propellants, maintaining the stability of the nanoparticle and avoiding its contact with the environment.

[44] In addition, the present invention provides for the use of

nanosal aerosol in reducing sodium contents.

Detailed Description of the Invention:

- Nanosal:

[45] This invention describes a nanosal, which presents altered organoleptic properties and greater salting power. Said nanosal is stoichiometric, that is, the molecules have the ratio of Na and Cl at 1: 1.

[46] Nanosal emerges as a new proposal for reducing the particle size of NaCI, which keeps the molecule intact and at the same time increases its supramolecular surface.

[47] Thus, the surface of NaCI particles is tenfold or tenfold, so that each particle contains only a few hundred molecules of the same sodium chloride instead of thousands or even millions.

[48] That is, each mol of nanosal has 58g of pure sodium chloride and has the same 6.02x10 ²⁸ molecules present in one mol of conventional salt. However, such molecules are aggregated and distributed in a larger number of particles, where the particles are smaller in size and about 500 nm.

[49] As stated earlier, it is not the amount of molecules that causes the papillary stimulus to be recognized as "like salf" but its distribution in the oral cavity.

[50] Thus, the same taste buds, stimulated by smaller but more numerous salt particles, convey the same salty sensation, with the same intensity, using only 40 to 60% of the equivalent of a common salt (iodized refined salt). .

[51] However, there are technical challenges involved in obtaining a nanosal such as the one proposed here, namely:

- How to keep particles of approximately 500 nm without re-grouping, knowing that there is a natural tendency of formation of larger crystals?

- Hygroscopicity is a function of the crystal's own surface of exposure to ambient humidity. Therefore, increasing the surface also increases the ability to absorb water in the same proportion. How to avoid moisture and physical instability of particles? [52] The difficulties encountered in nanosal and other molecules or associations presented in this concept are related to high supramolecular reactivity, where they are considered

intrinsic characteristics of matter in the solid state.

[53] Along with highly desirable characteristics, particles on this scale also exhibit paradoxical behaviors not expected for cations and anions.

[54] In the case of sodium chloride with D90 less than 1 micron and D50 less than 600 nanometers (where Dx is the particle size distribution in x%), more than half of the crystals are in sub-micron condition. In this case, there is a decrease in the density of almost four times compared with the conventional refined iodized salt: 1 10 to 1 15 g / cm ³ to 0.30 to 0.35 g / cm ^3, preferably 1, 12 g / cm ³ to 0.32 g / cm ³ . Additionally, the dissociation rate and the dissociation coefficient are increased.

[55] Hence comes the nanosal's "superior" ability to salt food, or rather to better spread over the surface of a food and, when eaten, to dissociate, reaching in a shorter time more taste buds. responsible for the feeling of salty.

- Cryomation process:

[56] The process of obtaining nanoparticles, such as nanosal, is based on the concept of increasing surface area of the particles through physical processes which can be briefly described as drying, liquid nitrogen micronizer cryomation or other liquid. refrigerant and, optionally, the adoption of extemporaneous process elements such as metal microspheres or other high rigidity materials to aid in grinding.

[57] In addition to iodized refined salt, other substances may have their supramolecular surface increased with the process of

cryomation of this invention. These include soluble and insoluble salts, oxides or complex bioactive substances (such as caffeine, coenzymes, metals, trace elements, vitamins, essential oils - pure or in

which may have quantum properties linked to metabolism, uptake, bioavailability, bio-efficacy or sensory perception by the human or animal organism.

[58] The cryomation process consists of introducing the

Particularly desired substance, such as nanosal, in high hardness, top and bottom-sealed, cylindrical trunk metal chambers, with a single upper centralized orifice of sufficient diameter to empty at appropriate times. The material is

introduced by dragging compressed air at high pressures (from 1 to 20 kg / cm ² ).

[59] The process takes place at very low temperatures, ranging from -10 to -150 ° C, where the particular particles desired are in circular motion.

[60] Smaller particles clash violently with larger ones in less effective frontal shocks and tangential shocks, more effective in thinning and particle reduction. Molecular crystal fractures do not intrinsically alter molecules, so nanosal retains its stoichiometry.

[61] The process occurs in chain reaction, in which an increasing number of smaller particles collide with the remaining larger particles.

[62] Upon reaching the appropriate size, the particles are "sucked" through an appropriate conductor and then transferred to the filling tanks.

[63] The cryomion process used to obtain the nanosal of the present invention completely disregards the adoption of extemporaneous elements of the process such as spheres.

[64] However, for other assets and the need for

lower particle size dispersions, an appropriate amount of metal or other spheres may optionally be added. high stiffness materials to assist in the cryocoupling process.

- Aerosol:

[65] As previously mentioned, there is a natural tendency for larger crystals to form from nanoparticles.

[66] Thus, nanoparticles such as nanosal particles must be made viable, considering their high hygroscopicity and physical instability, avoiding reaglomeration and preserving

nanometric particle characteristic.

[67] In view of this, the present invention proposes the use of aerosol, in which nanometer particles are associated with a propellant. Furthermore, the particles are isolated from physical contact with air, limited to a strictly controlled and moisture-free microenvironment.

[68] In addition to hygroscopicity, typical characteristics of these substances, such as photo- lability, oxidability, peroxidability, hydroperoxidability, and functional susceptibility to other gases may be controlled by aerosol presentation.

[69] For this purpose, aerosol-specific packaging (already commercially available) and chemicals are used.

duly approved by the local health authority and international regulatory bodies for food, cosmetic,

cosmeceutical, pharmaceutical and related.

[70] In addition, the package containing the nanoparticulate aerosol contains potential energy in the form of pressure generated by the propellant / expander, allowing the product to be expelled lightly and in a controlled manner. Container packaging can be adapted to various types of applicator nozzles, allowing for ease of application vertically, inverted or any other position.

[71] The aerosol proposed by the invention does not use CFCs in its composition and is harmless to the ozone layer, environmentally friendly and environmentally acceptable as its Packaging and propellant are recyclable and dispersible without environmental damage.

[72] The propellant gas combination fulfills the conventional function of propelling the solid phase into the external environment and,

Additionally, eliminate traces (parts per million) of water adhered to the surface of the NaCl molecules during the cryomion process, thus avoiding coalescences, recrystallizations and agglomerations typical of nanoparticles.

[73] Table 1 below lists possible propellants, which may be listed singly or in admixture in any proportion.

Table 1: Propellants for Aerosol Use

[74] Usually, the colloidal dispersion will have from 1 to 99% mass in gaseous propellants and from 1 to 99% nanoparticle to be dispensed.

[75] In the case of nanosai, the preferred proportion is around 5 to 25% mass of sodium chloride and 75 to 95% propellant gases, preferably 10 to 20% mass of chloride. sodium and 80% to 90% propellant gases.

[76] The aerosol packaging must be made of aluminum, tinplate, PET or other resistant material that can withstand the internal pressures safely.

[77] Also, the aerosol can be of the conventional or bi, t or multicompartmental type, ie the propellant is in direct contact with the nanoparticle or is restricted within a chamber and is expelled by propellant pressure, which is external to it.

[78] The valve may be aluminum, tinplate, high density polyethylene or other material that allows application in any position. Its internal mechanism, which is not the subject of this patent, allows smooth opening and closing via an actuator button / nozzle, which allows continuous flow or outflow or metered flow in predetermined quantities, this aerosol valve mechanism being known as "dosing valve".

- Nanoparticle filling in aerosol:

[79] In conventional type aerosol, the bulk of the nanoparticle is filled by mass (g) into the vacuum containing container up to 600; mmHg and the valve is crimped to maintain full tightness while preserving the vacuum.

[80] The propellant / expander is filled by grease (g) through the same valve mechanism and finally the nozzle is

actuator / actuator.

[81] In bicompartmental type aerosol, the valve supporting the pouch is recapped after injection of the external propellant, thus producing the pressurization required to expel the contents.

[82] Sometimes the process used is known as "undercap", in which the pressurization or vacuum occurs before the valve is recraped. At other times, the construction of the valve allows for its preliminary crimping with the pouch and subsequent injection of the external propellant. Once the container bottle has been pressurized, the bulk of the The formulation is injected through the valve mechanism into the inner chamber of the pouch. Following this process, the actuator / actuator nozzle is fitted.

- Aerosol use:

[83] The invention further relates to the use of nanoparticulate aerosol in the pharmaceutical, cosmetic, cosmeceutical, nutraceutical and phytotherapeutic fields.

[84] Specifically, as far as nanosal aerosol is concerned, its use is associated with reduced sodium content in the most diverse areas.

[85] Those skilled in the art will enhance the knowledge presented herein and may reproduce the invention in the embodiments disclosed and in other embodiments within the scope of the appended claims.

Claims

1 - Nanosal characterized by having altered organoleptic properties and a higher salting power, wherein said nanosal is stoichiometric regarding the proportion of Na and Cl and has increased supramolecular surface.

Nanosal according to claim 1, characterized in that the molecules are aggregated and distributed in a larger number of particles, where the particles are smaller in size and about 500 nm.

3. Cryo-forming process, characterized in that it comprises drying and cryogenating steps in a micronizer with liquid nitrogen or other refrigerant.

Cryo-forming process according to claim 3, characterized in that it consists of the introduction of the desired substance into high-hardness, cylindrical stem, closed-top, upper and lower metal chambers with a single centralized orifice. larger than sufficient diameter to empty at the appropriate times by means of compressed air dragging at high pressures, preferably from 1 to 20 kg / cm ² at temperatures ranging from -10 to -150 ° C, where the particles are in circular motion and collide with each other in chain reaction.

Cryomation process according to claim 4, characterized in that the substance is iodized refined salt or other substances selected from soluble and insoluble salts, oxides or complex bioactive substances such as caffeine, coenzymes, metals, trace elements, vitamins. , essential oils - pure or in combination.

Aerosol characterized by the fact that it comprises nanometric particles associated with a propellant agent, in a colloidal dispersion that has from 1 to 99% mass in gaseous propellants and from 1 to 99% nanoparticles.

Aerosol according to Claim 6, characterized in because it comprises the proportion of 5 to 25% by mass of sodium chloride and 75 to 95% of propellant gases, preferably 10 to 20% by mass of sodium chloride and 80% to 90% of propellant gases.

Aerosol according to claim 6 or 7,

propellants are selected from the group consisting of compressed air, butane, dimethyl ether, carbon dioxide, isobutane, isopentane, hydrofluorocarbon 134a, hydrofluorocarbon 152a, hydrofluorocarbon 227, nitrogen, nitrous oxide, pentane and propane, alone or in any proportions.

9- Use of aerosol characterized by being in the pharmaceutical, cosmetic, cosmeceutical, nutraceutical and phytotherapeutic fields.

Use of aerosol according to claim 9, characterized in that it is preferably in the reduction of sodium contents - in the most diverse areas.