WO2015026552A3 - Mucoadhesive devices for delivery of active agents - Google Patents

Mucoadhesive devices for delivery of active agents Download PDF

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Publication number
WO2015026552A3
WO2015026552A3 PCT/US2014/050527 US2014050527W WO2015026552A3 WO 2015026552 A3 WO2015026552 A3 WO 2015026552A3 US 2014050527 W US2014050527 W US 2014050527W WO 2015026552 A3 WO2015026552 A3 WO 2015026552A3
Authority
WO
WIPO (PCT)
Prior art keywords
region
active agents
delivery
mucoadhesive
mucoadhesive devices
Prior art date
Application number
PCT/US2014/050527
Other languages
French (fr)
Other versions
WO2015026552A2 (en
Inventor
Vijay M. K. MURTHY
David Adam STEINBERG
Rodney Pearlman
Howard Brian ROSEN
Robert Samuel Langer
Hila Epstein-Barash
Jonathan Robert Behr
Baruch Z. HARRIS
Samir Suresh MITRAGOTRI
Original Assignee
Entrega, Inc.
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Entrega, Inc., The Regents Of The University Of California filed Critical Entrega, Inc.
Publication of WO2015026552A2 publication Critical patent/WO2015026552A2/en
Publication of WO2015026552A3 publication Critical patent/WO2015026552A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)

Abstract

Described herein are systems and methods for transmucosal delivery of active agents. In some embodiments, a system may comprise one or more mucoadhesive devices configured for release of an active agent. In one aspect, a polymeric controlled release preparation is provided. The preparation comprises a mucoadhesive layer comprising a first region and a second region, the first region being substantially surrounded by the second region, wherein the first region comprises an active agent and the second region comprises a mucoadhesive material.
PCT/US2014/050527 2013-08-23 2014-08-11 Mucoadhesive devices for delivery of active agents WO2015026552A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361869289P 2013-08-23 2013-08-23
US61/869,289 2013-08-23

Publications (2)

Publication Number Publication Date
WO2015026552A2 WO2015026552A2 (en) 2015-02-26
WO2015026552A3 true WO2015026552A3 (en) 2015-11-05

Family

ID=52484251

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/050527 WO2015026552A2 (en) 2013-08-23 2014-08-11 Mucoadhesive devices for delivery of active agents

Country Status (1)

Country Link
WO (1) WO2015026552A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3209205A1 (en) 2021-03-15 2022-09-22 Gil Cohen Expandable devices for delivery of active agents to tissues
WO2024062466A1 (en) 2022-09-21 2024-03-28 Epitomee Medical Ltd. Controllably disintegrable self-expandable ingestible devices

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030017195A1 (en) * 2001-07-20 2003-01-23 Samir Mitragotri Method for oral drug delivery
US20040013688A1 (en) * 2002-07-03 2004-01-22 Cambridge Scientific, Inc. Vaccines to induce mucosal immunity
US20070148097A1 (en) * 2005-12-13 2007-06-28 Biodelivery Sciences International, Inc. Abuse resistant transmucosal drug delivery device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030017195A1 (en) * 2001-07-20 2003-01-23 Samir Mitragotri Method for oral drug delivery
US20040013688A1 (en) * 2002-07-03 2004-01-22 Cambridge Scientific, Inc. Vaccines to induce mucosal immunity
US20070148097A1 (en) * 2005-12-13 2007-06-28 Biodelivery Sciences International, Inc. Abuse resistant transmucosal drug delivery device

Also Published As

Publication number Publication date
WO2015026552A2 (en) 2015-02-26

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