WO2015024042A1 - Immunoreceptor modulation for treating cancer and viral infections - Google Patents
Immunoreceptor modulation for treating cancer and viral infections Download PDFInfo
- Publication number
- WO2015024042A1 WO2015024042A1 PCT/AU2013/001132 AU2013001132W WO2015024042A1 WO 2015024042 A1 WO2015024042 A1 WO 2015024042A1 AU 2013001132 W AU2013001132 W AU 2013001132W WO 2015024042 A1 WO2015024042 A1 WO 2015024042A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cells
- mammal
- inhibitory agent
- antibody
- immune
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Definitions
- NK cells are innate lymphocytes critical to limit early tumor growth and metastasis NK cell functions are also regulated by the integration of signals transmitted by a wide range of activating and inhibitory receptors 2 .
- activating receptors such as NCRs, NKG2D, or DNAM-1 stimulate NK cells cytotoxicity and the secretion of pro-inflammatory mediators such as interferon gamma (IFN-y) 3 .
- IFN-y interferon gamma
- inhibitory receptors protect target cells from NK cell- ⁇
- CD96 acts as a negative regulator of T cell and NK cell anti-tumor functions. Accordingly, the invention is broadly directed to use of agents that at least partly block or inhibit CD96 to thereby reduce or relieve CD96-mediated immune inhibition to enhance or restore immune surveillance in the mammal. In certain embodiments, this may facilitate treatment of diseases or conditions responsive at least partial blocking or inhibition of CD96, such as cancers and/or viral infections.
- the CD96-inhibitory agent is an anti- viral agent.
- FIG. 1 CD96 competes with DNAM-1 for CD155 binding
- a, b The expression of CD96 was analyzed by flow cytometry on the indicated spleen lymphocyte populations from C57BL/6 WT (light grey) and CD96 J - mice (dark grey). The representative FACS Histograms (a) and the mean + SD (b) of 3 mice from one representative experiment out of 3 are shown, c, d
- the expression of CD96, DNAM- 1 and TIGIT was determined on WT spleen NK cells freshly isolated or activated for 48 hrs with IL-2 (1000 U/ml). e.
- CD96 and TIGIT compete with DNAM-1 for the binding of CD155 at the cell surface of B16F10.
- the binding of DNAM-1 -Fc labeled with AF-647 (0.5-20 ⁇ g ml) at the cell surface of B16F10 cells was analyzed in the presence of 50 g ml of control Ig, recombinant CD96 or TIGIT-Fc.
- the FACS histograms and the mean + SD of triplicate wells from one representative experiment out of 3 are shown, d.
- a 4 hr 5l Cr release assay was performed between B16F10 cells and IL-2-activated NK cells from WT, DNAM-1 1' and CD9G 1' mice at the indicated effector target ratios.
- the elements of the immune system are one or more cells that normally express CD96, such as T cells, inclusive of CD4 + and CD8 + T cells ⁇ cells, NKT cells and natural killer (NK) cells.
- administering is meant the introduction of the CD96-inhibitory agent into the mammal by a particular route.
- a therapeutically effective amount of the CD96-inhibitory agent is administered to the mammal.
- the method of the invention may be useful in reducing or relieving CD96-mediated immune inhibition, suppression or peripheral tolerance.
- the method facilitates treatment or prevention of one or more diseases or conditions that are responsive to at least partly blocking CD96-mediated immune inhibition, suppression or peripheral tolerance.
- the one or more other agents that facilitate cancer treatment or prevention may be administered in combination with the CD96-inhibitory agent or be administered separately, as is well understood in the art.
- pharmaceutically-acceptable carrier diluent or excipient
- a solid or liquid filler diluent or encapsulating substance that may be safely used in systemic administration.
- carriers, diluents and excipients well known in the art may be used. These carriers, diluents and excipients may be selected from a group including sugars, f
- the CD96 deletion was backcrossed onto a C57BL/6 background, facilitated by a genome- wide screening of polymorphic microsatellite markers at 10- centiMorgan intervals at each generation.
- CD96 +/" >99% C57BL/6 mice were intercrossed to generate the CD96 ⁇ _ mice.
- DNAM-1 "A mice have already been described.
- DNAM-1 A CD96 'A were generated by intercrossing CD96 '7" with DNAM- Y 1' mice. Mice were bred and used between the ages of 6-14 weeks. All experiments were approved by animal ethics committee.
- mice were checked hourly for symptoms of sepsis. Serum from these mice was taken at various time points by retro-orbital or cardiac bleeding for cytokine analysis. Spleens were Jt"
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Claims
Priority Applications (36)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201380079711.6A CN105636983A (en) | 2013-08-22 | 2013-10-03 | Immunoreceptor modulation for treating cancer and viral infections |
MX2016002265A MX2016002265A (en) | 2013-08-22 | 2013-10-03 | Immunoreceptor modulation for treating cancer and viral infections. |
AU2013398294A AU2013398294A1 (en) | 2013-08-22 | 2013-10-03 | Immunoreceptor modulation for treating cancer and viral infections |
KR1020167007431A KR20160055818A (en) | 2013-08-22 | 2013-10-03 | Immunoreceptor modulation for treating cancer and viral infections |
US14/913,347 US20160200814A1 (en) | 2013-08-22 | 2013-10-03 | Immunoreceptor modulation for treating cancer and viral infections |
CA2921772A CA2921772A1 (en) | 2013-08-22 | 2013-10-03 | Immunoreceptor modulation for treating cancer and viral infections |
SG11201601285XA SG11201601285XA (en) | 2013-08-22 | 2013-10-03 | Immunoreceptor modulation for treating cancer and viral infections |
EP13891700.0A EP3036255A4 (en) | 2013-08-22 | 2013-10-03 | Immunoreceptor modulation for treating cancer and viral infections |
JP2016535268A JP2016530267A (en) | 2013-08-22 | 2013-10-03 | Immune receptor modulation to treat cancer and viral infections |
BR112016003528A BR112016003528A8 (en) | 2013-08-22 | 2013-10-03 | immune receptor modulation for cancer and viral infection treatment |
HRP20231186TT HRP20231186T1 (en) | 2013-08-22 | 2014-08-22 | Immunoreceptor modulation for treating cancer and viral infections |
MX2016002263A MX2016002263A (en) | 2013-08-22 | 2014-08-22 | Immunoreceptor modulation for treating cancer and viral infections. |
ES14838641T ES2967538T3 (en) | 2013-08-22 | 2014-08-22 | Immunoreceptor modulation for the treatment of cancer and viral infections |
SI201432042T SI3036258T1 (en) | 2013-08-22 | 2014-08-22 | Immunoreceptor modulation for treating cancer and viral infections |
JP2016535272A JP6618908B2 (en) | 2013-08-22 | 2014-08-22 | Use of a CD96 inhibitory antibody or antibody fragment to reduce or alleviate immunosuppression |
US14/913,348 US20160208000A1 (en) | 2013-08-22 | 2014-08-22 | Immunoreceptor modulation for treating cancer and viral infections |
SG11201601283PA SG11201601283PA (en) | 2013-08-22 | 2014-08-22 | Immunoreceptor modulation for treating cancer and viral infections |
CA2921774A CA2921774C (en) | 2013-08-22 | 2014-08-22 | Immunoreceptor modulation for treating cancer and viral infections |
AU2014308552A AU2014308552B2 (en) | 2013-08-22 | 2014-08-22 | Immunoreceptor modulation for treating cancer and viral infections |
NZ717534A NZ717534A (en) | 2013-08-22 | 2014-08-22 | Immunoreceptor modulation for treating cancer and viral infections |
PL14838641.0T PL3036258T3 (en) | 2013-08-22 | 2014-08-22 | Immunoreceptor modulation for treating cancer and viral infections |
CN201480052069.7A CN105636985A (en) | 2013-08-22 | 2014-08-22 | Immunoreceptor modulation for treating cancer and viral infections |
KR1020237018788A KR20230085220A (en) | 2013-08-22 | 2014-08-22 | Immunoreceptor modulation for treating cancer and viral infections |
EP14838641.0A EP3036258B1 (en) | 2013-08-22 | 2014-08-22 | Immunoreceptor modulation for treating cancer and viral infections |
MYPI2016000314A MY192043A (en) | 2013-08-22 | 2014-08-22 | Immunoreceptor modulation for treating cancer and viral infections |
DK14838641.0T DK3036258T3 (en) | 2013-08-22 | 2014-08-22 | Immune receptor modulation for the treatment of cancer and viral infections |
HUE14838641A HUE063307T2 (en) | 2013-08-22 | 2014-08-22 | Immunoreceptor modulation for treating cancer and viral infections |
PCT/AU2014/000830 WO2015024060A1 (en) | 2013-08-22 | 2014-08-22 | Immunoreceptor modulation for treating cancer and viral infections |
FIEP14838641.0T FI3036258T3 (en) | 2013-08-22 | 2014-08-22 | Immunoreceptor modulation for treating cancer and viral infections |
BR112016003532A BR112016003532A8 (en) | 2013-08-22 | 2014-08-22 | immunoreceptor modulation to treat cancer and viral infections |
KR1020167007435A KR20160055819A (en) | 2013-08-22 | 2014-08-22 | Immunoreceptor modulation for treating cancer and viral infections |
HK16113673A HK1225396A1 (en) | 2013-08-22 | 2016-12-01 | Immunoreceptor modulation for treating cancer and viral infections |
JP2019205385A JP2020059714A (en) | 2013-08-22 | 2019-11-13 | Immunoreceptor modulation for treating cancer and viral infections |
US16/938,214 US20210047403A1 (en) | 2013-08-22 | 2020-07-24 | Immunoreceptor modulation for treating cancer and viral infections |
JP2022012145A JP2022044808A (en) | 2013-08-22 | 2022-01-28 | Immunoreceptor modulation for treating cancer and viral infections |
JP2023134163A JP2023156487A (en) | 2013-08-22 | 2023-08-21 | Immunoreceptor modulation for treating cancer and viral infections |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2013903189 | 2013-08-22 | ||
AU2013903189A AU2013903189A0 (en) | 2013-08-22 | Immunomodulator |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2015024042A1 true WO2015024042A1 (en) | 2015-02-26 |
Family
ID=52482821
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/AU2013/001132 WO2015024042A1 (en) | 2013-08-22 | 2013-10-03 | Immunoreceptor modulation for treating cancer and viral infections |
Country Status (12)
Country | Link |
---|---|
US (1) | US20160200814A1 (en) |
EP (1) | EP3036255A4 (en) |
JP (1) | JP2016530267A (en) |
KR (1) | KR20160055818A (en) |
CN (1) | CN105636983A (en) |
AU (1) | AU2013398294A1 (en) |
BR (1) | BR112016003528A8 (en) |
CA (1) | CA2921772A1 (en) |
HK (1) | HK1225395A1 (en) |
MX (1) | MX2016002265A (en) |
SG (1) | SG11201601285XA (en) |
WO (1) | WO2015024042A1 (en) |
Cited By (11)
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US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
US9512227B2 (en) | 2014-03-12 | 2016-12-06 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of Alzheimer's disease |
WO2017220988A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Multispecific antibodies for immuno-oncology |
WO2019030377A1 (en) * | 2017-08-11 | 2019-02-14 | Blink Biomedical Sas | Cd96-binding agents as immunomodulators |
US10344090B2 (en) | 2013-12-12 | 2019-07-09 | Shanghai Hangrui Pharmaceutical Co., Ltd. | PD-1 antibody, antigen-binding fragment thereof, and medical application thereof |
US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
WO2020132034A1 (en) | 2018-12-20 | 2020-06-25 | 23Andme, Inc. | Anti-cd96 antibodies and methods of use thereof |
EP3565889A4 (en) * | 2017-01-06 | 2020-12-16 | Nantkwest, Inc. | Genetically modified nk-92 cells with decreased cd96/tigit expression |
US10995141B2 (en) | 2019-04-19 | 2021-05-04 | ImmunoBrain Checkpoint, Inc. | Modified anti-PD-L1 antibody and methods and uses for treating a neurodegenerative disease |
EP4052727A4 (en) * | 2019-10-30 | 2023-12-20 | University of Tsukuba | Immune response suppressor |
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SI3303394T1 (en) | 2015-05-29 | 2020-10-30 | Agenus Inc. | Anti-ctla-4 antibodies and methods of use thereof |
SG10201912560YA (en) | 2016-12-07 | 2020-02-27 | Agenus Inc | Anti-ctla-4 antibodies and methods of use thereof |
TWI758558B (en) * | 2017-11-10 | 2022-03-21 | 大陸商江蘇恒瑞醫藥股份有限公司 | Cd96 antibody, antigen-binding fragment and pharmaceutical uses thereof |
EP4034562A2 (en) * | 2019-09-27 | 2022-08-03 | GlaxoSmithKline Intellectual Property Development Limited | Antigen binding proteins |
CN116377061B (en) * | 2022-11-28 | 2024-01-16 | 中山大学孙逸仙纪念医院 | New auxiliary chemotherapy drug resistance marker for breast cancer and application thereof |
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WO2008073316A2 (en) * | 2006-12-07 | 2008-06-19 | The Board Of Trustees Of The Leland Stanford Junior University | Identification and isolation of acute myeloid leukemia stem cells |
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WO2011057216A1 (en) * | 2009-11-06 | 2011-05-12 | The Pennsylvania State Research Foundation | Bioconjugation of calcium phosphosilicate nanoparticles for selective targeting of cells in vivo |
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CN1777622A (en) * | 2003-02-24 | 2006-05-24 | 施里昂药品股份公司 | Modulation of the poliovirus receptor function |
EP1481993A1 (en) * | 2003-05-28 | 2004-12-01 | Xerion Pharmaceuticals AG | Modulation of the poliovirus receptor function |
WO2005107799A1 (en) * | 2004-05-06 | 2005-11-17 | Eisai R & D Management Co., Ltd. | REMEDY FOR CANCER CONTAINING ANTI-Necl-5 ANTIBODY AS THE ACTIVE INGREDIENT |
CN102204901A (en) * | 2010-03-30 | 2011-10-05 | 中国科学院上海生命科学研究院 | Reagent and method for regulating immune molecules |
SI3036258T1 (en) * | 2013-08-22 | 2023-11-30 | The Council Of The Queensland Institute Of Medical Research | Immunoreceptor modulation for treating cancer and viral infections |
-
2013
- 2013-10-03 US US14/913,347 patent/US20160200814A1/en not_active Abandoned
- 2013-10-03 KR KR1020167007431A patent/KR20160055818A/en not_active Application Discontinuation
- 2013-10-03 SG SG11201601285XA patent/SG11201601285XA/en unknown
- 2013-10-03 AU AU2013398294A patent/AU2013398294A1/en not_active Abandoned
- 2013-10-03 CA CA2921772A patent/CA2921772A1/en not_active Abandoned
- 2013-10-03 JP JP2016535268A patent/JP2016530267A/en active Pending
- 2013-10-03 CN CN201380079711.6A patent/CN105636983A/en active Pending
- 2013-10-03 WO PCT/AU2013/001132 patent/WO2015024042A1/en active Application Filing
- 2013-10-03 EP EP13891700.0A patent/EP3036255A4/en not_active Withdrawn
- 2013-10-03 MX MX2016002265A patent/MX2016002265A/en unknown
- 2013-10-03 BR BR112016003528A patent/BR112016003528A8/en not_active IP Right Cessation
-
2016
- 2016-12-01 HK HK16113672A patent/HK1225395A1/en unknown
Patent Citations (3)
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CA2921772A1 (en) | 2015-02-26 |
AU2013398294A1 (en) | 2016-03-17 |
CN105636983A (en) | 2016-06-01 |
EP3036255A4 (en) | 2017-03-22 |
BR112016003528A8 (en) | 2018-01-30 |
MX2016002265A (en) | 2016-12-16 |
US20160200814A1 (en) | 2016-07-14 |
EP3036255A1 (en) | 2016-06-29 |
HK1225395A1 (en) | 2017-09-08 |
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SG11201601285XA (en) | 2016-03-30 |
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