WO2015016729A8 - Urea compounds and their use as faah enzyme inhibitors - Google Patents
Urea compounds and their use as faah enzyme inhibitors Download PDFInfo
- Publication number
- WO2015016729A8 WO2015016729A8 PCT/PT2014/000052 PT2014000052W WO2015016729A8 WO 2015016729 A8 WO2015016729 A8 WO 2015016729A8 PT 2014000052 W PT2014000052 W PT 2014000052W WO 2015016729 A8 WO2015016729 A8 WO 2015016729A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hydroxyl
- aryl
- halogen
- compound
- aryl group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
There is provided a compound having Formula I:(I) wherein: R1 is aryl which is optionally substituted with one or more groups selected from hydroxyl, halogen and C1-4 alkoxy, or R1 is aryl which is substituted with a second aryl group or an aryloxy group, wherein the second aryl group or the aryloxy group is optionally substituted with one or more groups selected from hydroxyl, halogen and C1-4 alkoxy; R2 is C1-4 alkyl; R3 is selected from hydroxyl and OSO2CH3; R4 and R5 are independently selected from hydrogen, hydroxyl and halogen; and n is 0 or 1; or a pharmaceutically acceptable salt thereof; wherein when R3 is hydroxyl and R4 and R5 are not hydroxyl, the optionally substituted aryl group, second aryl group or aryloxy group of R1 is substituted with one or more hydroxyl groups or C1-4 alkoxy groups, or wherein when R3 is hydroxyl, one of R4 and R5 is hydroxyl, provided that the compound is not N-(1-benzylpiperidin-4-yl)-4-(3,4-dihydroxyphenyl)-N-methyl-1H-imidazole-1-carboxamide hydrobromide. The compound may be used as an inhibitor of fatty acid amide hydrolase.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1313903.5A GB201313903D0 (en) | 2013-08-02 | 2013-08-02 | Urea compounds and their use as enzyme inhibitors |
| GB1313903.5 | 2013-08-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2015016729A1 WO2015016729A1 (en) | 2015-02-05 |
| WO2015016729A8 true WO2015016729A8 (en) | 2015-09-11 |
Family
ID=49224098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/PT2014/000052 WO2015016729A1 (en) | 2013-08-02 | 2014-08-01 | Urea compounds and their use as faah enzyme inhibitors |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR097190A1 (en) |
| GB (1) | GB201313903D0 (en) |
| TW (1) | TW201536770A (en) |
| WO (1) | WO2015016729A1 (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009330821B2 (en) | 2008-12-24 | 2015-06-11 | Bial - Portela & Ca, S.A. | Pharmaceutical compounds |
| US9458111B2 (en) * | 2010-07-29 | 2016-10-04 | Bial—Portela & Ca, S.A. | Process for the synthesis of substituted urea compounds |
-
2013
- 2013-08-02 GB GBGB1313903.5A patent/GB201313903D0/en not_active Ceased
-
2014
- 2014-08-01 WO PCT/PT2014/000052 patent/WO2015016729A1/en active Application Filing
- 2014-08-01 TW TW103126395A patent/TW201536770A/en unknown
- 2014-08-01 AR ARP140102894A patent/AR097190A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015016729A1 (en) | 2015-02-05 |
| GB201313903D0 (en) | 2013-09-18 |
| AR097190A1 (en) | 2016-02-24 |
| TW201536770A (en) | 2015-10-01 |
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