WO2015015512A3 - Process for the preparation of silodosin and its gamma form - Google Patents

Process for the preparation of silodosin and its gamma form Download PDF

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Publication number
WO2015015512A3
WO2015015512A3 PCT/IN2014/000496 IN2014000496W WO2015015512A3 WO 2015015512 A3 WO2015015512 A3 WO 2015015512A3 IN 2014000496 W IN2014000496 W IN 2014000496W WO 2015015512 A3 WO2015015512 A3 WO 2015015512A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
silodosin
preparation
present
improved
Prior art date
Application number
PCT/IN2014/000496
Other languages
French (fr)
Other versions
WO2015015512A2 (en
Inventor
Vinodrai Naik Rajesh
Singh Sarin Gurdeep
Kumar VERMA NARESH
Rao KEERTHI C.G. JAGANNADHA
Kumar VERMA PRABHAT
Original Assignee
Ind-Swift Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind-Swift Laboratories Limited filed Critical Ind-Swift Laboratories Limited
Publication of WO2015015512A2 publication Critical patent/WO2015015512A2/en
Publication of WO2015015512A3 publication Critical patent/WO2015015512A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • C07C59/225—Saturated compounds having only one carboxyl group and containing keto groups containing —CHO groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides an improved and efficient process for the preparation silodosin of formula I and pharmaceutically acceptable salts thereof Formula I. through novel tartrate salt of cyano hydroxy intermediate of formula II. Formula II The present invention also provides an improved, industrially advantageous and novel process for preparation of pure polymorphic form gamma (γ) of silodosin, wherein residual solvents are present in specified limits as per ICH guidelines. ·
PCT/IN2014/000496 2013-07-29 2014-07-28 Process for the preparation of silodosin and its gamma form WO2015015512A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN2233DE2013 2013-07-29
IN2233/DEL/2013 2013-07-29
IN1602DE2014 2014-06-12
IN1602/DEL/2014 2014-06-12

Publications (2)

Publication Number Publication Date
WO2015015512A2 WO2015015512A2 (en) 2015-02-05
WO2015015512A3 true WO2015015512A3 (en) 2015-04-30

Family

ID=52432517

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2014/000496 WO2015015512A2 (en) 2013-07-29 2014-07-28 Process for the preparation of silodosin and its gamma form

Country Status (1)

Country Link
WO (1) WO2015015512A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016147811A (en) * 2015-02-10 2016-08-18 ダイト株式会社 METHOD FOR PRODUCING SILODOSIN γ-TYPE CRYSTAL
AU2016327159A1 (en) * 2015-09-23 2018-04-26 Biocon Limited The process of preparing indoline compounds and a novel indoline salt
ES2607639B1 (en) * 2015-09-30 2018-02-28 Urquima, S.A Maleic acid salt of a silodosin intermediate

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1541554A1 (en) * 2002-09-06 2005-06-15 Kissei Pharmaceutical Co., Ltd. Crystal for oral solid drug and oral solid drug for dysuria treatment containing the same
CN102382029A (en) * 2011-07-26 2012-03-21 浙江华海药业股份有限公司 Preparation method of salt formation of silodosin intermediate
WO2012077138A1 (en) * 2010-12-09 2012-06-14 Panacea Biotec Limited Methods of crystallizing (r) -1- (3 -hydroxypropyl) -5- [2- [2- [2- ( 2, 2, 2 - trifluoroethoxy) phenoxy] ethylamino] propyl] indoline-7 -carboxamide
WO2012131710A2 (en) * 2011-03-30 2012-10-04 Panacea Biotec Ltd Novel process for the synthesis of indoline derivatives
WO2012147019A1 (en) * 2011-04-26 2012-11-01 Orchid Chemicals And Pharamceuticals Limited An improved process for the preparation of silodosin
CN102010359B (en) * 2010-09-10 2013-01-23 北京阳光诺和药物研究有限公司 Method for preparing silodosin in beta crystal form

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1541554A1 (en) * 2002-09-06 2005-06-15 Kissei Pharmaceutical Co., Ltd. Crystal for oral solid drug and oral solid drug for dysuria treatment containing the same
CN102010359B (en) * 2010-09-10 2013-01-23 北京阳光诺和药物研究有限公司 Method for preparing silodosin in beta crystal form
WO2012077138A1 (en) * 2010-12-09 2012-06-14 Panacea Biotec Limited Methods of crystallizing (r) -1- (3 -hydroxypropyl) -5- [2- [2- [2- ( 2, 2, 2 - trifluoroethoxy) phenoxy] ethylamino] propyl] indoline-7 -carboxamide
WO2012131710A2 (en) * 2011-03-30 2012-10-04 Panacea Biotec Ltd Novel process for the synthesis of indoline derivatives
WO2012147019A1 (en) * 2011-04-26 2012-11-01 Orchid Chemicals And Pharamceuticals Limited An improved process for the preparation of silodosin
CN102382029A (en) * 2011-07-26 2012-03-21 浙江华海药业股份有限公司 Preparation method of salt formation of silodosin intermediate

Also Published As

Publication number Publication date
WO2015015512A2 (en) 2015-02-05

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