WO2015015403A3 - Compositions and methods for the treatment of diabetes and pre-diabetes - Google Patents

Compositions and methods for the treatment of diabetes and pre-diabetes Download PDF

Info

Publication number
WO2015015403A3
WO2015015403A3 PCT/IB2014/063492 IB2014063492W WO2015015403A3 WO 2015015403 A3 WO2015015403 A3 WO 2015015403A3 IB 2014063492 W IB2014063492 W IB 2014063492W WO 2015015403 A3 WO2015015403 A3 WO 2015015403A3
Authority
WO
WIPO (PCT)
Prior art keywords
diabetes
compositions
treatment
methods
pharmaceutical
Prior art date
Application number
PCT/IB2014/063492
Other languages
French (fr)
Other versions
WO2015015403A2 (en
Inventor
Mahesh Kandula
Original Assignee
Mahesh Kandula
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mahesh Kandula filed Critical Mahesh Kandula
Publication of WO2015015403A2 publication Critical patent/WO2015015403A2/en
Publication of WO2015015403A3 publication Critical patent/WO2015015403A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to the compositions of formula I or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprises a salt of metformin and the methods for treating or preventing metabolic syndrome, prediabetes and diabetes may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of diabetes mellitus, obesity, lipid disorders, hypertriglyceridemia, hyperglycemia, hyperinsulinemia and insulin resistance.
PCT/IB2014/063492 2013-08-01 2014-07-29 Compositions and methods for the treatment of diabetes and pre-diabetes WO2015015403A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3481/CHE/2013 2013-08-01
IN3481CH2013 2013-08-01

Publications (2)

Publication Number Publication Date
WO2015015403A2 WO2015015403A2 (en) 2015-02-05
WO2015015403A3 true WO2015015403A3 (en) 2015-04-23

Family

ID=52432505

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/063492 WO2015015403A2 (en) 2013-08-01 2014-07-29 Compositions and methods for the treatment of diabetes and pre-diabetes

Country Status (1)

Country Link
WO (1) WO2015015403A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005063226A1 (en) * 2003-12-19 2005-07-14 Omega Bio-Pharma (I.P.3) Limited Compositions and methods for treating diabetes
US20120289485A1 (en) * 2011-05-11 2012-11-15 Mylari Banavara L Metformin Salts of Salicylic Acid and Its Congeners

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005063226A1 (en) * 2003-12-19 2005-07-14 Omega Bio-Pharma (I.P.3) Limited Compositions and methods for treating diabetes
US20120289485A1 (en) * 2011-05-11 2012-11-15 Mylari Banavara L Metformin Salts of Salicylic Acid and Its Congeners

Also Published As

Publication number Publication date
WO2015015403A2 (en) 2015-02-05

Similar Documents

Publication Publication Date Title
WO2014087307A3 (en) Compositions and methods for the treatment of metabolic syndrome and diabetes
WO2013175377A3 (en) Compositions and methods for treatment of mucositis
WO2016046680A3 (en) Compositions and methods for the treatment of liver metabolic diseases
WO2011005811A8 (en) Combination therapy for the treatment of diabetes
PH12014502448A1 (en) Pharmaceutical combinations for the treatment of metabolic disorders
WO2013175376A3 (en) Compositions and methods for the treatment of local pain
MX2019007713A (en) Compositions and methods for the treatment of chronic pain.
WO2014174425A3 (en) Compositions and methods for the treatment of orthostasis and neurological diseases
WO2011085643A8 (en) Fused pyridine derivatives
WO2014068463A3 (en) Compositions and methods for the treatment of inflammation and metabolic disorders
WO2014091384A3 (en) Compositions and methods for the treatment of mucositis
WO2014080307A3 (en) Compositions and methods for the treatment of diabetes and pre-diabetes
WO2013175359A3 (en) Compositions and methods for the treatment of multiple sclerosis
WO2014106804A3 (en) Compositions and methods for the treatment of metabolic syndrome and diabetes
WO2014195810A3 (en) Compositions and methods for the treatment of diabetes and pre-diabetes
WO2014087323A3 (en) Compounds and compositions for the treatment of autoimmune and chronic metabolic diseases
WO2013167998A3 (en) Compositions and methods for the treatment of autonomic and other neurological disorders
WO2015015403A3 (en) Compositions and methods for the treatment of diabetes and pre-diabetes
MX2019005568A (en) Compositions and methods for the treatment of gastrointestinal polyps.
WO2013175344A3 (en) Compositions and methods for treatment of peridontitis and rheumatoid arthritis
WO2014097137A3 (en) Compositions and methods for the treatment of seizures and neurologic diseases
WO2013167995A3 (en) Compositions and methods for the treatment of hyperglycemia
WO2014106805A3 (en) Fatty acid conjugates and their uses
WO2015028976A3 (en) Compounds and methods for the treatment of inflammatory diseases
WO2014083476A3 (en) Compositions and methods for the treatment of metabolic and lipid disorders

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 14831926

Country of ref document: EP

Kind code of ref document: A2