WO2015015127A2

WO2015015127A2 - Method for injecting a product as part of an aesthetic intervention

Info

Publication number: WO2015015127A2
Application number: PCT/FR2014/052000
Authority: WO
Inventors: Sandrine SEBBAN
Original assignee: Soft Medical Aesthetics
Priority date: 2013-07-31
Filing date: 2014-07-31
Publication date: 2015-02-05
Also published as: WO2015015127A3; EP3027261A2; FR3009199A1

Abstract

A method for injecting a product as part of an aesthetic intervention. The invention concerns a method for injecting a product as part of an aesthetic intervention, said method including the following successive steps of: - piercing an area of the skin of a patient by means of a needle (1) having a sharp distal end (1a), said needle comprising a bore that extends between an upstream opening and a downstream opening that opens at said distal end; - inserting, into said bore, via said upstream opening, an injection cannula (3) that has at least one injection port (4); - sliding said injection cannula beyond the distal end (1a) until the injection port (4) opens into an area to be treated located under the skin; - injecting the product into said area to be treated via the injection cannula (3).

Description

Method of injecting a product as part of an aesthetic intervention

The invention relates to a method of injecting a product in the context of an aesthetic intervention, and an injection kit especially for the implementation of such a method.

It applies in particular to the injections of a filling product, in particular based on hyaluronic acid, under the skin of at least a part of the body of a patient, for example the face and / or neck of said patient , in order to temporarily remove the unsightly effects of aging of the skin, such as wrinkles and loosening of the skin, and / or to revitalize said skin by moisturizing the layers of the epidermis.

It can also be applied to autologous autologous pre-patient autologous injections, such as platelet-rich plasma (PRP), for example for fibroblastic and collagenic stimulation of the skin to correct the unsightly effects due to aging, or fat, for example to correct the loss of volume of the skin due to trauma such as an accident or surgery.

To perform such an operation, the practitioner generally uses an injection cannula which has a rounded distal end and at least one lateral injection port disposed near said distal end. Indeed, this type of cannula is particularly suitable for fillers, which are generally quite thick, and minimizes trauma to tissues and vessels deep layers of the skin, such as bruising, bruising or edema, as well as nervous trauma.

During the procedure, the practitioner begins by piercing, with a needle having a sharp distal end, an area of the skin located not far from an area to be treated, to provide access to said area to be treated. Then, the practitioner removes the piercing needle and introduced through the hole thus formed an injection cannula as described above, then slides under the skin said cannula until the injection port opens into the area treat. It then injects the product into the area to be treated via the cannula, the product being for example contained in a syringe or in another type of container on which the said cannula is mounted.

However, this type of technique is not entirely satisfactory, in that the hole formed by the piercing needle is sometimes difficult to identify, which can waste time for the practitioner.

In particular, to locate the hole, the practitioner may be forced to pinch the skin, sometimes several times, so as to cause bleeding through said hole, which can be painful for the patient and cause haematomas or swelling from the pinched area to bleeding. As a result, the patient's recovery is lengthened, and the presence of unsightly traces can be harmful to the patient, who is then forced to temporary eviction during the convalescence.

Moreover, such a technique requires many manipulations of the piercing needle, in particular to insert and remove it from the skin of the patient, which increases the risk of accidental punctures for the practitioner as well as the risk of loss of sterility. of said needle.

The invention aims to improve the prior art by proposing in particular an injection method allowing the practitioner to more easily and quickly perform the injection of a product, while significantly reducing the risk of trauma to the patient.

For this purpose, according to a first aspect, the invention proposes a method of injecting a product in the context of an aesthetic intervention, said method providing the following successive steps of: piercing an area of the skin of a patient by means of a needle having a sharp distal end, said needle comprising a bore which extends between an upstream opening and a downstream opening opening into said distal end;

introduction into said bore through said upstream opening of an injection cannula which has at least one injection orifice;

sliding of said injection cannula beyond the distal end until the injection orifice opens into a zone to be treated located under the skin;

injecting the product into said zone to be treated via the injection cannula.

According to a second aspect, the invention proposes a kit for injecting a product, particularly in the context of an aesthetic intervention, said kit comprising:

at least one injection cannula which has at least one injection orifice;

at least one piercing needle of the skin of a patient which has a sharp distal end, and a bore extending between an upstream opening and a downstream opening which opens into said distal end, said bore being arranged to allow sliding the injection cannula beyond the distal end to at least one area to be treated under the skin.

Other features and advantages of the invention will appear in the description which follows, made with reference to the appended figures, in which:

FIG. 1 represents an injection cannula according to one embodiment of the invention, FIG. 1a showing an enlarged view of zone A of FIG. 1;

FIG. 2 shows two injection kits according to one embodiment of the invention, respectively;

FIG. 3 represents an injection kit according to the invention, in which the injection cannula is introduced partially into the bore of the piercing needle; - Figure 4 shows schematically in longitudinal section an injection cannula;

- Figure 5 shows schematically in semi-longitudinal section a needle.

In connection with these figures, a method of injecting a product in the context of an aesthetic procedure, in particular in at least one treatment zone located under the skin of a patient, is described below. injection kit, especially for the implementation of such a method.

The kit may also be used for the injection of a biocompatible product in the context of a medical or veterinary intervention, said product containing for example primarily anesthetic. In particular, the injection kit may be a single-use medical device for use by qualified personnel, including medical or paramedical personnel.

In the context of an aesthetic intervention, the product to be injected may be a filling product, for example based on hyaluronic acid, to temporarily correct the unsightly effects of aging of the skin. In particular, a product based on hyaluronic acid fluid can be used to smooth the skin to reduce wrinkles. Similarly, a product based on crosslinked hyaluronic acid, therefore thicker, can be used to restore volume to the skin and / or to stretch said skin, in order to counterbalance a relaxation due to a loss of elasticity of said skin and / or to correct an asymmetry, in the case where an area of the skin has a loosening and / or loss of volume greater than its symmetrical zone.

The product to be injected may also comprise an additive having anesthetic properties, for example based on lidocaine, in order to reduce the pain that the patient may feel during the injection, this pain being all the more important that the said product is thick. The product to be injected may also comprise an additive having antioxidant properties, for example base of mannitol, as well as vitamins to revitalize the layers of the skin in the area to be treated.

The product to be injected may also be an autologous organic product previously taken from the patient, such as, for example, fat or platelet-rich plasma (PRP), for purely cosmetic purposes and / or to allow injections in auto-transplant, in particular to correct unsightly effects due to trauma such as an accident or surgery.

The area to be treated can be located on the face or neck of the patient, especially on the parts of the face or neck most prone to unsightly effects of aging of the skin, such as wrinkles or loosening. For example, the area to be treated may be located at a commissure of the lips (subject to "folds of bitterness"), at an outer corner of an eye (subject to wrinkles in "crow's feet"), on a temple , on the forehead, and especially at the level of the glabella (subject to "lion's wrinkles"), at an orbital zone (where dark circles and / or pockets may appear), the valley of tears (located under one eye) of a cheekbone or cheek (where looseness and / or loss of skin volume can be seen).

The area to be treated can also be located on other parts of the body particularly prone to such aging effects, as the hands, but also the arms, thighs, chest for women, especially at the neckline, the leather hairy, belly, or feet.

Depending on the product to be injected and the desired aesthetic effect, the area to be treated may be located at various depths of the patient's skin. For example, for the correction of wrinkles, the area to be treated is generally located in a superficial layer of the skin, especially the epidermis or dermis. On the contrary, for the correction of a looseness of the skin, a lack of volume, and a possible resulting asymmetry, the area to be treated is rather located in a deep layer of the skin, especially the hypodermis.

In particular, the area to be treated may be located in the stratum granulosum, that is to say the last layer of nucleated cells of the epidermis. The area to be treated may also be located under the epidermis, in particular between the dermis and the bone, and more particularly between the deep dermis and the periosteum of the bone.

Before proceeding to the intervention, the practitioner can determine the zones to be treated by a careful examination of the patient, in particular by means of adapted lighting, to identify the possible lack of volume and the asymmetries which can result from it, but also for identify the blood vessels that should be avoided so as not to cause trauma to the patient. This examination includes local observations but also a global observation, especially with regard to the face, in order to correct the unsightly effects in a harmonious way and thus to guarantee a natural result for the patient. Once the areas to be treated have been identified, the practitioner can mark them with a hypoallergenic pencil.

Moreover, to limit the risk of infection, the practitioner must obviously take hygiene measures, especially before proceeding to the marking of the areas to be treated. To do this, the practitioner can clean the skin to remove any impurities, including makeup, and apply an antiseptic solution on said skin.

The method provides a first step of piercing an area of the skin of the patient by means of a needle 1 having a sharp distal end 1a, to provide an access hole to the area to be treated.

To do this, the injection kit comprises at least one such needle 1, said needle having a bore which extends between an upstream opening and a downstream opening which opens into the sharp distal end 1a. In particular, the needle 1 is made of stainless steel, for example SUS 304 alloy or AISI 304 alloy.

In addition, the needle 1 comprises a base 2 on which its proximal end 1b, in which the upstream opening is formed, is mounted, the practitioner using said base to manipulate said needle.

For example, the proximal end 1b can be fixed by means of an adhesive in a housing provided for this purpose on the base. Alternatively, the needle 1 can be mounted retractable on the base 2, in particular to be retracted into said base after piercing the skin of the patient.

In relation to FIG. 5, the needle 1 also comprises a protection cap 8 intended to be mounted on the base 2 by covering said needle, in order to protect the practitioner from accidental punctures and possibly to ensure perfect sterility of said needle. needle before use.

The base 2 and the cap 8 may be made of a polymer that is harmless to the human body, for example polypropylene or a copolymer based on polypropylene, such as ethylene-polypropylene. In general, the base 2 and the cap 8 may be made of a non-flammable material, in particular without pyrogen.

In the embodiment shown, the method is implemented with a standard injection needle 1 provided with a plastic base 2 normally arranged to allow the mounting of said needle on the tip of a syringe, the drilling of the skin being made by grasping said base with two fingers.

Alternatively, the needle 1 may be modified, for example by being cut longitudinally to form a gutter on which the bore extends between an upstream opening and a downstream opening which opens into the sharp distal end 1a. According to one embodiment, the needle 1 has a hemicylindrical geometry, the upstream opening being able to be arranged at the level of the proximal end 1b or along said needle. Furthermore, the base 2 may also be modified to facilitate manual gripping of the needle 1 during piercing of the skin, for example by providing that said base has two lateral gripping arms which extend from both sides. other of said needle.

The area to be pierced may in particular be located on the patient's face, for example near an ear (retro-mandibular point), in a nasolabial area (at the level of the modiolus, naso-genital point), at the level of the zygomatic bone (zygomatic point), on a temple (temporal or frontal point) or above the glabella (glabellar point). Thus, the practitioner can reach several localized treatment areas on the face and / or the neck of the patient from the same hole in said area to be pierced, which limits the drilling of the skin, and thus the trauma for the patient. In particular, for a procedure on the face, the number of zones to be pierced can be between one and five for each side of said face.

The zone to be pierced may also be located on any other part of the patient's body, in particular on a hand, an arm or a thigh, on the chest, in particular at the level of the cleavage, on the scalp, on the stomach, or on a foot.

To inject the product, the method provides for the use of an injection cannula 3 having at least one injection port 4. In particular, the cannula 3 has a rounded distal end 3a, which makes it possible not only to avoid the blood vessels and nerve trauma during the introduction of the cannula 3 under the skin of the patient, and thus to limit trauma for said patient, but also to limit the risk of accidental puncture for the practitioner. To do this, the injection kit comprises at least one such cannula 3, said cannula further having at least one injection port 4 disposed laterally near the distal end 3a. In particular, the orifice 4 has a diameter between 0.05 mm and 1 mm and is located about 2 mm from the rounded distal end 3a.

To reach the zone to be treated with the cannula 3, the method provides a step following the piercing of the skin in which the needle 1 remains planted in the skin, the cannula 3 being introduced into the bore of said needle through its upstream opening. . Next, with reference to FIG. 3, the method provides for a subsequent step of sliding the cannula 3 beyond the distal end 1a of the needle 1, until the orifice 4 opens into the zone treat.

To do this, the bore of the needle 1 is arranged to allow the sliding of the cannula 3 beyond its distal end 1a to the area to be treated. In particular, the bore has a diameter greater than or equal to the outer diameter of the cannula 3, or substantially equal to said outer caliber. In addition, the upstream opening of the bore may be arranged to facilitate the insertion of the cannula 3 into the bore, and the base 2 of the needle 1 is wide enough to facilitate the introduction of the cannula 3 in the upstream opening and the bore.

Thus, the practitioner can save time compared to conventional injection techniques because he does not have to locate the hole formed by the needle 1, since it remains positioned in said hole and that access to the zone to be treated is materialized by the upstream opening of the bore, which is easily localizable. Therefore, the practitioner does not need to resort to traumatic practices for the patient, such as pinching the skin of said patient several times to locate the hole by risking bleeding.

In addition, by guiding the cannula 3 by the needle 1, the practitioner groping less during the introduction of said cannula, which is also less traumatic for the patient.

In addition, the handling operations of the needle 1 are limited, which limits the risk of accidental puncture for the practitioner and the risk of loss of sterility of said needle. The method then provides a step of injecting the product into the area to be treated via the cannula 3. In particular, during this step, the product is injected by means of a syringe or other type of container. on which the cannula 3 is mounted.

To do this, the cannula 3 has a base 5 on which the proximal end 3b of said cannula is mounted, for example by being fixed by means of an adhesive in a housing provided for this purpose on said base, said base being intended to be mounted on a tip of a syringe containing the product to be injected.

For example, the base 5 can be of Luer-Lock® or Luer-Slip® type, to be mounted respectively by screwing or by friction on the tip of the syringe, these types being advantageously universal to allow the use of the cannula 3 with all types of syringes or other containers.

In addition, the base 5 of the cannula 3 is arranged to fit into the base 2 of the needle 1 at the end of the sliding of said cannula into the bore, which ensures the practitioner stability of the positioning of the the cannula 3 before proceeding to the injection.

In connection with Figure 4, the cannula 3 also comprises a protective cap 9 to be mounted on the base 5 surrounding said cannula, to ensure the protection and possibly perfect sterility of said cannula before use.

Furthermore, the base 5 and the cap 9 may also be made of polypropylene or a polypropylene copolymer, especially ethylene-polypropylene. In general, the base 5 and the cap 9 may be made of a non-flammable material, in particular without pyrogen. Depending on the product to be injected, the depth of the zone to be treated and / or its location relative to the access hole, the dimensions of the cannula 3 may vary. In particular, the cannula 3 may have a reduced internal size if the product is fluid and on the contrary more important if the product is thick. Thus, with a large internal caliber, the practitioner can inject a thick product without applying too much pressure to said product, which facilitates said injection and reduce pain for the patient. Moreover, by applying less pressure, the molecules of the product are less subject to physical constraints and therefore less likely to be deteriorated.

For example, the cannula 3 may have an external gauge between 14G (14 gauges, which corresponds to a diameter of 2 mm) and 33G (0.2 mm), and especially between 22G (0.7 mm) and 25G ( 0.5 mm). The cannula 3 can also be flexible, to facilitate its guidance to the area to be treated, and then the positioning of its injection port 4 in said area to be treated. In particular, the flexibility of the cannula 3 is related to the outer caliber, said flexibility being all the more important that said outer caliber is reduced. In addition, the cannula 3 may be at least partially made of stainless steel, in particular alloy SUS 304 or alloy AISI 304 (crude chemical formula FeCnsNi-10), the latter being particularly remarkable for its good performance in terms of flexibility, robustness, elasticity and resistance to corrosion, and / or a shape memory alloy.

In addition, the outer surface of the cannula 3 may have undergone a special treatment, for example based on silicone, in order to facilitate the sliding of said cannula under the skin of the patient, and thus to minimize the trauma for said patient, in particular the hematomas, bruises or edema.

To allow the practitioner to quickly identify the external caliber and / or the internal size of the cannula 3, and thus select said cannula according to its needs, the base 5 of said cannula may include an identification marking of its outer caliber and / or its internal caliber.

In particular, the identification marking consists of a coloration of the base 5, the coloration corresponding to the internal gauge and / or the external gauge of the cannula 3, as defined in particular by the NF EN ISO 6009 standard.

Similarly, the base 2 of the needle 1 has a coloration identical to that of the base 5 of the cannula 3, which identifies said needle and said base as belonging to the same injection kit. In particular, the needle 1 and the cannula 3 of the same kit may be packaged in the same transparent sterile bag, in particular based on polypropylene and / or polyethylene, said bag may also be flexible or rigid and / or include at least one portion based on peelable paper.

The kit thus packaged can be stored in a box containing other kits also packaged in sachets to be protected from moisture and light during storage, the practitioner identifying at a glance the kit he has need by looking at the coloration of the bases 2, 5.

Moreover, before and / or after their packaging in a bag, the needle 1 and the cannula 3 of a kit are sterilized, for example by means of a process of sterilization by ethylene oxide (ETO), by ionizing radiation or by steam. In addition, the sachet may include indications for the practitioner, such as a lot number, the references of the conformity tests performed and / or the dimensions of the cannula 3 and / or the needle, and in particular information useful for safe use of the kit it contains, for example a date of sterilization and / or an expiry date, a notion restricting the use to qualified practitioners, a reference to the notified body and / or a marking of conformity to a standard, including the CE standard. In particular, if the bag has a poor condition and / or an opening, the practitioner can know immediately that the kit contained in said bag must be destroyed for the safety of the patient.

In relation with FIG. 2, the cannula 3 may have a variable length, depending on the depth and / or the location of the zone to be treated with said cannula relative to the access hole. This length may especially be between 13 mm and 1 10 mm, and more particularly between 25 mm and 70 mm.

In addition, as shown in Figure 2, the needle 1 has a greater or lesser length depending on the length of the associated cannula 3, to ensure a guide adapted to said length. The length of the needle 1 may in particular be between 4 mm and 30 mm.

To facilitate the positioning of the injection orifice 4 in the area to be treated, especially when the latter is located at a large depth and / or at a large distance from the access hole, the cannula 3 may have graduations 6. arranged at regular intervals along its length, for example every centimeter. Furthermore, the base 5 of the cannula 3 may comprise on its periphery a marking 7 for locating the injection orifice 4 which is aligned with said injection orifice, which allows the practitioner to correctly orient said orifice. when it is positioned in the area to be treated. In connection with the figures, the marking of marking comprises a point 7 formed on the periphery of the base 5, said point being made in a sufficiently bright color to contrast with the color of said base. In a variant, the marking may have another pattern, in particular in the form of an arrow. It can also be made in relief on the base 5, for example during the molding of said base, and optionally colored with a different shade of said base. To limit the pain felt by the patient during the procedure, the method may provide a step prior to piercing the skin, wherein an anesthetic is applied at least on and / or in the area to be pierced, thereby limiting both the pain due to said piercing and the pain due to the introduction of the cannula 3. In particular, the anesthetic product can be applied locally in the form of cream and / or patch, for example an Emla® type patch.

Furthermore, the method may provide for successively treating several zones, and this by accessing from the same access hole, which is greatly facilitated by the maintenance of the needle 1 in said hole to guide the cannulas 3 For example, if the practitioner has to change the cannula 3, in particular to change product or to use a cannula 3 of different length and / or internal gauge, leaving the needle 1 in place makes it easier to inserting new cannulas 3 through said access hole, and thus save time.

To do this, the same kit may include several cannulas 3 which have for example the same external template, but different internal templates and / or lengths, to allow the practitioner to perform several injections with several products and / or in multiple areas to be treated with one kit. In addition, the same kit may also include several needles 1 which have for example different lengths.

In particular, the practitioner can inject several products in the same area according to the aesthetic effects he wishes to bring to said area. For example, the practitioner can inject several products of the same type which have different viscosities and / or the same product at different depths.

Moreover, for the injection of the same product into several areas to be treated, the method can provide for moving a cannula 3 already introduced into the bore of the needle 1 to another area to be treated after injection of said product in a first zone. Advantageously, the practitioner may use a retractable mounted needle 1 on its base 2, said needle being retracted into said base after passage of the cannula 3 beyond the end 1a, that is to say after insertion of the cannula 3 under the skin by means of the needle 1. Thus, the injection can be performed only with the cannula 3 inserted into the skin, which allows the practitioner to more easily manipulate said cannula and perform an injection less traumatic for the patient.

In particular, when the product has to be injected into several areas, the needle 1 can be retracted before displacement of the cannula 3 to another area to be treated, in order to avoid injuring the patient in the area around the hole. access.

In particular, the method may provide a radial displacement between the area that has just been treated and a new area to be treated to proceed to a new injection in said new area.

In addition, the method may provide for repeating at least once such radial displacement from the treated area to another area to be treated and a subsequent step of injecting product into said other area. Thus, the practitioner can treat an entire area of the face, for example the forehead, a temple or a cheek, and this from a single access hole.

In order to correct a loosening of the skin which is widely spread over an area of the face, for example on the forehead, on a temple or on a cheek, a known technique consists in injecting the product by bolus, that is to say, depositing several small doses of product on the whole of said zone by making several displacements in said zone, in order to stretch said skin over the whole area while giving it back volume.

In particular, the practitioner can perform several bolus injections by performing several radial movements, including fan, in the same area. The practitioner can also use a particular technique called "topping" which is usually performed in a layer of the hypodermis, in order to achieve a smoothing surface and plump the skin deep. By radially moving the cannula 3 already inserted into the hypodermic layer from an already treated area of said layer to another area to be treated, said cannula remains in particular at a constant depth. Thus, the practitioner makes sure to perform all the injections of topping in the same layer, and in particular at the same depth in said layer.

Therefore, the practitioner can easily plump a layer under the skin with a constant thickness of product, which ensures the homogeneity and harmony of the final result. On the other hand, the method may provide for moving the cannula 3 back during the bolus injection of the product, i.e., in a retrograde motion, to distribute the product over a substantial depth range and / or a wider area, which allows a more harmonious and therefore more natural result. Alternatively, the method may provide for moving the cannula 3 forward, in antegrade motion, during the bolus injection of the product.

Once the injections are complete, the practitioner easily removes the cannula 3 through guiding in the bore of the needle 1 and can perform a massage on the treated area, in order to evenly distribute the product and give a more homogeneous appearance and therefore more natural to the correction made. The patient can then see results that are immediately visible and lasting.

Claims

1. A method of injecting a product in the context of an aesthetic intervention, said method providing the following successive steps of:

piercing an area of the skin of a patient by means of a needle (1) having a sharp distal end (1 a), said needle comprising a bore which extends between an upstream opening and a downstream opening opening in said distal end;

- introducing into said bore through said upstream opening of an injection cannula (3) which has at least one injection port (4);

sliding of said injection cannula beyond the distal end (1 a) until the injection orifice (4) opens into a zone to be treated situated under the skin;

injecting the product into said zone to be treated via the injection cannula (3).

2. Injection method according to claim 1, characterized in that it provides to inject a product successively in several areas to be treated, the cannula (3) introduced into the bore being moved to another area to be treated after injection of the product in an area to be treated.

3. Injection method according to claim 1 or 2, characterized in that it provides for retracting the needle (1) after passage of the cannula (3) beyond the sharp distal end (1a).

4. Injection method according to one of claims 1 to 3, characterized in that the product is a filler, in particular based on hyaluronic acid.

5. Injection method according to any one of claims 1 to 4, characterized in that the area of the pierced skin is located on the patient's face, the area to be treated being located on the face and / or the neck of the patient. patient.

6. Injection method according to any one of claims 1 to 5, characterized in that the area to be treated is located in the stratum granulosum or under the epidermis of the patient.

7. A product injection kit, particularly in the context of an aesthetic intervention, said kit comprising:

- At least one injection cannula (3) having at least one injection port (4);

at least one needle (1) for piercing the skin of a patient that has a sharp distal end (1 a), and a bore extending between an upstream opening and a downstream opening that opens into said distal end , said bore being arranged to allow the sliding of the injection cannula (3) beyond the distal end (1 a) to at least one area to be treated located under the skin.

8. Injection kit according to claim 7, characterized in that the injection cannula has a rounded distal end (3a), the injection port (4) being disposed laterally close to said rounded distal end.

9. Injection kit according to claim 7 or 8, characterized in that the injection cannula (3) has a length of between 13 mm and 1 10 mm, in particular between 25 mm and 70 mm.

10. Injection kit according to any one of claims 7 to 9, characterized in that the injection cannula (3) has an outer gauge between 14G and 33G, especially between 22G and 25G.

1 1. Injection kit according to one of claims 7 to 10, characterized in that the injection cannula (3) is flexible.

Injection kit according to one of claims 7 to 11, characterized in that the piercing needle (1) and the injection cannula (3) each have a base (2, 5) on which their proximal ends (1b, 3b) respectively are fixed, the base (5) of the injection cannula (3) being arranged to fit into the base (2) of the piercing needle (1) at the end of the sliding of said cannula in the bore of said needle.

13. injection kit according to claim 12, characterized in that the bases (2, 5) each comprise an identical identification marking of the outer caliber and / or the inner caliber of the cannula (3).

14. Injection kit according to claim 12 or 13, characterized in that the needle (1) is retractably mounted on its base (2).