WO2014205652A1

WO2014205652A1 - Artificial orbicularis oculi muscle for replacing eye closing function of orbicularis oculi muscle in artificial facial nerve

Info

Publication number: WO2014205652A1
Application number: PCT/CN2013/077887
Authority: WO
Inventors: 李克勇
Original assignee: 上海市第一人民医院
Priority date: 2013-06-25
Filing date: 2013-06-25
Publication date: 2014-12-31
Also published as: CN104582785A

Abstract

An artificial orbicularis oculi muscle for replacing an eye closing function of an orbicularis oculi muscle in an artificial facial nerve comprises a signal acquisition module, a control and processing module, an energy supply module, a pulse stimulation module, a south pole magnetic core coil, and north pole magnetic core coil. The signal acquisition module can acquire an electromyographic signal of eyelids on an unaffected side, and transferring the electromyographic signal to the control and processing module. The energy supply module supplies energy to the control and processing module. The control and processing module processes and analyzes the electromyographic signal, generates and transfers a stimulation pulse to the pulse stimulation module, triggers the pulse stimulation module to emit a current, drive the south pole magnetic core coil and the north pole magnetic core coil to attract each other, and drives an upper eyelid and a lower eyelid on an affected side to close. In the artificial orbicularis oculi muscle, based on a fact that most of facial expressions are symmetrically performed on two sides, an orbicularis oculi muscle on the unaffected side is used as a signal source, and eyelids on the affected side are closed by means of the driving of the south pole magnetic core coil and north pole magnetic core coil, thereby providing a new treatment means for maintaining the symmetry and consistency of the closing function of two-side eyelids of a patient losing an orbicularis oculi muscle function.

Description

Artificial orbicularis oculi muscle used in artificial facial nerve instead of orbital aponeurosis

Technical field

The present invention relates to an artificial prosthesis in the field of biomedical engineering, and more particularly to an artificial orbicularis oculi muscle for replacing the function of the orbicularis muscle in the artificial facial nerve.

Background technique

Peripheral facial paralysis is a common clinical and frequently-occurring disease, accounting for 73% of the total incidence of facial paralysis, the annual incidence rate is 0.2%; more common on one side, bilateral simultaneous occurrence is rare (accounting for 0.3%-2 of peripheral facial paralysis) %), because of its incomplete treatment, not timely, it will cause different degrees of complications, there is no effective and targeted treatment. Nerve transplantation is the gold standard for functional recovery. Because of limited efficacy (can not maintain facial dynamic symmetry), and limited by donor nerve collection and vascular anastomosis, it is currently used less in clinical treatment. In recent years, "artificial nerves" have made great progress, and can replace the autonomic nerves with limited sources for the treatment of peripheral nerve defects. The research focused on various nerve bridging materials, nerve factors and extracellular matrix is mainly used for nerve repair. However, facial anatomical features and functional complexity are major challenges in artificial facial nerve research. Current stimulation has certain value in the diagnosis and treatment of peripheral facial paralysis.

Chinese patent document CN 200710170756.0, application date November 22, 2007, discloses a artificial facial nerve prosthesis that replaces facial nerve function in the field of biomedical engineering, wherein: the signal acquisition module collects facial muscle electromyography signals on the healthy side of the face, The signal is transmitted to the control and processing module to complete the analysis and processing of the signal, and the conversion processing of the stimulation pulse is realized, the energy supply module is energized, the stimulation pulse is transmitted to the multi-channel pulse stimulation module, and the affected side muscle is realized by the micro-stimulation electrode. Electrical stimulation, causing facial muscle contraction; the feedback module collects myoelectric signals on the affected side of the face, and feeds back to the control and processing module to control the stimulation pulse. The wireless transmitting and receiving module transmits the information in the body to the outside, and The control signals input in vitro are received to achieve calibration and regulation of artificial prostheses for facial nerve function. The artificial facial nerve prosthesis generates corresponding symmetry movement according to the received contralateral normal electrical signal to stimulate the lateral muscles, maintains the symmetry and consistency of the facial expression muscles, and also stimulates the muscles to prevent atrophy and promote the nerve growth of the disconnection. Chinese Journal of Modern Biomedical Progress, 2011, Volll, No. 15, published the paper "Establishing artificial facial nerve technology to restore the closed eye function of peripheral facial rex rabbits", which is the preparation of unilateral peripheral facial rex rabbits, establishing health The ocular rim muscle myoelectric signal acquisition, the central signal processing pattern recognition, and the ipsilateral current stimulation of the orbicularis oculi muscle system. When the myoelectric signal collected by the contralateral orbicularis muscle is signal-recognized, extracted, and analyzed by computer, it is consistent with When the closed eye stimulates the sputum value, the artificial electric stimulator is given a command, and the stimulating electrode directly acts on the affected side of the orbicularis muscle, causing the eyelid to completely close. However, the artificial facial nerve prosthesis described above is suitable for patients with facial nerve dysfunction but with good muscle function, and for facial nerve dysfunction and facial muscle function loss, such as patients who have lost facial nerve innervation and lost orbital atrophy due to long-term loss of facial nerve innervation The artificial facial nerve prosthesis above can not achieve the effect of restoring the contraction of the orbital occipital muscles of the affected side and maintaining the symmetry and synchronization of the bilateral closed eyes. Summary of the invention

SUMMARY OF THE INVENTION The object of the present invention is to provide an artificial orbicularis oculi muscle for replacing the function of the orbicularis muscle closed eye in an artificial facial nerve in view of the deficiencies in the prior art.

In order to achieve the above object, the technical solution adopted by the present invention is:

An artificial orbicularis oculi muscle for replacing the orbicularis muscle closed eye function in an artificial facial nerve, comprising a signal acquisition module, a control and processing module, a power supply module, a pulse stimulation module, an Antarctic core coil and a North Pole core coil The signal acquisition module collects the myoelectric signal of the healthy side eyelid and transmits it to the control and processing module. The control and processing module is powered by the energy supply module, processes and analyzes the myoelectric signal and generates the stimulation pulse to The pulse stimulation module, the trigger pulse stimulation module issues a current, drives the south pole electromagnetic coil and the north pole electromagnetic coil to attract each other, and drives the upper and lower eyelids of the affected side to close.

The signal acquisition module is composed of a microelectrode, and collects the myoelectric signal of the diaphragm of the healthy side of the orb.

The control and processing module analyzes and processes the EMG signal transmitted from the signal acquisition module to generate a stimulation pulse and transmits it to the pulse stimulation module.

The pulse stimulator module includes an electrical stimulator chip, and the current generated by the stimulator chip is conducted to the south pole core coil and the north pole core coil to drive the two to attract each other.

The attraction of the South Pole core coil and the North Pole core coil is 50-1500 mg.

The magnetic core of the south pole magnetic core coil and the north pole magnetic core coil is 15 mm * 4 mm * 0.6 mm A3 soft iron, which is wound by 10-100 turns of 0.02 insulated wire.

The power supply module is a radio frequency coil with a frequency of 5.0 MHz.

The advantages of the invention are:

The invention is based on the fact that most facial symmetry movements of facial expressions use the contralateral orbicularis oculi muscle as a signal source to collect, conduct and analyze the myoelectric signals generated by the closure of the contralateral eyelids, and trigger the electricity in the pulse stimulation module. The stimulator chip generates current, drives the south and north pole magnetic core coils implanted in the upper and lower eyelids of the affected side to attract each other, realizes complete closure of the affected eyelid, and maintains the symmetry of bilateral eyelid closure function in patients with orbital sacral function loss. And consistency provides a new treatment.

DRAWINGS

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a block diagram showing the structure of an artificial orbicularis oculi muscle for replacing the function of the orbicularis oculi muscle in the artificial facial nerve. detailed description

The specific embodiments provided by the present invention are described in detail below with reference to the accompanying drawings. Example 1

Referring to FIG. 1, FIG. 1 is a structural block diagram of an artificial orbicularis oculi muscle for replacing the orbicularis muscle closed eye function in the artificial facial nerve. The artificial orbicularis oculi muscle for replacing the orbicularis muscle closed eye function in the artificial facial nerve includes a signal acquisition module, a control and processing module, a power supply module, a pulse stimulation module, an Antarctic core coil and an Arctic magnetic core coil. The signal acquisition module collects the myoelectric signal of the healthy side of the face, and connects and transmits the myoelectric signal to the control and processing module; the control and processing module is connected to the energy supply module on one hand, and is provided by the energy supply module. Controlling and processing the energy required for analyzing the myoelectric signal, and connecting the pulse stimulation module on the other hand, and transmitting the stimulation pulse generated after analyzing the myoelectric signal to the electrical stimulator chip in the pulse stimulation module, wherein the pulse stimulation module is The electric stimulator chip emits current under the trigger of the stimulation pulse; the pulse stimulation module is also connected to the south pole electromagnetic coil and the north pole electromagnetic coil implanted on the upper and lower sides of the affected eyelid, and the current distributed by the electric stimulator chip is transmitted to The Antarctic electromagnetic coil and the North Pole electromagnetic coil, the South Pole electromagnetic coil and the North Pole electromagnetic coil generate a magnetic field under the current drive, and the opposite sex attracts.

The signal acquisition module is made of a flexible microelectrode prepared by an integrated circuit process technology, using parylene as a substrate for the microelectrode and an electrode insulating layer, and the parylene has a good sealing property. The orbicularis muscle of the healthy side of the face was selected, and the myoelectric expression of the contralateral eyelid was closed by collecting the electrode of the myoelectric signal. Acquisition voltage range

0.5-50mv, continuous real-time acquisition.

The control and processing module includes a general-purpose programmable device (FPGA, CPLD or DSP, etc.), which processes and analyzes signals transmitted from the signal acquisition module to determine the excitation mode of the diaphragm of the healthy side of the orb, and generates a defect. The excitation pulse is used to trigger the pulse stimulation module to generate current. The stimuli pulse mainly uses biphasic pulses: positive and negative biphasic electrical pulse output, amplitude l-50mV, stimulation current 0.5-100mA, stimulation interval 0.1-1000ms or random.

The power supply module is powered by a radio frequency coil and has a frequency of 5.0 MHz.

The pulse stimulator module includes an electrical stimulator chip, and the current generated by the stimulator chip can be conducted to the south pole core coil and the north pole core coil.

The south pole magnetic core coil and the north pole magnetic core coil are respectively implanted on the upper side of the affected side and the lower eyelid, and the north and south poles are not limited. The attractiveness of both is preferably 50-1500mg. The core of the Antarctic core coil and the Arctic core coil is 15mm*4mm*0.6mm A3 soft iron, which is wound 10-100 turns by 0.02 insulated wire. The two are shaped by the action of current, and the movement of the upper and lower eyelids is closed to maintain the symmetry and consistency of the action of closing the eye.

The principle of the artificial orbicularis oculi muscle used in the artificial facial nerve to replace the orbicularis muscle closed eye function is: when the healthy side eyelid is closed, the healthy side of the orbicularis muscle is excited, the myoelectric activity is increased, and the signal acquisition is performed. The module collects the myoelectric signal generated by the diaphragm of the healthy side of the orb, transmits the myoelectric signal to the control and processing module to complete the analysis and processing of the signal, and realizes the conversion processing of the stimulation pulse, which is powered by the energy supply module, and the stimulation pulse is transmitted to the module. In the pulse stimulation module, the pulse stimulation module includes an electrical excitation device chip, and the excitation pulse triggers the electrical stimulation device chip to discharge current, and the current flows into the patient's eye. The upper and lower Antarctic core coils and the Arctic core coils generate a magnetic field, which in turn generates suction on the affected side due to suction from the opposite sex, and finally closes the eye. When the contralateral side blinks, the contralateral orbicularis muscle does not have a large amount of myoelectric activity, and the electromyographic signal collected by the signal acquisition module is transmitted to the control and processing module, and analyzed and processed by the control module. Processing, the strength of the myoelectric signal is insufficient, so the control and processing module will not further generate stimulation pulses to the pulse stimulation module, and the electrical stimulation device chip in the pulse stimulation module will not generate current to cause the South Pole core coil. The magnetic field coil of the Arctic generates a magnetic field, and finally the eyelid of the affected side is synchronized with the healthy side to maintain the blinking state. In this way, the south and north pole magnetic core coils implanted in the upper and lower eyelids of the affected side complete the closed eye and blink function of the orbicularis muscle by energization and power failure.

Claims

Rights request

1. An artificial orbicularis oculi muscle for replacing the orbicularis muscle closed eye function in an artificial facial nerve, comprising: a signal acquisition module, a control and processing module, an energy supply module, a pulse stimulation module, an Antarctic magnetic core The coil and the north pole magnetic core coil; the signal acquisition module can collect the myoelectric signal of the healthy side eyelid and transmit it to the control and processing module, and the control and processing module is powered by the energy supply module to process and analyze the myoelectric signal The excitation pulse is transmitted to the pulse stimulation module, and the trigger pulse stimulation module issues a current, driving the south pole electromagnetic coil and the north pole electromagnetic coil to attract each other, and driving the upper and lower eyelids of the affected side to close.

2. The artificial orbicularis oculi muscle for replacing the orbicularis muscle closed eye function in an artificial facial nerve according to claim 1, wherein the signal acquisition module is composed of a microelectrode, and the healthy side rim is collected. Myoelectric signal of the muscle.

3. The artificial orbicularis oculi muscle for replacing the orbicularis muscle closed eye function in the artificial facial nerve according to claim 1, wherein the control and processing module transmits the myoelectric signal transmitted by the signal acquisition module. Analysis and processing are performed to generate a pulse and pass it to the pulse stimulation module.

4. The artificial orbicularis oculi muscle for replacing the orbicularis muscle closed eye function in an artificial facial nerve according to claim 1, wherein the pulse stimulation module comprises an electrical excitation device chip, and the electrical stimulation The current generated by the chip is conducted to the south pole core coil and the north pole core coil, driving the two to attract each other.

5. The artificial orbicularis oculi muscle for replacing the orbicularis muscle closed eye function in an artificial facial nerve according to claim 1, wherein the attraction force of the south pole magnetic core coil and the north pole magnetic core coil is 50. -1500 mg.

6. The artificial orbicularis oculi muscle for replacing the orbicularis muscle closed eye function in an artificial facial nerve according to claim 5, wherein the magnetic core of the south pole magnetic core coil and the north pole magnetic core coil is 15 mm *4mm*0.6mm A3 soft iron, wound by 0.02 insulated wire 10-100 turns.

The artificial orbicularis oculi muscle for replacing the orbicularis muscle closed eye function in the artificial facial nerve according to claim 1, wherein the energy supply module is a radio frequency coil and has a frequency of 5.0 MHz.