CN101185788A - Artificial facial nerve prosthesis with facial nerve substituting function - Google Patents
Artificial facial nerve prosthesis with facial nerve substituting function Download PDFInfo
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- CN101185788A CN101185788A CNA2007101707560A CN200710170756A CN101185788A CN 101185788 A CN101185788 A CN 101185788A CN A2007101707560 A CNA2007101707560 A CN A2007101707560A CN 200710170756 A CN200710170756 A CN 200710170756A CN 101185788 A CN101185788 A CN 101185788A
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Abstract
The invention relates to an artificial facial neural prostheses to replace the function of facial nerves, which pertains to the biomedical engineering field, wherein, a signal collection module collects the electromyographic signals of facial muscles at the healthy side of the face, the signals are sent to a control and treatment module to complete the analysis and treatment of the signals, the conversion treatment of the stimulation pulse is realized, the energy is supplied by an energy supply module, the stimulation pulse is sent to a multi-line pulse stimulation module, and the electric stimulation on the muscles of the affected side is realized by a micro-stimulation electrode so as to cause the contraction of facial muscles; a feedback module collects the electromyographic signals of the affected side of the face, the signals are sent back to the control and treatment module to realize the regulation of the stimulation pulse, a wireless transmitting and receiving module transmits the information in vivo to the outside and receives the control signals for in vitro input, so as to realize the calibration and regulation of the artificial prostheses with the function of facial nerves. The invention can generate the corresponding symmetrical movements of the affected facial muscles according to the received stimulation of the normal electrical signals of the opposite side, so as to maintain the symmetry and consistency of the facial expression muscles; furthermore, the invention can stimulate the muscles for the prevention of atrophy and promote the growth of the transected nerves.
Description
Technical field
The present invention relates to a kind of artificial prosthesis of biomedical engineering field, specifically is a kind of artificial nervus facialis prosthese of alternative facial nerve function.
Background technology
Peripheral facial paralysis is that nervus facialis goes out behind the brain stem dialysis or pressurized usually causes the facial nerve function obstacle clinically.The pathological changes of nervus facialis can be caused by various tumor operations such as infectious disease, wound, ear source property disease, nervus facialis, acoustic nerve, and some is inevitable and does not heal all the life.Because neurocyte non-renewable and can not proliferative, facial nerve damage still lacks effective treatment means clinically, and main treatment clinically at present has facial nerve decompression operation and facial nerve grafting to perform the operation.In addition, also has the treatment of some non-operative treatments such as electronic stimulation and Chinese medicine.Facial nerve decompression is suitable for the nervus facialis pressurized, and its prerequisite is must be kept perfectly on the anatomical facial nerve, and the regular hour restriction is arranged, even the operation of nerve compression overlong time also can't reach good effect, so more to the sufferer restriction, using has limitation.What be applied to nervus facialis dialysis patient is facial nerve anastomosis (sew up connect two broken ends of fractured bone of nervus facialis) and nerve grafting (nerve of getting one section other position is connected the nervus facialis of dialysis).But these two kinds of Therapeutic Method still exist some problems to be solved, mainly be that neural axon growth is to grow towards periphery from proximal end, the nerve of transplanting only serves as a connection, if the dialysis position is very high, the nervus facialis of growth needs could arrive for a long time the muscle of domination.Nerve anastomosis and transplantation are limited from disconnected curative effect to nervus facialis clinically at present, especially for elevated nervus facialis from disconnected, and, still do not have any Therapeutic Method clinically to nervus facialis disappearance person.
Find by prior art documents, elder brother's list etc. is write articles " development of hand-held face nerve muscle stimulation treatment instrument " at " medical equipment information " 19 (3) (2003) pp14-16, this technology is that the local skin electricity irritation promotes the nervus facialis growth, but in the above-mentioned experiment, stimulation is not what continue, long-time stimulus also only is meant and continues 6 months treatment at 6 hours every day, even and stimulation instrument easy to carry, when treatment, patient's activity is also had certain restricted.But implanted control just can continue to send electricity irritation, makes facial muscle keep certain tonicity, the prevention amyotrophy, and also therapeutic process incorporates patient's daily life, and low to patient's influence.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art and defective, a kind of artificial nervus facialis prosthese of alternative facial nerve function is proposed, make it utilize implant electrode and chip directly to substitute the function of nervus facialis, normal electrical signal according to the strong side of accepting stimulates the Ipsilateral facial muscle to produce corresponding symmetric motion, keep the symmetry and the concordance of facial expression muscle, can also stimulated muscle prevent atrophy, promote to be used for the treatment of peripheral facial paralysis from disconnected nerve growth.
The present invention is achieved by the following technical solutions, the present invention includes signal acquisition module, control and processing module, energy supply module, impulse stimulation module, feedback module, wireless transmit and accept module.Signal acquisition module is gathered the facial muscle electromyographic signal in the strong side of face, signal is passed to control and processing module is finished the analysis and the processing of signal, and the conversion processing of realization boost pulse, by the energy supply of energy supply module, boost pulse is passed to multi-way impulse stimulation module, by the electricity irritation of microstimulation electrode realization, cause facial muscle and shrink Ipsilateral muscle.Feedback module is gathered electromyographic signal at face's Ipsilateral, feed back to control and processing module, realization is to the regulation and control of boost pulse, wireless transmit is transmitted into intravital information external with accepting module, and the control signal of external input is received calibration and the regulation and control of realization to the artificial prosthesis of facial nerve function.
Described signal acquisition module is to be made of multi-way microelectrode with flexibility, gathers the nervus facialis or the facial muscle signal of the strong side of face.
Described control and processing module are analyzed the signal that the acquisition module of electromyographic signal transmits and handle, and judge the facial muscle motion of strong side, produce the electric stimulation pulse of Ipsilateral muscle, and pass to multi-way impulse stimulation module.Control and processing module are by the energy supply of energy supply module.Control and processing module can be analyzed the electromyographic signal of feedback module collection and handle, and analyze Ipsilateral muscular movement situation.Control and processing module can and be accepted module with intravital wireless transmit and carry out both-way communication.Control and processing module can be realized by universal programmable chips, also can realize by the design specialized integrated circuit.
Described energy supply module realizes energy supply for the artificial prosthesis that recovers facial nerve function, is meant by battery, capacitor, wireless radiofrequency energy supply, ultrasonic energy supply, vibrates energy supply, temperature difference energy supply, infrared function or directly utilize biological intravital energy energy supply.
Described impulse stimulation module is to be made of multi-way microelectrode with flexibility, realizes the control of boost pulse to face's Ipsilateral muscle.
Described feedback module is to be made of multi-way microelectrode with flexibility, gathers face's Ipsilateral facial muscle signal, and signal feedback is arrived control and processing module, adjusts pulse-stimulating signal.
Described wireless transmit with accept module, be connected with processing module with control, pass to intravital signal external through wireless mode, analyze external, pulse-stimulating signal parameter to control and processing module output is adjusted, and external control signal received in the body, realize external the artificial prosthesis of implanting being detected and adjust control.This wireless transmit with accept module and can adopt Bluetooth technology, infrared, radio frequency and ultrasonic technique to realize the transmission and the reception of signal.
Be compared with the prior art, the present invention accepts the excitatory potential information of strong side nerve or facial muscle by a plurality of electromyographic signal collection electrodes, the analytical judgment of process control and processing module goes out the excited pattern to side face muscle, then with corresponding pattern output current, directly stimulate the facial muscle of Ipsilateral by a plurality of stimulating electrodes, impel Ipsilateral facial muscle and strong side common mode to coordinate to shrink, keeping the facial expression symmetrical structure, correct close one's eyes can not, distortion of commissure, the clinical symptoms of gargling and can not shoal with nasolabial fold.In addition, provide electric current when quiet at random, stimulate the Ipsilateral facial muscle to keep the slight shrinkage function, can prevent the facial muscle disuse atrophy.Its function mainly comprises three aspects, the one, and the nervus facialis maincenter and the nervus facialis of alternative Ipsilateral directly stimulate facial muscle, finishing the expression action, keep Ipsilateral and strong side symmetry.The 2nd, temporarily keep the facial muscle muscular tension at the facial nerve grafting postoperative, prevent the facial muscle disuse atrophy, treat to stop using after facial nerve function recovers.The 3rd, as the supplementary functions of facial nerve grafting operation, the invalid or weak effect when facial nerve transplantation can provide stimulating current, increases the facial muscle contraction intensity, makes Ipsilateral facial muscle and strong side symmetry.
The present invention is with the difference of simple electronic stimulation maximum in the past, inserting of electrode except the stimulated muscle motion, prevent atrophy, promote outside the nerve growth, can also directly substitute the function of nervus facialis, directly stimulate facial muscle to produce corresponding symmetric motion, keep the symmetry and the concordance of expression according to the offside normal electrical signal of accepting.It is demand side neuro anatomy structure complete not, also do not need the participation of neuromuscular junction, is a kind of method of independent treatment facial paralysis.
Description of drawings
Fig. 1 is a structured flowchart of the present invention
The specific embodiment
Below in conjunction with accompanying drawing embodiments of the invention are elaborated: present embodiment has provided detailed embodiment and process being to implement under the prerequisite with the technical solution of the present invention, but protection scope of the present invention is not limited to following embodiment.
As shown in Figure 1, present embodiment comprises signal acquisition module, control and processing module, energy supply module, impulse stimulation module, feedback module, wireless transmit and accepts module.Gather electromyographic signal by the multiplexed signal sampling module in the strong side of face, signal is passed to control and processing module is finished the analysis and the processing of signal, and the conversion processing of realization boost pulse, by the energy supply of energy supply module, boost pulse is passed to multi-way impulse stimulation module, by the stimulation of microstimulation electrode realization to Ipsilateral muscle, utilize feedback module to gather electromyographic signal at face's Ipsilateral, feed back to control and processing module, realization is to the regulation and control of boost pulse, wireless transmit is transmitted into intravital information external with accepting module, and the control signal of external input is received calibration and the regulation and control of realization to the artificial prosthesis of facial nerve function.
Described signal acquisition module be the substrate and the electrode dielectric layer of microelectrode with the Parylene, and Parylene has good sealing property by the flexible microelectrode of integrated circuit processing technique preparation.For facial paralysis, choose the muscle of 5-6 significant points of the strong side of face: orbicularis oculi, buccinator muscle, Albinus' muscle and orbicularis oris etc., by imbedding the acquisition electrode of 5-6 road electromyographic signal, gather daily emotion and express as myoelectricity sad, that smile, laugh.Gather voltage range 0.5-50mv, gather in real time continuously.
Described control and processing module are by general programmable device (FPGA, CPLD or DSP etc.), the signal that will transmit from the acquisition module of electromyographic signal is handled and is analyzed, judge the excited pattern of strong side face muscle, as expressions such as laughing, cry, and produce the muscle that boost pulse is used for the exciting face Ipsilateral.Boost pulse mainly adopts diphasic pulse: promptly positive and negative biphasic electrical pulse output, wave amplitude 1mV-50mV, stimulating current 0.5-100mA, stimulus intervals 0.1-1000ms or appearance at random.
Described impulse stimulation module is the flexible microelectrode of integrated circuit processing technique preparation, is the substrate and the electrode dielectric layer of microelectrode with the Parylene.Stimulating electrode is implanted the muscle of Ipsilateral, and as orbicularis oculi, buccinator muscle and orbicularis oris etc., stimulated muscle produces corresponding symmetric motion, keeps the symmetry and the concordance of expression.
Described feedback module is by the flexible microelectrode of integrated circuit processing technique preparation, acquisition electrode is implanted the muscle of Ipsilateral, as orbicularis oculi, buccinator muscle and orbicularis oris etc., pick up muscle and produce the corresponding signal of telecommunication because of shrinking, signal feedback is arrived control and processing module.Adjust stimulus signal by control and processing module.
Described wireless transmit with accept module intravital signal passed to external and external signal is received in the body through wireless mode, analyze external, pulse-stimulating signal parameter to control and processing module output is adjusted, and external control signal received in the body, adjust the frequency, pulsewidth of pulse-stimulating signal etc.This wireless transmit and transmission and the acceptance of accepting module employing Bluetooth technology.
Described energy supply module adopts the radio-frequency coil energy supply, and frequency is 5.0MHz.
The present invention utilizes implant electrode directly to substitute the function of nervus facialis, directly stimulate facial muscle to produce corresponding symmetric motion according to the offside normal electrical signal of accepting, keep the symmetry and the concordance of expression, random stimulus muscle prevents atrophy at ordinary times, promotes outside the nerve growth.This is that a kind of treatment anatomical facial nerve is imperfect, and function lacks fully, and also can't recover patient's unique method from now on.And all demand side neuro anatomy and functional integrity of all Therapeutic Method at present.
Claims (8)
1. the artificial nervus facialis prosthese of an alternative facial nerve function, comprise signal acquisition module, control and processing module, energy supply module, impulse stimulation module, feedback module, wireless transmit and accept module, it is characterized in that: described signal acquisition module is gathered the facial muscle electromyographic signal in the strong side of face, and signal is passed to control and processing module; Described control and processing module are finished the analysis and the processing of signal, and realize the conversion processing of boost pulse, and by the energy supply of energy supply module, boost pulse is passed to multi-way impulse stimulation module; Described impulse stimulation module causes facial muscle and shrinks by the electricity irritation of microstimulation electrode realization to Ipsilateral muscle; Described feedback module is gathered electromyographic signal at face's Ipsilateral, feeds back to control and processing module, realizes the regulation and control to boost pulse; Described wireless transmit is transmitted into intravital information external with accepting module, and the control signal of external input is received calibration and the regulation and control of realization to the artificial prosthesis of facial nerve function.
2. the artificial nervus facialis prosthese of alternative facial nerve function according to claim 1 is characterized in that, described signal acquisition module is to be made of multi-way microelectrode, gathers the nervus facialis or the facial muscle signal of the strong side of face.
3. the artificial nervus facialis prosthese of alternative facial nerve function according to claim 1, it is characterized in that, described control and processing module, the signal that the acquisition module of electromyographic signal transmits is analyzed and handled, judge the facial muscle motion of strong side, produce the electric stimulation pulse of Ipsilateral muscle, and pass to multi-way impulse stimulation module, control and processing module are by the energy supply of energy supply module, control and processing module are analyzed the electromyographic signal of feedback module collection and handle, analyze Ipsilateral muscular movement situation, control and processing module and intravital wireless transmit and accept module and carry out both-way communication.
4. the artificial nervus facialis prosthese of alternative facial nerve function according to claim 1 is characterized in that, described impulse stimulation module is to be made of the multichannel microelectrode, realizes the control of boost pulse to face's Ipsilateral muscle.
5. the artificial nervus facialis prosthese of alternative facial nerve function according to claim 1 is characterized in that described feedback module, be to constitute by multi-way microelectrode, gather face's Ipsilateral facial muscle signal, and signal feedback is arrived control and processing module, adjust pulse-stimulating signal.
6. the artificial nervus facialis prosthese of alternative facial nerve function according to claim 1, it is characterized in that, described wireless transmit with accept module, pass to intravital signal external through wireless mode, analyze external, pulse-stimulating signal parameter to control and processing module output is adjusted, and external control signal is received in the body, realizes that external artificial prosthesis to implantation detects and adjust control.
7. the artificial nervus facialis prosthese of alternative facial nerve function according to claim 1, it is characterized in that, described energy supply module, realize energy supply for the artificial prosthesis that recovers facial nerve function, specifically adopt battery, capacitor, wireless radiofrequency energy supply, ultrasonic energy supply, vibration energy supply, temperature difference energy supply, infrared function or directly utilize biological intravital energy energy supply.
8. according to the artificial nervus facialis prosthese of claim 1 or 7 described alternative facial nerve functions, it is characterized in that described energy supply module is a radio-frequency coil, frequency is 5.0MHz.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200710170756A CN100579603C (en) | 2007-11-22 | 2007-11-22 | Artificial facial nerve prosthesis with facial nerve substituting function |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200710170756A CN100579603C (en) | 2007-11-22 | 2007-11-22 | Artificial facial nerve prosthesis with facial nerve substituting function |
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| CN101185788A true CN101185788A (en) | 2008-05-28 |
| CN100579603C CN100579603C (en) | 2010-01-13 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614033A (en) * | 2011-01-31 | 2012-08-01 | 上海市第一人民医院 | Prosthesis of artificial larynx recurrent nerves |
| CN102649003A (en) * | 2012-04-18 | 2012-08-29 | 上海诺诚电气有限公司 | Constant-current stimulation circuit based on electromyographic feedback stimulation |
| CN103212156A (en) * | 2013-04-03 | 2013-07-24 | 重庆绿色智能技术研究院 | Hemiplegic patient self-recovery meter based on body mirror image theory |
| CN104225790A (en) * | 2014-09-19 | 2014-12-24 | 清华大学 | Closed loop nerve stimulation system |
| WO2014205652A1 (en) * | 2013-06-25 | 2014-12-31 | 上海市第一人民医院 | Artificial orbicularis oculi muscle for replacing eye closing function of orbicularis oculi muscle in artificial facial nerve |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1861210B (en) * | 2005-05-12 | 2010-04-28 | 财团法人工业技术研究院 | Optimized positioning energy-transfer device for implanted electric stimulator |
-
2007
- 2007-11-22 CN CN200710170756A patent/CN100579603C/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614033A (en) * | 2011-01-31 | 2012-08-01 | 上海市第一人民医院 | Prosthesis of artificial larynx recurrent nerves |
| CN102649003A (en) * | 2012-04-18 | 2012-08-29 | 上海诺诚电气有限公司 | Constant-current stimulation circuit based on electromyographic feedback stimulation |
| CN102649003B (en) * | 2012-04-18 | 2015-08-26 | 上海诺诚电气有限公司 | Based on the constant current stimulation circuit that EMG feedback stimulates |
| CN103212156A (en) * | 2013-04-03 | 2013-07-24 | 重庆绿色智能技术研究院 | Hemiplegic patient self-recovery meter based on body mirror image theory |
| CN103212156B (en) * | 2013-04-03 | 2015-10-28 | 重庆德领科技有限公司 | The autonomous instrument of hemiplegic patient based on body image theory |
| WO2014205652A1 (en) * | 2013-06-25 | 2014-12-31 | 上海市第一人民医院 | Artificial orbicularis oculi muscle for replacing eye closing function of orbicularis oculi muscle in artificial facial nerve |
| CN104582785A (en) * | 2013-06-25 | 2015-04-29 | 上海市第一人民医院 | Artificial orbicularis oculi muscle for replacing eye closing function of orbicularis oculi muscle in artificial facial nerve |
| CN104225790A (en) * | 2014-09-19 | 2014-12-24 | 清华大学 | Closed loop nerve stimulation system |
| CN104225790B (en) * | 2014-09-19 | 2017-06-16 | 清华大学 | Closed loop neural stimulation system |
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| CN100579603C (en) | 2010-01-13 |
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