WO2014203231A3 - Process for preparation of dimethyl-(e)-butenedioate - Google Patents

Process for preparation of dimethyl-(e)-butenedioate Download PDF

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Publication number
WO2014203231A3
WO2014203231A3 PCT/IB2014/065440 IB2014065440W WO2014203231A3 WO 2014203231 A3 WO2014203231 A3 WO 2014203231A3 IB 2014065440 W IB2014065440 W IB 2014065440W WO 2014203231 A3 WO2014203231 A3 WO 2014203231A3
Authority
WO
WIPO (PCT)
Prior art keywords
dimethyl
preparation
butenedioate
enedioate
methanol
Prior art date
Application number
PCT/IB2014/065440
Other languages
French (fr)
Other versions
WO2014203231A2 (en
Inventor
Rafiuddin DR.
Bhagat Raj PIPAL
Ravindra Reddy UMMADI
Akshay Kant CHATURVEDI
Original Assignee
Shilpa Medicare Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shilpa Medicare Limited filed Critical Shilpa Medicare Limited
Priority to US15/110,104 priority Critical patent/US20160326087A1/en
Priority to EP14812977.8A priority patent/EP3097075A4/en
Publication of WO2014203231A2 publication Critical patent/WO2014203231A2/en
Publication of WO2014203231A3 publication Critical patent/WO2014203231A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to a process for preparation of dimethyl-(E)-butenedioate (I). The process for preparation of dimethyl-(E) -but enedioate (I), comprises reaction of Fumaric acid with methanol in the presence of C2-C4 alkanoyl halide as coupling catalyst.
PCT/IB2014/065440 2014-01-24 2014-10-18 Process for preparation of dimethyl-(e)-butenedioate WO2014203231A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US15/110,104 US20160326087A1 (en) 2014-01-24 2014-10-18 Process for preparation of dimethyl-(e)-butenedioate
EP14812977.8A EP3097075A4 (en) 2014-01-24 2014-10-18 Process for preparation of dimethyl-(e)-butenedioate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN0308/CHE/2014 2014-01-24
IN308CH2014 IN2014CH00308A (en) 2014-01-24 2014-10-18

Publications (2)

Publication Number Publication Date
WO2014203231A2 WO2014203231A2 (en) 2014-12-24
WO2014203231A3 true WO2014203231A3 (en) 2015-07-30

Family

ID=52105418

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/065440 WO2014203231A2 (en) 2014-01-24 2014-10-18 Process for preparation of dimethyl-(e)-butenedioate

Country Status (3)

Country Link
EP (1) EP3097075A4 (en)
IN (1) IN2014CH00308A (en)
WO (1) WO2014203231A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017013672A1 (en) 2015-07-23 2017-01-26 Natco Pharma Ltd Process for the preparation of pharmaceutical grade dimethyl fumarate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3078302A (en) * 1958-09-25 1963-02-19 Monsanto Chemicals Production of dialkyl fumarates
US3905943A (en) * 1973-04-16 1975-09-16 Koppers Co Inc Preparation of fumarates
WO2012170923A1 (en) * 2011-06-08 2012-12-13 Biogen Idec Ma Inc. Process for preparing high purity and crystalline dimethyl fumarate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102766050A (en) * 2012-08-10 2012-11-07 太仓市运通化工厂 Method for synthesizing dimethyl fumarate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3078302A (en) * 1958-09-25 1963-02-19 Monsanto Chemicals Production of dialkyl fumarates
US3905943A (en) * 1973-04-16 1975-09-16 Koppers Co Inc Preparation of fumarates
WO2012170923A1 (en) * 2011-06-08 2012-12-13 Biogen Idec Ma Inc. Process for preparing high purity and crystalline dimethyl fumarate

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3097075A4 *

Also Published As

Publication number Publication date
WO2014203231A2 (en) 2014-12-24
IN2014CH00308A (en) 2015-07-31
EP3097075A2 (en) 2016-11-30
EP3097075A4 (en) 2017-06-21

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