WO2014200987A3 - Ms1 gas-phase enrichment using notched isolation waveforms - Google Patents

Ms1 gas-phase enrichment using notched isolation waveforms Download PDF

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Publication number
WO2014200987A3
WO2014200987A3 PCT/US2014/041686 US2014041686W WO2014200987A3 WO 2014200987 A3 WO2014200987 A3 WO 2014200987A3 US 2014041686 W US2014041686 W US 2014041686W WO 2014200987 A3 WO2014200987 A3 WO 2014200987A3
Authority
WO
WIPO (PCT)
Prior art keywords
notched
gas
discrete
spectrum
phase enrichment
Prior art date
Application number
PCT/US2014/041686
Other languages
French (fr)
Other versions
WO2014200987A2 (en
Inventor
Graeme Conrad MCALISTER
Steven P. Gygi
Brian Erickson
Original Assignee
President And Fellows Of Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by President And Fellows Of Harvard College filed Critical President And Fellows Of Harvard College
Publication of WO2014200987A2 publication Critical patent/WO2014200987A2/en
Publication of WO2014200987A3 publication Critical patent/WO2014200987A3/en

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions
    • H01J49/427—Ejection and selection methods
    • H01J49/428—Applying a notched broadband signal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

A method of performing mass spectrometry survey scans. The method includes using at least one isolation waveform of an ion trap, the isolation waveform with at least a first and second notch. Methods may include determining a first mass-to-charge ratio (m/z) spectrum of a first plurality of ions from a first plurality of discrete m/z ranges; determining a second m/z spectrum of a second plurality of ions from a second plurality of discrete m/z ranges different from the first plurality of discrete m/z ranges; and creating a combined m/z spectrum by combining the first and second m/z spectra.
PCT/US2014/041686 2013-06-10 2014-06-10 Ms1 gas-phase enrichment using notched isolation waveforms WO2014200987A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361833370P 2013-06-10 2013-06-10
US61/833,370 2013-06-10

Publications (2)

Publication Number Publication Date
WO2014200987A2 WO2014200987A2 (en) 2014-12-18
WO2014200987A3 true WO2014200987A3 (en) 2015-03-05

Family

ID=52022916

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/041686 WO2014200987A2 (en) 2013-06-10 2014-06-10 Ms1 gas-phase enrichment using notched isolation waveforms

Country Status (1)

Country Link
WO (1) WO2014200987A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9818595B2 (en) 2015-05-11 2017-11-14 Thermo Finnigan Llc Systems and methods for ion isolation using a dual waveform
US9911585B1 (en) * 2016-12-21 2018-03-06 Thermo Finnigan Llc Data-independent mass spectral data acquisition including data-dependent precursor-ion surveys
WO2018134346A1 (en) 2017-01-19 2018-07-26 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Mass spectrometry with improved dynamic range
GB2563565B (en) * 2017-04-13 2022-05-11 Micromass Ltd Mass spectrometry with increased duty cycle
US20220403001A1 (en) 2018-06-12 2022-12-22 Obsidian Therapeutics, Inc. Pde5 derived regulatory constructs and methods of use in immunotherapy
EP3870600A1 (en) 2018-10-24 2021-09-01 Obsidian Therapeutics, Inc. Er tunable protein regulation

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4849628A (en) * 1987-05-29 1989-07-18 Martin Marietta Energy Systems, Inc. Atmospheric sampling glow discharge ionization source
US5696376A (en) * 1996-05-20 1997-12-09 The Johns Hopkins University Method and apparatus for isolating ions in an ion trap with increased resolving power
US20050242278A1 (en) * 2004-04-16 2005-11-03 Syage Jack A High speed, multiple mass spectrometry for ion sequencing
US7569814B2 (en) * 2004-06-08 2009-08-04 Hitachi High-Technologies Corporation Mass spectrometer
WO2012051392A2 (en) * 2010-10-13 2012-04-19 Purdue Research Foundation Tandem mass spectrometry using composite waveforms
WO2012164378A2 (en) * 2011-06-03 2012-12-06 Dh Technologies Development Pte. Ltd. Removal of ions from survey scans using variable window band-pass filtering to improve intrascan dynamic range
US20120305762A1 (en) * 2010-03-24 2012-12-06 Akihito Kaneko Ion isolation method and mass spectrometer

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4849628A (en) * 1987-05-29 1989-07-18 Martin Marietta Energy Systems, Inc. Atmospheric sampling glow discharge ionization source
US5696376A (en) * 1996-05-20 1997-12-09 The Johns Hopkins University Method and apparatus for isolating ions in an ion trap with increased resolving power
US20050242278A1 (en) * 2004-04-16 2005-11-03 Syage Jack A High speed, multiple mass spectrometry for ion sequencing
US7569814B2 (en) * 2004-06-08 2009-08-04 Hitachi High-Technologies Corporation Mass spectrometer
US20120305762A1 (en) * 2010-03-24 2012-12-06 Akihito Kaneko Ion isolation method and mass spectrometer
WO2012051392A2 (en) * 2010-10-13 2012-04-19 Purdue Research Foundation Tandem mass spectrometry using composite waveforms
WO2012164378A2 (en) * 2011-06-03 2012-12-06 Dh Technologies Development Pte. Ltd. Removal of ions from survey scans using variable window band-pass filtering to improve intrascan dynamic range

Also Published As

Publication number Publication date
WO2014200987A2 (en) 2014-12-18

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