SG10201900563YA - Systems and methods for mass calibration - Google Patents

Systems and methods for mass calibration

Info

Publication number
SG10201900563YA
SG10201900563YA SG10201900563YA SG10201900563YA SG10201900563YA SG 10201900563Y A SG10201900563Y A SG 10201900563YA SG 10201900563Y A SG10201900563Y A SG 10201900563YA SG 10201900563Y A SG10201900563Y A SG 10201900563YA SG 10201900563Y A SG10201900563Y A SG 10201900563YA
Authority
SG
Singapore
Prior art keywords
mass
ions
related physical
species
calibrant
Prior art date
Application number
SG10201900563YA
Inventor
Scott T Quarmby
George B Guckenberger
Original Assignee
Thermo Finnigan Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thermo Finnigan Llc filed Critical Thermo Finnigan Llc
Publication of SG10201900563YA publication Critical patent/SG10201900563YA/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0009—Calibration of the apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7206—Mass spectrometers interfaced to gas chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/422—Two-dimensional RF ion traps
    • H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

SYSTEMS AND METHODS FOR MASS CALIBRATION A method includes producing ions from one or more calibrant species and delivering the ions to a mass analyzer, and measuring a first set of mass related physical values for the ions from the one or more calibrant species. The method further includes producing ions from a sample and delivering the ions to a mass analyzer, and measuring a second mass related physical value for a first sample ion species. The first sample ion species has a mass-to-charge ratio outside of the range of the mass-to-charge ratios of the calibrant ion species. Additionally, the method includes calculating a calibration curve based on the first set of mass related physical values and second mass related physical value, and modifying at least one instrument parameter based on the calibration curve. Figure 1
SG10201900563YA 2015-03-25 2016-03-21 Systems and methods for mass calibration SG10201900563YA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562138239P 2015-03-25 2015-03-25

Publications (1)

Publication Number Publication Date
SG10201900563YA true SG10201900563YA (en) 2019-02-27

Family

ID=55588141

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201602193WA SG10201602193WA (en) 2015-03-25 2016-03-21 Systems and methods for mass calibration
SG10201900563YA SG10201900563YA (en) 2015-03-25 2016-03-21 Systems and methods for mass calibration

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201602193WA SG10201602193WA (en) 2015-03-25 2016-03-21 Systems and methods for mass calibration

Country Status (4)

Country Link
US (2) US10242850B2 (en)
EP (1) EP3073510B1 (en)
CN (1) CN106024571B (en)
SG (2) SG10201602193WA (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10067141B2 (en) * 2016-06-21 2018-09-04 Thermo Finnigan Llc Systems and methods for improving loading capacity of a segmented reaction cell by utilizing all available segments
US10429364B2 (en) * 2017-01-31 2019-10-01 Thermo Finnigan Llc Detecting low level LCMS components by chromatographic reconstruction
US10056244B1 (en) * 2017-07-28 2018-08-21 Thermo Finnigan Llc Tuning multipole RF amplitude for ions not present in calibrant
EP3660504B1 (en) 2018-11-30 2025-01-01 Thermo Fisher Scientific (Bremen) GmbH Systems and methods for determining mass of an ion species
GB201912494D0 (en) 2019-08-30 2019-10-16 Micromass Ltd Mass spectometer calibration
GB202005715D0 (en) * 2020-04-20 2020-06-03 Micromass Ltd Calibration of analytical instrument

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6437325B1 (en) * 1999-05-18 2002-08-20 Advanced Research And Technology Institute, Inc. System and method for calibrating time-of-flight mass spectra
GB0021901D0 (en) * 2000-09-06 2000-10-25 Kratos Analytical Ltd Calibration method
GB2390934B (en) * 2002-03-15 2005-09-14 Kratos Analytical Ltd Calibration method
GB0308278D0 (en) 2003-04-10 2003-05-14 Micromass Ltd Mass spectrometer
US6983213B2 (en) * 2003-10-20 2006-01-03 Cerno Bioscience Llc Methods for operating mass spectrometry (MS) instrument systems
GB0511083D0 (en) * 2005-05-31 2005-07-06 Thermo Finnigan Llc Multiple ion injection in mass spectrometry
US7700912B2 (en) * 2006-05-26 2010-04-20 University Of Georgia Research Foundation, Inc. Mass spectrometry calibration methods
GB0714040D0 (en) * 2007-07-19 2007-08-29 Xceleron Ltd Quantification of analytes
US7569813B2 (en) 2007-08-21 2009-08-04 Mds Analytical Technologies, A Business Unit Of Mds Inc. Method for enhancing mass assignment accuracy
EP2186111A4 (en) 2007-08-21 2011-12-21 Mds Analytical Tech Bu Mds Inc Method for enhancing mass assignment accuracy
US8067728B2 (en) * 2008-02-22 2011-11-29 Dh Technologies Development Pte. Ltd. Method of improving signal-to-noise for quantitation by mass spectrometry
US7804065B2 (en) 2008-09-05 2010-09-28 Thermo Finnigan Llc Methods of calibrating and operating an ion trap mass analyzer to optimize mass spectral peak characteristics
US8258462B2 (en) 2008-09-05 2012-09-04 Thermo Finnigan Llc Methods of calibrating and operating an ion trap mass analyzer to optimize mass spectral peak characteristics
US8748811B2 (en) * 2009-02-05 2014-06-10 Shimadzu Corporation MS/MS mass spectrometer
WO2011106640A2 (en) * 2010-02-26 2011-09-01 Zoex Licensing Corporation Pulsed mass calibration in time-of-flight mass spectrometry
WO2012025821A2 (en) 2010-08-25 2012-03-01 Dh Technologies Development Pte. Ltd. Methods and systems for providing a substantially quadrupole field with significant hexapole and octapole components
CN103282770B (en) * 2011-01-07 2015-08-12 株式会社日立高新技术 Quality analysis apparatus, analytic approach and calibration sample
WO2013104004A1 (en) * 2012-01-08 2013-07-11 Cerno Bioscience Llc Comprehensive interference treatment for icp-ms analysis
US8759752B2 (en) * 2012-03-12 2014-06-24 Thermo Finnigan Llc Corrected mass analyte values in a mass spectrum
GB201304040D0 (en) 2013-03-06 2013-04-17 Micromass Ltd Improved lock component corrections
EP2965343B1 (en) 2013-03-06 2019-08-07 Micromass UK Limited Improved lock component corrections

Also Published As

Publication number Publication date
CN106024571B (en) 2018-08-24
SG10201602193WA (en) 2016-10-28
US10438782B2 (en) 2019-10-08
US20160284527A1 (en) 2016-09-29
EP3073510A1 (en) 2016-09-28
CN106024571A (en) 2016-10-12
US20190172692A1 (en) 2019-06-06
EP3073510B1 (en) 2024-12-04
US10242850B2 (en) 2019-03-26

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