WO2014200206A1

WO2014200206A1 - Sensor strip for measuring blood glucose level, manufacturing method therefor, and monitoring device using same

Info

Publication number: WO2014200206A1
Application number: PCT/KR2014/004686
Authority: WO
Inventors: 정상국; 이정현; 양지선
Original assignee: 명지대학교 산학협력단
Priority date: 2013-06-13
Filing date: 2014-05-27
Publication date: 2014-12-18
Also published as: KR101447970B1

Abstract

Disclosed are a sensor strip for measuring a blood glucose level, a manufacturing method therefor, and a monitoring device using the same. The method for manufacturing a sensor strip, according to one aspect of the present invention, comprises the steps of: forming a first structure layer by forming an electrode on a first substrate; forming a chamber-shaped insert on a second substrate; applying a molding material on the second substrate; curing the molding material; removing the second substrate and the chamber-shaped insert from the cured molding material so as to form a second structure layer having a chamber formed at one side thereof; applying a reactive material to a position corresponding to the chamber; and coupling the first structure layer and the second structure layer such that the reactive material is positioned in the chamber, thereby forming the volume of the chamber filled with blood at high precision so as to increase the reliability of measurement of the blood glucose level.

Description

Blood glucose measurement sensor strip, manufacturing method and monitoring device using same

The present invention relates to a sensor strip for blood glucose measurement, and more particularly, to a sensor strip and a manufacturing method thereof and a monitoring device using the same that can increase the accuracy of blood glucose measurement.

Diabetes is a disease in which the human body does not produce enough insulin or respond properly to insulin. Insulin is a hormone produced by the pancreas that allows cells to convert glucose into energy. In diabetics, sugar can accumulate in the blood and adversely affect tissues such as the eye, kidneys, heart, and circulatory system.

To deal effectively with diabetes, diabetics often need to measure their blood sugar levels to determine how much insulin they should take. To this end, various blood glucose meters using various methods have been produced by various companies.

A typical method of the self-glucometer is a method in which a small amount of blood is collected and reacted with glucose oxidase to measure blood glucose using electrochemical analysis. In this case, the blood glucose meter may be composed of a sensor strip and a meter.

The sensor strip includes a chamber filled with blood and an electrode coated with an enzyme on the bottom surface, and when the blood is filled in the chamber of the sensor strip and connected to a meter, the sensor strip is configured to generate a current generated by the interaction between the enzyme and blood glucose. The instrument can measure and calculate blood glucose levels.

According to a survey by Samsung Medical Center, the accuracy of the domestic self glucose meter is about 5% and the accuracy varies by 30 ~ 50%. In particular, when the blood sugar is low or the sample amount is large, the deviation is greater.

However, in the case of the current sensor strip for electrochemical analysis, the size of the chamber filled with blood is not constant for each sensor strip to be manufactured, there is a problem that the sample amount varies for each sensor strip. In addition, a material such as paper is used for mass production, which can reduce the uniformity of the sample amount in the sensor strip due to the characteristics such as relatively low smoothness and absorbency.

On the other hand, the sensor strip of the self-glucometer must be filled with blood in the chamber of the sensor strip every time it is used. Therefore, if the blood glucose measurement can be performed with a smaller amount of blood by making the chamber of the sensor strip smaller but maintaining the precision, the invasion size can be made smaller when the user pokes the skin to collect blood, and thus suffers. You will be able to mitigate.

One aspect of the present invention is to provide a sensor strip, a method for manufacturing the same, and a monitoring device capable of increasing the reliability of blood glucose measurement by manufacturing a volume of a chamber filled with blood with high precision.

In addition, one aspect of the present invention is to provide a sensor strip using a smaller amount of blood, a method of manufacturing the same and a monitoring device.

According to one aspect of the invention, forming an electrode on the first substrate to form a first structural layer; Forming a chambered insert in the second substrate; Applying a molding material on the second substrate; Curing the molding material; Removing the second substrate and the chamber-shaped insert from the cured molding material to form a second structural layer having a chamber formed on one side; Applying a reactant at a location corresponding to the chamber; And coupling the first structure layer and the second structure layer such that the reactant is positioned in the chamber.

Forming the chambered insert includes: forming a photoresist on the second substrate; Disposing a mask on which the shape of the chamber-shaped insert is patterned on the photoresist; Irradiating light onto the photoresist; Removing the mask; And developing the photoresist.

Forming the first structural layer includes disposing a mask on which the shape of the electrode is patterned on the first substrate; Depositing an electrode material on the first substrate; And removing the mask.

The forming of the first structure layer may include depositing an electrode material on one surface of the first substrate; Disposing a mask on which the shape of the electrode is patterned on the electrode material; Etching the electrode material exposed through the mask; And removing the mask.

Forming the first structural layer, forming a chamber-shaped insert, applying a molding material, forming a second structural layer, applying a reactant, and first and second structural layers At least one of the step of joining the layers may be performed by a micro-electro-mechanical systems (MEMS) process.

In one embodiment of the present invention, the method for manufacturing a sensor strip for measuring blood glucose may further include forming at least one electrode on the chamber-type insert before applying the molding material. In this case, the electrode formed on the chamber-type insert may be electrically connected to the electrode formed on the first substrate by the blood filled in the chamber.

The molding material may include, for example, polydimethylsiloxane (PDMS).

According to another aspect of the invention, the first structure layer in which the electrode is formed on one surface; A second structure layer having a chamber formed on the surface thereof and coupled to the first structure layer such that the surface on which the chamber is formed faces one surface of the first structure layer; And a reactant applied to the chamber corresponding to the chamber.

The second structural layer may be integrally formed by molding the molding material. Here, the molding material may include polydimethylsiloxane (PDMS).

At least one of the first structure layer and the second structure layer may be manufactured by a micro-electro-mechanical systems (MEMS) process.

According to another aspect of the present invention, there is provided a blood sugar monitoring device comprising a sensor strip and a meter, the sensor strip is configured to receive the blood on one side and the electrode extending from one side to the other side, the meter is in contact with the electrode And a terminal and configured to measure at least one of current and voltage in a circuit obtained by contact between the electrode and the terminal. Here, the sensor strip may include a first structure layer having an electrode formed on one surface thereof; A second structure layer having a chamber formed on the surface thereof and coupled to the first structure layer such that the surface on which the chamber is formed faces one surface of the first structure layer; And a reactant applied at a location corresponding to the chamber.

According to an embodiment of the present invention, the volume of the chamber filled with blood may be manufactured with high precision to increase the reliability of blood glucose measurement.

In addition, the MEMS process can be used to reduce the volume of the chamber, thereby reducing the amount of blood used for blood glucose measurements. This allows the user to reduce the size of the invasion when he pokes the skin to collect blood, thereby reducing the pain.

1 is an exploded perspective view showing a blood glucose measurement sensor strip according to an embodiment of the present invention.

FIG. 2 is a plan view illustrating a first structural layer of a blood glucose measurement sensor strip shown in FIG. 1 of the present invention.

3 is a conceptual diagram illustrating a process of manufacturing a blood glucose measurement sensor strip according to an embodiment of the present invention.

4 is a flowchart illustrating a method of manufacturing a blood glucose measurement sensor strip according to an embodiment of the present invention.

5 is an exploded perspective view showing a blood glucose measurement sensor strip according to another embodiment of the present invention.

As the invention allows for various changes and numerous embodiments, particular embodiments will be illustrated in the drawings and described in detail in the written description. However, this is not intended to limit the present invention to specific embodiments, it should be understood to include all modifications, equivalents, and substitutes included in the spirit and scope of the present invention. In describing the drawings, similar reference numerals are used for similar elements.

Terms such as first and second may be used to describe various components, but the components should not be limited by the terms. The terms are used only for the purpose of distinguishing one component from another. For example, without departing from the scope of the present invention, the first component may be referred to as the second component, and similarly, the second component may also be referred to as the first component. Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

1 is an exploded perspective view showing a blood glucose measurement sensor strip according to an embodiment of the present invention, Figure 2 is a plan view showing a first structural layer of the blood sugar measurement sensor strip shown in Figure 1 of the present invention.

Referring to FIG. 1, a blood glucose measurement sensor strip 100 according to an embodiment of the present invention includes a first structure layer 110, a second structure layer 120, and a reactant 130.

The first structure layer 110 may include an electrode 116 formed on one surface of the first substrate 112, and the second structure layer 120 may include a chamber formed on a surface facing the first structure layer 110. 123). The reactant 130 is added at a position corresponding to the chamber 123, but may be applied to the first structural layer 110, but may be added in the chamber 123 of the second structural layer 120.

The reactant 130 may include an enzyme and a delivery material. When blood is filled in the chamber 123 of the glucose strip sensor strip 100, an enzyme such as glucose oxidase reacts with sugar components in the blood to separate electrons from sugar molecules. A transfer material such as potassium ferricyanide transfers the electrons thus separated to the electrode. Thus, by measuring the change in the current formed, it is possible to measure the sugar concentration in the injected blood.

That is, the blood glucose measurement sensor strip 100 may be part of a blood sugar monitoring device (not shown), and the blood sugar monitoring device may include a sensor strip 100 and a meter (not shown). The meter may have a terminal in contact with the electrode 116, and when blood is filled in the chamber portion of the sensor strip 100, at least one of current and voltage in the circuit obtained by the electrode 116, the terminal and the blood Blood glucose levels can be measured by measuring.

The first structural layer 110 includes an electrode 116 formed on the first substrate 112, which leads to a connection 117 configured to contact the terminal of the instrument. As the connecting portion 117 contacts the terminal of the meter and the electrode 116 is electrically connected by the blood filled in the chamber 123, a circuit is formed to sense the current generated by the electrons separated from the sugar in the blood. It becomes possible.

In the present specification, the formation of the electrode 116 in the first structure layer 110 includes not only a case in which one electrode is formed but also a case in which two or more electrodes are formed. That is, the electrode 116 formed on the first structure layer 110 may include a working electrode and a counter electrode. If necessary, a reference electrode or the like may be formed.

For example, two electrodes 116 may be formed on both sides of the first substrate 112, so that a certain amount of blood must be filled in the chamber 123 so that the blood is electrically connected to both electrodes. Can be. Such a configuration may provide a function of checking whether the chamber 123 is filled with the required amount of blood.

The reactant 130 may be applied to the first structural layer 110, and may be applied at a position corresponding to the chamber 123 of the second structural layer 120. As described above, the reactant 130 may be directly applied to the chamber 123 of the second structure layer 120.

According to one embodiment of the present invention, the chamber 123 is formed on the surface of the second structural layer 120 itself instead of being formed by stacking several layers. For example, the second structural layer 120 may be formed by molding using an insert corresponding to the shape of the chamber 123. Here, the insert means an object that is formed in a desired shape for casting of a molding material and is subsequently removed so that the shape of the inserter remains in a negative shape in the molding material.

By forming the chamber 123 on the surface of the second structural layer 120 itself, the shape and volume of the chamber 123 is formed with higher precision than in the prior art in which the chamber 123 is formed by stacking several layers. To do it.

In particular, by using a micro-electro-mechanical systems (MEMS) process, the formation of the chambered insert 121, ie chamber 123, can be performed with very high precision. As the volume of the chamber 123 approaches the design dimension with high precision, the accuracy of blood glucose measurement is also very high. In addition, using the MEMS process to form the insert in the order of hundreds to several tens of micrometers, it is possible to further reduce the volume of the chamber 123, which is an advantage that the blood glucose measurement can be performed with less blood To provide.

Hereinafter, a process of manufacturing the first structure layer 110 and the second structure layer 120 will be described in more detail with reference to FIG. 3.

3 is a conceptual diagram illustrating a process of manufacturing a blood glucose measurement sensor strip according to an embodiment of the present invention. 3A to 3D show a process of manufacturing the second structural layer 120, and FIGS. 3E to 3G show a process of manufacturing the first structural layer 110. 3 (h) shows a state in which the first structural layer 110 and the second structural layer 120 are combined.

Referring to FIG. 3A, a photoresist 124 may be formed on one surface of the second substrate 122. Subsequently, as shown in FIG. 3B, the mask 128 having the pattern of the chamber-shaped insert 121 is patterned is disposed on the photoresist 124, the photoresist 124 is irradiated with light, and then the photoresist ( 124 can be developed. As described above, the process of laminating and developing the photoresist 124 may be performed using a MEMS process.

As will be apparent to those skilled in the art, when a positive type photoresist is used, a portion other than the shape of the chamber-type insert 121 transmits light in the mask, and a negative type photoresist is used. In the mask, the shaped part of the chamber insert transmits light. 3B illustrates a case of using a negative photoresist, but the present invention is not limited thereto.

In the example shown in FIG. 3B, the portion of the photoresist 124 exposed to light is cured, and the remaining portions other than the portion are removed by the developer, leaving only the chamber-type insert 121.

Referring to FIG. 3C, the molding material 125 may be coated on the second substrate 122 on which the chamber-type insert 121 is formed. As the molding material 125, a material capable of molding in a molten state and protecting and insulating the chamber 123 and the electrode 116 after curing may be used. For example, polydimethylsiloxane (PDMS) may be used. The molding material 125 may be applied in a molten or semi-melt state to be in close contact with the outer edge of the chamber-type insert 121.

Next, when the second substrate 122 and the chamber-type insert 121 are removed after the molding material 125 is cured, a chamber 123 is formed in the cured molding material 125 to form the second structural layer 120. Can be formed. Of course, for mass production, a plurality of chamber-like inserts 121 are formed on one substrate having a relatively large size, and the second cured molding material 125 is cut to plural second structural layers 120. It can also manufacture.

3E to 3G illustrate a process of manufacturing the first structural layer 110. Referring to FIG. 3E, the conductive material 115 may be deposited on one surface of the first substrate 112. Of course, various deposition methods such as sputtering and PVD may be used in this process. The conductive material 115 may use gold (Au) having high conductivity, but may also use other metals or other conductive materials.

Referring to FIG. 3F, after the mask 118 having a pattern corresponding to the shape of the electrode 116 is disposed on the conductive material 115, the conductive material exposed through the mask 118 ( 115) can be etched. That is, the mask 118 is formed so that portions other than the electrode 116 are exposed, and portions to be etched may be portions other than the electrode 116. As a result, the conductive material 115 remaining on the first substrate 112 after the etching process substantially forms the electrode 116.

Of course, various methods may be used to form the electrode 116 on the first substrate 112. For example, unlike the example shown in FIG. 3F, after the mask 118 having the portion corresponding to the shape of the electrode 116 is opened is disposed on the first substrate 112, the first substrate is disposed. Depositing the conductive material 115 at 112 may allow the conductive material 115 remaining after removing the mask 118 to form the electrode 116.

As described above, the process of manufacturing the first structure layer 110 by forming the electrode 116 on the first substrate 112 may be performed using a MEMS process.

Referring to FIG. 3G, after removing the mask 118, the reactant 130 may be applied to a portion corresponding to the chamber 123. As described above, the reactant 130 may include an enzyme such as glucose oxidase and a transfer material such as potassium ferricyanide. 3 illustrates an example in which the reactant 130 is applied to the first structural layer 110, but as described above, the reactant 130 is disposed in the chamber 123 of the second structural layer 120. An example is possible.

3 (h) shows a state in which the blood glucose measurement sensor strip 100 is completed by combining the first structure layer 110 and the second structure layer 120. The first structure layer 110 and the second structure layer 120 may be coupled and aligned such that the reactant 130 is positioned in the chamber 123.

As described above, if the chamber 123 is formed on the surface of the second structure layer 120 itself using the MEMS process, the size of the chamber 123 in each of the sensor strips 100 can be uniformed with a very high precision. This, in turn, gives the result of improving the precision of blood glucose measurements.

[Table 1] below shows the conventional blood glucose measurement performance of the blood glucose measurement sensor strip (marked as "MEMS" in [Table 1]) manufactured using the MEMS process according to an embodiment of the present invention ([Table Table 1 shows the value compared with the performance of "A product".

Table 1

	A product (I _pa )	A product (I _pc )	MEMS (I _pa )	MEMS (I _pc )	A product (E _pa )	A product (E _pc )	MEMS (E _pa )	MEMS (E _pc )
Normalized mean	0.87381	0.790556	0.90509	0.87381	0.770299	0.734177	0.83025	0.83539
Normalized Standard Deviation	0.101534	0.143629	0.08660	0.10153	0.157252	0.170171	0.07558	0.07451
% Improvement			14.7	29.3			51.94	56.21

The blood glucose measurement sensor strip according to the embodiment of the present invention used in [Table 1] was manufactured using a MEMS process, and gold (Au) was deposited to a thickness of 1000 μs by sputtering to form an electrode 116. Subsequently, a SU-8 material was deposited on a glass substrate to a thickness of 100 μm to form a chamber-type insert 121, and a PDMS material was molded thereon to prepare a second structural layer 120 having a chamber 123. In Table 1, I _pa is an anodic peak current, I _pc is a cathodic peak current, E _pa is an anodic peak potential, E _pc is a cathodic peak potential.

Table 1 compares the cyclic voltage current test results for each of the blood glucose measurement sensor strips and the existing 30 products according to an embodiment of the present invention. The I _pa and I _pc values of the MEMS sensor strip according to the embodiment of the present invention are improved by 14.7% and 29.3%, respectively, based on the dimensionless standard deviation value, and the E _pa and E _pc values are also improved. 51.9% and 56.2% improved results, respectively. This is a result obtained by maximizing the uniformity of the volume of the microchambers in the sensor strip through the production of the sensor strip standardized by ultra-precision microprocessing technology, and can greatly improve the reliability of blood glucose measurement.

Referring to FIG. 4, the method for manufacturing a blood glucose measurement sensor strip according to an embodiment of the present invention may include forming a first structure layer (S410). This process may include forming an electrode 115 on the first substrate 112 (S415).

Forming the first structure layer (S410) may be performed using a MEMS process. For example, forming the first structural layer (S410) may include disposing a mask 118 on the first substrate 112 having a pattern corresponding to the electrode 116 on the first substrate 112. Depositing the conductive material 115, and removing the mask 118. Of course, in this case, the mask 118 may be patterned to have an open shape.

Alternatively, depositing a conductive material 115 on one surface of the first substrate 112, disposing a mask 118 on which the shape corresponding to the electrode 116 is patterned on the conductive material 115. The method may include etching the exposed portion of the conductive material 115 through the mask 118, and removing the mask 118. Of course, in this case, portions other than the shape of the electrode 116 may be patterned in the mask 118 in an open form.

The method for manufacturing a blood glucose measurement sensor strip according to an embodiment of the present invention may also include forming a second structure layer (S420). In this step, the chamber-type insert 121 is formed on the second substrate 122 (S422), and the molding material 125 is coated on the second substrate 122 on which the chamber-type insert 121 is formed (S424). The step S426 of curing the molding material 125 and the step S428 of removing the second substrate 122 and the molding material 125 may be included. Forming the second structure layer (S420) may be performed using a MEMS process.

As described above, in the step S422 of forming the chamber-type insert 121 on the second substrate, the photoresist 124 is formed on the second substrate 122, and the mask 128 is formed on the photoresist 124. And placing the photoresist 124 after irradiating light. When a positive type photoresist is used, the mask transmits light other than the shape of the chamber-type insert 121, and when a negative type photoresist is used, the mask transmits the light through the shape of the chamber-type insert. will be.

When a molding material 125 such as polydimethylsiloxane (PDMS) is applied onto the chamber-type insert 121, the molding material 125 may be molded along the chamber-type insert 121. After the molding material 125 is cured, the second substrate 122 and the molding material 125 are removed to complete the second structure layer 120.

The method for manufacturing a blood glucose measurement sensor strip according to an exemplary embodiment of the present invention may also include applying the reactant 130 to a position corresponding to the chamber (S430). This process may be performed by applying the reactant 130 to a position corresponding to the chamber 123 in the first structure layer 110 after the step (S410) of forming the first structure layer 110 is completed, After forming the second structure layer 120 (S420), the reaction material 130 may be applied in the chamber 123.

After the first structure layer 110 and the second structure layer 120 are completed, the step of combining them with each other (S440) may be included. For mass production, the first structural layer 110 and the second structural layer 120 may have a structure for a plurality of sensor strips formed in one member, and the first structural layer 110 and the second structural layer After step 120 of combining 120, they may be cut into individual sensor strips. Of course, in manufacturing the first structural layer 110 and the second structural layer 120, a structure for a plurality of sensor strips is formed in one member, and the first structural layer 110 and the second structural layer 120 are formed. It is also possible to cut each of the first structural layer 110 and the second structural layer 120 individually after cutting them into individual components before joining the C).

The above-described method for manufacturing a blood glucose measurement sensor strip uses a MEMS process and forms a chamber 123 on the surface of the second structural layer 120 itself, thereby significantly reducing an error in the dimensions of the chamber 123 in manufacturing. have. Precisely manufacturing the chamber 123 to the designed dimension may greatly improve the accuracy of blood glucose measurement when using the sensor strip 100, as described above with reference to Table 1.

Referring to FIG. 5, the blood glucose measurement sensor strip 100 according to another embodiment of the present invention includes a first structure layer 110, a second structure layer 120, and a reactant 130. In addition to the first structural layer 110 including the electrode 116, the second structural layer 120 may also include the electrode 126.

When manufacturing the sensor strip 100 by using the MEMS process, the size of the sensor strip 100 itself can be considerably miniaturized. In the case of forming a plurality of electrodes, forming all the electrodes on the first structural layer 110 Space may be insufficient, so some of the electrodes are formed in the second structure layer 120. For example, the working electrode mainly used for blood glucose measurement may be formed in the first structure layer 110, and at least one of the counter electrode and the reference electrode may be formed in the second structure layer 120.

In this case, after the chamber-type insert 121 is formed on the second substrate 122 in the manufacture of the second structural layer 120, at least one electrode (eg, on the chamber-shaped insert) before the molding material 125 is applied. 126). After forming the electrode 126 of the second structural layer 120, the molding material 125 may be applied in a molten or semi-melt state, and the electrode 126 may be located in the molding material 125, but a part of the chamber may be applied. It may be exposed to one surface of the (123). Accordingly, when the molding material 125 is cured, the blood filled in the chamber 123 electrically connects the electrode 116 of the first structural layer 110 and the electrode 126 of the second structural layer 120. The structure that forms the circuit will be completed.

The connecting portion 127 may also be formed on the electrode 126 of the second structural layer 120, and a measuring instrument (not shown) on which the sensor strip 100 is mounted may be formed on the electrode 116 of the first structural layer 110. It may be configured to contact both the connecting portion 117 and the connecting portion 127 of the electrode 126 of the second structural layer 120. For easier contact, the molding material 125 may not be applied to a portion of the connection portion 127 of the second structure layer 120.

According to some exemplary embodiments of the present invention described above, the volume of the chamber 123 can be manufactured with high precision using the MEMS process, thereby greatly increasing the reliability of blood glucose measurement. In addition, the MEMS process can be used to reduce the volume of the chamber 123 and to reduce the size of the entire sensor strip 100, thus reducing the amount of blood used for blood glucose measurement. This can reduce the size of the invasion when the user pokes the skin to collect blood, and can prevent the case where the amount of blood obtained after one poke is so small that it must be stabbed again.

In the present invention as described above has been described by the specific embodiments, such as specific components and limited embodiments and drawings, but this is provided to help a more general understanding of the present invention, the present invention is not limited to the above embodiments. For those skilled in the art, various modifications and variations are possible from these descriptions. Therefore, the spirit of the present invention should not be limited to the described embodiments, and all the things that are equivalent to or equivalent to the claims as well as the following claims will belong to the scope of the present invention. .

Claims

A method of manufacturing a sensor strip for measuring blood glucose,

Forming an electrode on the first substrate to form a first structural layer;

Forming a chambered insert in the second substrate;

Applying a molding material on the second substrate;

Curing the molding material;

Removing the second substrate and the chamber-type insert from the cured molding material to form a second structural layer having a chamber formed on one side thereof;

Applying a reactant at a location corresponding to the chamber; And

And coupling the first structure layer and the second structure layer such that the reactant is positioned in the chamber.
The method of claim 1,

Forming the chamber-shaped insert,

Forming a photoresist on the second substrate;

Disposing a mask on which the shape of the chamber insert is patterned, on the photoresist;

Irradiating light onto the photoresist;

Removing the mask; And

A method for manufacturing a sensor strip for measuring blood glucose, comprising developing the photoresist.
The method of claim 1,

Forming the first structural layer,

Disposing a mask on which the shape of the electrode is patterned, on the first substrate;

Depositing a conductive material on the first substrate; And

A method for manufacturing a sensor strip for measuring glucose, comprising removing the mask.
The method of claim 1,

Forming the first structural layer,

Depositing a conductive material on one surface of the first substrate;

Disposing a mask on which the shape of the electrode is patterned on the conductive material;

Etching the conductive material exposed through the mask; And

A method for manufacturing a sensor strip for measuring glucose, comprising removing the mask.
The method of claim 1,

Forming the first structural layer, forming the chamber-shaped insert, applying the molding material, forming the second structural layer, applying the reactant, and the first structure At least one of the step of combining the layer and the second structure layer is a method for manufacturing a blood glucose measurement sensor strip, characterized in that carried out by a micro-electro-mechanical systems (MEMS) process.
The method of claim 1,

Before applying the molding material,

Forming at least one electrode on the chamber-type insert further comprises a method for manufacturing a blood glucose measurement sensor strip.
The method of claim 6,

The electrode formed on the chamber-type insert is electrically connected to the electrode formed on the first substrate by the blood filled in the chamber, the method for manufacturing a blood glucose measurement sensor strip.
The method of claim 1,

The molding material is a blood glucose measurement sensor strip manufacturing method comprising a polydimethylsiloxane (PDMS).
Sensor strip for blood glucose measurement

A first structural layer on which one electrode is formed;

A second structure layer formed on a surface thereof, the second structure layer being coupled to the first structure layer such that the surface on which the chamber is formed faces the one surface of the first structure layer; And

And a reactant applied to a position corresponding to the chamber.
The method of claim 9,

And the second structural layer is integrally formed by molding the molding material.
The method of claim 10,

The molding material is a glucose strip sensor strip characterized in that it comprises a PDMS (polydimethylsiloxane).
The method of claim 9,

At least one of the first structure layer and the second structure layer is a blood glucose measurement sensor strip, characterized in that manufactured by a micro-electro-mechanical systems (MEMS) process.
As a monitoring device for measuring blood glucose,

A sensor strip extending from one side to the other side and configured to receive blood on the one side; And

A meter having a terminal in contact with the electrode and configured to measure at least one of a current and a voltage in a circuit obtained by contact between the electrode and the terminal,

The sensor strip,

A first structural layer on which one electrode is formed;

A second structure layer having a chamber formed on a surface thereof, the second structure layer being coupled to the first structure layer such that the surface on which the chamber is formed faces the one surface of the first structure layer; And

And a reactant applied to a position corresponding to the chamber.