WO2014198366A1 - Glove with a cooling effect - Google Patents

Glove with a cooling effect Download PDF

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Publication number
WO2014198366A1
WO2014198366A1 PCT/EP2014/001239 EP2014001239W WO2014198366A1 WO 2014198366 A1 WO2014198366 A1 WO 2014198366A1 EP 2014001239 W EP2014001239 W EP 2014001239W WO 2014198366 A1 WO2014198366 A1 WO 2014198366A1
Authority
WO
WIPO (PCT)
Prior art keywords
glove
carboxamide
active ingredient
menthane
isopropyl
Prior art date
Application number
PCT/EP2014/001239
Other languages
German (de)
French (fr)
Inventor
Karl-Ludwig Gibis
Julia VON GROTE-PASTRÉ
Norbert Weis
Original Assignee
Carl Freudenberg Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carl Freudenberg Kg filed Critical Carl Freudenberg Kg
Publication of WO2014198366A1 publication Critical patent/WO2014198366A1/en

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Classifications

    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D19/00—Gloves
    • A41D19/015—Protective gloves
    • A41D19/01529—Protective gloves with thermal or fire protection
    • A41D19/01541—Cooled gloves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B42/00—Surgical gloves; Finger-stalls specially adapted for surgery; Devices for handling or treatment thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C41/14—Dipping a core
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D99/00—Subject matter not provided for in other groups of this subclass
    • B29D99/0064—Producing wearing apparel
    • B29D99/0067—Gloves
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M23/00—Treatment of fibres, threads, yarns, fabrics or fibrous goods made from such materials, characterised by the process
    • D06M23/12—Processes in which the treating agent is incorporated in microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action

Definitions

  • the invention relates to a glove with cooling effect and a method for its preparation.
  • Gloves made of flexible materials are used for a variety of purposes, for example in the household, in industry or in the medical field for protection against chemicals,
  • so-called glove former prepared in various dipping baths containing, for example, elastomeric materials or precursors thereof.
  • the glove former can be slipped over in advance a textile glove. This can then be completely or partially in the different
  • Dipping baths are immersed.
  • the elastomeric material can then be
  • CONFIRMATION COPY cured, for example, vulcanized and then stripped or detached from the glove former.
  • the gloves have to meet a wide variety of requirements. First, they must have a high density to a high
  • the invention has for its object to overcome the disadvantages mentioned above and in particular to provide a glove, the
  • a glove comprising at least one layer of flexible material which forms a cavity to receive a hand and a proportion of at least one active substance which is able to stimulate cold receptors on and / or in the human skin.
  • the glove according to the invention has a cold receptor stimulating agent.
  • the cold receptors on and / or in the human skin are stimulated, whereby a cooling effect is achieved.
  • This cooling effect signals to the body that the glove is at a lower temperature than the actual temperature Case is.
  • the sweat production can be reduced and the wearing comfort of the glove can be significantly improved.
  • a stimulation of the cold receptors TRPM8 (CMR1) and / or TRPA1 in the skin by suitable active ingredients is suitable for the perception of a cooling effect.
  • the glove of the invention can be made of a variety of materials, provided that it has at least one layer of a flexible material.
  • flexible materials for example, natural polymers, in particular natural rubber, synthetic polymers, in particular synthetic rubber and / or mixtures thereof can be used.
  • the synthetic polymer may be selected from the group consisting of polychloroprene, carboxylated acrylonitrile, butadiene, polyisoprene,
  • Polyurethane Polyurethane, styrene-butadiene, polyvinyl chloride, polyacrylate and / or mixtures thereof.
  • a natural polymer in particular rubber has proven to be particularly suitable.
  • a synthetic polymer in particular acrylonitrile is mentioned.
  • the active ingredient a variety of chemical substances can be used, which are capable of cold receptors, in particular the
  • the active ingredient may be selected from the group consisting of menthol, preferably (-) - menthol, furthermore from isopulegol, in particular (-) - isopulegol, N-2,3-trimethyl-2-isopropylbutamide, menthyl lactate,
  • Menthylpyrrolidonecarboxylic acid menthylmethyl ether, menthoxypropane-1,2-diol, menthoglycerol acetal (9-methyl-6- (1-methylethyl) -1, 4-dioxaspiro (4.5) decane-2-methanol), monomenthyl succinate, menthyl ethylamido oxalates, 2-hydroxymethyl -3,5,5-trimethylcyclohexanol, 2-isopropyl-N, 2,3-trimethylbutyramide, N-ethyl-p-menthane-3-carboxamide, especially 1R, 3R, 4S-N-ethyl-p-menthane-3-carboxamide, Ethyl 3- (p-menthane-3-carboxamido) acetate, (1R, 2S, 5R) -N- (4-methoxyphenyl) pentanhane carboxamide, N-ethyl-2,2-d
  • FEMA 4684 N- (2-hydroxyethyl) -2,3-dimethyl-2-isopropylbutyramide (now FEMA 4602), N- (1, 1-dimethyl-2-ydroxyethyl) 2,2-diethylbutanamide (now FEMA 4603), N- ( 2-hydroxyethyl) -2,3-dimethyl-2-isopropylbutyramide (now FEMA 4602), WS-12 ((1R, 2S, 5R) -N- (4-methoxyphenyl) pentanhane carboxamide), N-cyclopropyl 5-methyl-2-isopropylcyclohexanecarboxamide, (2S, 5R) -N- [4- (2-amino-2-oxo-ethyl) -phenyl] -p-pentane-carboxamide, FEMA 4684,
  • FEMA 4053 ice & trans p-menthane-3,8-diols (PMD38 CoolAct 38D ®), Questice ® (menthyl pyrrolidone carboxylate), (1 R, 3R, 4S) -3-menthyl 3,6-dioxaheptanoate, (1 R, 2S, 5R) - 3-menthyl methoxyacetate, (1R, 2S, 5R) -3-menthyl 3,6,9-trioxadecanoate,
  • N- (4-cyanomethylphenyl) p-menthane carboxamide FEMA 4496
  • Givaudan's Evercool G-180 Givaudan's Evercool G-180
  • neo-menthane carboxamide such as neo isomer (1S, 2S, 5R) -N- (4- (cyanomethyl) phenyl) -2- isopropyl 5-methylcyclohexanecarboxamide, Neo G-180
  • the active ingredient can be present in the glove in free form. It is also conceivable, however, that the active ingredient is present, for example, embedded in microcapsules.
  • An advantage of the use of microcapsules is that the release of active ingredient can be controlled and thus, for example, a sustained release can be achieved.
  • the microcapsules are selected so that a release of the active ingredient under pressure, for example when putting on the glove, under heat and / or moisture is triggered.
  • the active ingredient can be uniformly distributed in the glove and in particular in the flexible material.
  • the glove is preferably designed as a disposable glove.
  • Disposable gloves have the advantage that they are easy to manufacture and hygienic due to their one-time use. As with this
  • Embodiment may be a part of the drug is not exploited, since it does not come into direct contact with the skin, it is advantageous if the gloves have only a small thickness, preferably from 0.02 mm to 0.2 mm, in particular between 0 , 04 mm and 0.15 mm.
  • the active ingredient is thus advantageously present on the inside of the glove. If the glove has a multilayer structure, then expediently at least the innermost layer contains the active substance. In this case, the active ingredient, if it is present in a sufficient concentration, even form an innermost layer.
  • This embodiment has the advantage that the concentration of the active ingredient, based on the total amount of active ingredient on the skin, can be maximized.
  • the active ingredient may also be present embedded in and / or on the innermost layer of the glove.
  • the innermost layer consist of the flexible material.
  • the innermost layer can also be a layer other than that of the flexible material and, for example, as open-pore and / or
  • closed-pore layer in particular as a textile, foam and / or
  • Flocking especially cotton and / or viscose flocking be configured.
  • This embodiment has the advantage that, by suitable choice of the inner layer, the fixation of the active substance on the glove can be improved.
  • the active ingredient can be contained in an emulsion or suspension arranged on the inside of the glove, which contains skin-care and / or moisturizing substances, preferably glycerol, aloe vera, chamomile and / or fragrances.
  • skin-care and / or moisturizing substances preferably glycerol, aloe vera, chamomile and / or fragrances.
  • the glove according to the invention may also have further layers. These may be on one or both sides of the flexible layer and / or, if present, the innermost layer. It is also conceivable that one or more further layers between flexible layer and innermost layer are arranged.
  • the provision of further layers, in particular outer layers, has the advantage that the durability and waterproofness of the glove can be further improved.
  • the further layers may likewise be flexible layers and consist of the same materials as the flexible layer described above.
  • the further layers can also be configured as textile layers, in particular woven, knitted, laid, nonwoven and / or nonwoven fabrics. These textile layers can consist of the most diverse materials,
  • cotton For example, cotton, viscose, nylon, PA, PE, PP, and / or mixtures thereof.
  • the concentration of the active ingredient may vary depending on the materials used and the cooling effect desired. So can the concentration of the active ingredient.
  • Concentration of the active ingredient for example, to values of 0.005-0.6 wt.%, Preferably 0.02-0.25 wt.%, In each case based on the total weight of the glove set.
  • Another object of the invention is a process for the preparation of the glove according to the invention, containing a proportion of at least one active ingredient which is able to stimulate cold receptors on the human skin.
  • a flexible material and / or a precursor thereof is molded in the form of a solution, suspension or emulsion onto the surface of a hand-shaped one
  • the flexible material and / or the precursor thereof after it has been optionally cured and / or dried, detached from the glove former.
  • the application and / or introduction of the active ingredient is advantageously carried out in one of the following ways and means:
  • the active ingredient is incorporated directly into the solution, suspension or emulsion of the flexible material and / or precursor thereof.
  • This embodiment is particularly suitable for the production of thin gloves.
  • the active ingredient is usually due to production, evenly distributed in the flexible material. As already discussed above, however, only the part of the active substance which is present on the surface of the glove is usually relevant for the cooling effect.
  • a solution or emulsion containing the active ingredient may be sprayed into the interior of the detached glove. This type of application is procedurally very simple and inexpensive.
  • the active ingredient is applied to the glove during the drying process.
  • the active ingredient can be present for example as an aerosol in the drying atmosphere. This approach has the advantage that no separate process step for the application of the drug must be applied.
  • the active ingredient is applied to the inside of the glove together with an emulsion or suspension which contains skin-care and / or moisturizing substances, preferably glycerol, aloe vera, chamomile and / or fragrances.
  • an emulsion or suspension which contains skin-care and / or moisturizing substances, preferably glycerol, aloe vera, chamomile and / or fragrances.
  • the mixture can be sprayed into the interior of the glove.
  • the active ingredient in emulsions or suspensions can be easily embedded and released from them.
  • a coating in particular in the form of a flocking, a textile material and / or a foam, comprising the active ingredient is applied to the inside of the glove.
  • an adhesive layer can first be applied to the flexible material and then provided with flock fibers.
  • the adhesive layer while the same materials can be used as they have been described above for the flexible material already.
  • An alternative form of producing a flocked layer is that the flock fibers are first mixed with the adhesive material and then this mixture is applied to the inside of the glove.
  • This embodiment has the advantage that the flock fibers adhere better and there are less loose flock fibers unbonded on the inside of the glove.
  • Example 1 Here, after cleaning, a ceramic former is dipped in a coagulant bath and subsequently dried, followed by immersion in a bath with a latex formulation.
  • the latex formulation contains natural latex or synthetic latex, or mixtures of both, as well as crosslinkers,
  • Vulcanization accelerators wetting agents and various additives.
  • This formulation contains the active ingredient, for example in encapsulated form.
  • the latex formulation is then dried on the former and then dipped into several leaching tanks and then coagulated in an oven. Afterwards, further wash baths are run through. Then the glove is released from the former and turned to the right. The gloves are then dried in a dryer.
  • Example 2
  • the ceramic former is dipped in a coagulant bath and subsequently dried, followed by immersion in a bath with a latex formulation (the latex formulation contains natural latex or synthetic latex, or mixtures of both, as well as crosslinkers,
  • Vulcanization accelerators, wetting agents and various additives in the
  • the latex formulation is dried on the former and then immersed in several leaching tanks and then coagulated in an oven. Afterwards follow again various wash baths. Then the glove is released from the former and turned to the right. The gloves are then dried in a dryer, at the end of the drying cycle, the active ingredient may be added together with other substances by spraying into the dryer.
  • the ceramic former is dipped in a coagulant bath and subsequently dried, followed by immersion in a bath with a latex formulation (the latex formulation contains natural latex or synthetic latex, or mixtures of both, as well as crosslinkers,
  • the latex formulation is then dried on the former and then dipped into several leaching tanks and then coagulated in an oven.
  • the gloves then undergo an online chlorination followed by several wash baths. Then the glove is released from the former and turned to the right.
  • the gloves are then dried in a dryer, towards the end of the drying cycle of the Active substance may be added together with other substances by spraying in the dryer.
  • the ceramic former is dipped in a coagulant bath and subsequently dried, followed by immersion in a bath with a latex formulation (the latex formulation contains natural latex or synthetic latex, or mixtures of both, as well as crosslinkers,
  • Vulcanization accelerators, wetting agents and various additives in the
  • Example 5 Following the latex formulation is dried on the former and then immersed in several leaching tanks and then coagulated in an oven. The gloves then undergo an online chlorination followed by several wash baths. Then the glove is released from the former and turned to the right. The gloves are then chlorinated offline and then dried in a dryer, at the end of the drying cycle, the active ingredient may be added together with other substances by spraying into the dryer.
  • Example 5 Following the latex formulation is dried on the former and then immersed in several leaching tanks and then coagulated in an oven. The gloves then undergo an online chlorination followed by several wash baths. Then the glove is released from the former and turned to the right. The gloves are then chlorinated offline and then dried in a dryer, at the end of the drying cycle, the active ingredient may be added together with other substances by spraying into the dryer.
  • Example 5 Example 5:
  • the ceramic former is dipped in a coagulant bath and subsequently dried, followed by immersion in a bath with a latex formulation (the latex formulation contains natural latex or synthetic latex, or mixtures of both, as well as crosslinkers,
  • Vulcanization accelerators, wetting agents and various additives in the
  • the latex formulation is dried on the former and then immersed in several leaching tanks and then coagulated in an oven. Afterwards follow again various wash baths. Then the glove is released from the former and turned to the right. The gloves are then chlorinated off-line and then dried in a dryer, at the end of the drying cycle, the active ingredient may be added together with other substances by spraying into the dryer.
  • the ceramic former is dipped in a coagulant bath and subsequently dried, followed by immersion in a bath with a latex formulation (the latex formulation contains natural latex or synthetic latex, or mixtures of both, as well as crosslinkers,
  • Vulcanization accelerators, wetting agents and various additives in the
  • the latex formulation is dried on the former and then immersed in several leaching tanks and then coagulated in an oven. Subsequently, the glove is coated with a polymer layer and again driven through an oven. Then again followed by various baths. Then the glove is released from the former and turned to the right. The gloves are then dried in a dryer, wherein towards the end of the drying cycle, the active ingredient may be added together with other substances by spraying into the dryer.
  • Example 7 Here, after cleaning, the ceramic former is immersed in a coagulant bath which also contains polymer and subsequently dried, followed by immersion in a bath containing a latex formulation (the latex formulation contains natural latex or synthetic latex, or mixtures of both Crosslinker, vulcanization accelerator, wetting agent and various additives) is followed by the latex formulation on the former dried and then dipped in several leaching tanks and then coagulated in an oven. Subsequently, the glove is coated with a polymer layer and again driven through an oven. Then again followed by various baths. Then the glove is released from the former and turned to the right. The gloves are then dried in a dryer, wherein towards the end of the drying cycle, the active ingredient may be added together with other substances by spraying into the dryer.
  • Multilayer gloves Multilayer gloves:
  • the ceramic former is dipped in a coagulant bath and subsequently dried, followed by immersion in a bath with a latex formulation (the latex formulation contains natural latex or synthetic latex, or mixtures of both, as well as crosslinkers,
  • Vulcanization accelerators wetting agents, optional color pigments and
  • a latex mixture which, in addition to the natural and or synthetic latex, crosslinker, vulcanization accelerator, wetting agent, optional
  • this second layer may already contain the jib fibers or act as a carrier layer for a flock lining, in which case the glove is driven directly thereafter through a flocking chamber or becomes this second layer not as a latex film but as a foam which optionally also contains flock fibers.
  • the second layer is then dried again with or without flock fibers and then immersed in several leaching tanks and then in an oven coagulated. Followed by an online chlorination and then again various baths. Then the glove is released from the former and turned to the right. The gloves are then dried in a dryer.
  • the ceramic former is dipped in a coagulant bath and subsequently dried, followed by immersion in a bath with a latex formulation (the latex formulation contains natural latex or synthetic latex, or mixtures of both, as well as crosslinkers,
  • Vulcanization accelerators wetting agents, optional color pigments and
  • the latex formulation is then dried on the former and submerged again in a second bath with a latex mixture (these too, besides the natural and / or synthetic latex, crosslinker, vulcanization accelerator, wetting agent, optional
  • This second layer can already contain the Fockmaschinen or act as a support layer for a flock lining, in this case, the glove is driven directly through a flocking chamber, or this second layer is not executed as a latex film but as a foam possibly also
  • Flock fibers dried again and then dipped into several leaching tanks and then coagulated in an oven. Following an online chlorination followed by various washing baths. Then the glove is released from the former and turned to the right.
  • Gloves will be chlorinated offline afterwards. The gloves will either be removed after shedding from the shaper or after being taken offline
  • Chlorination subsequently dried in a dryer, towards the end of the Drying cycle of the active ingredient may be added together with other substances by spraying in the dryer.
  • the ceramic former is dipped in a coagulant bath and subsequently dried, followed by immersion in a bath with a latex formulation (the latex formulation contains natural latex or synthetic latex, or mixtures of both, as well as crosslinkers,
  • Vulcanization accelerators wetting agents, optional color pigments and
  • the latex formulation is then dried on the former and submerged again in a second bath with a latex mixture (these too, besides the natural and / or synthetic latex, crosslinker, vulcanization accelerator, wetting agent, optional
  • This second layer can already contain the Fockmaschinen or act as a support layer for a flock lining, in this case, the glove is driven directly through a flocking chamber, or this second layer is not executed as a latex film but as a foam possibly also
  • Flock fibers dried again and then dipped into several leaching tanks and then coagulated in an oven. This is followed by an online chlorination followed by various washing baths. After that, the
  • the gloves detached from the former and turned to the right.
  • the gloves can then be chlorinated offline.
  • the gloves will either be removed after shedding from the shaper or after being taken offline
  • Chlorination predried in a dryer Following is the
  • Formulation that may contain the active substance together with other substances sprayed inside the gloves and the gloves in the
  • the multi-layered gloves may also have three or more layers, and then between the first and the second layer further latex layer (consisting of natural and / or synthetic latex, crosslinker, vulcanization accelerator, wetting agent, optional
  • Color pigments and various additives were applied by dipping.

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Abstract

The invention relates to a glove comprising at least one layer of a flexible material which forms a cavity for receiving a hand. Part of said glove also comprises at least one active agent which is capable of stimulating cooling receptors on and/or in the human skin.

Description

Handschuh mit Kühlwirkung Beschreibung  Glove with cooling effect Description
Technisches Gebiet  Technical area
Die Erfindung betrifft einen Handschuh mit Kühlwirkung sowie ein Verfahren zu seiner Herstellung. The invention relates to a glove with cooling effect and a method for its preparation.
Stand der Technik State of the art
Handschuhe aus flexiblen Materialien, insbesondere Gummihandschuhe, werden zu den vielfältigsten Zwecken, beispielsweise im Haushalt, in der Industrie oder im Medizinbereich zum Schutz gegenüber Chemikalien, Gloves made of flexible materials, especially rubber gloves, are used for a variety of purposes, for example in the household, in industry or in the medical field for protection against chemicals,
Reinigern, Schmutz, Bakterien, Viren, mechanischen Risiken, usw. eingesetzt.  Cleaners, dirt, bacteria, viruses, mechanical risks, etc. used.
Herkömmliche Gummihandschuhe, Einweghandschuhe oder auch mehrmals verwendbare Handschuhe, werden üblicherweise durch das Eintauchen von einem Keramikformteil, das eine Hand mit Unterarm darstellt, einem Conventional rubber gloves, disposable gloves or reusable gloves are usually by the immersion of a ceramic molding, which represents a hand with forearm, a
sogenannten Handschuhformer, in diverse Tauchbäder hergestellt, die beispielsweise elastomere Materialien oder Vorprodukte hiervon enthalten. Dem Handschuhformer kann im Vorfeld ein textiler Handschuh übergestülpt werden. Dieser kann dann ganz oder teilweise in die verschiedenen so-called glove former, prepared in various dipping baths containing, for example, elastomeric materials or precursors thereof. The glove former can be slipped over in advance a textile glove. This can then be completely or partially in the different
Tauchbäder eingetaucht werden. Das elastomere Material kann dann Dipping baths are immersed. The elastomeric material can then
BESTÄTIGUNGSKOPIE ausgehärtet, beispielsweise vulkanisiert und im Anschluss von dem Handschuhformer abgestreift bzw. abgelöst werden. CONFIRMATION COPY cured, for example, vulcanized and then stripped or detached from the glove former.
Die Handschuhe müssen den verschiedensten Anforderungen genügen. Zum einen müssen sie eine hohe Dichtigkeit aufweisen, um eine hohe The gloves have to meet a wide variety of requirements. First, they must have a high density to a high
Schutzfunktion bieten zu können. Zum anderen sollen sie einen möglichst hohen Tragekomfort bieten. Diese Anforderungen sind grundsätzlich schwer miteinander in Einklang zu bringen, da eine hohe Dichtigkeit mit sich bringt, dass von der Haut abgesonderter Schweiß nicht aus dem Handschuh austreten kann, was dem Handschuhträger ein unangenehmes Tragegefühl vermittelt.  To provide protection. On the other hand, they should offer the highest possible wearing comfort. These requirements are fundamentally difficult to reconcile, since a high density entails that sweat secreted by the skin can not escape from the glove, giving the glove wearer an uncomfortable wearing sensation.
Darstellung der Erfindung Presentation of the invention
Der Erfindung liegt die Aufgabe zugrunde, die oben genannten Nachteile zu beseitigen und insbesondere einen Handschuh bereit zu stellen, der The invention has for its object to overcome the disadvantages mentioned above and in particular to provide a glove, the
gleichzeitig eine hohe Dichtigkeit, eine hohe Schutzwirkung und ein at the same time a high tightness, a high protective effect and a
angenehmes Tragefühl bietet. offers a pleasant wearing sensation.
Ausführung der Erfindung Embodiment of the invention
Diese Aufgabe wird gelöst durch einen Handschuh umfassend mindestens eine Schicht eines flexiblen Materials, welches einen Hohlraum ausbildet, um eine Hand aufzunehmen sowie einen Anteil mindestens eines Wirkstoffs, der in der Lage ist Kälterezeptoren auf und/oder in der menschlichen Haut zu stimulieren. This object is achieved by a glove comprising at least one layer of flexible material which forms a cavity to receive a hand and a proportion of at least one active substance which is able to stimulate cold receptors on and / or in the human skin.
Der erfindungsgemäße Handschuh weist einen Kälterezeptoren stimulierenden Wirkstoff auf. Kommt der Handschuh in Kontakt mit der menschlichen Haut so werden die Kälterezeptoren auf und/oder in der menschlichen Haut stimuliert, wodurch ein Kühleffekt erzielt wird. Dieser Kühleffekt signalisiert dem Körper, dass im Handschuh eine niedrigere Temperatur vorliegt, als dies tatsächlich der Fall ist. Hierdurch kann die Schweißproduktion verringert und der Tragekomfort des Handschuhs signifikant verbessert werden. Insbesondere eine Stimulation der Kälterezeptoren TRPM8 (CMR1) und/oder TRPA1 in der Haut durch geeignete Wirkstoffe ist zur Wahrnehmung eines Kühleffektes geeignet. The glove according to the invention has a cold receptor stimulating agent. When the glove comes in contact with the human skin, the cold receptors on and / or in the human skin are stimulated, whereby a cooling effect is achieved. This cooling effect signals to the body that the glove is at a lower temperature than the actual temperature Case is. As a result, the sweat production can be reduced and the wearing comfort of the glove can be significantly improved. In particular, a stimulation of the cold receptors TRPM8 (CMR1) and / or TRPA1 in the skin by suitable active ingredients is suitable for the perception of a cooling effect.
Der erfindungsgemäße Handschuh kann aus den verschiedensten Materialien bestehen, sofern er zumindest eine Schicht aus einem flexiblen Material aufweist. Als flexible Materialen können beispielsweise natürliche Polymere, insbesondere natürlicher Gummi, synthetische Polymere, insbesondere synthetischer Gummi und/oder Gemische hiervon eingesetzt werden. The glove of the invention can be made of a variety of materials, provided that it has at least one layer of a flexible material. As flexible materials, for example, natural polymers, in particular natural rubber, synthetic polymers, in particular synthetic rubber and / or mixtures thereof can be used.
Das synthetische Polymer kann ausgewählt sein aus der Gruppe bestehend aus Polychloropren, carboxyliertem Acrylnitril, Butadien, Polyisopren, The synthetic polymer may be selected from the group consisting of polychloroprene, carboxylated acrylonitrile, butadiene, polyisoprene,
Polyurethan, Styrol-Butadien, Polyvinylchlorid, Polyacrylat und/oder Gemischen hiervon. Ais natürliches Polymer hat sich insbesondere Kautschuk als besonders geeignet erwiesen. Als synthetisches Polymer ist insbesondere Acrylnitril zu erwähnen. Polyurethane, styrene-butadiene, polyvinyl chloride, polyacrylate and / or mixtures thereof. As a natural polymer, in particular rubber has proven to be particularly suitable. As a synthetic polymer in particular acrylonitrile is mentioned.
Als Wirkstoff können die verschiedensten chemischen Substanzen eingesetzt werden, die in der Lage sind Kälterezeptoren, insbesondere die As the active ingredient, a variety of chemical substances can be used, which are capable of cold receptors, in particular the
Kälterezeptoren TRPM8 (CMR1) und/oder TRPA1 auf und/oder in der menschlichen Haut zu stimulieren. Als zweckmäßig hat sich hierbei erwiesen, wenn die ausgewählten chemischen Substanzen sowohl in der Lage sind Kälterezeptoren zu stimulieren als auch als Inhibitoren für Schweißrezeptoren, auf und/oder in der menschlichen Haut zu wirken. Ferner kann es vorteilhaft sein, wenn die chemischen Substanzen derart ausgewählt werden, dass sie keinen oder nur einen geringen Eigengeruch aufweisen. Dies ermöglicht die Herstellung von geruchsfreien Handschuhen. Alternativ dazu können die Handschuhe während oder nach der Herstellung mit einem spezifischen ausgewählten Geruch versehen werden. Beispielsweise kann der Wirkstoff ausgewählt sein aus der Gruppe bestehend aus Menthol, bevorzugt (-)-Menthol, weiterhin aus Isopulegol, insbesondere (-)- Isopulegol, N-2,3-Trimethyl-2-lsopropylbutamid, Menthyllactat, Cooling receptors TRPM8 (CMR1) and / or TRPA1 on and / or in human skin to stimulate. It has proved to be expedient in this case if the selected chemical substances are both able to stimulate cold receptors and to act as inhibitors of sweat receptors on and / or in the human skin. Furthermore, it may be advantageous if the chemical substances are selected such that they have no odor or only a slight odor. This allows the production of odorless gloves. Alternatively, the gloves may be provided with a specific selected odor during or after manufacture. For example, the active ingredient may be selected from the group consisting of menthol, preferably (-) - menthol, furthermore from isopulegol, in particular (-) - isopulegol, N-2,3-trimethyl-2-isopropylbutamide, menthyl lactate,
Menthylpyrrolidoncarbonsäure, Menthylmethylether, Menthoxypropan-1 ,2- diol, Menthonglycerinacetal (9-Methyl-6-(1-methylethyl)-1 ,4-dioxaspiro(4.5)decan-2- methanol), Monomenthylsuccinat, Menthyl Ethylamido Oxalate, 2- Hydroxymethyl-3,5,5-trimethylcyclohexanol, 2-lsopropyl-N,2,3- trimethylbutyramid, N-Ethyl-pmenthan-3-carboxamid, insbesondere 1R,3R,4S- N-Ethyl-p-menthane-3-carboxamid, Ethyl-3-(p-menthan-3-carboxamido)acetat, (1R,2S,5R)-N-(4-Methoxyphenyl)-p-menthancarboxamid, N-Ethyl-2,2- diisopropylbutanamid, NCyclopropyl-5-methyl-2-propan-2-ylcyclohexan-1- carboxamid, N-(4-Cyanomethylphenyl)-p-menthancarboxamid, N-(2-(Pyridin-2- yl)ethyl)-3-p-menthancarboxamid, N-(2-Hydroxyethyl)-2-isopropyl-2,3- dimethylbutanamid, N-(1 ,1-Dimethyl-2-hydroxyethyl)-2,2-diethylbutanamid, (2S,5R)-N-[4-(2-Amino-2-oxoethyl)phenyl]-p-menthancarboxamid, 2-[(2-p- Menthoxy)ethoxy]ethanol, (2,6-Diethyl-5-isopropyl-2-methyltetrahydropyran, 3- (l-Menthoxy)-2-methylpropan-1 ,2-diol, p-Menthan-3,8-diol, insbesondere (+)-cis- p-Menthan-3,8-diol und (-)-trans-p-Menthan-3,8-diol sowie Mischungen aus (+)- cisp-Menthan-3,8-diol und (-)-trans-p-Menthan-3,8-diol, insbesondere eine Mischung im Gewichtsverhältnis 62:38, (1 R,3R,4S)-3-Menthyl-3,6- dioxaheptanoat, (1 R,2S,5R)-3-Menthylmethoxyacetat, (1 R,2S,5R)-3-Menthyl- 3,6,9-trioxadecanoat, (1 R,2S,5R)-3-Menthyl-3,6,9-trioxadecanoat, (1 R,2S,5R)- 3-Menthyl-(2-hydroxyethoxy)acetat, (1 R,2S,5R)-Menthyl-11-hydroxy-3,6,9- trioxaundecanoat, (-)-Cubebol, N-(4-Cyanomethylphenyl)-p- menthancarboxamid, Ν,Ν-Dimethylmenthylsuccinamid (2-lsopropyl-5- methylcyclohexyl-4-(dimethylamino)-4-oxobutanoat, 6-lsopropyl-3,9-dimethyl- 1 ,4-dioxaspiro[4.5]decan-2-on, N-Benzo[1 ,3]-dioxol-5-yl-3-p- menthancarboxamid, N-Benzoxazol-4-yl-3-p-menthancarboxamid, N-4-([1 ,2,4]- Triazol-l-yl)-phenyl-3-p-menthancarboxamid, N-4-(Pyrazol-l-yl)-phenyl-3-p- menthancarboxamid, N-(1-lsopropyl-1 ,2-dimethylpropyl)-1 ,3-benzodioxol-5- carboxamid, Mischungen von 2,2,5,6,6-Pentamethyl-2,3,6,6a- tetrahydropentalen-3a(1 H)-ol und 5-(2-Hydroxy-2-methylpropyl)-3,4,4- trimethylcyclopent-2-en-1-on,(1 S,2S,5R)-N-(4-(Cyanomethyl)phenyl)-2- isopropyl-5-methylcyclohexancarboxamid, Neo-Menthyllactat (2S), Neo- Menthyllactatacetat [(1S,2S,5R)-2-lsopropyl-5-methylcyclohexyl-2(S)- acetoxypropanoat], 1-lsopropyl-4-methyl-bicyclo[2.2.21oct-5-ene-2,3-dicarbinol, sowie Mischungen dieser Substanzen. Menthylpyrrolidonecarboxylic acid, menthylmethyl ether, menthoxypropane-1,2-diol, menthoglycerol acetal (9-methyl-6- (1-methylethyl) -1, 4-dioxaspiro (4.5) decane-2-methanol), monomenthyl succinate, menthyl ethylamido oxalates, 2-hydroxymethyl -3,5,5-trimethylcyclohexanol, 2-isopropyl-N, 2,3-trimethylbutyramide, N-ethyl-p-menthane-3-carboxamide, especially 1R, 3R, 4S-N-ethyl-p-menthane-3-carboxamide, Ethyl 3- (p-menthane-3-carboxamido) acetate, (1R, 2S, 5R) -N- (4-methoxyphenyl) pentanhane carboxamide, N-ethyl-2,2-diisopropylbutanamide, NCyclopropyl-5-methyl -2-propan-2-ylcyclohexane-1-carboxamide, N- (4-cyanomethylphenyl) -p-pentane-carboxamide, N- (2- (pyridin-2-yl) -ethyl) -3-p-menthane-carboxamide, N- (2 -Hydroxyethyl) -2-isopropyl-2,3-dimethylbutanamide, N- (1,1-dimethyl-2-hydroxyethyl) -2,2-diethylbutanamide, (2S, 5R) -N- [4- (2-amino- 2-oxoethyl) phenyl] -p-menthane carboxamide, 2 - [(2-p-menthoxy) ethoxy] ethanol, (2,6-diethyl-5-isopropyl-2-methyltetrahydropyran, 3- (1-menthoxy) -2- methylpropane-1,2-diol, p-menthane-3,8-diol, especially ere (+) - cis-p-menthane-3,8-diol and (-) - trans-p-menthane-3,8-diol and mixtures of (+) - cis-menthane-3,8-diol and ( -) - trans-p-menthane-3,8-diol, in particular a mixture in a weight ratio of 62:38, (1R, 3R, 4S) -3-menthyl-3,6-dioxaheptanoate, (1R, 2S, 5R ) -3-menthylmethoxyacetate, (1R, 2S, 5R) -3-menthyl-3,6,9-trioxadecanoate, (1R, 2S, 5R) -3-menthyl-3,6,9-trioxadecanoate, (1 R, 2S, 5R) - 3-menthyl- (2-hydroxyethoxy) acetate, (1R, 2S, 5R) -menthyl-11-hydroxy-3,6,9-trioxaundecanoate, (-) - cubebol, N- ( 4-cyanomethylphenyl) pentanhane carboxamide, Ν, Ν-dimethylmenthyl succinamide (2-isopropyl-5-methylcyclohexyl-4- (dimethylamino) -4-oxobutanoate, 6-isopropyl-3,9-dimethyl-1,4-dioxaspiro [4.5 ] decan-2-one, N-benzo [1,3] -dioxol-5-yl-3-p-menthane-carboxamide, N-benzoxazol-4-yl-3-p-menthane-carboxamide, N-4 - ([1, 2,4] - triazol-1-yl) -phenyl-3-p-menthane carboxamide, N-4- (pyrazol-1-yl) -phenyl-3-p- menthane carboxamide, N- (1-isopropyl-1,2-dimethylpropyl) -1,3-benzodioxole-5-carboxamide, mixtures of 2,2,5,6,6-pentamethyl-2,3,6,6-tetrahydropental- 3a (1H) -ol and 5- (2-hydroxy-2-methylpropyl) -3,4,4-trimethylcyclopent-2-en-1-one, (1S, 2S, 5R) -N- (4- (Cyanomethyl) phenyl) -2-isopropyl-5-methylcyclohexanecarboxamide, neo-menthyl lactate (2S), neo-menthyl lactate acetate [(1S, 2S, 5R) -2-isopropyl-5-methylcyclohexyl-2 (S) -acetoxypropanoate], 1 -lsopropyl-4-methyl-bicyclo [2.2.21oct-5-ene-2,3-dicarbinol, as well as mixtures of these substances.
Praktische Versuche haben ergeben, dass mit TRPM8-modulierenden Practical experiments have shown that using TRPM8-modulating
Verbindungen gute Resultate erzielt werden können. Good results can be achieved.
Ebenfalls denkbar ist der Einsatz von Verbindungen ausgewählt aus der Gruppe bestehend aus WS-23 (2-lsopropyl-N,2,3-trimethylbutyramid), FEMA 3804; WS-3 (N-Ethyl-p-menthan-3-carboxamid), FEMA 3455; WS-5 [Ethyl 3-(p- menthan-3-carboxamido)acetat], FEMA 4309; WS-12 (1 R,2S,5R)-N-(4- Methoxyphenyl)-p-menthancarboxamid, FEMA 4681 ; WS-27 (N-Ethyl-2,2- diisopropylbutanamid), FEMA 4557; N-Cyclopropyl-5-methyl-2- isopropylcyclohexancarboxamid, FEMA 4693, WS-116 (N-(1 ,1-Dimethyl-2- hydroxyethyl)-2,2-diethylbutanamid), FEMA 4603, - N-(4-Cyanomethylphenyl)- p-menthancarboxamid, FEMA 4496; N-(2-(Pyridin-2-yl)ethyl)-3-p- menthancarboxamid, FEMA 4549; und N-(2-Hydroxyethyl)-2-isopropyl-2,3- dimethylbutanamid, FEMA 4602, Cyclopropancarbonsäure (2-isopropyl-5- methyl-cyclohexyl)-amid (FEMA 4558), WS-5 (FEMA 4309), N-Ethyl-2,2- diisopropylbutanamid, FEMA 4557, N-(2-Hydroxyethyl)-2-isopropyl-2,3- dimethylbutanamid, FEMA 4602, N-(1 ,1-Dimethyl-2-hydroxyethyl)-2,2- diethylbutanamid, FEMA 4603, N-(4-Cyanomethylphenyl)-p- menthancarboxamid, FEMA 4496 und N-(2-(Pyridin-2-yl)ethyl)-3-p- menthancarboxamid, FEMA 4549, (1 R,2S,5R)-N-(4-Methoxyphenyl)-p- menthancarboxamid (WS-12), FEMA 4681 ; (2S,5R)-N-[4-(2-Amino-2- oxoethyl)phenyl]-p-menthancarboxamid, FEMA 4684; N-Cyclopropyl-5-methyl- 2-isopropylcyclohexancarboncarboxamid, FEMA 4693; 2-[(2-p- Menthoxy)ethoxy]ethanol, FEMA 4718, (2,6-Diethyl-5-isopropyl-2- methyltetrahydropyran, FEMA 4680), (trans-4-tert-Butylcyclohexanol, FEMA 4724) Also conceivable is the use of compounds selected from the group consisting of WS-23 (2-isopropyl-N, 2,3-trimethylbutyramide), FEMA 3804; WS-3 (N-ethyl-p-menthane-3-carboxamide), FEMA 3455; WS-5 [ethyl 3- (p-menthane-3-carboxamido) acetate], FEMA 4309; WS-12 (1R, 2S, 5R) -N- (4-methoxyphenyl) pentanhane carboxamide, FEMA 4681; WS-27 (N-ethyl-2,2-diisopropylbutanamide), FEMA 4557; N-cyclopropyl-5-methyl-2-isopropylcyclohexanecarboxamide, FEMA 4693, WS-116 (N- (1, 1-dimethyl-2-hydroxyethyl) -2,2-diethylbutanamide), FEMA 4603, N- (4-cyanomethylphenyl ) - p-menthane carboxamide, FEMA 4496; N- (2- (pyridin-2-yl) ethyl) -3-p-menthane carboxamide, FEMA 4549; and N- (2-hydroxyethyl) -2-isopropyl-2,3-dimethylbutanamide, FEMA 4602, cyclopropanecarboxylic acid (2-isopropyl-5-methyl-cyclohexyl) -amide (FEMA 4558), WS-5 (FEMA 4309), N Ethyl 2,2-diisopropylbutanamide, FEMA 4557, N- (2-hydroxyethyl) -2-isopropyl-2,3-dimethylbutanamide, FEMA 4602, N- (1,1-dimethyl-2-hydroxyethyl) -2,2 - diethylbutanamide, FEMA 4603, N- (4-cyanomethylphenyl) -pentanhane carboxamide, FEMA 4496 and N- (2- (pyridin-2-yl) ethyl) -3-p-menthane carboxamide, FEMA 4549, (1R, 2S , 5R) -N- (4-methoxyphenyl) pentanhane carboxamide (WS-12), FEMA 4681; (2S, 5R) -N- [4- (2-Amino-2- oxoethyl) phenyl] -p-menthane carboxamide, FEMA 4684; N-cyclopropyl-5-methyl-2-isopropylcyclohexanecarboxamide, FEMA 4693; 2 - [(2-p-menthoxy) ethoxy] ethanol, FEMA 4718, (2,6-diethyl-5-isopropyl-2-methyltetrahydropyran, FEMA 4680), (trans-4-tert-butylcyclohexanol, FEMA 4724)
Figure imgf000007_0001
Figure imgf000007_0001
WS-3 1R,3 ,4S- S-3 WS-5 WS-23 FEMA 3455 FEMA 3455 FEMA 4309  WS-3 1R, 3, 4S-S-3 WS-5 WS-23 FEMA 3455 FEMA 3455 FEMA 4309
Figure imgf000007_0002
Figure imgf000007_0002
FEMA 4558 WS-27 FEMA 4558 WS-27
FEMA 4496 FEMA 4549 FEMA 4496 FEMA 4549
Figure imgf000007_0003
Figure imgf000007_0003
FEMA 4602 -116) FEMA 4693 FEMA 4681 (WS- 2)
Figure imgf000007_0004
FEMA 4602-116) FEMA 4693 FEMA 4681 (WS- 2)
Figure imgf000007_0004
FEMA 4684 N-(2-Hydroxyethyl)-2,3-dimethyl-2-isopropylbutyramid (jetzt FEMA 4602), N- (1 ,1-Dimethyl-2- ydroxyethyl)2,2-diethylbutanamid (jetzt FEMA 4603), N-(2- Hydroxyethyl)-2,3-dimethyl-2-isopropylbutyramid (jetzt FEMA 4602), WS-12 ((1 R,2S,5R)-N-(4-Methoxyphenyl)-p-menthancarboxamid), N-Cyclopropyl-5- methyl-2-isopropylcyclohexancarboncarboxamid, (2S,5R)-N-[4-(2-Amino-2- oxoethyl)phenyl]-p-menthancarboxamid, FEMA 4684, FEMA 4684 N- (2-hydroxyethyl) -2,3-dimethyl-2-isopropylbutyramide (now FEMA 4602), N- (1, 1-dimethyl-2-ydroxyethyl) 2,2-diethylbutanamide (now FEMA 4603), N- ( 2-hydroxyethyl) -2,3-dimethyl-2-isopropylbutyramide (now FEMA 4602), WS-12 ((1R, 2S, 5R) -N- (4-methoxyphenyl) pentanhane carboxamide), N-cyclopropyl 5-methyl-2-isopropylcyclohexanecarboxamide, (2S, 5R) -N- [4- (2-amino-2-oxo-ethyl) -phenyl] -p-pentane-carboxamide, FEMA 4684,
Figure imgf000008_0001
Figure imgf000008_0001
n = 1 ,2 & R = OMe , OEt, OPr, O-iPR, OBu  n = 1, 2 & R = OMe, OEt, OPr, O-iPR, OBu
Menthon glycerol ketal, (-)-Menthyl lactat, Menthone glycerol ketal, (-) - menthyl lactate,
Figure imgf000008_0002
Figure imgf000008_0002
Frescolat MGA - 2  Frescolat MGA - 2
Frescolat ML  Frescolat ML
Isomere  isomers
FEMA 3748  FEMA 3748
FEMA 3807  FEMA 3807
(-)-Menthoxypropan-l ,2-diol,3-(l-menthoxy)propan-1 ,2-diol (-) - menthoxypropane-1,2-diol, 3- (1-menthoxy) propane-1,2-diol
Figure imgf000009_0001
Figure imgf000009_0001
FEMA 3784/2S lsomer/2R Isomer, FEMA 3784 / 2S isomer / 2R isomer,
3-(l-Menthoxy)-2-methylpropan-1 ,2-diol, (-)-lsopulegol "Coolact P 3- (1-Menthoxy) -2-methylpropane-1,2-diol, (-) - isopulegol "Coolact P
Figure imgf000009_0002
Figure imgf000009_0002
(-)-lsopulegol (Coolact P® ) (+)-cis & (-)-trans p-Menthan-3,8- diol (-) - isopulegol (CoolAct P ®) (+) - cis & (-) - trans-p-menthane-3,8-diol
FEMA 2962  FEMA 2962
FEMA 4053 eis & trans p-Menthan-3,8-diole (PMD38 Coolact 38D®), Questice® (Menthyl pyrrolidon carboxylat), (1 R,3R,4S)-3-Menthyl-3,6-dioxaheptanoat, (1 R,2S,5R)- 3-Menthyl methoxyacetat, (1 R,2S,5R)-3-Menthyl 3,6,9-trioxadecanoat, FEMA 4053 ice & trans p-menthane-3,8-diols (PMD38 CoolAct 38D ®), Questice ® (menthyl pyrrolidone carboxylate), (1 R, 3R, 4S) -3-menthyl 3,6-dioxaheptanoate, (1 R, 2S, 5R) - 3-menthyl methoxyacetate, (1R, 2S, 5R) -3-menthyl 3,6,9-trioxadecanoate,
(1 R,2S,5R)-3-Menthyl 3,6,9-trioxadecanoat, (1 R,2S,5R)-3-Menthyl (2- hydroxyethoxy)acetat, (1R,2S,5R)-Menthyl 11-hydroxy-3,6,9-trioxaundecanoat, (1R, 2S, 5R) -3-menthyl 3,6,9-trioxadecanoate, (1R, 2S, 5R) -3-menthyl (2-hydroxyethoxy) acetate, (1R, 2S, 5R) -menthyl 11- hydroxy-3,6,9-trioxaundecanoat,
Figure imgf000010_0001
Figure imgf000010_0001
(-) -Cubebol  (-) - Cubebol
FEMA 4497 FEMA 4497
Cubebol, FEMA 4497, p-Menthan carboxamid,[ N-(4-Cyanomethylphenyl) p- Menthancarboxamid ] Cubebol, FEMA 4497, p-menthane carboxamide, [N- (4-cyanomethylphenyl) p-menthane carboxamide]
Figure imgf000010_0002
Figure imgf000010_0002
FEMA 4230  FEMA 4230
Ν,Ν-Dimethyl menthyl succinamid (oder 2-lsopropyl-5-methylcyclohexyl 4- (Dimethylamino)-4-oxobutanoate) (FEMA 4230), ICE 1500, N-(4- Cyanomethylphenyl) p-menthancarboxamid (FEMA 4496), N-(2-Pyridin-2- ylethyl) p-menthancarboxamid (FEMA 4549), Menthyl lactat (FEMA 3748), Menthol, WS-3, WS-23 und (-)-Menthoxypropan-1,2-diol (TK-10), 6-lsopropyl- 3,9-dimethyl-1 ,4-dioxaspiro[4.5]decan-2-on, Ν, Ν-dimethyl menthyl succinamide (or 2-isopropyl-5-methylcyclohexyl 4- (dimethylamino) -4-oxobutanoate) (FEMA 4230), ICE 1500, N- (4-cyanomethylphenyl) p-menthane carboxamide (FEMA 4496), N - (2-pyridin-2-yl-ethyl) -p-menthane-carboxamide (FEMA 4549), menthyl lactate (FEMA 3748), menthol, WS-3, WS-23 and (-) - menthoxypropane-1,2-diol (TK-10 ), 6-isopropyl-3,9-dimethyl-1,4-dioxaspiro [4.5] decan-2-one,
Figure imgf000010_0003
Figure imgf000010_0003
6-lsopropyl-3,9-dimethyl-1 ,4-dioxaspiro[4.5]decan-2-on FEMA 4285 6-isopropyl-3,9-dimethyl-1,4-dioxaspiro [4.5] decan-2-one FEMA 4285
Figure imgf000011_0001
Figure imgf000011_0001
N-Benzo[1 ,3] dioxol-5-yl-3-p-menthancarboxamid N-benzo [1,3] dioxol-5-yl-3-p-menthane carboxamide
N-Benzo[1 ,3] dioxol-5-yl-3-p-menthancarboxamid, N-Benzooxazol-4-yl-3-p- menthancarboxamid, N-4-([1 ,2,4]Triazol-l-yl)-phenyl-3-p-menthancarboxamid & N-4-(pyrazol-l -yl)-phenyl-3-p-menthancarboxamid) N-benzo [1,3] dioxol-5-yl-3-p-menthane carboxamide, N-benzooxazol-4-yl-3-p-menthane carboxamide, N-4 - [[1, 2,4] triazole-1-one yl) -phenyl-3-p-menthane carboxamide & N-4- (pyrazol-1-yl) -phenyl-3-p-menthane carboxamide)
Figure imgf000011_0002
Figure imgf000011_0002
N-(1-lsopropyl-1 ,2-dimethylpropyl)-1 ,3-benzodioxol-5-carboxamid,  N- (1-isopropyl-1,2-dimethylpropyl) -1,3-benzodioxole-5-carboxamide,
Figure imgf000011_0003
Figure imgf000011_0003
D-Ala-O-Et D-Ala-O-Me
Figure imgf000011_0004
D-Ala-O-Et D-Ala-O-Me
Figure imgf000011_0004
D-HSL CPS-195  D-HSL CPS-195
WS-5 (D-Ala-O-Me und D-Ala-O-Et), N-( R)-2-Oxotetrahydrofuran-3-yl- (1 R,2S,5R)-p-menthan-3-carboxamid ("D-HSL") L-Phenylephrin p-menthan carboxamid, ( CPS-195), Alkylcarbonyl-aminosäureester, N-Alkylcarbonyl- aminolacton, N-Arylhydroxyalkyliden-carboxamid WS-5 (D-Ala-O-Me and D-Ala-O-Et), N- (R) -2-Oxotetrahydrofuran-3-yl (1R, 2S, 5R) -p-menthane-3 carboxamide ("D-HSL") L-phenylephrine p-menthane carboxamide, (CPS-195), alkylcarbonyl-amino acid ester, N-alkylcarbonyl-aminolactone, N-arylhydroxyalkylidene-carboxamide
Figure imgf000012_0001
Figure imgf000012_0001
Ratio: -65:30  Ratio: -65: 30
2,2,5,6,6-Pentamethyl-2,3,6,6a-tetrahydropentalen-3a(1 H)-ol und 5-(2-Hydroxy- 2-methylpropyl)-3,4,4-trimethylcyclopent-2-en-1-on, (1 R,2S,5R)- 2-lsopropyl-5- methyl-N-(2-(Pyridinalkyl)yclohexancarboxamid, (1 R.2S.5R)- 2-lsopropyl-5- methyl-N-(2-(pyridin-2~yl)ethyl)cyclohexancarboxamid (FEMA 4549), (2S,5R)- 2-lsopropyl-5-methyl-N-(2-(pyridin-4-yl)ethyl)cyclohexancarboxamid,  2,2,5,6,6-pentamethyl-2,3,6,6a-tetrahydropental-3a (1H) -ol and 5- (2-hydroxy-2-methylpropyl) -3,4,4-trimethylcyclopentene 2-en-1-one, (1R, 2S, 5R) -2-isopropyl-5-methyl-N- (2- (pyridinalkyl) cyclohexanecarboxamide, (1R.2S.5R) -2-isopropyl-5- Methyl-N- (2- (pyridin-2-yl) ethyl) cyclohexanecarboxamide (FEMA 4549), (2S, 5R) -2-isopropyl-5-methyl-N- (2- (pyridin-4-yl) -ethyl) cyclohexanecarboxamide,
(1 R.2S.5R)- 2-lsopropyl-5-methyl-N-(2-(pyridin-2- yl)ethyl)cyclohexaricarboxamid, (1 R,2S,5R)- 2-lsopropyl-5-methyl-N-(2-(pyridin- 2-yi)ethyl)cyclohexancarboxamid (1 R.2S.5R) - 2-isopropyl-5-methyl-N- (2- (pyridin-2-yl) ethyl) cyclohexanedicarboxamide, (1R, 2S, 5R) -2-isopropyl-5-methyl- N- (2- (pyridin-2-yl) ethyl) cyclohexanecarboxamide
Figure imgf000012_0002
Figure imgf000012_0002
FEMA 4496 FEMA 4549  FEMA 4496 FEMA 4549
N-(4-Cyanomethylphenyl) p-Menthancarboxamid (FEMA 4496), Givaudan's Evercool G-180, Neo-menthan carboxamid (wie Neo isomer (1S,2S,5R)-N-(4- (Cyanomethyl)phenyl)-2-isopropyl-5-methylcyclohexancarboxamid, Neo G-180), N- (4-cyanomethylphenyl) p-menthane carboxamide (FEMA 4496), Givaudan's Evercool G-180, neo-menthane carboxamide (such as neo isomer (1S, 2S, 5R) -N- (4- (cyanomethyl) phenyl) -2- isopropyl 5-methylcyclohexanecarboxamide, Neo G-180),
Figure imgf000013_0001
Figure imgf000013_0001
G-180  G-180
Neo G-180 neo-Derivative von Menthyl lactat, Neo-menthyl lactat (2S), Neo-menthyl lactat acetat [(1 S,2S,5R)-2-isopropyl-5-methylcyclohexyl-2(S)-acetoxypropanoat], 1 ,7- lsopropyl-4,5-methyl-bicyclo[2.2.2]oct-5-en Derivative wie 1-lsopropyl-4-methyl- bicyclo[2.2.21oct-5-en-2,3-dicarbinol, 4-Methoxy-N-phenyl-N-[2-(pyridin-2- yl)ethyl]benzamid, 4-Methoxy-N-phenyl-N-[2- (pyridin-2- yl)ethyl]benzensulfonamid, 4-Chlo-N-phenyl-N-[2-(pyridin-2- yl)ethyl]benzensulfonamid, 4-Cyano-N-phenyl-N-[2-(pyridin-2- yl)ethyl]benzensulfonamid, 4-((Benzhydrylamino)methyl)-2-methoxyphenol, 4- ((Bis(4-methoxyphenyl)-methylamino)-methyl)-2-methoxyphenol, 4-((1 ,2- Diphenylethylamino)methyl)-2-methoxyphenol, 4- ((Benzhydryloxy)methyl)-2- methoxyphenol, 4-((9H-Fluen-9-ylamino)methyl)-2- methoxyphenol 4- ((benzhydrylamino)methyl)-2-ethoxyphenol, Benzimidazol, 1-(4- Methoxyphenyl)-2-(1-methyl-1 H-benzo[d]imidazol-2-yl)vinyl4-methoxybenzoat, 2-(1 -lsopropyl-6-methyl-1 H-benzo[d]imidazol-2-yl)-1 -(4-methoxyphenyl)vinyl4- methoxybenzoat und (Z)-2-(1-lsoprop yl-5-methyl-1 H-benzo[d]imidazol-2-y1)-1- (4-methoxy-phenyl)vinyl-4-methoxybenzoat, 3-Alkyl-p-methan-3-ol derivative  Neo G-180 neo-derivatives of menthyl lactate, neo-menthyl lactate (2S), neo-menthyl lactate acetate [(1S, 2S, 5R) -2-isopropyl-5-methylcyclohexyl-2 (S) -acetoxypropanoate], 1, 7-isopropyl-4,5-methyl-bicyclo [2.2.2] oct-5-ene derivatives such as 1-isopropyl-4-methyl-bicyclo [2.2.21oct-5-ene-2,3-dicarbinol, 4 -Methoxy-N-phenyl-N- [2- (pyridin-2-yl) ethyl] benzamide, 4-methoxy-N-phenyl-N- [2- (pyridin-2-yl) ethyl] benzenesulfonamide, 4-chloro -N-phenyl-N- [2- (pyridin-2-yl) ethyl] benzenesulfonamide, 4-cyano-N-phenyl-N- [2- (pyridin-2-yl) ethyl] benzenesulfonamide, 4 - ((Benzhydrylamino ) methyl) -2-methoxyphenol, 4- ((bis (4-methoxyphenyl) methylamino) methyl) -2-methoxyphenol, 4 - ((1, 2-diphenylethylamino) methyl) -2-methoxyphenol, 4- (( Benzhydryloxy) methyl) -2-methoxyphenol, 4 - ((9H-Fluen-9-ylamino) methyl) -2-methoxyphenol 4- ((benzhydrylamino) methyl) -2-ethoxyphenol, benzimidazole, 1- (4-methoxyphenyl) - 2- (1-methyl-1H-benzo [d] imidazol-2-yl) vinyl 4-methoxybenzoate, 2- (1-isopropyl-6-methyl-1H-benzo [d] imidazol-2-yl) -1 - (4-methoxyphenyl) v inyl 4-methoxybenzoate and (Z) -2- (1-isopropyl-5-methyl-1H-benzo [d] imidazol-2-yl) -1- (4-methoxyphenyl) vinyl-4-methoxybenzoate, 3 Alkyl p-methan-3-ol derivative
Figure imgf000013_0002
Figure imgf000013_0002
(-)-38 (-M2 (1 R,4S)-3-(Hydroxymethyl)-p-menthan-3-ol Diastereoisomere (-)-38 & (-)-42, N- (1-Methyl-1-isopropylbutyl)benzamid, (-) - 38 (-M2 (1R, 4S) -3- (hydroxymethyl) -p-menthane-3-ol diastereoisomers (-) - 38 & (-) - 42, N- (1-methyl-1-isopropylbutyl) benzamide,
Figure imgf000014_0001
Figure imgf000014_0001
-670X menthol - men o  -670X menthol-men o
Derivative von Fenchyl, D-bnyl, L-bnyl, exo-nbnyl, 2-Methylisobnyl, 2- Ethylfenchyl, 2-Methylbnyl, cis-Pinan-2-yl, Verbanyl und Isobnyl, 4-Oxo-4- ((IR,2R,4R)-1 ,7,7-trimethylbicyclo[2.2. l]heptan-2-yloxy)butansäure), Menthyl oxamatderivative, Menthyl 3-oxocarbonsäure ester (wie L-Menthyl 3-oxobutyrat und L-Menthyl 3-oxopentanoat), N alpha-(Menthancarbonyl)aminosäureamide Derivatives of fenchyl, D -bnyl, L -bnyl, exo-n-butyl, 2-methylisobnyl, 2-ethylfencyl, 2-methylbnyl, cis -pinan-2-yl, verbanyl and isobnyl, 4-oxo-4- ((IR, 2R, 4R) -1, 7,7-trimethylbicyclo [2.2.1] heptan-2-yloxy) butanoic acid), menthyl oxamate derivative, menthyl 3-oxocarboxylic acid ester (such as L-menthyl 3-oxobutyrate and L-menthyl 3-oxopentanoate) , N alpha- (menthane carbonyl) amino acid amides
Figure imgf000014_0002
Figure imgf000014_0002
Figure imgf000015_0001
Figure imgf000015_0001
(-)-(1R,2R,4S)-Dihydroumbellulol  (-) - (1R, 2R, 4S) -Dihydroumbellulol
Figure imgf000015_0002
Figure imgf000015_0002
Senomyx  Senomyx
Icilin (AG-3-5, 1-[2-hydroxyphenyl]-4-[2-nitrophenyl- tetrahydropyrimidin-2-οη) Icilin (AG-3-5, 1- [2-hydroxyphenyl] -4- [2-nitrophenyltetrahydropyrimidin-2-one])
Figure imgf000015_0003
Figure imgf000015_0003
Ebenfalls geeignet sind Gemische der vorgenannten Substanzen. Praktische Versuche haben ergeben, dass gute Ergebnisse beispielsweise mit den folgenden Verbindungen oder Gemischen hiervon erhalten werden: 1 R- [1.alpha.(R*),2.beta.,5.alpha.]]-5-Methyl-2-(1-methylethyl)cyclohexyllactat, Frescolat ® x-cool: Menthyl Ethylamido Oxalat, Frescolat ® MGA: Menthon Glycerin Acetal (1 ,4-Dioxaspiro[4.5]decan-2-methanol,9-methyl-6-(1- methylethyl)-) Frescolat ® ML: Menthyl Lactat (5-Methyl-2-(1- methylethyl)cyclohexyllactat). Also suitable are mixtures of the aforementioned substances. Practical experiments have shown that good results are obtained, for example, with the following compounds or mixtures thereof: 1 R- [1.alpha. (R * ), 2.beta., 5.alpha.]] - 5-methyl-2- (1-methylethyl) cyclohexyllactate, Frescolat® x-cool: menthyl ethylamido oxalate, Frescolat® MGA: menthone glycerol acetal (1,4-dioxaspiro [4.5] decane-2-methanol, 9-methyl-6- (1- methylethyl) -) Frescolat® ML: menthyl lactate (5-methyl-2- (1-methylethyl) cyclohexyllactate).
Der Wirkstoff kann im Handschuh in freier Form vorliegen. Denkbar ist aber auch, dass der Wirkstoff beispielsweise in Mikrokapseln eingebettet vorliegt. Vorteilhaft an der Verwendung von Mikrokapseln ist, dass die Wirkstoffabgabe gesteuert und so beispielsweise eine retardierte Freisetzung erzielt werden kann. Gemäß einer bevorzugten Ausführungsform der Erfindung werden die Mikrokapseln so ausgewählt, dass eine Freisetzung des Wirkstoffs unter Druck, beispielsweise beim Anziehen des Handschuhes, unter Wärme und/oder Feuchtigkeit ausgelöst wird. The active ingredient can be present in the glove in free form. It is also conceivable, however, that the active ingredient is present, for example, embedded in microcapsules. An advantage of the use of microcapsules is that the release of active ingredient can be controlled and thus, for example, a sustained release can be achieved. According to a preferred embodiment of the invention, the microcapsules are selected so that a release of the active ingredient under pressure, for example when putting on the glove, under heat and / or moisture is triggered.
Der Wirkstoff kann im Handschuh und insbesondere im flexiblen Material gleichmäßig verteilt vorliegen. In dieser Ausführungsform der Erfindung ist der Handschuh vorzugsweise als Einweghandschuh ausgebildet. The active ingredient can be uniformly distributed in the glove and in particular in the flexible material. In this embodiment of the invention, the glove is preferably designed as a disposable glove.
Einweghandschuhe weisen den Vorteil auf, dass sie einfach herzustellen und aufgrund ihres einmaligen Gebrauchs hygienisch sind. Da bei dieser  Disposable gloves have the advantage that they are easy to manufacture and hygienic due to their one-time use. As with this
Ausführungsform möglicherweise ein Teil des Wirkstoffs nicht ausgenutzt wird, da er nicht in direkten Kontakt mit der Haut kommt, ist es von Vorteil, wenn die Handschuhe nur eine geringe Dicke, vorzugsweise von 0,02 mm bis 0,2 mm aufweisen, insbesondere zwischen 0,04 mm und 0,15 mm. Embodiment may be a part of the drug is not exploited, since it does not come into direct contact with the skin, it is advantageous if the gloves have only a small thickness, preferably from 0.02 mm to 0.2 mm, in particular between 0 , 04 mm and 0.15 mm.
Gemäß einer alternativen Ausführungsform der Erfindung liegt im Handschuh keine gleichmäßige Verteilung des Wirkstoffs vor, wobei vorzugsweise die Innenseite des Handschuhs eine höhere Konzentration an Wirkstoff aufweist als die Außenseite. Vorteilhaft an dieser Ausgestaltung ist, dass eine maximale Ausnutzung des im Handschuh vorhandenen Wirkstoffs möglich ist. According to an alternative embodiment of the invention, there is no uniform distribution of the active ingredient in the glove, wherein preferably the inside of the glove has a higher concentration of active ingredient than the outside. An advantage of this design is that maximum utilization of the active ingredient present in the glove is possible.
Weist der Handschuh einen einschichtigen Aufbau auf, so liegt der Wirkstoff somit vorteilhafterweise auf der Innenseite des Handschuhes vor. Weist der Handschuh einen mehrschichtigen Aufbau auf, so enthält zweckmäßigerweise zumindest die innerste Schicht den Wirkstoff. Dabei kann der Wirkstoff sofern er in einer ausreichenden Konzentration vorliegt, selbst eine innerste Schicht ausbilden. Diese Ausgestaltung hat den Vorteil, dass die Konzentration des Wirkstoffs, bezogen auf die Gesamtmenge an Wirkstoff auf der Haut maximiert werden kann. If the glove has a single-layer structure, the active ingredient is thus advantageously present on the inside of the glove. If the glove has a multilayer structure, then expediently at least the innermost layer contains the active substance. In this case, the active ingredient, if it is present in a sufficient concentration, even form an innermost layer. This embodiment has the advantage that the concentration of the active ingredient, based on the total amount of active ingredient on the skin, can be maximized.
Alternativ kann der Wirkstoff auch in und/oder auf der innersten Schicht des Handschuhes eingebettet vorliegen. Dabei kann die innerste Schicht aus dem flexiblen Material bestehen. Alternatively, the active ingredient may also be present embedded in and / or on the innermost layer of the glove. In this case, the innermost layer consist of the flexible material.
Die innerste Schicht kann aber auch eine andere Schicht als die aus dem flexiblen Material sein und beispielsweise als offenporige und/oder The innermost layer can also be a layer other than that of the flexible material and, for example, as open-pore and / or
geschlossenporige Schicht, insbesondere als Textil, Schaum und/oder closed-pore layer, in particular as a textile, foam and / or
Beflockung, insbesondere Baumwoll- und/oder Viskosebeflockung, ausgestaltet sein. Diese Ausführungsform weist den Vorteil auf, dass durch geeignete Wahl der inneren Schicht die Fixierung des Wirkstoffs am Handschuh verbessert werden kann.  Flocking, especially cotton and / or viscose flocking be configured. This embodiment has the advantage that, by suitable choice of the inner layer, the fixation of the active substance on the glove can be improved.
Alternativ kann der Wirkstoff in einer auf der Innenseite des Handschuhs angeordneten Emulsion oder Suspension enthalten sein, die hautpflegende und/oder rückfettende Substanzen, vorzugsweise Glycerin, Aloe Vera, Kamille und/oder Duftstoffe enthält. Hierdurch kann der Tragekomfort weiter erhöht werden. Alternatively, the active ingredient can be contained in an emulsion or suspension arranged on the inside of the glove, which contains skin-care and / or moisturizing substances, preferably glycerol, aloe vera, chamomile and / or fragrances. As a result, the comfort can be further increased.
Der erfindungsgemäße Handschuh kann auch noch weitere Schichten aufweisen. Diese können auf einer oder beiden Seiten der flexiblen Schicht und/oder, wenn vorhanden, der innersten Schicht vorliegen. Denkbar ist auch, dass eine oder mehrere weitere Schichten zwischen flexibler Schicht und innerster Schicht angeordnet sind. Die Vorsehung weiterer Schichten, insbesondere äußerer Schichten, hat den Vorteil, dass die Beständigkeit und Wasserdichtheit des Handschuhes weiter verbessert werden kann. Dabei können die weiteren Schichten ebenfalls flexible Schichten sein und aus den gleichen Materialien wie die oben beschriebene flexible Schicht bestehen. Die weiteren Schichten können auch als textile Schichten, insbesondere Gewebe, Gewirke, Gelege, Vliese und/oder Vliesstoffe ausgestaltet sein. Diese textilen Schichten können aus den verschiedensten Materialien bestehen, The glove according to the invention may also have further layers. These may be on one or both sides of the flexible layer and / or, if present, the innermost layer. It is also conceivable that one or more further layers between flexible layer and innermost layer are arranged. The provision of further layers, in particular outer layers, has the advantage that the durability and waterproofness of the glove can be further improved. The further layers may likewise be flexible layers and consist of the same materials as the flexible layer described above. The further layers can also be configured as textile layers, in particular woven, knitted, laid, nonwoven and / or nonwoven fabrics. These textile layers can consist of the most diverse materials,
beispielsweise Baumwolle, Viskose, Nylon, PA, PE, PP, und/oder Gemische hiervon. For example, cotton, viscose, nylon, PA, PE, PP, and / or mixtures thereof.
Die Konzentration des Wirkstoffs kann in Abhängigkeit von den eingesetzten Materialien und dem erwünschten Kühleffekt variieren. So kann die The concentration of the active ingredient may vary depending on the materials used and the cooling effect desired. So can the
Konzentration des Wirkstoffs beispielsweise auf Werte von 0,005-0,6 Gew.%, bevorzugt von 0,02-0,25 Gew.%, jeweils bezogen auf das Gesamtgewicht des Handschuhs, eingestellt werden. Concentration of the active ingredient, for example, to values of 0.005-0.6 wt.%, Preferably 0.02-0.25 wt.%, In each case based on the total weight of the glove set.
Ein weiterer Gegenstand der Erfindung ist ein Verfahren zur Herstellung des erfindungsgemäßen Handschuhs, enthaltend einen Anteil mindestens eines Wirkstoffs, der in der Lage ist Kälterezeptoren auf der menschlichen Haut zu stimulieren. Im erfindungsgemäßen Verfahren wird ein flexibles Material und/oder ein Vorprodukt hiervon in Form einer Lösung, Suspension oder Emulsion auf die Oberfläche eines in Form einer Hand geformten Another object of the invention is a process for the preparation of the glove according to the invention, containing a proportion of at least one active ingredient which is able to stimulate cold receptors on the human skin. In the process of the invention, a flexible material and / or a precursor thereof is molded in the form of a solution, suspension or emulsion onto the surface of a hand-shaped one
Handschuhformers aufgebracht. Dabei kann die Oberfläche des Glove former applied. The surface of the
Handschuhformers unbeschichtet oder beschichtet, beispielsweise mit einem Elastomer, vorliegen. Das flexible Material und/oder das Vorprodukt hiervon wird, nachdem es gegebenenfalls ausgehärtet und/oder getrocknet wurde, vom Handschuhformer abgelöst. Das Auf- und/oder Einbringen des Wirkstoffs erfolgt dabei vorteilhafterweise auf eine der folgenden Arten und Weisen: Der Wirkstoff wird direkt in die Lösung, Suspension oder Emulsion des flexiblen Materials und/oder Vorprodukts hiervon eingebracht. Diese Ausführungsform eignet sich insbesondere für die Herstellung von dünnen Handschuhen. Der Wirkstoff wird herstellungsbedingt nämlich üblicherweise gleichmäßig im flexiblen Material verteilt vorliegen. Wie bereits oben diskutiert, ist für den Kühleffekt jedoch üblicherweise nur der Teil des Wirkstoffs relevant, der an der Oberfläche des Handschuhes vorliegt. Glove former uncoated or coated, for example with an elastomer present. The flexible material and / or the precursor thereof, after it has been optionally cured and / or dried, detached from the glove former. The application and / or introduction of the active ingredient is advantageously carried out in one of the following ways and means: The active ingredient is incorporated directly into the solution, suspension or emulsion of the flexible material and / or precursor thereof. This embodiment is particularly suitable for the production of thin gloves. The active ingredient is usually due to production, evenly distributed in the flexible material. As already discussed above, however, only the part of the active substance which is present on the surface of the glove is usually relevant for the cooling effect.
Alternativ kann eine Lösung oder Emulsion, die den Wirkstoff enthält, ins Innere des abgelösten Handschuhs eingesprüht werden. Diese Aufbringungsart ist verfahrenstechnisch sehr einfach und wenig kostenintensiv. Alternatively, a solution or emulsion containing the active ingredient may be sprayed into the interior of the detached glove. This type of application is procedurally very simple and inexpensive.
Denkbar ist auch, dass der Wirkstoff während des Trocknungsvorgangs auf den Handschuh aufgebracht wird. Dabei kann der Wirkstoff beispielsweise als ein Aerosol in der Trocknungsatmosphäre vorliegen. Diese Vorgehensweise weist den Vorteil auf, dass kein separater Verfahrensschritt für die Aufbringung des Wirkstoffs angewandt werden muss. It is also conceivable that the active ingredient is applied to the glove during the drying process. In this case, the active ingredient can be present for example as an aerosol in the drying atmosphere. This approach has the advantage that no separate process step for the application of the drug must be applied.
Gemäß einer besonders bevorzugten Ausführungsform wird der Wirkstoff gemeinsam mit einer Emulsion oder Suspension, die hautpflegende und/oder rückfettende Substanzen, vorzugsweise Glycerin, Aloe Vera, Kamille und/oder Duftstoffe enthält, auf die Innenseite des Handschuhs aufgebracht. Hierzu kann die Mischung in das Innere des Handschuhs gesprüht werden. Dazu kommt, dass der Wirkstoff in Emulsionen oder Suspensionen sehr einfach eingebettet und problemlos aus ihnen freigesetzt werden kann. According to a particularly preferred embodiment, the active ingredient is applied to the inside of the glove together with an emulsion or suspension which contains skin-care and / or moisturizing substances, preferably glycerol, aloe vera, chamomile and / or fragrances. For this purpose, the mixture can be sprayed into the interior of the glove. In addition, the active ingredient in emulsions or suspensions can be easily embedded and released from them.
Gemäß einer weiteren bevorzugten Ausführungsform der Erfindung wird eine Beschichtung, insbesondere in Form einer Beflockung, eines textilen Materials und/oder eines Schaums, umfassend den Wirkstoff auf die Innenseite des Handschuhs aufgebracht. Diese Vorgehensweise ist vorteilhaft, da hier auf einfache Weise realisiert werden kann, dass der Wirkstoff insbesondere in und/oder auf der innersten Schicht des Handschuhs vorliegt. According to a further preferred embodiment of the invention, a coating, in particular in the form of a flocking, a textile material and / or a foam, comprising the active ingredient is applied to the inside of the glove. This approach is advantageous because here on can be realized in a simple manner that the active ingredient is present in particular in and / or on the innermost layer of the glove.
Zur Herstellung einer Beflockung kann zunächst eine Klebeschicht auf das flexible Material aufgebracht und diese anschließend mit Flockfasern versehen werden. Als Klebeschicht können dabei die gleichen Materialien eingesetzt werden, wie sie oben für das flexible Material bereits beschrieben worden sind. To produce a flock, an adhesive layer can first be applied to the flexible material and then provided with flock fibers. As the adhesive layer while the same materials can be used as they have been described above for the flexible material already.
Eine alternative Form der Herstellung einer beflockten Schicht besteht darin, dass die Flockfasern zunächst mit dem Klebematerial vermengt und dieses Gemisch anschließend auf die Innenseite des Handschuhs aufgebracht wird. Diese Ausführungsform hat den Vorteil, dass die Flockfasern besser haften und weniger lose Flockfasern auf der Handschuhinnenseite ungebunden vorliegen. Im folgenden wird die Erfindung anhand mehrerer Beispiele näher erläutert. An alternative form of producing a flocked layer is that the flock fibers are first mixed with the adhesive material and then this mixture is applied to the inside of the glove. This embodiment has the advantage that the flock fibers adhere better and there are less loose flock fibers unbonded on the inside of the glove. In the following the invention will be explained in more detail with reference to several examples.
Herstellung einschichtiger Handschuhe nach dem Tauchverfahren Production of single-layer gloves after the dipping process
Beispiel 1 : Hierbei wird ein Keramik Former nach dem Reinigen in ein Coagulant Bad getaucht und im Anschluss getrocknet, gefolgt vom Eintauchen in ein Bad mit einer Latexformulierung. Die Latexformulierung enthält natürlichen Latex oder synthetischen Latex, oder Mischungen aus beiden, sowie Vernetzer, Example 1: Here, after cleaning, a ceramic former is dipped in a coagulant bath and subsequently dried, followed by immersion in a bath with a latex formulation. The latex formulation contains natural latex or synthetic latex, or mixtures of both, as well as crosslinkers,
Vulkanisationsbeschleuniger, Netzmittel und verschiedene Additive. Diese Formulierung enthält den Wirkstoff beispielsweise in gekapselter Form. Im Anschluss wird die Latexformulierung auf dem Former getrocknet und danach in mehrere Waschbäder (leaching tanks) getaucht und dann in einem Ofen koaguliert. Im Anschluss werden weitere Waschbäder durchlaufen. Danach wird der Handschuh vom Former gelöst und dabei auf rechts gedreht. Die Handschuhe werden im Anschluss in einem Trockner getrocknet. Beispiel 2: Vulcanization accelerators, wetting agents and various additives. This formulation contains the active ingredient, for example in encapsulated form. The latex formulation is then dried on the former and then dipped into several leaching tanks and then coagulated in an oven. Afterwards, further wash baths are run through. Then the glove is released from the former and turned to the right. The gloves are then dried in a dryer. Example 2:
Hierbei wird der Keramik Former nach dem Reinigen in ein Coagulant Bad getaucht und im Anschluss getrocknet, gefolgt vom Eintauchen in ein Bad mit einer Latexformulierung (die Latexformulierung enthält natürlichen Latex oder synthetischer Latex, oder Mischungen aus beiden, sowie Vernetzer, Here, after cleaning, the ceramic former is dipped in a coagulant bath and subsequently dried, followed by immersion in a bath with a latex formulation (the latex formulation contains natural latex or synthetic latex, or mixtures of both, as well as crosslinkers,
Vulkanisationsbeschleuniger, Netzmittel und verschiedene Additive) im Vulcanization accelerators, wetting agents and various additives) in the
Anschluss wird die Latexformulierung auf dem Former getrocknet und danach in mehrere Waschbäder (leaching tanks) getaucht und dann in einem Ofen koaguliert. Im Anschluss folgen wieder diverse Waschbäder. Danach wird der Handschuh vom Former gelöst und dabei auf rechts gedreht. Die Handschuhe werden im Anschluss in einem Trockner getrocknet, wobei gegen Ende des Trocknungscyklus der Wirkstoff eventuell zusammen mit weiteren Substanzen durch sprühen in den Trockner zugegeben wird. Following the latex formulation is dried on the former and then immersed in several leaching tanks and then coagulated in an oven. Afterwards follow again various wash baths. Then the glove is released from the former and turned to the right. The gloves are then dried in a dryer, at the end of the drying cycle, the active ingredient may be added together with other substances by spraying into the dryer.
Beispiel 3: Example 3:
Hierbei wird der Keramik Former nach dem Reinigen in ein Coagulant Bad getaucht und im Anschluss getrocknet, gefolgt vom Eintauchen in ein Bad mit einer Latexformulierung (die Latexformulierung enthält natürlichen Latex oder synthetischer Latex, oder Mischungen aus beiden, sowie Vernetzer, Here, after cleaning, the ceramic former is dipped in a coagulant bath and subsequently dried, followed by immersion in a bath with a latex formulation (the latex formulation contains natural latex or synthetic latex, or mixtures of both, as well as crosslinkers,
Vulkanisationsbeschleuniger, Netzmittel und verschiedene Additive). Im Anschluss wird die Latexformulierung auf dem Former getrocknet und danach in mehrere Waschbäder (leaching tanks) getaucht und dann in einem Ofen koaguliert. Im Anschluss durchläuft der Handschuhe eine online Chlorierung gefolgt von diverse Waschbädern. Danach wird der Handschuh vom Former gelöst und dabei auf rechts gedreht. Die Handschuhe werden im Anschluss in einem Trockner getrocknet, wobei gegen Ende des Trocknungscyklus der Wirkstoff eventuell zusammen mit weiteren Substanzen durch sprühen in den Trockner zugegeben wird. Vulcanization accelerators, wetting agents and various additives). The latex formulation is then dried on the former and then dipped into several leaching tanks and then coagulated in an oven. The gloves then undergo an online chlorination followed by several wash baths. Then the glove is released from the former and turned to the right. The gloves are then dried in a dryer, towards the end of the drying cycle of the Active substance may be added together with other substances by spraying in the dryer.
Beispiel 4: Example 4:
Hierbei wird der Keramik Former nach dem Reinigen in ein Coagulant Bad getaucht und im Anschluss getrocknet, gefolgt vom Eintauchen in ein Bad mit einer Latexformulierung (die Latexformulierung enthält natürlichen Latex oder synthetischer Latex, oder Mischungen aus beiden, sowie Vernetzer, Here, after cleaning, the ceramic former is dipped in a coagulant bath and subsequently dried, followed by immersion in a bath with a latex formulation (the latex formulation contains natural latex or synthetic latex, or mixtures of both, as well as crosslinkers,
Vulkanisationsbeschleuniger, Netzmittel und verschiedene Additive) im Vulcanization accelerators, wetting agents and various additives) in the
Anschluss wird die Latexformulierung auf dem Former getrocknet und danach in mehrere Waschbäder (leaching tanks) getaucht und dann in einem Ofen koaguliert. Im Anschluss durchläuft der Handschuhe eine online Chlorierung gefolgt von diverse Waschbädern. Danach wird der Handschuh vom Former gelöst und dabei auf rechts gedreht. Die Handschuhe werden im Anschluss offline chloriert und danach in einem Trockner getrocknet, wobei gegen Ende des Trocknungscyklus der Wirkstoff eventuell zusammen mit weiteren Substanzen durch sprühen in den Trockner zugegeben wird. Beispiel 5:  Following the latex formulation is dried on the former and then immersed in several leaching tanks and then coagulated in an oven. The gloves then undergo an online chlorination followed by several wash baths. Then the glove is released from the former and turned to the right. The gloves are then chlorinated offline and then dried in a dryer, at the end of the drying cycle, the active ingredient may be added together with other substances by spraying into the dryer. Example 5:
Hierbei wird der Keramik Former nach dem Reinigen in ein Coagulant Bad getaucht und im Anschluss getrocknet, gefolgt vom Eintauchen in ein Bad mit einer Latexformulierung (die Latexformulierung enthält natürlichen Latex oder synthetischer Latex, oder Mischungen aus beiden, sowie Vernetzer, Here, after cleaning, the ceramic former is dipped in a coagulant bath and subsequently dried, followed by immersion in a bath with a latex formulation (the latex formulation contains natural latex or synthetic latex, or mixtures of both, as well as crosslinkers,
Vulkanisationsbeschleuniger, Netzmittel und verschiedene Additive) im Vulcanization accelerators, wetting agents and various additives) in the
Anschluss wird die Latexformulierung auf dem Former getrocknet und danach in mehrere Waschbäder (leaching tanks) getaucht und dann in einem Ofen koaguliert. Im Anschluss folgen wieder diverse Waschbäder. Danach wird der Handschuh vom Former gelöst und dabei auf rechts gedreht. Die Handschuhe werden im Anschluss off-line chloriert und danach in einem Trockner getrocknet, wobei gegen Ende des Trocknungscyklus der Wirkstoff eventuell zusammen mit weiteren Substanzen durch sprühen in den Trockner zugegeben wird. Following the latex formulation is dried on the former and then immersed in several leaching tanks and then coagulated in an oven. Afterwards follow again various wash baths. Then the glove is released from the former and turned to the right. The gloves are then chlorinated off-line and then dried in a dryer, at the end of the drying cycle, the active ingredient may be added together with other substances by spraying into the dryer.
Beispiel 6: Example 6:
Hierbei wird der Keramik Former nach dem Reinigen in ein Coagulant Bad getaucht und im Anschluss getrocknet, gefolgt vom Eintauchen in ein Bad mit einer Latexformulierung (die Latexformulierung enthält natürlichen Latex oder synthetischer Latex, oder Mischungen aus beiden, sowie Vernetzer, Here, after cleaning, the ceramic former is dipped in a coagulant bath and subsequently dried, followed by immersion in a bath with a latex formulation (the latex formulation contains natural latex or synthetic latex, or mixtures of both, as well as crosslinkers,
Vulkanisationsbeschleuniger, Netzmittel und verschiedene Additive) im Vulcanization accelerators, wetting agents and various additives) in the
Anschluss wird die Latexformulierung auf dem Former getrocknet und danach in mehrere Waschbäder (leaching tanks) getaucht und dann in einem Ofen koaguliert. Im Anschluss wird der Handschuh mit einer Polymerschicht beschichtet und nochmals durch einen Ofen gefahren. Darauf folgen wieder diverse Waschbäder. Danach wird der Handschuh vom Former gelöst und dabei auf rechts gedreht. Die Handschuhe werden danach in einem Trockner getrocknet, wobei gegen Ende des Trocknungscyklus der Wirkstoff eventuell zusammen mit weiteren Substanzen durch sprühen in den Trockner zugegeben wird. Following the latex formulation is dried on the former and then immersed in several leaching tanks and then coagulated in an oven. Subsequently, the glove is coated with a polymer layer and again driven through an oven. Then again followed by various baths. Then the glove is released from the former and turned to the right. The gloves are then dried in a dryer, wherein towards the end of the drying cycle, the active ingredient may be added together with other substances by spraying into the dryer.
Beispiel 7: Hierbei wird der Keramik Former nach dem Reinigen in ein Coagulant Bad getaucht dass auch Polymer enthält und im Anschluss getrocknet, gefolgt vom Eintauchen in ein Bad mit einer Latexformulierung (die Latexformulierung enthält natürlichen Latex oder synthetischer Latex, oder Mischungen aus beiden, sowie Vernetzer, Vulkanisationsbeschleuniger, Netzmittel und verschiedene Additive) im Anschluss wird die Latexformulierung auf dem Former getrocknet und danach in mehrere Waschbäder (leaching tanks) getaucht und dann in einem Ofen koaguliert. Im Anschluss wird der Handschuh mit einer Polymerschicht beschichtet und nochmals durch einen Ofen gefahren. Darauf folgen wieder diverse Waschbäder. Danach wird der Handschuh vom Former gelöst und dabei auf rechts gedreht. Die Handschuhe werden danach in einem Trockner getrocknet, wobei gegen Ende des Trocknungscyklus der Wirkstoff eventuell zusammen mit weiteren Substanzen durch sprühen in den Trockner zugegeben wird. Mehrschichtige Handschuhe: Example 7: Here, after cleaning, the ceramic former is immersed in a coagulant bath which also contains polymer and subsequently dried, followed by immersion in a bath containing a latex formulation (the latex formulation contains natural latex or synthetic latex, or mixtures of both Crosslinker, vulcanization accelerator, wetting agent and various additives) is followed by the latex formulation on the Former dried and then dipped in several leaching tanks and then coagulated in an oven. Subsequently, the glove is coated with a polymer layer and again driven through an oven. Then again followed by various baths. Then the glove is released from the former and turned to the right. The gloves are then dried in a dryer, wherein towards the end of the drying cycle, the active ingredient may be added together with other substances by spraying into the dryer. Multilayer gloves:
Beispiel 8: Example 8:
Hierbei wird der Keramik Former nach dem Reinigen in ein Coagulant Bad getaucht und im Anschluss getrocknet, gefolgt vom Eintauchen in ein Bad mit einer Latexformulierung (die Latexformulierung enthält natürlichen Latex oder synthetischer Latex, oder Mischungen aus beiden, sowie Vernetzer, Here, after cleaning, the ceramic former is dipped in a coagulant bath and subsequently dried, followed by immersion in a bath with a latex formulation (the latex formulation contains natural latex or synthetic latex, or mixtures of both, as well as crosslinkers,
Vulkanisationsbeschleuniger, Netzmittel, optional Farbpigmente und Vulcanization accelerators, wetting agents, optional color pigments and
verschiedene Additive) im Anschluss wird die Latexformulierung auf dem various additives) is followed by the latex formulation on the
Former getrocknet und erneut in ein zweites Bad mit einer Latexmischung getaucht (wobei auch diese neben dem natürlichen und oder synthetischen Latex, Vernetzer, Vulkanisationsbeschleuniger, Netzmittel, optional Former dried and dipped again in a second bath with a latex mixture (which, in addition to the natural and or synthetic latex, crosslinker, vulcanization accelerator, wetting agent, optional
Farbpigmente und verschiedene Additive sowie den Wirkstoff eventuell in gekapselter Form beinhaltet), diese zweite Schicht kann die Fockfasern schon enthalten oder als Trägerschicht für ein Flocklining wirken, in diesem Fall wird der Handschuh direkt im Anschluss durch eine Beflockungskammer gefahren, oder aber diese zweite Schicht wird nicht als Latexfilm sondern als Schaum ausgeführt der gegebenenfalls ebenfalls Flockfasern enthält. Im Anschluss wird die zweite Schicht mit oder ohne Flockfasern wieder getrocknet und danach in mehrere Waschbäder (leaching tanks) getaucht und dann in einem Ofen koaguliert. Im Anschluss folgen eine online Chlorierung und danach wieder diverse Waschbäder. Danach wird der Handschuh vom Former gelöst und dabei auf rechts gedreht. Die Handschuhe werden im Anschluss in einem Trockner getrocknet. Color pigments and various additives as well as the active ingredient possibly in encapsulated form), this second layer may already contain the jib fibers or act as a carrier layer for a flock lining, in which case the glove is driven directly thereafter through a flocking chamber or becomes this second layer not as a latex film but as a foam which optionally also contains flock fibers. The second layer is then dried again with or without flock fibers and then immersed in several leaching tanks and then in an oven coagulated. Followed by an online chlorination and then again various baths. Then the glove is released from the former and turned to the right. The gloves are then dried in a dryer.
Beispiel 9: Example 9:
Hierbei wird der Keramik Former nach dem Reinigen in ein Coagulant Bad getaucht und im Anschluss getrocknet, gefolgt vom Eintauchen in ein Bad mit einer Latexformulierung (die Latexformulierung enthält natürlichen Latex oder synthetischer Latex, oder Mischungen aus beiden, sowie Vernetzer, Here, after cleaning, the ceramic former is dipped in a coagulant bath and subsequently dried, followed by immersion in a bath with a latex formulation (the latex formulation contains natural latex or synthetic latex, or mixtures of both, as well as crosslinkers,
Vulkanisationsbeschleuniger, Netzmittel, optional Farbpigmente und Vulcanization accelerators, wetting agents, optional color pigments and
verschiedene Additive) im Anschluss wird die Latexformulierung auf dem Former getrocknet und erneut in ein zweites Bad mit einer Latexmischung getaucht (wobei auch diese neben dem natürlichen und oder synthetischen Latex, Vernetzer, Vulkanisationsbeschleuniger, Netzmittel, optional various additives), the latex formulation is then dried on the former and submerged again in a second bath with a latex mixture (these too, besides the natural and / or synthetic latex, crosslinker, vulcanization accelerator, wetting agent, optional
Farbpigmente und verschiedene Additive beinhaltet) diese zweite Schicht kann die Fockfasern schon enthalten oder als Trägerschicht für ein Flocklining wirken, in diesem Fall wird der Handschuh direkt im Anschluss durch eine Beflockungskammer gefahren, oder aber diese zweite Schicht wird nicht als Latexfilm sondern als Schaum ausgeführt der gegebenenfalls ebenfalls This second layer can already contain the Fockfasern or act as a support layer for a flock lining, in this case, the glove is driven directly through a flocking chamber, or this second layer is not executed as a latex film but as a foam possibly also
Flockfasern enthält. Im Anschluss wird die zweite Schicht mit oder ohne Contains flock fibers. Subsequently, the second layer with or without
Flockfasern wieder getrocknet und danach in mehrere Waschbäder (leaching tanks) getaucht und dann in einem Ofen koaguliert. Im Anschluss eine online Chlorierung fefolgt von diverse Waschbädern. Danach wird der Handschuh vom Former gelöst und dabei auf rechts gedreht. Optional können die Flock fibers dried again and then dipped into several leaching tanks and then coagulated in an oven. Following an online chlorination followed by various washing baths. Then the glove is released from the former and turned to the right. Optionally, the
Handschuhe im Anschluss offline chloriert werden. Die Handschuhe werden entweder nach dem Ablösen vom Former oder aber nach der offline Gloves will be chlorinated offline afterwards. The gloves will either be removed after shedding from the shaper or after being taken offline
Chlorierung im Anschluss in einem Trockner getrocknet, wobei gegen Ende des Trocknungscyklus der Wirkstoff eventuell zusammen mit weiteren Substanzen durch sprühen in den Trockner zugegeben wird. Chlorination subsequently dried in a dryer, towards the end of the Drying cycle of the active ingredient may be added together with other substances by spraying in the dryer.
Beispiel 10: Example 10:
Hierbei wird der Keramik Former nach dem Reinigen in ein Coagulant Bad getaucht und im Anschluss getrocknet, gefolgt vom Eintauchen in ein Bad mit einer Latexformulierung (die Latexformulierung enthält natürlichen Latex oder synthetischer Latex, oder Mischungen aus beiden, sowie Vernetzer, Here, after cleaning, the ceramic former is dipped in a coagulant bath and subsequently dried, followed by immersion in a bath with a latex formulation (the latex formulation contains natural latex or synthetic latex, or mixtures of both, as well as crosslinkers,
Vulkanisationsbeschleuniger, Netzmittel, optional Farbpigmente und Vulcanization accelerators, wetting agents, optional color pigments and
verschiedene Additive) im Anschluss wird die Latexformulierung auf dem Former getrocknet und erneut in ein zweites Bad mit einer Latexmischung getaucht (wobei auch diese neben dem natürlichen und oder synthetischen Latex, Vernetzer, Vulkanisationsbeschleuniger, Netzmittel, optional various additives), the latex formulation is then dried on the former and submerged again in a second bath with a latex mixture (these too, besides the natural and / or synthetic latex, crosslinker, vulcanization accelerator, wetting agent, optional
Farbpigmente und verschiedene Additive beinhaltet) diese zweite Schicht kann die Fockfasern schon enthalten oder als Trägerschicht für ein Flocklining wirken, in diesem Fall wird der Handschuh direkt im Anschluss durch eine Beflockungskammer gefahren, oder aber diese zweite Schicht wird nicht als Latexfilm sondern als Schaum ausgeführt der gegebenenfalls ebenfalls This second layer can already contain the Fockfasern or act as a support layer for a flock lining, in this case, the glove is driven directly through a flocking chamber, or this second layer is not executed as a latex film but as a foam possibly also
Flockfasern enthält. Im Anschluss wird die zweite Schicht mit oder ohne Contains flock fibers. Subsequently, the second layer with or without
Flockfasern wieder getrocknet und danach in mehrere Waschbäder (leaching tanks) getaucht und dann in einem Ofen koaguliert. Im Anschluss folgt eine online Chlorierung gefolgt von diverse Waschbäder. Danach wird der  Flock fibers dried again and then dipped into several leaching tanks and then coagulated in an oven. This is followed by an online chlorination followed by various washing baths. After that, the
Handschuh vom Former gelöst und dabei auf rechts gedreht. Optional können die Handschuhe im Anschluss offline chloriert werden. Die Handschuhe werden entweder nach dem Ablösen vom Former oder aber nach der offline Glove detached from the former and turned to the right. Optionally, the gloves can then be chlorinated offline. The gloves will either be removed after shedding from the shaper or after being taken offline
Chlorierung in einem Trockner vorgetrocknet. Im Anschluss wird die Chlorination predried in a dryer. Following is the
Formulierung, die den Wirkstoff eventuell zusammen mit weiteren Substanzen beinhaltet, ins innere der Handschuhe gesprüht und die Handschuhe im Formulation that may contain the active substance together with other substances sprayed inside the gloves and the gloves in the
Anschluss nochmals in einem Trockner getrocknet. Optional können die mehrschichtigen Handschuhe auch drei oder mehr Schichten aufweisen, wobei dann zwischen der ersten und der zweiten Schicht weitere Latexschicht (bestehend aus natürlichem und oder synthetischem Latex, Vernetzer, Vulkanisationsbeschleuniger, Netzmittel, optional Connection dried again in a dryer. Optionally, the multi-layered gloves may also have three or more layers, and then between the first and the second layer further latex layer (consisting of natural and / or synthetic latex, crosslinker, vulcanization accelerator, wetting agent, optional
Farbpigmente und verschiedene Additiven) im Tauchverfahren aufgebracht wurden.  Color pigments and various additives) were applied by dipping.

Claims

Patentansprüche claims
1. Handschuh umfassend mindestens eine Schicht eines flexiblen 1. Glove comprising at least one layer of a flexible
Materials, welches einen Hohlraum ausbildet, um eine Hand  Material that forms a cavity around a hand
aufzunehmen und einen Anteil mindestens eines Wirkstoffs, der in der Lage ist Kälterezeptoren auf und/oder in der menschlichen Haut zu stimulieren.  and a proportion of at least one active substance which is able to stimulate cold receptors on and / or in the human skin.
2. Handschuh nach Anspruch 1 , dadurch gekennzeichnet, dass die 2. Glove according to claim 1, characterized in that the
Schicht des flexiblen Materials natürliche Polymere, insbesondere natürlichen Gummi, synthetische Polymere, insbesondere synthetischen Gummi und/oder Gemische hiervon umfasst.  Layer of the flexible material, natural polymers, especially natural rubber, synthetic polymers, especially synthetic rubber and / or mixtures thereof.
3. Handschuh nach Anspruch 1 oder 2, dadurch gekennzeichnet, dass das synthetische Polymer ausgewählt ist aus der Gruppe bestehend aus Polychloropren, carboxyliertem Acrylnitril, Butadien, Polyisopren, 3. Glove according to claim 1 or 2, characterized in that the synthetic polymer is selected from the group consisting of polychloroprene, carboxylated acrylonitrile, butadiene, polyisoprene,
Polyurethan, Styrol-Butadien, Polyvinylchlorid, Polyacn/Iat und/oder Gemischen hiervon und/oder dass das natürliche Polymer Kautschuk ist.  Polyurethane, styrene-butadiene, polyvinyl chloride, polyacrylate, and / or mixtures thereof and / or that the natural polymer is rubber.
4. Handschuh nach einem oder mehreren der vorangehenden Ansprüche, dadurch gekennzeichnet, dass der der Wirkstoff ausgewählt ist aus der Gruppe bestehend aus Menthol, bevorzugt (-)-Menthol, weiterhin aus Isopulegol, insbesondere (-)-lsopulegol, N-2,3-Trimethyl-2- Isopropylbutamid, Menthyllactat, Menthylpyrrolidoncarbonsäure, 4. Glove according to one or more of the preceding claims, characterized in that the active ingredient is selected from the group consisting of menthol, preferably (-) - menthol, further from isopulegol, in particular (-) - isopulegol, N-2.3 Trimethyl-2-isopropylbutamide, menthyl lactate, menthylpyrrolidonecarboxylic acid,
Menthylmethylether, Menthoxypropan-1 ,2- diol, Menthonglycerinacetal (9-Methyl-6-(1-methylethyl)-1 ,4-dioxaspiro(4.5)decan-2-methanol), Monomenthylsuccinat, Menthyl Ethylamido Oxalate, 2-Hydroxymethyl- 3,5,5-trimethylcyclohexanol, 2-lsopropyl-N,2,3-trimethylbutyramid, N- Ethyl-pmenthan-3-carboxamid, insbesondere 1 R,3R,4S-N-Ethyl-p- menthane-3-carboxamid, Ethyl-3-(p-menthan-3-carboxamido)acetat, (1R,2S,5R)-N-(4-Methoxyphenyl)-p-menthancarboxamid, N-Ethyl-2,2- diisopropylbutanamid, NCyclopropyl-5-methyl-2-propan-2-ylcyclohexan- 1 -carboxamid, N-(4-Cyanomethylphenyl)-p-menthancarboxamid, N-(2- (Pyridin-2-yl)ethyl)-3-p-menthancarboxamid, N-(2-Hydroxyethyl)-2- isopropyl-2,3-dimethylbutanamid, N-(1 ,1-Dimethyl-2-hydroxyethyl)-2,2- diethylbutanamid, (2S,5R)-N-[4-(2-Amino-2-oxoethyl)phenyl]-p- menthancarboxamid, 2-[(2-p-Menthoxy)ethoxy]ethanol, (2,6-Diethyl-5- isopropyl-2-methyltetrahydropyran, 3-(l-Menthoxy)-2-methylpropan-1 ,2- diol, p-Menthan-3,8-diol, insbesondere (+)-cis-p-Menthan-3,8-diol und (-) -trans-p-Menthan-3,8-diol sowie Mischungen aus (+)-cisp-Menthan-3,8- diol und (-)-trans-p-Menthan-3,8-diol, insbesondere eine Mischung im Gewichtsverhältnis 62:38, (1 R,3R,4S)-3-Menthyl-3,6-dioxaheptanoat, (1 R,2S,5R)-3-Menthylmethoxyacetat, (1 R,2S,5R)-3-Menthyl-3,6,9- trioxadecanoat, (1 R^S.öRJ-S-Menthyl-S.ö.g-trioxadecanoat, (1 R,2S,5R)- 3-Menthyl-(2-hydroxyethoxy)acetat, (1 R,2S,5R)-Menthyl-11-hydroxy- 3,6,9-trioxaundecanoat, (-)-Cubebol, N-(4-Cyanomethylphenyl)-p- menthancarboxamid, Ν,Ν-Dimethylmenthylsuccinamid (2-lsopropyl-5- methylcyclohexyl-4-(dimethylamino)-4-oxobutanoat, 6-lsopropyl-3,9- dimethyl-1 ,4-dioxaspiro[4.5]decan-2-on, N-Benzo[1 ,3]-dioxol-5-yl-3-p- menthancarboxamid, N-Benzoxazol-4-yl-3-p-menthancarboxamid, N-4- ([1 ,2,4]-Triazol-l-yl)-phenyl-3-p-menthancarboxamid, N-4-(Pyrazol-l-yl)- phenyl-3-p-menthancarboxamid, N-(1-lsopropyl-1 ,2-dimethylpropyl)-1 ,3- benzodioxol-5-carboxamid, Mischungen von 2,2,5,6,6-Pentamethyl- 2,3,6,6a-tetrahydropentalen-3a(1 H)-ol und 5-(2-Hydroxy-2-methylpropyl)- 3,4,4-trimethylcyclopent-2-en-1-on,(1S,2S,5R)-N-(4- (Cyanomethyl)phenyl)-2-isopropyl-5-methylcyclohexancarboxamid, Neo- Menthyllactat (2S), Neo-Menthyllactatacetat [(1S,2S,5R)-2-lsopropyl-5- methylcyclohexyl-2(S)-acetoxypropanoat], 1 -lsopropyl-4-methyl- bicyclo[2.2.21oct-5-ene-2,3-dicarbinol, sowie Mischungen dieser Menthyl methyl ether, menthoxypropane-1,2-diol, menthone-glycerol acetal (9-methyl-6- (1-methylethyl) -1,4-dioxaspiro (4.5) decane-2-methanol), monomethyl succinate, menthyl ethylamido oxalate, 2-hydroxymethyl-3 , 5,5-trimethylcyclohexanol, 2-isopropyl-N, 2,3-trimethylbutyramide, N-ethyl-p-menthane-3-carboxamide, especially 1R, 3R, 4S-N-ethyl-p-menthane-3-carboxamide, ethyl -3- (p-menthane-3-carboxamido) acetate, (1R, 2S, 5R) -N- (4-methoxyphenyl) pentanhane carboxamide, N-ethyl-2,2- diisopropylbutanamide, NCyclopropyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide, N- (4-cyanomethylphenyl) -p-pentane-carboxamide, N- (2- (pyridin-2-yl) -ethyl) -3-p -menthancarboxamide, N- (2-hydroxyethyl) -2-isopropyl-2,3-dimethylbutanamide, N- (1,1-dimethyl-2-hydroxyethyl) -2,2-diethylbutanamide, (2S, 5R) -N- [ 4- (2-Amino-2-oxo-ethyl) -phenyl] -pentanhane-carboxamide, 2 - [(2-p-menthoxy) -ethoxy] -ethanol, (2,6-diethyl-5-isopropyl-2-methyltetrahydropyran, 3-) 1-menthoxy) -2-methylpropane-1,2-diol, p-menthane-3,8-diol, in particular (+) - cis-p-menthane-3,8-diol and (-) - trans-p- Menthan-3,8-diol and mixtures of (+) - cis-menthane-3,8-diol and (-) - trans-p-menthane-3,8-diol, in particular a mixture in a weight ratio of 62:38, ( 1 R, 3R, 4S) -3-menthyl-3,6-dioxaheptanoate, (1R, 2S, 5R) -3-menthylmethoxyacetate, (1R, 2S, 5R) -3-menthyl-3,6,9- trioxadecanoate, (1 R 1, 2-hydroxyethoxy) acetate, (1 R 1, 2-hydroxyethoxy) acetate, (1 R, 2 S, 5 R) -ORR-S-menthyl-S, g-trioxadecanoate, (1R, 2S, 5R) Menthyl-11-hydroxy-3,6,9-trioxaundecanoate, (-) - cubebol, N- ( 4-cyanomethylphenyl) -pentanhane carboxamide, Ν, Ν-dimethylmenthylsuccinamide (2-isopropyl-5-methylcyclohexyl-4- (dimethylamino) -4-oxobutanoate, 6-isopropyl-3,9-dimethyl-1,4-dioxaspiro [4.5 ] decan-2-one, N-benzo [1,3-dioxol-5-yl-3-p-menthane carboxamide, N-benzoxazol-4-yl-3-p-menthane carboxamide, N-4- ([1, 2,4] -triazol-1-yl) -phenyl-3-p-menthane-carboxamide, N-4- (pyrazol-1-yl) -phenyl-3-p-menthane-carboxamide, N- (1-isopropyl-1, 2 -dimethylpropyl) -1,3-benzodioxole-5-carboxamide, mixtures of 2,2,5,6,6-pentamethyl-2,3,6,6a-tetrahydropentalene-3a (1H) -ol and 5- (2 -Hydroxy-2-methylpropyl) -3,4,4-trimethylcyclopent-2-en-1-one, (1S, 2S, 5R) -N- (4- (cyanomethyl) phenyl) -2-isopropyl-5-methylcyclohexanecarboxamide , Neo-menthyl lactate (2S), neo-menthyl lactate acetate [(1S, 2S, 5R) -2-isopropyl-5-methylcyclohexyl-2 (S) -acetoxypropanoate], 1-isopropyl-4-methyl-bicyclo [2.2.21oct- 5-ene-2,3-dicarbinol, as well as mixtures of these
Substanzen. Substances.
5. Handschuh nach einem oder mehreren der vorangehenden Ansprüche, dadurch gekennzeichnet, dass der Wirkstoff in Mikrokapseln 5. Glove according to one or more of the preceding claims, characterized in that the active ingredient in microcapsules
eingebettet ist.  is embedded.
6. Handschuh nach einem oder mehreren der vorangehenden Ansprüche, dadurch gekennzeichnet, dass keine gleichmäßige Verteilung des Wirkstoffs im Handschuh vorliegt und insbesondere die Innenseite des Handschuhs eine höhere Konzentration an Wirkstoff aufweist als die Außenseite. 6. Glove according to one or more of the preceding claims, characterized in that there is no uniform distribution of the active ingredient in the glove and in particular the inside of the glove has a higher concentration of active ingredient than the outside.
7. Handschuh nach einem oder mehreren der vorangehenden Ansprüche, dadurch gekennzeichnet, dass der Wirkstoff auf der Innenseite des Handschuhs vorliegt. 7. Glove according to one or more of the preceding claims, characterized in that the active ingredient is present on the inside of the glove.
8. Handschuh nach einem oder mehreren der vorangehenden Ansprüche, dadurch gekennzeichnet, dass die innerste Schicht den Wirkstoff aufweist und/oder vom Wirkstoff gebildet wird. 8. Glove according to one or more of the preceding claims, characterized in that the innermost layer comprises the active ingredient and / or is formed by the active ingredient.
9. Handschuh nach einem oder mehreren der vorangehenden Ansprüche, dadurch gekennzeichnet, dass die innerste Schicht als offenporige und/oder geschlossenporige Schicht, insbesondere als Textil, Schaum und/oder Beflockung, insbesondere Baumwoll- und/oder 9. glove according to one or more of the preceding claims, characterized in that the innermost layer as an open-pored and / or closed-cell layer, in particular as a textile, foam and / or flocking, especially cotton and / or
Viskosebeflockung, ausgestaltet ist.  Viscose flocking, is designed.
10. Handschuh nach einem oder mehreren der vorangehenden Ansprüche, dadurch gekennzeichnet, dass der Wirkstoff in einer auf der Innenseite des Handschuhs angeordneten Emulsion oder Suspension enthalten ist, die hautpflegende und/oder rückfettende Substanzen, vorzugsweise Glycerin, Aloe Vera, Kamille und/oder Duftstoffe enthält. 10. Glove according to one or more of the preceding claims, characterized in that the active ingredient is contained in an arranged on the inside of the glove emulsion or suspension, the skin-care and / or refatting substances, preferably glycerol, aloe vera, chamomile and / or fragrances contains.
11. Verfahren zur Herstellung eines Handschuhes nach einem oder mehreren der vorangehenden Ansprüche, enthaltend einen Anteil mindestens eines Wirkstoffs, der in der Lage ist Kälterezeptoren auf der menschlichen Haut zu stimulieren, indem ein flexibles Material und/oder Vorprodukt hiervon in Form einer Lösung, Suspension und/oder 11. A process for the preparation of a glove according to one or more of the preceding claims, comprising a proportion of at least one active ingredient capable of stimulating cold receptors on the human skin by a flexible material and / or precursor thereof in the form of a solution, suspension and or
Emulsion auf die Oberfläche eines in Form einer Hand geformten  Emulsion on the surface of a hand-shaped
Handschuhformers aufgebracht wird, das flexible Material und/oder das Vorprodukt hiervon gegebenenfalls ausgehärtet und/oder getrocknet wird und der Handschuh von dem Handschuhformer abgelöst wird, dadurch gekennzeichnet, dass:  Glove former is applied, the flexible material and / or the precursor thereof is optionally cured and / or dried and the glove is peeled off from the glove former, characterized in that
a) eine Lösung, Suspension und/oder Emulsion des flexiblen  a) a solution, suspension and / or emulsion of the flexible
Materials und/oder Vorprodukts hiervon eingesetzt wird, die den Wirkstoff enthält und/oder  Material and / or precursor thereof is used, which contains the active ingredient and / or
b) eine Lösung oder Emulsion, die den Wirkstoff enthält, ins Innere des abgelösten Handschuhs eingesprüht wird und/oder  b) a solution or emulsion containing the active ingredient is sprayed into the interior of the detached glove and / or
c) der Wirkstoff während des Trocknungsvorgangs auf den  c) the active substance during the drying process on the
Handschuh aufgebracht wird und/oder  Glove is applied and / or
d) eine Pflegelotion, umfassend Glycerin und/oder Duftstoffe, die den Wirkstoff enthält, ins Innere des abgelösten Handschuhs aufgebracht wird und/oder  d) a care lotion comprising glycerin and / or fragrance containing the active ingredient is applied inside the detached glove and / or
e) eine Beschichtung, insbesondere in Form einer Beflockung, eines textilen Materials und/oder eines Schaums, umfassend den Wirkstoff, auf die Innenseite des Handschuhs aufgebracht wird und/oder  e) a coating, in particular in the form of a flocking, a textile material and / or a foam, comprising the active substance, is applied to the inside of the glove and / or
f) eine Beschichtung, in der Flockfasern in einem Klebematerial eingebettet sind, auf die Innenseite des Handschuhs aufgebracht wird.  f) a coating in which flock fibers are embedded in an adhesive material is applied to the inside of the glove.
PCT/EP2014/001239 2013-06-14 2014-05-08 Glove with a cooling effect WO2014198366A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102013009963.3 2013-06-14
DE102013009963.3A DE102013009963A1 (en) 2013-06-14 2013-06-14 Glove with cooling effect

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WO (1) WO2014198366A1 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY190527A (en) * 2019-11-20 2022-04-27 Top Glove Int Sdn Bhd Coating composition and elastomeric article containing the same

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