DE10300433A1 - Antimicrobially treated textile product, especially overall garment of silk, useful for the treatment of skin diseases, obtained by immersion in a bath containing a quaternary ammonium compound to be polymerized on the fibers - Google Patents

Abstract

Preparation of a product (A) useful for treating skin diseases comprises: (1) immersing a cloth, a roll or at least part of an article of clothing in a bath of antimicrobial agent based on a solution of a quaternary ammonium compound (I) and a catalyst; (2) polymerization of (I) on the clothing fibers; (3) drying; and (4) optionally dyeing. Alternatively dyeing may be carried out before treatment with (I). An Independent claim is also included for a product (A') of silk cord obtained by the process, comprising a garment of overall type (covering the whole body apart from the head and neck), comprising a middle (body) part, two sleeve parts ending in closed glove-like parts, two leg parts ending in closed sock-like parts and openings at the back adjacent to the ends of the arm and leg parts.

Description

The subject of the present invention is a method for producing a Silk product for the treatment of skin diseases of the human body.

The proposal applies in particular, if not exclusively, to the field of specialist products for use in healthcare to support of therapies to treat atopic dermatitis.

Skin diseases are no doubt known, of which the dermatitis types are one are a classic example.

In patients who suffer from it, they cause skin irritation that sometimes can be localized, while it can be extended just as often until it almost reaches that whole body.

This is certainly a not inconsiderable problem, since it can be assumed that the part of the body affected by the disease not only with medication treated, but must also be protected in the best possible way. The protection is therefore an indispensable aspect, not only to regenerate the skin favor, but mostly to avoid the phenomenon itself aggravated or even repeated. Indeed, it can happen because of insufficient protection Bacterial colonies arise, with the triggering of repeated annoying and dangerous infections affecting the course of the disease slow it down. On the other hand, one should not forget that skin infections the most common diseases as a result of the most important skin diseases.

The same applies to other diseases, such as diabetic foot and more in the treatment of burns. Definitely are in these and others Special clothing, bandages or covers may be necessary.

For example, in DE 41 01 580 (Faeth) the problem is addressed by looking for some diseases suggest a one-piece pajamas, a so-called Overall that is completely closed at the ends of the sleeves and legs. The In this case, pajamas consist of a cotton fabric that is kind to the skin.

In any case, in addition to the clothing, there are also the elastic bandages known that are widely made from commercially available textiles. Expandable Fabric or extendable fibers and elastic garments are in and of themselves not new and are therefore available in many types. Textiles that moisture absorb, are also known and not new. Many of these products are for Example made of elastic synthetic fiber, such as Lycra® (registered trademark of DuPont de Nemours & Co.), and are characterized by an elongation of the Elastomer by at least 500-600%. In the manufacture of the garments never use this material alone, but always together with other fibers, such as polyester, cotton, nylon and other commercially available Substances. Depending on the different compositions, there are also Manufacturing methods of the fabric are different, for example when knitting is Leotards fairly common.

US 60 63 049 (Watkins) proposes a protective garment, especially for post-operative use, made from two layers of fabric, each by connecting a polyester fiber with a second elastic fiber. The fabric has an elasticity of approx. 200-220 ± 10% in the direction of the weft and the Chain on, with a tolerance of between 3% and 5% each. Said substance is also characterized by modular compression from about 1 to about 4, with a good perspiration capacity, resulting in a moisture loss of about 70-100% leads, up to 30 '.

These and other solutions not yet described are certainly high quality, however the articles mentioned only serve to protect the skin from contact, not antimicrobial purposes.

The properties of silk are known in the literature. This excellent Fiber has always been used to make traditional garments, from Shirt up to the stockings, and also other accessories.

Also known is the fact that some have tried a substance to give antimicrobial properties, especially for the treatment of some Skin diseases.

This is the case with CN1044964 (Wang), which has the problem of transferring Skin diseases caused by contact with textiles. In particular, he hits you Nonwoven fabric that uses chemically modified acrylic fibers, to achieve a uniform fiber, antiseptic and odorless, connected with a polyester fiber, viscose and polypropylene fiber that make up a type of Net is created, onto which acrylic latex is then applied. This substance is said to be according to the patent owner, particularly suitable for hygienic sanitary napkins with anti-inflammatory properties, protection against itching and against Softening of the skin, skin diseases and other skin complaints.

The applicant also has rough information regarding the Proposal CN1211652 (Yutang). From this is known the fact that it is is acting to prevent allergic asthma caused by Mite dust is caused. In essence, it seems that the fabric is made with one Mite control, adhesive and water-treated emulsion treated becomes. Said fabric seems particularly suitable for mattress upholstery, Bed covers and also to treat allergic nasal catarrh, allergic Skin diseases and conjunctivitis caused by mites.

Although the proposed solutions achieve their goals, the Most are still considered insufficient because they are unable to Material, especially a substance, with high therapeutic and antiseptic Offer properties.

At the same time, none of the above solutions are versatile, and therefore they seem not to be suitable at the same time against a variety of skin diseases Act.

The structure of the fibers or the material thus obtained are neither flexible nor open adequate way to clean as it should be a substance to make it special To offer comfort and high hygiene at the same time.

Regarding the garments, in this case one is referring to the solution of DE 41 01 580 (Faeth) serves, apart from the above-mentioned circumstances, the fact that they are made of cotton, not avoiding skin irritation as the Short cotton fibers absorb and release moisture and constantly lengthen and shorten, which leads to continuous rubbing of the skin, what skin that is already suffering from other irritations is even more irritating. Your hygroscopic capacity therefore proves to be limited so that they appear wet for long periods.

Taking all of this into account, the need appears obvious finding alternative solutions and much more efficient than those available so far standing or derived from it.

The aim of the present invention is therefore to find an optimal material on the market offer to garments for health use too to produce therapeutic and antiseptic purposes.

• a) Herstellung des Produkts unter Ausführung der Bearbeitung mit unbehandelter und gespülter Rohseide;
• b) Eintauchen des so erhaltenen Produkts in ein Bad mit einer Zusammensetzung auf der Grundlage von vierteiligem Ammonium, mit einem Katalysator legiert, der auf den Fasern polymerisiert;
• c) Trocknung;
• d) eventuelle Färbung des so erhaltenen Produkts, die auch vor der Phase (b) ausgeführt werden kann;

und wobei das Produkt aus einem Kleidungsstück besteht, das besonders für Kinder geeignet ist, in Form eines therapeutischen Ganzkörperanzugs, aus Seidenstrick, mit Strickteilen an den Enden der Ärmel und Beine sowie, an besagten Enden, Öffnungen nach Ösenart für das zeitweise Herausstrecken der Hände und der Füße. This and other objects are achieved with the help of the present invention according to the features emerging from the appended claims, by solving the problems presented by means of a method to obtain a product, especially silk, for the treatment of the indicated skin diseases, the following The phases are:

• a) Manufacture of the product by processing with untreated and rinsed raw silk;
• b) immersing the product so obtained in a bath with a composition based on four-part ammonium, alloyed with a catalyst which polymerizes on the fibers;
• c) drying;
• d) any coloring of the product thus obtained, which can also be carried out before phase (b);

and wherein the product consists of a garment that is particularly suitable for children, in the form of a therapeutic full-body suit, of silk knit, with knitted parts on the ends of the sleeves and legs and, at said ends, openings in the manner of eyelets for the temporary stretching of the hands and the feet.

In this way, through the remarkable creative contribution, its impact represents an immediate technical advance, several goals are achieved.

First of all, it should be pointed out that the product thus realized is a The basis, namely silk, is known for its remarkable qualities are. In particular, she is allergic and does not irritate, is perspiring, has one heat regulating function by reducing sweating, There are no electrostatic charges, they don't have pike, they have mold and Moths off, it does not felt, it does not shrink, is resistant and elastic and is finally washable with neutral means. Applications in this direction for the therapeutic uses are not known. For example, in the above solutions mentioned the fibers for making a garment either synthetic or natural, but in the latter case only cotton is used, see for example the proposal DE 41 01 580 (Faeth). The most important Features of the silk include the fact that the garment is made from a silk knit has a large hygroscopic capacity because the very long rubberized Silk threads absorb and release moisture through enlargement and Reducing their diameter without causing irritation to sensitive skin cause. This not only maintains the skin's water balance, but also there are other positive effects on the epidermis, especially the Preference to exercise a micro massage that activates the cells, what their Regeneration favors.

Since the silk is also treated with an antimicrobial product, it has Product also other advantages. In detail, it does not just provide an optimal barrier against skin irritation and abrasions as it actively hurts the Protects the cornea, but also inhibits the development of bacteria (especially Stafilococcus aureus) and reduces the risk of infection essential. Overall, one can say that the present product is special is suitable for the care and treatment of skin diseases, treatment of burns and skin regeneration, in the female genital area for the treatment of candidiasis, as well as for the skin symptoms due to Diabetes, like the diabetic foot.

In addition, its function is unlimited in time, unlike the others Solutions that have a temporary function.

Regarding the specific benefits of a full body suit from the above You can tell that the treated silk knit method described here is by means of the openings at the ends of the hands and / or the Feet allowed with logical advantages for the treated patient and for the patient People who look after him. Another advantage is that the full body suit is all Seams on the outside, which has the advantage of significantly rubbing the skin reduce.

A product is definitely executable that has good technological content is equipped that integrates as many functions as possible.

These and other advantages are evident from the detailed description below at least one preferred solution, using the attached schematic Drawings, the details of which are not to be understood as restrictive are, but only as an example.

Figure 1 is a front view of a silk product treated with an antimicrobial agent in accordance with the subject invention, particularly a full body suit for children.

Figure 2 is a rear view of the full body suit for children of the previous illustration.

Finally, FIG. 3 is a block diagram of a processing procedure to obtain an antimicrobial-treated product.

The subject of the present invention is a method for producing a Silk product for the treatment of skin diseases and so obtained with silk garment treated with an antimicrobial agent.

In this case, the successive phases require the execution of the mentioned method first the availability of natural silk fiber, raw, that is untreated. This essentially assumes that the fiber is rubberized, by performing a process that involves removing the rubber.

Phase (a)

With the said raw silk fiber, which can possibly be coated with lubricant, for example oil, one obtains the garment in a hypothesis ( 1 ).

Phase (b)

A liquid bath is prepared, at a temperature of about 25 ° C, inside which an antimicrobial solution has been added. Said solution consists of an antimicrobial agent based on four-part ammonium, specifically of the type of the product ÆGIS Dow Corning 5700 (3-trimethoxysilylpropyldimethyloctadecylammonium chloride), distributed by ÆGIS Environmental Management, Inc., previously dissolved in a water portion with the addition of SILANE (from the family of silicone plasticizers) as a binder. The proportion in the solution of the antimicrobial ÆGIS active ingredient is approximately 8% for 1 kg of fabric or dry garment to be treated. In principle, therefore, 30/35 kg of solution per 1 kg of substance are necessary. The garment ( 1 ) is immersed and then kept in motion, and the bath with PH 5 is first heated to a temperature of 30 ° and then to 50 ° C with a pH of 8, for a total period of 45 '/ 60'.

Phase (c)

The drying then takes place, by means of a centrifuge cycle, of the fabric or garment ( 1 ) treated in this way.

Phase (d)

Finally, one goes to the coloring phase, which in one case is also before the phase (b) can be executed.

It is important that even when using raw material other than silk optimal Results are achieved, e.g. B. nonwoven fabric, synthetic or acrylic fibers, and also Polypropylene.

• - Stafilococcus aureus-Mikroorganismen ATCC 6538
• - Einimpfung: es werden parallele Streifen einer flüssigen Anpflanzung von S. aureus auf vollständigem Agar eingebracht.
• - Zeit und Kontakttemperatur: 24 h bei 37°C
• - Menge der getesteten Probe: Stoffprobestücke der Maße 3 cm × 5 cm
• - Sterilisation der Probe: keine

Ergebnisse

Several tests have also been carried out to verify the effectiveness of the treatment for the fiber subjected to the process described above. For example, test report No. 010327/1 from 07/27/2001 from the experimental station, analysis service of the TH Milan is interesting. It was performed using the AATCC 147-1998 test method:

• - Stafilococcus aureus microorganisms ATCC 6538
• - Inoculation: parallel strips of a liquid planting of S. aureus are introduced on complete agar.
• - Time and contact temperature: 24 h at 37 ° C
• - Quantity of the tested sample: fabric test pieces measuring 3 cm × 5 cm
• - Sterilization of the sample: none

Results

After 24 h incubation of the plates, there is no growth-inhibiting formation Plaque has been found, which shows that the antimicrobial product is from the treated sample is not released to the agar.

As seen, one possible application of the treated fabric has allowed the production of a garment ( 1 ), in this case a silk knit full body suit for children, particularly suitable for the treatment of atopic dermatitis. It is a garment that almost completely covers the human body and only leaves the neck and head free. It consists of a middle part, the body ( 10 ), and four appendages: two sleeves ( 11 ), diametrically opposite at the level of the shoulders, and two ( 12 ) almost parallel in the lower part of the middle body ( 10 ), suitable for the legs to cover the patient. All four appendages have an end part ( 110 , 120 ), closed like a handle or like a stocking, which is part of the sleeve ( 11 ) or leg ( 12 ) and completely covers the affected limb, i.e. hand or foot. The main characteristic of said garment ( 1 ) are the openings ( 13 ), each in a reset position compared to the end of the appendages ( 11 , 12 ). Said openings ( 13 ) according to the type of eyelet allow the child's caregiver, if only temporarily, to let the hands or feet come out, so that a certain freedom of movement is possible without interrupting the treatment.

What is relevant is the fact that all the seams ( 14 ) are directed outside the body suit ( 1 ) as a result of the preparation process of the garment ( 1 ), so that an essentially smooth and uniform inner surface is created, without any irritating surfaces. Finally, in terms of portability, it can be seen that it has been worked out on the back by means of the intersection of two openings along the vertical and horizontal axis, the tips of which are closed when overlapped by conventional means of hooking.

Claims (15)

1. A process for the manufacture of a product for the treatment of skin diseases, characterized in that it provides the following phases: a) manufacture of the product ( 1 ), in the form of cloth as a rag or roll, or garment or part of a garment already made; b) immersing the product ( 1 ) thus obtained in a bath containing an antimicrobial agent, which is a solution based on four-part ammonium, alloyed with a catalyst which polymerizes on the fibers; c) drying; d) possible coloring of the product thus obtained ( 1 ). 2. A process for producing a product according to claim 1, characterized in that phase (d) of the coloring of the product ( 1 ) thus obtained is carried out before phase (b). 3. A process for producing a product according to claims 1 and 2, characterized in that in phase (a) for the manufacture of the product ( 1 ) the processing of raw, untreated and rinsed silk is required, from which the rubber is removed. 4. A method for producing a product according to the previous claims, characterized in that the raw silk is coated with oil. 5. A method for producing a product according to the previous claims, characterized in that in phase (b) that used in the solution imGIS Dow Corning 5700 (3- trimethoxysilylpropyldimethyloctadecylaxnmonium chloride). 6. A process for producing a product according to the preceding claims, characterized in that in phase (b) the antimicrobial agent and the water of the solution is a product of the family of silicone softeners Binder is added. 7. A process for producing a product according to the preceding claims, characterized in that in phase (b) the proportion of the antimicrobial active ingredient ÆGIS in the solution is approximately 8% per 1 kilogram of fabric or dry article of clothing to be treated, and wherein the product ( 1 ) after being immersed, is kept in motion and the pH 5 bath is first heated to a temperature of 30 ° and then to 50 ° C with pH 8 for a total period of 45 '/ 60'. 8. product of silk knit according to the preceding claims, characterized in that it is a body suit in the manner of an overalls, of silk knit that covers the human body, leaving the neck and the head free, and it consists of a middle part, the Body ( 10 ), and four appendages: two sleeves ( 11 ), diametrically opposite at the level of the shoulders, and two ( 12 ) almost parallel in the lower part of the middle body ( 10 ), suitable to cover the legs of the subject, the four appendages have an end part ( 110 , 120 ) which is closed in the manner of a handle and in the manner of a stocking, with openings ( 13 ) in a reset position compared to the ends of the appendages ( 11 , 12 ). 9. product made of silk knit according to the preceding claims, characterized in that the full body suit ( 1 ) has the seams ( 14 ) outside of the full body suit ( 1 ). 10. Product according to claims 1 to 6, characterized in that it is a is semi-finished fabric. 11. Product according to claims 1 to 6, characterized in that it is a Shell is. 12. Product according to claims 1 to 6, characterized in that it is a part of a patch with an adhesive support. 13. Product according to claims 1 to 6, characterized in that it is a Association is. 14. Product according to claims 1 to 6, characterized in that it is a finished garment is like underwear. 15. Product according to claims 1, 2 and 5, characterized in that the product ( 1 ) is made of nonwoven, or of synthetic or acrylic fibers, or of polypropylene.