WO2014195730A3 - Biomarqueurs d'auto-antigènes du lupus - Google Patents

Biomarqueurs d'auto-antigènes du lupus Download PDF

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Publication number
WO2014195730A3
WO2014195730A3 PCT/GB2014/051760 GB2014051760W WO2014195730A3 WO 2014195730 A3 WO2014195730 A3 WO 2014195730A3 GB 2014051760 W GB2014051760 W GB 2014051760W WO 2014195730 A3 WO2014195730 A3 WO 2014195730A3
Authority
WO
WIPO (PCT)
Prior art keywords
auto
lupus
antibodies
biomarkers
antigen biomarkers
Prior art date
Application number
PCT/GB2014/051760
Other languages
English (en)
Other versions
WO2014195730A2 (fr
Inventor
Timothy VYSE
Michael Bernard Mcandrew
Colin Henry Wheeler
Jens-Oliver Koopmann
Original Assignee
Sense Proteomic Limited
King's College London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sense Proteomic Limited, King's College London filed Critical Sense Proteomic Limited
Publication of WO2014195730A2 publication Critical patent/WO2014195730A2/fr
Publication of WO2014195730A3 publication Critical patent/WO2014195730A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/104—Lupus erythematosus [SLE]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présence de certains auto-anticorps indique qu'un sujet est atteint d'un lupus. Les auto-anticorps reconnaissent les antigènes énumérés dans le tableau 1 indiqué. Ces auto-anticorps et/ou les antigènes eux-mêmes peuvent être utilisés comme biomarqueurs destinés à mettre en évidence un lupus chez un sujet.
PCT/GB2014/051760 2013-06-07 2014-06-06 Biomarqueurs d'auto-antigènes du lupus WO2014195730A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1310216.5 2013-06-07
GB201310216A GB201310216D0 (en) 2013-06-07 2013-06-07 SLE(IV): Auto-antigen biomarkers for lupus

Publications (2)

Publication Number Publication Date
WO2014195730A2 WO2014195730A2 (fr) 2014-12-11
WO2014195730A3 true WO2014195730A3 (fr) 2015-03-12

Family

ID=48875961

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2014/051760 WO2014195730A2 (fr) 2013-06-07 2014-06-06 Biomarqueurs d'auto-antigènes du lupus

Country Status (2)

Country Link
GB (1) GB201310216D0 (fr)
WO (1) WO2014195730A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10928398B2 (en) * 2008-12-17 2021-02-23 Cornell University Method for double staining colocalized nuclear-markers in histological lymphoid or bone marrow tissue sample
US10545144B2 (en) 2013-12-31 2020-01-28 Yeda Research And Development Co., Ltd. Diagnosis of systemic lupus erythematosus using oligonucleotides antigens
CN107533058A (zh) 2015-03-01 2018-01-02 免疫阵列有限公司 使用蛋白、肽和寡核苷酸抗原诊断系统性红斑狼疮
WO2017025954A1 (fr) * 2015-08-09 2017-02-16 Immunarray Ltd Méthodes de détermination du risque qu'un patient atteint d'un lupus érythémateux systémique (sle) développe des syndromes neuropsychiatriques
CN107290539B (zh) * 2017-06-07 2019-06-07 哈尔滨医科大学 用于检测自身免疫病患者血清标志物的多肽组合物及其应用
CN109142730B (zh) * 2018-06-14 2021-04-23 郑州大学第一附属医院 一种肺癌标志物抗-psip1自身抗体及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010023837A1 (fr) * 2008-08-27 2010-03-04 Oncotherapy Science, Inc. Gène rqcd1 associé au cancer du sein
US20100273671A1 (en) * 2007-03-01 2010-10-28 Universite Catholique De Louvain Method for the determination and the classification of rheumatic conditions
WO2012049664A2 (fr) * 2010-10-15 2012-04-19 Sense Proteomic Limited Biomarqueurs auto-antigéniques pour le lupus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100273671A1 (en) * 2007-03-01 2010-10-28 Universite Catholique De Louvain Method for the determination and the classification of rheumatic conditions
WO2010023837A1 (fr) * 2008-08-27 2010-03-04 Oncotherapy Science, Inc. Gène rqcd1 associé au cancer du sein
WO2012049664A2 (fr) * 2010-10-15 2012-04-19 Sense Proteomic Limited Biomarqueurs auto-antigéniques pour le lupus

Also Published As

Publication number Publication date
GB201310216D0 (en) 2013-07-24
WO2014195730A2 (fr) 2014-12-11

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