WO2014193237A3 - Protéase de c. difficile - Google Patents
Protéase de c. difficile Download PDFInfo
- Publication number
- WO2014193237A3 WO2014193237A3 PCT/NL2014/050349 NL2014050349W WO2014193237A3 WO 2014193237 A3 WO2014193237 A3 WO 2014193237A3 NL 2014050349 W NL2014050349 W NL 2014050349W WO 2014193237 A3 WO2014193237 A3 WO 2014193237A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- protease
- diff
- peptide
- invention further
- clostridium difficile
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La présente invention concerne un peptide contenant la séquence d'acides aminés A/P- A/P-V/P/I/C/T-P en tant que substrat pour la protéase CD2830 de Clostridium difficile. L'invention concerne, en outre, un nécessaire ou un dispositif comprenant ledit peptide, et ce, à des fins de détermination de la présence de Clostridium difficile dans un échantillon, ainsi que d'identification d'un agent capable de moduler l'activité de la protéase CD2830. L'invention concerne, en outre, une composition, de préférence une composition pharmaceutique, contenant un inhibiteur de l'activité de la protéase CD2830.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13169930 | 2013-05-30 | ||
EP13169930.8 | 2013-05-30 | ||
EP13197876 | 2013-12-17 | ||
EP13197876.9 | 2013-12-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2014193237A2 WO2014193237A2 (fr) | 2014-12-04 |
WO2014193237A3 true WO2014193237A3 (fr) | 2015-03-19 |
Family
ID=50928203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/NL2014/050349 WO2014193237A2 (fr) | 2013-05-30 | 2014-05-30 | Protéase de c. difficile |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2014193237A2 (fr) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060121544A1 (en) * | 1997-09-15 | 2006-06-08 | Annegret Boge | Molecular modification assays |
WO2009010765A2 (fr) * | 2007-07-18 | 2009-01-22 | Novacta Biosystems Limited | Composes a base de lanthibiotique a activite antimicrobienne |
US20100291100A1 (en) * | 2009-03-27 | 2010-11-18 | Gojo Industries, Inc. | Compositions And Methods For Screening And Using Compounds Antagonizing Spore-Surface Interactions |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69737977T2 (de) | 1997-05-01 | 2008-04-17 | Minnesota Mining And Manufacturing Company, St. Paul | Fluorogene protease-substrate basierend auf farbstoffdimerisierung |
CA2398583A1 (fr) | 2000-02-11 | 2001-08-16 | Cellomics, Inc. | Biocapteurs peptidiques destines a la protease du charbon bacteridien |
-
2014
- 2014-05-30 WO PCT/NL2014/050349 patent/WO2014193237A2/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060121544A1 (en) * | 1997-09-15 | 2006-06-08 | Annegret Boge | Molecular modification assays |
WO2009010765A2 (fr) * | 2007-07-18 | 2009-01-22 | Novacta Biosystems Limited | Composes a base de lanthibiotique a activite antimicrobienne |
US20100291100A1 (en) * | 2009-03-27 | 2010-11-18 | Gojo Industries, Inc. | Compositions And Methods For Screening And Using Compounds Antagonizing Spore-Surface Interactions |
Non-Patent Citations (2)
Title |
---|
JACQUOT ET AL: "High affinity Grb2-SH3 domain ligand incorporating C<b>eta-substituted prolines in a Sos-derived decapeptide", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 15, no. 3, 19 January 2007 (2007-01-19), pages 1439 - 1447, XP005823084, ISSN: 0968-0896, DOI: 10.1016/J.BMC.2006.11.002 * |
M. VIDAL ET AL: "Design of Peptoid Analogue Dimers and Measure of Their Affinity for Grb2 SH3 Domains +", BIOCHEMISTRY, vol. 43, no. 23, 1 June 2004 (2004-06-01), pages 7336 - 7344, XP055087222, ISSN: 0006-2960, DOI: 10.1021/bi030252n * |
Also Published As
Publication number | Publication date |
---|---|
WO2014193237A2 (fr) | 2014-12-04 |
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