WO2014163588A1 - Dispositif pour collecter un échantillon de fluide, réceptacle pour recevoir le dispositif, ensemble pour collecter un échantillon de fluide et procédé de collecte d'un échantillon de fluide - Google Patents

Dispositif pour collecter un échantillon de fluide, réceptacle pour recevoir le dispositif, ensemble pour collecter un échantillon de fluide et procédé de collecte d'un échantillon de fluide Download PDF

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Publication number
WO2014163588A1
WO2014163588A1 PCT/SG2014/000153 SG2014000153W WO2014163588A1 WO 2014163588 A1 WO2014163588 A1 WO 2014163588A1 SG 2014000153 W SG2014000153 W SG 2014000153W WO 2014163588 A1 WO2014163588 A1 WO 2014163588A1
Authority
WO
WIPO (PCT)
Prior art keywords
absorptive material
carrier
tip portion
receptacle
channel
Prior art date
Application number
PCT/SG2014/000153
Other languages
English (en)
Inventor
Jianxiong Xu
Bipin Sewakram Bhola
Hong Xie
Peini CHONG
Xinyan Bi
Original Assignee
Nitto Denko Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nitto Denko Corporation filed Critical Nitto Denko Corporation
Priority to JP2016506297A priority Critical patent/JP6389870B2/ja
Priority to SG11201506455SA priority patent/SG11201506455SA/en
Publication of WO2014163588A1 publication Critical patent/WO2014163588A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B10/007—Devices for taking samples of body liquids for taking urine samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/126—Paper
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers

Definitions

  • the present invention relates broadly to a device for collection of a fluid sample, to a receptacle for receiving the device, to an assembly for collection of a fluid sample, and to a method of collecting a fluid sample.
  • the invention relates to collecting fluid samples and extracting the filtered or unfiltered fluid onto a dispensing channel and directing the fluid to predetermined locations via micro-fluidic channeling structures.
  • Collection and delivery of fluidic samples in a clean and contamination free way is desired for many applications, for example urine sample collection, water sample collection or blood sample collection.
  • Some existing techniques include use of a pipette and disposable chip, a disposable syringe, or a microfluidic system with pump and valve.
  • the existing methods can work well with measurement systems that perform qualitative measurements for various hormones or other analytes in liquid sample solution.
  • the collected sample is transported from the collection device, for example a collection cup, into the measurement system by using a pipette. This procedure can typically be used only by trained professionals and there is a very high chance of spillage when used at home by untrained users.
  • US 7,060,223 describes a polymeric medium for the retention of reagent species for use in a hand-held device for the relatively rapid detection of the presence of an analyte of interest in a sample.
  • An exposed swab disposed on the end of a sample wand is used to collect the sample, and the sample wand is inserted with the swab first into a chamber, where the swab and a seal disposed above the swab are pierced to release a reagent solution stored within a reservoir in the sample wand.
  • US 8,025,851 describes a specimen sample collection device and test system.
  • An exposed absorbent pad forming the free end of a handle is used to collect the sample, and the handle is inserted with the pad first into a compression tube, where the pad is compressed and sample fluid can be collected through outlets formed in the compression tube.
  • Figure 1 Schematic top view of an assembly for collection of a fluid sample according to an example embodiment.
  • Figure 2 Schematic perspective view of part of the assembly for collection of a fluid sample of Figure 1.
  • Figure 3 Schematic perspective view of a device for collection of a fluid sample according to an example embodiment.
  • Figure 4 Schematic top view illustrating insertion of the device of Figure 3 into a sensor receptacle, according to an example embodiment.
  • Figure 5 Schematic front view illustrating the device of Figure 3 inserted into the receptacle of Figure 4, according to an example embodiment.
  • Figure 6 Schematic cross-sectional view illustrating direction of fluidic flow during use of an assembly for collection of a fluid sample according to an example embodiment.
  • Figure 7 Schematic top view of a device for collection of a fluid sample according to an example embodiment.
  • Figure 8 Schematic top view, partly in cross section, illustrating movement of a tip of the device of Figure 7 during insertion into a receptacle, according to an example embodiment.
  • Figure 9 Schematic top view, partly in cross-section, illustrating locking of the tip of the device of Figure 7 upon full insertion into a receptacle, according to an example embodiment.
  • Embodiments of the present invention relate to collection of fluid samples through absorption by a material having a suitable absorptive power, for example an absorptive sponge, to extraction of filtered or unfiltered fluid by compressing the volume of the absorptive material into a pre-defined port of a microfluidic channel, and to compression of the absorptive sponge, either due to its own elasticity or aided by an external spring.
  • a material having a suitable absorptive power for example an absorptive sponge
  • the absorptive material can, by itself, also act as a filtering mechanism through which the fluidic sample can be filtered, for example filtering of substances that are considerably larger than the organisms present in the fluidic sample.
  • the amount of fluidic sample extracted from the absorptive material can preferably be controlled by the amount of compression and the corresponding volume change experienced by the absorptive material. This amount of fluidic sample dispensed can be critical for the microfluidic channels that transport the fluidic sample expelled by e.g. the sponge to the designated sensing regions through either active or passive microfluidic action.
  • the diameter of the collection stick can be made to be smaller than a receiving channel of a receptacle and increasing along the length of the collection stick to equal the diameter of the channel. This feature can also help in accommodating trapped/remaining air in the sponge and can prevent the formation of air bubbles inside the microfluidic channels.
  • Figure 1 shows a schematic top view of an assembly 100 for collection of a fluid sample according to an example embodiment.
  • the example embodiment includes a sample collection and delivery device, here in the form of a collection stick 102 that can be used with a sensing device, here in the form of a card sensor 104.
  • the sample collection stick 102 has a region (hidden in Figure 1, compare Figure 3 below) where a substance capable of absorbing fluid, for example a sponge or paper, is incorporated.
  • the overall size of the collection stick 102 is preferably similar to that of a regular pen, and can be utilized to collect the sample either directly by wetting the absorptive material by dropping a fluid on the absorptive region or by dipping the collection stick's absorptive region into a container containing the sample fluid.
  • the entire collection stick 102 is then inserted into a receptacle 106 which is designed to squeeze the absorptive material, to remove the fluid trapped inside the absorptive material, and to direct the removed fluid into an the exit port 108 of the receptacle 106.
  • the receptacle 106 is attached to the card sensor 104, and the exit port 108 of the receptacle 106 is aligned to a microfluidic input port 110 of the card sensor 104. After the fluid is drawn out from the absorbent sponge and into the input port 110 of the microfluidic channel in the card sensor 104, the fluid is transported to various sensing regions e.g. 112, 114 on the card sensor 104.
  • the volume of the fluid dispensed into the microfluidic channels e.g. 116 depends, inter alia, on the absorptive nature of the absorptive material, its surface to volume ratio and also on the compression experienced by the absorptive material.
  • a desired dispensing volume can preferably be achieved by controlling one or more of these parameters of the absorptive material.
  • the parameters that decide the dispensing volume include void volume, absorptive capacity, and the retaining capacity of the sponge. Air may get trapped in the absorptive material, for example if the fluid does not completely saturate the absorbent sponge.
  • the collection stick 102 in one embodiment, has a designated tapered section, as will be described in more detail below.
  • the diameter of the collection stick 102 can be made to be smaller than the channel 1 18 of the receptacle 106, see Figure 2, and increasing along the length of the collection stick 102 to equal the diameter of the channel 118. This can allow for the air to escape into the space between the collection stick 102 and the wall of the channel 1 18 in the region towards the closed end of the receptacle 106, i.e. where the diameter of the stick 102 is less than the diameter of the channel 118, when the absorbent material is compressed and the stick 102 is snapped into the receptacle 106.
  • the chances of spillage of the fluid by the user can preferably be reduced and the embodiments can also preferably provide for collecting a fluidic sample and inserting the collected fluid into the microfluidic channels of the measurement system.
  • the stick 102 has a non-absorptive tip portion, here in the form of a rigid tip 300. This can advantageously reduce or eliminate spillage of the absorbed sample fluid through inadvertent compression of the absorptive material 302, for example through misalignment with the channel 118 ( Figure 2) and resulting hitting or touching of the wall of the receptacle.
  • the tip 300 has substantially the same cross-sectional dimensions as the absorptive material 302.
  • the tip 300 and the absorptive material 302 are adjoining cylinders or discs. Accordingly, a force applied to the rigid tip 300 as a result of hitting or touching the wall of the receptacle prior to or during insertion is preferably spread and the resulting pressure on the absorptive material 302 is reduced, compared to localized pressure that would result from hitting or touching the wall with a portion of the absorptive material directly. Such localized higher pressure could result in localized compression and undesired expulsion of absorbed sample fluid.
  • the absorptive material 302 can preferably also be utilized to filter the fluidic sample.
  • the absorptive material 302 can be designed to have a certain specific pore size in order to exclude particles having sizes larger than the pore size. In this way, contaminants in the form of macroscopic particles such as dust or sediments can preferably be excluded from the fluidic sample during sample collection, and such macroscopic particles are thus preferably not delivered into the microfluidic channel sensing structure.
  • an example embodiment provides an integrated way of collecting and delivering a fluidic sample through microfluidic channels into the designated sensing regions on the sensing device.
  • the stick 102 provides a rod like support structure for the absorptive material 302.
  • the absorptive material 302 is attached, at one end thereof, to a face 400 of a first rod like support portion 402.
  • the absorptive material 302 may be attached to the face 400 using an adhesive material such as a suitable bonding material such as acrylic or epoxy glue and/or through mechanical means such as hooks (not shown) mounted or formed on the face 400 and mechanically engaging the absorptive material 302.
  • the mechanical means comprises a biasing structure in the form of a spring 600 connected to the face 601 of a first rod like portion 602 and extending towards a face 603 of the rigid tip 604 to provide mechanical strength and tensile properties to the absorptive material 606.
  • the rigid tip 300 preferably acts as a point of resistance during insertion of the stick 102 into the receptacle 106.
  • the hollow receptacle channel 1 18 has a lengthwise dimension shorter than the length 404 from the free end of the rigid tip 300 to a rim 406 between a second rod like support portion 408 and a grip portion 410 of the stick 102 by a specific amount. Accordingly, during the last part of insertion of the stick 102 into the receptacle 106, the rigid tip 300 will move towards the face 400, thereby exerting a force on the absorptive material 302, resulting in compression of the absorptive material 302 for expulsion of the fluidic sample.
  • the exit port 108 perpendicular to the receptacle channel 1 18 is aligned to the micro fluidic channel 1 16 on the card sensor 104.
  • the snap feature and the alignment feature advantageously function as indicators that the stick 102 is fully inserted and in correct alignment.
  • the fluidic sample can be collected by wetting the absorptive material 302 directly by contacting a fluidic stream or by dipping the absorptive material 302 into the sample after the sample is collected in a container.
  • all surfaces of the stick 102, other than the absorptive material 302 are made of hydrophobic material(s) to ensure that only the designated region, i.e. the absorptive material 302, will be wet and excess sample does not remain on the stick 102.
  • the stick 102 is inserted into the receptacle 106.
  • the combination of the rigid tip 300 and the support structure including the first and second rod like support portions 402, 408 will preferably allow the stick 102 to maintain its mechanical strength as the stick 102 is being inserted into the receptacle 106t.
  • the collection stick 102 also comprises a tapered section 411 disposed between the first and second rod like support portions 402, 408.
  • the dimensions (here the diameter) of the first rod like support portion 402 is smaller than that of the channel 1 18 of the receptacle 106, while the dimensions (here the diameter) of the second rod like support portion 408 is substantially equal to that of the channel 1 18.
  • the tapered section 41 1 provides for a gradual change in dimensions between the first and second rod like support portions 402, 408.
  • the volume dispensed from the absorptive material can preferably be controlled and any backflow of the fluidic sample can preferably be prevented.
  • the free end of the tip 300 has a concave shape, and is received in a corresponding convex wall 500 terminating the hollow channel 118 of the receptacle 106.
  • the length of the spring 600 is preferably less than or equal to the total uncompressed length of the absorptive material 606 and the diameter of the spring 600 is preferably less than that of the absorptive material 606.
  • the compression of the absorptive material 606, and the spring 600 in this embodiment in turn preferably cause the fluidic sample collected within the absorptive material 606 to be squeezed out and into the exit port 608 located perpendicular of the direction of insertion indicated at numeral 610, i.e. perpendicular to the insertion channel 61 1 formed in the receptacle 612.
  • the fluidic sample e.g. a liquid, preferably then flows through the microfluidic systems e.g. 614 to the respective designated sensing locations e.g. 616, 618 on the card sensor 620.
  • Figure 7 shows a schematic top view of a device 700 for collection of a fluid sample according to another embodiment.
  • the support structure includes first and second rod like support portions 702, 704, a taper portion 705, and a cover 706 around the absorptive material 708 to maintain the mechanical strength of the device 700 once fluid has been absorbed and collected by the absorptive material 707, which can cause the absorptive material 707 to have a reduced mechanical strength and tensile properties.
  • the cover 706 comprises one or more openings 709 for fluid communication to and from the absorptive material 707.
  • the cover 706 is attached to the first rod like support portion 702 at a periphery thereof and is coupled to the rigid tip 710 via a uni-directional locking mechanism that preferably prevents the absorptive material 707 from springing back after compression, as will be described below in more detail with reference to Figures 8 and 9.
  • Figure 8 shows a schematic top view, partly in cross-section, illustrating movement of the rigid tip 710 of the device 700 during insertion into a receptacle (not shown).
  • the rigid tip 710 In a first state for use of the device 700 to collect a fluidic sample, the rigid tip 710 is disposed with a protrusion 800 received in a corresponding groove 802 formed on the cover 706.
  • the protrusion 800 and the groove 802 extend ring like in this embodiment
  • the protrusion and/or the groove can take different forms, including one or more, preferably at least two, more preferably at least three, individual protrusions and a corresponding groove or grooves.
  • the groove 802 has a higher wall 804 facing towards the free end of the tip 710 compared to the wall 806 at the opposite site of the groove 802. Accordingly, dislodging of the tip 710 is preferably inhibited.
  • the lower wall 806 requires a predetermined force to be applied to the tip 710 so as to initiate movement of the tip in a direction as indicated at numeral 808, i.e. for achieving flexing to dislodge the protrusion 800 from the groove 802. This preferably inhibits un-iritentional movement of the tip 710 as a result of hitting or touching the wall of the receptacle (not shown) prior or during insertion, which may otherwise result compression and undesired expulsion of absorbed sample fluid.
  • the rigid tip 710 is disposed with the protrusion 800 received in a second corresponding groove 900 formed on the cover 706.
  • the protrusion 800 and the groove 900 extend ring like in this embodiment It will be appreciated that in different embodiments, the protrusion and/or the groove can take different forms, including one or more, preferably at least two, more preferably at least three, individual protrusions and a corresponding groove or grooves.
  • the groove 900 has a higher wall 902 facing towards the first rod like support portion 702 compared to the wall 904 at the opposite site of the groove 900.
  • the higher wall 902 advantageously prevents further compression of the absorptive material 707, facilitating control of the volume of the fluidic sample delivered.
  • the rigid cap is locked in place, whereby springing back of the absorptive material can preferably be prevented, which may otherwise result in undesired backflow of the delivered fluidic sample.
  • the rigid tip 710 in this embodiment comprises an inner rod like portion 906 disposed within a jacket 908 and joint together at a base 910 of the tip 710.
  • the inner rod like portion 906 has a dimension suitable to be slidably received in an inner channel 912 within the cover 706, to compress the absorptive material 707 during movement from the first to the second state.
  • the dimensions (here the diameter) of the inner rod like portion 906 is substantially the same as that of the absorptive material 707.
  • the collection and delivery mechanisms in the described embodiments can be used to collect and deliver fluidic samples including, but not limited to, urine, water, blood, or any other types of fluids to designated sensing locations on a sensing device.
  • the absorptive material in example embodiments can be modified to incorporate different forms of absorption and filtration capabilities. This can be done by for example controlling the pore size and material type of the absorptive material.
  • Different volumes of the fluidic sample can be delivered in different embodiments by controlling the length difference between the receptacle channel and the insert length of the collection stick.
  • the absorptive material can be impregnated e.g. with a desired colorimetric reagent in its dry form, which changes color on reaction with the analytes in the fluidic sample.
  • the colored solution can be delivered to a specific region on the sensing device for detection through the microfluidic channels.
  • non-limiting examples of materials for respective components can include: Rod like support structure including the first and second rod like support portions and the grip portion: Any form of hydrophobic plastics, such as Polymethylmethacrylat (PMMA), Polypropylen (PP), etc.
  • PMMA Polymethylmethacrylat
  • PP Polypropylen
  • Absorptive material Any form of common sponge materials such as cellulose wood fibers, foamed plastic polymers, low density polyether, polyvinyl acetal (PVA) or polyester.
  • Bias structure Non-corrosive materials, such as stainless steel or Acrylnitril-Butadien-Styrol (ABS), PP.
  • Rigid tip Any form of hydrophobic plastics, such as PMMA, PP, etc.
  • Hollow receptacle Any form of hydrophobic plastics, such as PMMA, PP, etc.
  • Sensing device Any form of sensing chip that could include optical and/or electronic components.
  • the material is plastic but it can also be either glass or silicon as well.
  • Snap feature and alignment feature Any form of hydrophobic plastics, such as PMMA, PP, etc.
  • One or more of the various parts of the described embodiments may be formed separately and the attached to each other, for example using a suitable glue or adhesive or mechanical means, or may be formed integrally.

Abstract

L'invention concerne un dispositif pour collecter un échantillon de fluide, un réceptacle pour un dispositif de collecte d'échantillon de fluide, un ensemble pour collecter un échantillon de fluide et un procédé pour collecter un échantillon de fluide. Le dispositif comprend un support ; une matière absorbante disposée sur le support ; et un mécanisme de compression disposé sur le support pour comprimer la matière absorbante sous l'effet d'une force appliquée au mécanisme de compression, le mécanisme de compression comprenant une partie pointe non absorbante du support, la partie pointe étant déplaçable pour comprimer la matière absorbante sous l'effet de la force appliquée à la partie pointe.
PCT/SG2014/000153 2013-04-05 2014-04-04 Dispositif pour collecter un échantillon de fluide, réceptacle pour recevoir le dispositif, ensemble pour collecter un échantillon de fluide et procédé de collecte d'un échantillon de fluide WO2014163588A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2016506297A JP6389870B2 (ja) 2013-04-05 2014-04-04 流体試料の収集用装置、装置を受けるレセプタクル、流体試料の収集用アセンブリ、及び流体試料を収集する方法
SG11201506455SA SG11201506455SA (en) 2013-04-05 2014-04-04 Device for collection of a fluid sample, receptacle for receiving the device, an assembly for collection of a fluid sample, and a method of collecting a fluid sample

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361809070P 2013-04-05 2013-04-05
US61/809,070 2013-04-05

Publications (1)

Publication Number Publication Date
WO2014163588A1 true WO2014163588A1 (fr) 2014-10-09

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Application Number Title Priority Date Filing Date
PCT/SG2014/000153 WO2014163588A1 (fr) 2013-04-05 2014-04-04 Dispositif pour collecter un échantillon de fluide, réceptacle pour recevoir le dispositif, ensemble pour collecter un échantillon de fluide et procédé de collecte d'un échantillon de fluide

Country Status (3)

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JP (1) JP6389870B2 (fr)
SG (1) SG11201506455SA (fr)
WO (1) WO2014163588A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10980520B2 (en) 2015-10-19 2021-04-20 Green Panther, LLC Urine sampling vessel

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US4014322A (en) * 1975-10-23 1977-03-29 The Kendall Company Specimen collecting device and method
US4877036A (en) * 1987-10-13 1989-10-31 Saint Amand Elmer F Swab transport system
US5000193A (en) * 1988-08-01 1991-03-19 Adi Diagnostics Inc. Medical swab device
US7282181B2 (en) * 2004-09-16 2007-10-16 Varian Inc. Fluid collection and testing device
US7915032B2 (en) * 2006-03-03 2011-03-29 Capitol Vial Inc. Sample collection system and method

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AU611003B2 (en) * 1988-12-23 1991-05-30 Saint Amand Manufacturing, Inc. Swab transport apparatus
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JP2005017281A (ja) * 2003-06-03 2005-01-20 Enomoto Co Ltd 使い捨てピペット及び微量採血器
CN1921803B (zh) * 2004-02-23 2011-01-26 伊西康公司 诊断拭子和活组织检查穿刺器,以及用在这些系统中的诊断帽
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Publication number Priority date Publication date Assignee Title
US4014322A (en) * 1975-10-23 1977-03-29 The Kendall Company Specimen collecting device and method
US4877036A (en) * 1987-10-13 1989-10-31 Saint Amand Elmer F Swab transport system
US5000193A (en) * 1988-08-01 1991-03-19 Adi Diagnostics Inc. Medical swab device
US7282181B2 (en) * 2004-09-16 2007-10-16 Varian Inc. Fluid collection and testing device
US7915032B2 (en) * 2006-03-03 2011-03-29 Capitol Vial Inc. Sample collection system and method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10980520B2 (en) 2015-10-19 2021-04-20 Green Panther, LLC Urine sampling vessel

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SG11201506455SA (en) 2015-09-29
JP2016514843A (ja) 2016-05-23
JP6389870B2 (ja) 2018-09-12

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