WO2014153416A1 - Compositions and methods for producing elevated and sustained ketosis - Google Patents
Compositions and methods for producing elevated and sustained ketosis Download PDFInfo
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- WO2014153416A1 WO2014153416A1 PCT/US2014/031237 US2014031237W WO2014153416A1 WO 2014153416 A1 WO2014153416 A1 WO 2014153416A1 US 2014031237 W US2014031237 W US 2014031237W WO 2014153416 A1 WO2014153416 A1 WO 2014153416A1
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- WIPO (PCT)
- Prior art keywords
- beta
- hydroxybutyrate
- grams
- composition
- acid
- Prior art date
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Definitions
- This invention relates to the use of ketogenic precursors to quickly produce elevated and sustained levels of ketone bodies in the biood and methods for assisting the body's transition into nutritional ketosis.
- MCT medium chain triglycerides
- ⁇ beta-hydroxybutyrate
- ketosis is the physioiogicai state of elevated biood ketone body levels (typically above 0.5 mmo!/L) resulting from ketogenic diets, calorie restriction, therapeutic fasting and/or supplementation with ketogenic precursors.
- Ketone bodies represent alternative energy substrates for both peripheral tissues and the central nervous system.
- the two most abundant and physiologically significant ketone bodies are acetoacetate and ⁇ -hydroxybutyrate ( ⁇ ), while the third ketone body, acetone, is produced as a byproduct that the lungs breathe off.
- the body produces ketone bodies during nutritional or therapeutic ketosis in the range of 2 - 16 mmol/L.
- ketone bodies The metabolism of ketone bodies is associated with anticonvulsant effects, enhanced brain metabolism, neuroprotective, muscle sparing properties and improvement in cognitive and physical performance.
- Science-based improvements in efficiency of cellular metabolism, managed through ketone supplementation, could have beneficial impacts on physical, cognitive health, psychological health, warfighter resilience and a long-term impact on health with respect to the common avoidable diseases such as obesity, neurodegenerative diseases, diabetes and cancer.
- Ketones can replace glucose to supply most of the brain's metabolic energy needs ⁇ > 50%) during periods of limited glucose availability resulting from starvation/fasting, caloric restriction or carbohydrate restriction as in ketogenic diets.
- carbohydrate deprivation glucose availability decreases causing a metabolic shift towards fatty acid beta-oxidation and the production of ketone bodies for energy homeostasis.
- Dietary carbohydrates include simple sugars, such as table sugar (sucrose) and complex carbohydrates (starch) found in foods like potatoes and pasta. Carbohydrate and sugar consumption have dramatically increased in the last two centuries in Western societies. When sugars and carbohydrates are consumed by humans, the pancreas secretes insulin, a hormone used to convert the sugars and carbohydrates into glucose. The glucose is then used by the body as a fuel source, in most Western diets, glucose is the body's primary fuel source.
- Ketone bodies can be used by every cell of the body as a replacement fuel to satisfy the body's energy needs, including the needs of the brain.
- blood ketone levels will increase to as high as 2 or 3 mmol/L. It is conventionally understood and agreed that when blood ketones rise above 0.5 mmol/L, the heart, brain and peripheral tissues are using ketone bodies (beta hydroxybutyrate and acetoacetate) as the primary fuel source.
- ketosis This condition is referred to as ketosis, or "nutritional ketosis.” This is distinguished from, and should not be confused with, diabetic or alcoholic ketoacidosis, which is the runaway accumulation of ketone bodies and associated drop in blood pH. Diabetic ketoacidosis is associated with the absence of insulin as occurs in those suffering from type 1 diabetes. Ketoacidosis typically results in blood ketone levels in excess of 25 mmol/L in combination with metabolic derangement and electrolyte imbalance.
- the body When in ketosis, the body essentially burns fat for fuel. This is accomplished because fat stores in the body are utilized to create the water soluble ketone bodies beta- hydroxybutyrate ( ⁇ ) and acetoacetate (also known as acetyiacetonate). These ketone bodies are then used by the body as its primary energy source. The body enters a state of ketosis when it has no dietary source of glucose or sugar and its stores of glycogen have been depleted. This typically occurs during fasting, exercise, and/or pursuing a carbohydrate restricted ketogenic diet.
- ⁇ beta- hydroxybutyrate
- acetoacetate also known as acetyiacetonate
- ketosis Upon transitioning into ketosis, the body begins cleaving fats into fatty acids and glycerol and transforms the fatty acids into acetyl CoA molecules which are then eventually transformed into ketone bodies in the liver.
- the body uses dietary and bodily fats as its primary energy source. Consequently, once in ketosis, one can easily induce loss of body fat by reducing dietary fat intake and adjusting carbohydrate intake low enough to sustain ketosis.
- ketogenic diet including anti-aging and mood stabilizing effects.
- Recent animal studies have demonstrated superior performance with respect to endurance time, volume of oxygen consumed, heart rate, blood lactate levels and power output when blood ketone levels are elevated.
- the ketogenic diet has been established to be efficacious in treating drug-resistant seizure disorders. This therapeutic method is well established in children and adults.
- the ketogenic diet has been used to treat pediatric intractable seizures since the 1920s.
- the diet is currently being investigated as treatment for a broad list of disease states from cardiovascular health and type II diabetes to cancer and neurological disorders such as amyotrophic lateral sclerosis (ALS) and traumatic brain injury
- ALS amyotrophic lateral sclerosis
- ROS reactive oxygen species
- Alzheimer's disease was attributed to decreased neuronal metabolism and reduced glucose availability to neurons, it was suggested that elevating ketone bodies in these patients provides an alternative fuel source for the neurons.
- Lipases hydrolyze the medium chain triglycerides to medium chain fatty acids in the duodenum, permitting uptake of the medium chain fatty acids that are subsequently oxidized by the liver to form ketone bodies.
- Henderson, et a/ suggested intravenous administration of medium chain triglycerides, medium chain fatty acids, or ketone bodies. The increase in blood ketone levels provides neurons with a supplemental fuel where glucose is not accessible to the neuron, such as in Alzheimer's disease. Henderson (U.S. Pat. No.
- compositions of medium chain triglycerides used oral compositions of medium chain triglycerides to treat age-associated memory impairment, thereby increasing ketone body levels in the blood.
- Veech U.S. Pat. No. 6,323,237 also disclosed compositions containing ketone bodies for treating neuronal damage, and also found the compositions useful for increasing cardiac efficiency, providing energy to diabetics and patients suffering from insulin resistance.
- the compositions include esters and polymers.
- amyloid proteins responsible for Alzheimer's disease block pyruvate dehydrogenase which is part of glucose metabolism
- ketone bodies such as D-R-3- hydroxybutarate, acetoacetate, and derivatives of these compounds are useful fuel sources.
- Ketogenic diets ars weight ioss
- a keiogenic diet is one that is high in dietary fat and low in carbohydrates with moderate levels of protein (approximately 1 - 2 g/kg).
- the classical ketogenic diet consists of a strict regimen of 4 parts fat to 1 part protein with less than 25-50 g of carbohydrates per day. it has been suggested that the ideal macronutrient ratio to maintain a ketogenic diet is 65-85 percent of calories from fats, 10-20 percent of calories from proteins, and 5 percent of calories from carbohydrates.
- ketogenic diet may result in loss of fat stores while maintaining and protecting muscle mass.
- Some studies have suggested that the muscle sparing properties of a ketogenic diet result in improvement in physical performance.
- Athletes who maintain nutritional ketosis maintain lower insulin Ieveis and can better utilize fatty acids and ketones for fuel, effectively sparing blood glucose, which optimizes and prolongs physical and mental performance. This state is referred to as being "keto adapted.”
- Keto adaptation occurs when the body adjusts to ketosis by building up the necessary fat-burning enzymes, hormone ieveis are changed to accommodate ketosis, glycogen stored in muscles and liver is reduced, and the body is carrying less water.
- Keto-adapted Individuals draw proportionally more substrate from fats and ketones (sparing glycogen) and can shift the peak to much higher VCh levels and thus sustain effort for an extended duration. Transitioning to a keto-adapted state ⁇ blood ketones > 0.5 mmol/L) typically requires 1 to 2 weeks with severe restriction of carbohydrates ( ⁇ 25 g/day) and moderate protein restriction (1 g/kg/day) with the balance of macronutrient from fat. A sustained physiological decrease in glucose and insulin are required for sustained hepatic ketogenesis, which is very difficult for most humans.
- Viahakos U.S. Pat. No. 6,613,356 ⁇ provides a weight-loss composition using n-butyrate ions from potassium butyrate or related compounds. Butyric acid stimulates receptors in the stomach that the stomach is full and food is stagnant in the stomach. Thus, consuming butyric acid precursors prior to eating reduces food consumption. Testing showed the compositions improved a patient's ability to withstand rigorous exercise, improved hypercholesterolemia and hypertriglyceridemia, and reduced fatigue.
- ketosis Another advantage to pursuing weight loss through a ketogenic diet is that being in ketosis reduces hunger. Indeed, hunger is the major barrier that is often cited for the inability to maintain a traditional calorie restricted diet.
- ketosis The ability for much larger numbers of people to utilize the significant advantages of ketosis are severely restricted by the ability to get into ketosis.
- This invention opens up the potential for large numbers of people to quickly and easily get into ketosis and be able to sustain a ketogenic lifestyle without the physiological and emotional challenges brought on through the process of getting into and sustaining ketosis.
- the transition into ketosis causes lethargy and light-headedness in many, resulting in an uncomfortable physiological and mental state commonly referred to as the "low carb flu.”
- the symptoms associated with transitioning from a sugar and carbohydrate- rich diet into a state of ketosis will vary according to the physiology of the particular subject. Thus, some people may experience minimal discomfort as they transition into ketosis. On the other hand, however, some people may experience these symptoms to such a degree that the symptoms present what may seem to be an insurmountable impediment to getting into ketosis and taking advantage of the positive health effects that can be achieved by living in a state of ketosis. The vast majority of those who attempt to induce ketosis through some combination of diet, fasting, and exercise will experience some of these symptoms.
- ketogenic diet requires eliminating substantially ail sugars and carboydrates from the diet.
- candies, breads, and other non-ketogenic foods the necessary modification to their diet will pose an additional hurdle to pursuing nutritional keiosis.
- implementing a ketogenic meal plan at home is manageable for many.
- restaurant dining is part of the social fabric for many people
- maintaining a ketogenic diet in such social settings requires further education and may place one in awkward social settings, providing yet another impediment to widespread implementation of a ketogenic diet.
- many people frequently travel. For a frequent traveler to maintain a ketogenic diet will typically require that they either carry appropriate food with them or attempt to maintain the ketogenic diet in settings where few, if any, ketogenic foods may be available.
- ketosis may be aided by taking ketogenic medical foods or exogenous supplemental ketones.
- ketogenic fats like medium chain triglyceride oil (MCT oil) are generally not well tolerated by the gastrointestinal system in quantities necessary to aid in inducing ketosis.
- MCT oil medium chain triglyceride oil
- oral administration of ⁇ and acetoacetate in their free acid form is expensive and ineffective at producing sustained ketosis.
- One idea has been to buffer the free acid form of ⁇ with sodium salts, but this causes a potentially harmful sodium overload and mineral imbalance at therapeutic levels of ketosis and is largely ineffective at preventing seizures in animal models.
- Ketone salts with a balance of minerals are needed to prevent the sodium overload, but these ketone mineral salts have not been developed or commercialized yet.
- ketogenic diets increasing total cholesterol and triglycerides while decreasing high density lipoprotein (HDL) levels.
- HDL high density lipoprotein
- This lipid profile is a key predictor of heart health: atherosclerotic lesions, fatty streaks and fibrous plaques in the aorta and coronary arteries. This is more limiting during adult treatment with the ketogenic diet.
- Based on the broad therapeutic potential for pursuing and sustatining a ketogenic lifestyle the need to develop an oral ketone supplement that could safely elevate blood ketone levels to therapeutic ranges of nutritional ketosis without severe dietary restriction and the associated side effects is greater than ever.
- composition and corresponding treatment and maintenance method that permits the establishment of ketosis in a patient quickly, and the maintenance of ketosis with little to no perceived impact on the patient's physiology or mental comfort.
- a ketogenic diet is effective at raising blood ketone levels and has potential broad applications, but achieving the advantages of those applications requires strict compliance with the diet.
- the present invention provides a strategy to elevate and sustain blood ketone body levels through the administration of novel combinations of ketogenic supplements and causes a rapid and sustained elevation of blood ketones with a single oral administration.
- the invention exploits the metabolic and physiological advantages of sustained ketosis (e.g. keto-adaptation) which utilizes ketones as an alternative fuel to improve metabolic health, physical performance and enhance disease prevention.
- ketone precursors which comprises at least one medium chain fatty acid, or an ester thereof such as a medium chain triglyceride, and a ⁇ hydroxybutyrate ketone source or precursor.
- medium chain fatty acid or an ester thereof such as a medium chain triglyceride
- ⁇ hydroxybutyrate ketone source or precursor There are numerous sources of ketones and ketogenic precursors.
- Noniimiting examples of the beta-hydroxybutyrate compound include beta-hydroxybutyrate salts such as sodium beta-hydroxybutyrate and arginine beta- hydroxybutyrate, potassium beta-hydroxybutyrate, calcium beta-hydroxybutyrate, magnesium beta-hydroxybutyrate, lithium beta-hydroxybutyrate, lysine beta- hydroxybutyrate, histidine beta-hydroxybutyrate, ornithine beta-hydroxybutyrate, creatine beta-hydroxybutyrate, agmatine beta-hydroxybutyrate, citrulline beta-hydroxybutyrate, beta-hydroxy butyraie sodium salt, beta-hydroxy butyraie potassium salt, beta-hydroxy butyraie calcium salt, beta-hydroxy butyraie magnesium salt, or a combination of salts.
- beta-hydroxybutyrate salts such as sodium beta-hydroxybutyrate and arginine beta- hydroxybutyrate, potassium beta-hydroxybutyrate, calcium beta-hydroxybutyrate, magnesium beta-hydroxybutyrate, lithium beta-hydroxybutyrate,
- Nonlimiting examples of combinations of beta-hydroxybutyrate salts include sodium beta- hydroxybutyrate and arginine beta-hyd oxybutyrate, or beta-hydroxy butyrate sodium salt and beta-hydroxy butyrate potassium salt.
- Other ⁇ -hydroxybutyrate ketone sources include, without limiting the scope, 1 ,3-butanediol. ethyl acetoacetate, and ethyl beta- hydroxybutyrate.
- the compounds are optionally administered between 2 grams and 50 grams, between 5 grams and 30 grams, or between 10 grams and 20 grams.
- the ketone compounds are optionally administered at 2 grams, 4 grams, 5 grams, 6 grams, 7 grams, 8 grams, 9 grams, 10 grams, 11 grams, 12 grams, 13 grams, 14 grams, 15 grams, 17 grams, 19 grams, 20 grams, 22 grams, 24 grams, 26 grams, 28 grams, 30 grams, 32 grams, 34 grams, 36 grams, 38 grams, 40 grams, 42 grams, 44 grams, 46 grams, 48 grams, or 50 grams.
- the beta-hydroxy butyrate compound is histidine beta- hydroxybutyrate, ornithine beta-hydroxybutyrate, creatine beta-hydroxybutyrate, agmatine beta-hydroxybutyrate, or citrulline beta-hydroxybutyrate.
- the compound is optionally a racemic DL-beta hydroxybutyrate or the single isomer R-beta hydroxybutyrate.
- additional ketone precursors or supplements might be used in combination with beta hydroxybutyrate and medium chain triglycerides.
- additional ketone precursors or supplements might include acetoacetate, ketone esters, and other compounds that cause a rise in blood ketone levels.
- the low carb flu caused by glucose withdraw in the brain and to a depletion of minerals, especially sodium and potassium in the plasma when entering ketosis through a ketogenic diet. These symptoms can be attenuated or reversed with sufficient supplementation of sodium, potassium, calcium and magnesium. Supplemental administration of minerals prevents potassium depletion via the renal-adrenal aldosterone pathway.
- the invention optionally uses mineral salts of beta-hydroxybutyrate ( ⁇ ).
- Mineral salts of ⁇ are described above and include, without limiting the scope of the invention, potassium ⁇ , sodium ⁇ , calcium ⁇ , magnesium ⁇ , lithium BHB and any other feasible non-toxic mineral salts of ⁇ .
- Organic salts of BHB include, without limiting the scope of the invention, salts of organic bases such as arginine ⁇ , lysine ⁇ , histidine BHB, ornithine ⁇ , creatine ⁇ , agmatine ⁇ , and citrulline ⁇ .
- the salts may contain the racemic DL-beta hydroxybutyrate or the single isomer R-beta hydroxybutyrate.
- Non-iimiting examples and sources of the medium chain fatty acid, or an ester thereof such as a medium chain triglyceride include coconut oil, coconut milk powder, fractionated coconut oil, palm oil, palm kernel oil, capriiic acid, isolated medium chain fatty acids, such as isolated hexanoic acid, isolated octanoic acid, isolated decanoic acid, medium chain triglycerides either purified or in natural form such as coconut oil, and ester derivatives of the medium chain fatty acids ethoxyiated triglyceride, enone triglyceride derivatives, aldehyde triglyceride derivatives, monoglyceride derivatives, diglyceride derivatives, and triglyceride derivatives, and salts of the medium chain triglycerides.
- Ester derivatives optionally include alkyl ester derivatives, such as methyl, ethyl, propyl, butyl, hexyl, etc. Oils may be spray dried onto solid supports such as maltodextrin to facilitate delivery in powder form.
- the at least one medium chain triglyceride is optionally administered at between 5 grams and 50 grams, between 10 grams and 40 grams, or between 15 grams and 30 grams.
- the medium chain triglyceride is administered at 5 grams, 6 grams, 7 grams, 8 grams, 9 grams, 10 grams, 1 1 grams, 12 grams, 13 grams, 14 grams, 15 grams, 17 grams, 19 grams, 20 grams, 22 grams, 24 grams, 26 grams, 28 grams, 30 grams, 32 grams, 34 grams, 36 grams, 38 grams 40 grams.
- the composition optionally includes at least one non-toxic mineral salt.
- non-toxic mineral salt include the minerals Na, g, V, K, Cr, Mn, Co, Cu. Zn, As, Mo and Se associated with an ion of chlorine, sulfate, iodine, bromine, or other known ion in the art. Examples include sodium chloride, zinc sulfide, potassium iodine.
- the ketone precursors are preferably ingested along with nutritional substrates such as free amino acids, amino acid metaboliies, vitamins, minerals, electrolytes and metabolic optimizers such as NADH, soluble ublqulnol, tetrahydrobiopeterin, aipha-ketoglutaric acid, carnitine, and/or alpha lipoic acid, nutritional co-factors, calcium beta-methyi-beta- hydroxybutyrate, arginine alpha-kefogiutarate, sodium R-alpha lipoic acid, thiamine, riboflavin, niacin, pyridoxine, ascorbic acid, citric acid, malic acid, sodium benzoate, potassium sorbate, acesulfame K, aspartame, xanthan gum, or a combination thereof.
- nutritional substrates such as free amino acids, amino acid metaboliies, vitamins, minerals, electrolytes and metabolic optimizers such as NADH, soluble ub
- Noniimiting examples of nutritional co-factors include R-a!pha lipoic acid, acetyl-l-carnitine, ketoisocaproate, alpha-ketoglutarate, alpha-hydroxyisocaproate, creatine, branched chain amino acids (leucine, isoieucine, valine), beta-hydroxy-beta methylbutyrate (HMB), B vitamins, vitamin C, soluble ubiquinoi, and carnitine that assist in mitochondrial function, in some variations, the supplemental mixture shall provide no more than 400 calories per day.
- compositions are useful for weight loss and treatment of high blood glucose or type II diabetes and can improve the user's general health in a short period of time.
- the ⁇ salt / medium chain triglyceride formula is used to facilitate weight loss, as a brain tonic, to enhance athletic performance, to help prevent diseases related to metabolic dysfunction, mitochondrial defect, and insulin resistance, as an adjunct to a ketogenic diet, as an anti-aging supplement, and other uses associated with improved metabolic health.
- a combination SHB / ' MOT composition is optionally administered in a range of 1 : 1 to 1 :2 mixture to elevate blood ketones to a level that would be considered a state of nutritional ketosis.
- Administration can be performed with or without dietary restriction, in some variations, the patient preferably follows a ketogenic diet that restricts intake of carbohydrates and protein during the period of administration of the SHB / MCT composition, in specific embodiments, the patient restricts the dietary intake to a ratio of about 65% fat, 25% protein, and 10% carbohydrates.
- the therapeutic ketosis produced herein provides a rapid and sustained keto-adaptation as a metabolic therapy for a wide range of metabolic disorders, and provides nutritional support for therapeutic fasting, weight loss, and performance enhancement.
- the composition is optionally administered once per day, twice per day, or three times per day to a subject desiring to promote and/or sustain a state of ketosis.
- the preferred route of administration of the mixture of ⁇ salts and MCT oil is oral.
- the product may be delivered as a powdered mixture, as a ready-to-drink liquid, in hard or soft gelatin caps, as hard-pressed tablets, concentrated gels, or any other dosage form known to those trained in the art.
- the product is preferably delivered in the form of a ready-to-drink formula consisting of a mixture of sodium and potassium BHB along with coconut milk powder.
- the drink may be pH adjusted with citric and/or malic acid, and artificial sweetener and flavoring can be added.
- the drink should be homogenized and pasteurized.
- the subject may enjoy greater flexibility in the diet that must be followed to maintain a state of ketosis.
- a subject may be able to enjoy an occasional carbohydrate or sugar "cheat" and not significantly jeopardize their ketogenic state, indeed, because the present invention facilitates the quick and easy transition into ketosis, should one need to depart from a strict ketogenic diet for a day or two, getting back into ketosis can be accomplished quickly and without the difficult symptoms which heretofore impeded the process.
- Figure 1 is a graph depicting summary data of mean blood BHB levels of a human subject that received BHB salts (4% solution containing 1 1 grams sodium BHB and 7.1 grams potassium BHB), MCT oil, or the combination of BHB salts and MCT oil, at 15, 30, 60, 120,
- Figure 2 is a graph depicting mean blood ⁇ levels after a single administration of BHB salts (4% solution containing 1 1 grams sodium BHB and 7.1 grams potassium BHB) in a fasted 70 kg male subject on three consecutive days at 30, 60, 120, 240 and 480 minutes after oral administration.
- BHB salts 4% solution containing 1 1 grams sodium BHB and 7.1 grams potassium BHB
- Figure 3 is an graph depicting mean blood BHB and glucose levels after a single administration of BHB salts (4% solution containing 1 1 grams sodium BHB and 7.1 grams potassium BHB) in a fasted 70 kg male subject on 3 consecutive days at 30, 60, 120, 240 and 480 minutes after administration.
- BHB salts 4% solution containing 1 1 grams sodium BHB and 7.1 grams potassium BHB
- Figure 4 is a graph showing that ketone supplementation does not affect lipid profile. At week 0 (prior to administration) and week 4 total cholesterol were not significantly different from control in any of the test substances. Statistical analysis was performed using two- way analysis of variance (ANOVA) with Dunriett's post hoc test, results are considered significant if p ⁇ 0.05. Error bars represent ⁇ the standard error of the mean (SEM).
- Figure 5 is a graph showing that ketone supplementation does not affect lipid profile. At week 0 and week 4, HDL levels were not significantly different from the control in any of the treatment groups. Two-way ANOVA with Dunriett's post hoc test results considered significant if p ⁇ 0.05. Error bars represent +SEM.
- Figure 6 is a graph showing that ketone supplementation does not affect lipid profile. At week 0 and week 4 triglycerides were not significantly different from control in any of the treatment groups. Two-way ANOVA with Dunnett's post hoc test, results considered significant if p ⁇ 0.05. Error bars represent +SEM.
- Figures 7(A) and (B) are graphs showing the effects of ketone supplementation on blood ketone levels in rats. Ketone supplementation demonstrated significant elevation of blood ketones over 4 weeks.
- Week 0 and (B) week 1 ketone supplements were given in an oral dosage of 5g per kg body weight. Animals given MCT oil supplementation alone showed significantly elevated blood ketones starting at 30 min and lasting for 8 hours; The combination of BHB salt/ CT oil significantly elevated ketones at 4 hrs. BHB salt alone did not significantly elevate ketones.
- Two-way ANOVA with Dunnett's post hoc test results considered significant if p ⁇ G.05. Error bars represent ⁇ SEM.
- Figures 8(A) and (B) are graphs showing the effects of ketone supplementation on blood ketone levels in rats. Ketone supplementation demonstrated significant elevation of ketones over 4 weeks.
- week 2 Figure 8(a)
- week 3 Figure 8(b)
- the dose of ketone supplements was increased to 10 g/kg for both !JHB sa!t/MCT oil and MCT oil.
- Blood ketone levels were significantly elevated at 30 minutes, lasting until 12 hours with ⁇ salt MCT oil peaking at 8 hours and MCT oil peaking at 4 hours.
- Supplementation with MCT oil alone resulted in significantly elevated blood ketones starting at 30 minutes and lasting for 8 hours; Treatment with a combination of ⁇ salt/MCT oil caused significantly elevated blood ketones at 4 hours.
- ⁇ salt alone did not significantly elevate ketones.
- Figure 9 is a graph showing the effects of ketone supplementation on blood ketone levels in rats.
- Ketone supplementation demonstrated significant elevation of blood ketones over 4 weeks, in week 4, the dose of ketone supplements was increased to 10 g/kg for both the ⁇ salt/MCT oil combination treatment group and the MCT oil alone treatment group.
- Blood ketones were significantly elevated beginning at 30 minutes and lasting for 12 hours, with ⁇ salt/MCT oil peaking at 8 hours and MCT oil peaking at 4 hours.
- Ketone supplementation with MCT oil resulted in significantly elevated ketones starting at 30 min and lasting for 8 hours; supplementation with the combination of ⁇ salt and MCT oil resulted in significantly elevated ketones at 4 hours.
- Supplementation with ⁇ salt alone did not significantly elevate ketones.
- Two-way ANOVA with Dunnett's post hoc test results considered significant if p ⁇ 0.05. Error bars represent ⁇ SEM.
- Figures 10(A) and (B) are graphs showing the effects of ketone supplementation in rats on blood glucose levels at (A) week 0 and (B) week 1. Two-way ANOVA with Dunnett's post hoc test, results considered significant if p ⁇ 0.05. Error bars represent ⁇ SEM.
- Figures 1 1 (A) and (B) are graphs showing the effects of ketone supplementation in rats on blood glucose levels at (A) week 2 and (B) week 3. Two-way ANOVA with Dunnett's post hoc test, results considered significant if p ⁇ 0.05. Error bars represent ⁇ SEM.
- Figure 12 is a graph showing the effects of ketone supplementation in rats on blood glucose levels at week 4. Two-way ANOVA with Dunnett's post hoc test, results considered significant if p ⁇ 0.05. Error bars represent ⁇ SEM.
- Figures 13(A) and (B) are graphs showing the effects of ketone supplementation in rats on
- liver weights were significantly decreased in rats fed a combination of ⁇ Salt and MCT oil and those fed only ⁇ salt, whereas liver weights were significantiy increased in animals supplemented with only CT oil.
- Figure 14 is a graph showing the effects of ketone supplementation in rats on change of body weight.
- Concentrations, amounts, solubilities, and other numerical data may be expressed or presented herein in a range format. It is to be understood that such a range format is used merely for convenience and brevity and thus should be interpreted flexibly to include not only the numerical values explicitly recited as the limits of the range, but also to include all the individual numerical values or sub-ranges encompassed within that range as if each numerical value and sub-range is explicitly recited. As an illustration, a numerical range of "about 1 to about 5" should be interpreted to include not only the explicitly recited values of about 1 to about 5, but also include the individual values and sub-ranges within the indicated range.
- beta-hydroxybutyrate also known as ⁇ or BHB, is a carboxyiic acid having the general formula CH3CH2OHCH2COOH which may be utilized by a patient's body as a fuel source during instances of low glucose levels in the patient and is considered a ketone body.
- salt variants of beta-hydroxybutyrate are disclosed.
- patient means members of the animal kingdom, including mammals, such as but not limited to, primates including humans, gorillas and monkeys; rodents, such as mice, fish, reptiles and birds. The patient may be any animal requiring therapy, treatment, or prophylaxis, or any animal suspected of requiring therapy, treatment, or prophylaxis.
- treatment is intended to mean that regiment described is continued until the underlying disease is resolved, whereas therapy requires that the regiment alleviate one or more symptoms of the underlying disease.
- Prophylaxis means that regiment is undertaken to prevent a possible occurrence, such as where a high glucose or diabetes is identified.
- Patient and “subject” are used interchangeably herein.
- Ketosis refers to a subject having blood ketone levels within the range of about 0.5 mmoi/L and about 18 mmol/L in a subject. Ketosis may improve mitochondrial function, decrease reactive oxygen species production, reduce inflammation and increase the activity of neurotrophic factors.
- Keto-adaptation refers to prolonged nutritional ketosis (>1 week) to achieve a sustained nonpathologicai “mild ketosis” or “therapeutic ketosis.”
- MCT medium chain triglycerides
- exemplary fatty acids are caprylic acid, also known as octanoic acid, comprising 8 carbon molecules, and capric acid, also known as decanoic acid, comprising 10 carbon molecules.
- administration or “administering” is used to describe the process in which individual ketone esters or beta-hydroxybutyrate salts in any combination with medium chain fatty acid derivatives are delivered to a subject.
- the composition may be administered in various ways including oral, intragastric, and parenteral (referring to intravenous and intra-arteriai and other appropriate parenteral routes), among others. Each of these conditions may be readily treated using other administration routes of beta-hydroxybutyrate salts in combination with medium chain triglycerides, derivatives, or any combination thereof to treat a disease or condition.
- Administration will often depend upon the amount of compound administered, the number of doses, and duration of treatment.
- multiple doses of the agent are administered.
- the frequency of administration of the agent can vary depending on any of a variety of factors, such as timing of treatment from previous treatments, objectives of the treatment, i.e., weight loss or treatment of cancer or neurological disease, and the like.
- the duration of administration of the agent e.g., the period of time over which the agent is administered, can vary, depending on any of a variety of factors, including patient response, desired effect of treatment, etc.
- the amount of the agent contacted can vary according to factors such as the degree of susceptibility of the individual, the age, sex, and weight of the individual, idiosyncratic responses of the individual, the dosimetry, and the like. Detectabiy effective amounts of the agent of the present disclosure can also vary according to instrument and film-related factors. Optimization of such factors is well within the level of skill in the art.
- the "therapeutically effective amount" for purposes herein is thus determined by such considerations as are known in the art.
- a therapeutically effective amount of individual beta-hydroxybutyrate salts in combination with medium chain triglycerides, derivatives, or any combination thereof is that amount necessary to provide a therapeutically effective result in vivo.
- a suitable single dose size is a dose that is capable of preventing or alleviating (reducing or eliminating) a symptom in a patient when administered one or more times over a suitable time period.
- One of skill in the art can readily determine appropriate single dose sizes for systemic administration based on the size of a mammal and the route of administration.
- the amount of the beta-hydroxybutyrate salts in combination with medium chain triglycerides or derivatives will depend on absorption, distribution, metabolism, and excretion rates of the beta-hydroxybutyrate salts in combination with medium chain triglycerides or derivatives, the particular beta-hydroxybutyrate salts in combination with medium chain triglycerides or derivatives, the method of administration, and the particular disorder being treated, as well as other factors known to those of skill in the art.
- the dose should be sufficient to affect a desirable response, such as a therapeutic or prophylactic response against a particular disorder or condition, taking into account the severity of the condition to be alleviated.
- the compounds may be administered once, or may be divided and administered over intervals of time. It is to be understood that administration may be adjusted according to individual need and professional judgment of a person administrating or supervising the administration of the compounds used in the present invention.
- the invention presented herein details the unexpected benefit of the combination of medium chain triglycerides with ⁇ salts for the sustained elevation of ketone bodies when taken orally by mammals.
- the combination of BHB salts with medium chain triglycerides disclosed herein produced blood ketone levels at a rate and peak level greater than what was achieved with either component alone. Unexpectedly, in later time periods, this elevation in blood ketones is sustained at a higher level than what would be anticipated based on the sum of data from the ingestion of each component separately.
- the combination of medium chain triglycerides with BHB salts allows for lower dosing of the components as compared to administering the individual compounds, thereby reducing side effects and resulting in a novel blood ketone profile.
- Fasting can have many health benefits; however, it is often accompanied by discomfort due to hunger and lack of energy substrate (glucose) for proper brain function and depletion of sodium and potassium. Additionally it can be associated with deleterious loss of lean body mass.
- This invention reduces hunger, supplies an alternative energy substrate to the brain (ketones) and confers a protein sparing effect that preserves skeletal muscle mass.
- supplemental ketones to elevate and sustain blood levels of BHB while maintaining low and controlled blood glucose.
- Example 1 A 100 kg male subject
- BHB salts and MCT oil were given to human subjects as a ketogenic food supplement and blood measurements of BHB and/or glucose were taken at predetermined time points.
- a BHB salt solution 450 mL; 4%, approximately 18 g
- an MCT oil (30 rnL, approximately 30 g)
- a combination of the a BHB salt solution and an MCT oil a commercially available giucose/ketone monitoring system (Precision Xtra ® blood glucose and ketone meter) at defined time points (0, 15, 30, 80, 120, 240 and 480 minutes following ingestion of the test substances).
- the subject was administered a BHB salt solution containing 4% Na + /K + BHB salts in solution, an MCT oil, or a combination of the 4% Na + /K + BHB salts and the MCT oil.
- a BHB salt solution containing 4% Na + /K + BHB salts in solution, an MCT oil, or a combination of the 4% Na + /K + BHB salts and the MCT oil.
- the subject returned on days 2 and 3 for additional supplements, with blood taken as on day 1.
- Levels of BHB in the blood were determined as described above.
- Administration of the Na + /K + BHB salt solution showed that plasma levels of BHB peaked at 30 to 60 minutes after administration, as seen in Table 1 and Figure 1.
- Example 2- A 70 kg male subject
- Subject 70 kg male was instructed to fast for three days, and was given a single daily oral administration of either ⁇ salts (4% solution containing 1 1 grams sodium ⁇ and 7.1 grams potassium BHB), MCT oil or ⁇ salts + MCT oil at 15, 30, 60, 120, 240 and 480 minutes on 3 consecutive days.
- ⁇ salts 4% solution containing 1 1 grams sodium ⁇ and 7.1 grams potassium BHB
- MCT oil or ⁇ salts + MCT oil At 15, 30, 60, 120, 240 and 480 minutes after administration, blood was drawn.
- the subject returned on days 2 and 3 for additional supplements, with blood taken as on day 1 , as in Example 1.
- BHB levels were determined as discussed in example 1 .
- Administration of the combination of MCT oil and BHB salts over concurrent days resulted in elevated and sustained BHB levels after oral administration, as seen in Figure 2.
- supplementation progressed to day 2 and day 3 elevated levels of BHB were observed sooner after supplementation and were sustained for a considerably longer time after administration, while peak BHB levels were
- a combination of CT and ⁇ salts, seen in the examples 1 and 2 was orally administered to fasting individuals to accelerate the induction of ketosis and to study the impact of the supplement in short-term severe caloric restriction, short term fasting or intermittent fasting (e.g. , alternate day fasting).
- the supplement provided no more than 400 calories per day and the length of time of the various restrictions and fasts were between 2 and 7 days. Rapid induction of ketosis was associated with improved compliance with caloric restriction and fasting, presumably by reducing hunger and "glucose withdrawal" symptoms ⁇ e.g. , brain fog).
- Caloric restriction and/or fasting resulted in substantial improvements in metabolic biomarkers related to inflammation and insulin resistance, thereby permitting individuals to lose weight and improve general health in a short period of time.
- Individuals with high blood glucose or type II diabetes may receive particular benefits from this supplement as it has the potential to cause a lasting improvemenst in insulin sensitivity and overall metabolic health (e.g., improved glucose and lipid profiles).
- This invention is useful for initiating and sustaining a ketogenic lifestyle by helping a subject get into ketosis quickly.
- the utilization of the supplement in conjunction with fasting accelerates a subject's ability to induce ketosis and is accompanied by a minimum degree of physical and mental discomfort and a minimal amount of loss of lean body mass,
- MCT medium chain triglyceride
- SO mineral
- SQ+MO 1 : 1 combination SQ+MO 1 : 1 combination
- the ketone mineral salt was developed and synthesized by Dr. Patrick Arnold from Prototype Nutrition. Pure pharmaceutical grade MCT oil was purchased from Now Foods (Bloomingdale, IL). SM was mixed at a 1 : 1 ratio.
- Rats were supplemented with medium chain triglyceride (MCT) oil (MO), or a mineral (Na+/K+) salt of ⁇ -hydroxybutyrate ( ⁇ ) (SO), or SQ-s-MQ 1 :1 mixture (SM) and force fed a daily at a dose of 5 g/kg body weight on days 1 - 14, followed by a 10 g/kg dose on days 15 - 28 rats Supplementation was given between 10am and 1 pm daily to eliminate variance based on regular eating patterns. Diets were not restricted for this study.
- MCT medium chain triglyceride
- SO mineral
- SQ-s-MQ 1 :1 mixture Supplementation was given between 10am and 1 pm daily to eliminate variance based on regular eating patterns. Diets were not restricted for this study.
- Total Cholesterol and HDL taken at week 0 and again at week 4, showed a reduction in all samples, including the control, as seen in Figures 4 and 5.
- Analysis showed the levels in all supplements were not significantly different from control after a 4-week chronic dosage of ketone supplements.
- Triglyceride levels were mildly elevated at week 4 in the control, ⁇ /MCT sample, or ⁇ salt sample, with little change in levels of MCT sample, as seen in Figure 6. However, none of the levels were significantly different from control after a 4- week chronic dosage of ketone supplements.
- Ketone supplementation causes rapid and sustained elevation of ⁇
- Ketone supplementation causes rapid reduction in blood glucose.
- SO supplementation did not show any significant difference compared to control at week 0, whereas MO and SM reduced glucose through 4 hours after supplementation, seen in Figure 10(A) and (B). However, SO began reducing glucose by 8 hours at week 1. By week 2 onward, with an increase in supplementation dosage to 10 g/kg, SO, MO and SM had reduced glucose levels at 30 minutes through 8 hours, with normalization to about control levels by 12 hours, as seen in Figures 1 1 through 12.
- rats were force fed at time 0 then sacrificed by CO2 between 4-8 hours, which were determined to be peak BHB level elevation.
- Brain, lungs, liver, kidneys, spleen and heart were harvest and weighed using AWS-100G 1 kg portable digital scale (AWS, Washington, SC). Organs were then either flash frozen in liquid nitrogen or preserved in paraformaldehyde for future analysis.
- livers were harvested and weighed per subject rats, SO and SM ketone supplements significantly decreased the weight of the liver.
- Rats were administered SO, MO, or SM daily for 28 days as described above. Each week the animals were weighed. Rats that were treated with SO, MO, or SM gained significantly less weight compared to controls, as seen in Figure 14. The control animals continued to gain weight throughout the month long study, in comparison, the ketone supplement treatment groups ail gained less wight. A 2 to 3 fold reduction in weight gain was noted in the SO and SM groups. A key finding of this study is that the SM group was able to limit wight gain in an unexpected way as the amounts of BHB and MCT when combined were much lower than the amounts of those ingredients used in the SO and MO treatment groups. This effect on body weight gain is likely due to appetite suppression caused by the supplements, rather than a reduced intake of the supplement itself, as force feeding controlled for dosing.
- a 16-ounce drink formula containing the following ingredients is consumed by an individual three times a day.
- Flavoring The data presented herein supports the use of a unique combination of beta hydroxybutyrate and medium chain triglycerides in order to generate a unique blood ketone profiie necessary for effectively entering therapeutic ketosis.
- adherence to a ketogenic, carbohydrate-restricted diet as a means of generating ketosis is limited by the difficulty of generating blood ketone levels that are sufficiently elevated and prolonged. Slow entry into ketosis leads to prolonged side effects such as physical distress and mood depression.
- BHB and MCT are unique in that it also avoids the complications that arise from using either substance alone. Consuming sufficient amounts of BHB salts in order to quickly enter and maintain ketosis results in sodium overload and electrolyte imbalances and therefore is not praticai. Consuming sufficient quantities of MCT in order to quickly enter and maintain ketosis results in severe gastrointestinal distress and therefore is also not practical.
- the data presented herein shows that reduced amounts of both substances can be used in combination, and not only improves tolerability, but also generates a unique blood ketone profile that has benefits not seen with the individual components when used in isolation.
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US20200061023A1 (en) * | 2018-08-27 | 2020-02-27 | Axcess Global Sciences, Llc | Compositions and methods for delivering tetrahydrocannabinol and ketone bodies |
US11484542B2 (en) | 2018-05-30 | 2022-11-01 | Adam Slank | Specialized tongue spray containing gymnemic acid and exogenous ketones |
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US20210267251A1 (en) * | 2018-06-21 | 2021-09-02 | Societe Des Produits Nestle S.A. | Compositions and methods using a nicotinamide adenine dinucleotide (nad+) precursor and at least one ketone or ketone precursor |
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CA3118317A1 (en) * | 2018-10-29 | 2020-05-07 | Keto Patent Group, Inc. | Administration of butyrate, bete-hydroxybutyrate, cannabidiol, and related compounds in humans |
CN109480284A (en) * | 2018-12-05 | 2019-03-19 | 上海欣海生物科技有限公司 | A kind of Ketogenic diet and preparation method thereof |
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WO2023278240A1 (en) | 2021-06-28 | 2023-01-05 | Phb Industrial S.A. | Methods to produce therapeutic formulations comprising hydroxybutirate and hydroxyvalerate, therapeutic formulations and uses thereof |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5093044A (en) * | 1988-09-07 | 1992-03-03 | Kabivitrum Ab | Triglyercide nutrient for humans and animals |
US6323237B1 (en) | 1997-03-17 | 2001-11-27 | Btg International Limited | Therapeutic compositions |
US20080287372A1 (en) * | 2000-05-01 | 2008-11-20 | Accera, Inc. | Use of Ketogenic Compounds for Treatment of Age-Associated Memory Impairment |
US20100041751A1 (en) * | 2005-06-20 | 2010-02-18 | Accera, Inc. | Method to Reduce Oxidative Damage and Improve Mitochondrial Efficiency |
US20100197758A1 (en) * | 2007-04-12 | 2010-08-05 | Andrews Matthew T | Ischemia/reperfusion protection compositions and methods of using |
US20100298294A1 (en) * | 2008-01-04 | 2010-11-25 | Isis Innovation Limited | Ketone bodies and ketone body esters as blood lipid lowering agents |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5654266A (en) * | 1992-02-10 | 1997-08-05 | Chen; Chung-Ho | Composition for tissues to sustain viability and biological functions in surgery and storage |
US20090253781A1 (en) | 2002-05-24 | 2009-10-08 | Btg International Limited | Therapeutic compositions |
AU749638B2 (en) * | 1997-03-17 | 2002-06-27 | Btg International Limited | Therapeutic compositions |
US6316038B1 (en) | 1997-03-17 | 2001-11-13 | Btg International Limited | Therapeutic compositions |
JPH1160434A (en) | 1997-08-12 | 1999-03-02 | Kanebo Ltd | Cosmetic for preventing skin aging |
ATE283056T1 (en) * | 1998-07-22 | 2004-12-15 | Metabolix Inc | DIETARY AND THERAPEUTIC USE OF HYDROXYALKANOATE OLIGOMERS |
NZ509739A (en) | 1998-09-15 | 2003-10-31 | Btg Int Ltd | A cyclic ester of (R)-3-hydroxybutyrate useful for increasing cardiac efficiency |
TWI249401B (en) * | 1999-04-14 | 2006-02-21 | Takeda Chemical Industries Ltd | Agent for improving ketosis |
DE60138019D1 (en) | 2000-05-01 | 2009-04-30 | Accera Inc | USE OF TRIGLYCERIDES WITH MEDIUM-WIDE CHAINS FOR THE TREATMENT AND PREVENTION OF ALZHEIMER'S DISEASE |
US6613356B1 (en) | 2000-10-10 | 2003-09-02 | Victor Vlahakos | Weight loss medication and method |
US20050129783A1 (en) * | 2001-04-19 | 2005-06-16 | Mccleary Edward L. | Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health |
US8158184B2 (en) * | 2004-03-08 | 2012-04-17 | Bunge Oils, Inc. | Structured lipid containing compositions and methods with health and nutrition promoting characteristics |
GB0410266D0 (en) * | 2004-05-07 | 2004-06-09 | Ketocytonyx Inc | Treatment of apoptosis |
GB0420856D0 (en) | 2004-09-20 | 2004-10-20 | Ketocytonyx Inc | Cns modulators |
WO2008005818A1 (en) | 2006-06-30 | 2008-01-10 | Stepan Co | Glyceride esters for the treatment of diseases associated with reduced neuronal metabolism of glucose |
GB201002983D0 (en) * | 2010-02-22 | 2010-04-07 | Tdeltas Ltd | Nutritinal composition |
GB201206192D0 (en) | 2012-04-05 | 2012-05-23 | Tdeltas Ltd | Ketone bodies and ketone body esters and for maintaining or improving muscle power output |
-
2014
- 2014-03-19 MX MX2015013312A patent/MX371259B/en active IP Right Grant
- 2014-03-19 SG SG10201808690PA patent/SG10201808690PA/en unknown
- 2014-03-19 BR BR112015024186-7A patent/BR112015024186B1/en active IP Right Grant
- 2014-03-19 KR KR1020227001002A patent/KR102499654B1/en active IP Right Grant
- 2014-03-19 RU RU2018120938A patent/RU2018120938A/en not_active Application Discontinuation
- 2014-03-19 AU AU2014236004A patent/AU2014236004B2/en active Active
- 2014-03-19 NZ NZ711433A patent/NZ711433A/en unknown
- 2014-03-19 PE PE2015002047A patent/PE20151949A1/en unknown
- 2014-03-19 MY MYPI2015703228A patent/MY180761A/en unknown
- 2014-03-19 WO PCT/US2014/031237 patent/WO2014153416A1/en active Application Filing
- 2014-03-19 JP JP2016504350A patent/JP6491189B2/en active Active
- 2014-03-19 SG SG11201506780RA patent/SG11201506780RA/en unknown
- 2014-03-19 CN CN201480016818.0A patent/CN105050594B/en active Active
- 2014-03-19 EP EP14770025.6A patent/EP2976073B1/en active Active
- 2014-03-19 RU RU2015136190A patent/RU2659386C2/en active
- 2014-03-19 KR KR1020157025528A patent/KR20150130312A/en not_active IP Right Cessation
- 2014-03-19 CA CA2902603A patent/CA2902603C/en active Active
- 2014-08-08 US US14/455,385 patent/US9138420B2/en active Active
-
2015
- 2015-09-01 ZA ZA2015/06387A patent/ZA201506387B/en unknown
- 2015-09-04 PH PH12015501966A patent/PH12015501966B1/en unknown
- 2015-09-08 IL IL241316A patent/IL241316B/en active IP Right Grant
- 2015-09-17 CL CL2015002802A patent/CL2015002802A1/en unknown
- 2015-09-17 MX MX2019010248A patent/MX2019010248A/en unknown
- 2015-09-21 US US14/860,092 patent/US9675577B2/en active Active
- 2015-10-19 CR CR20150579A patent/CR20150579A/en unknown
-
2016
- 2016-04-26 HK HK16104766.6A patent/HK1216847A1/en unknown
-
2017
- 2017-06-01 US US15/610,668 patent/US10646462B2/en active Active
-
2018
- 2018-04-17 CL CL2018000983A patent/CL2018000983A1/en unknown
- 2018-05-21 IL IL259502A patent/IL259502B/en not_active IP Right Cessation
- 2018-12-04 JP JP2018227049A patent/JP2019031578A/en active Pending
-
2019
- 2019-01-25 AU AU2019200511A patent/AU2019200511A1/en not_active Abandoned
-
2020
- 2020-05-11 US US16/871,686 patent/US20200268701A1/en not_active Abandoned
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5093044A (en) * | 1988-09-07 | 1992-03-03 | Kabivitrum Ab | Triglyercide nutrient for humans and animals |
US6323237B1 (en) | 1997-03-17 | 2001-11-27 | Btg International Limited | Therapeutic compositions |
US20120071548A1 (en) * | 1997-03-17 | 2012-03-22 | Btg International Limited | Therapeutic compositions |
US20080287372A1 (en) * | 2000-05-01 | 2008-11-20 | Accera, Inc. | Use of Ketogenic Compounds for Treatment of Age-Associated Memory Impairment |
US8124589B2 (en) | 2000-05-01 | 2012-02-28 | Accera, Inc. | Use of ketogenic compounds for treatment of age-associated memory impairment |
US20100041751A1 (en) * | 2005-06-20 | 2010-02-18 | Accera, Inc. | Method to Reduce Oxidative Damage and Improve Mitochondrial Efficiency |
US20100197758A1 (en) * | 2007-04-12 | 2010-08-05 | Andrews Matthew T | Ischemia/reperfusion protection compositions and methods of using |
US20100298294A1 (en) * | 2008-01-04 | 2010-11-25 | Isis Innovation Limited | Ketone bodies and ketone body esters as blood lipid lowering agents |
Non-Patent Citations (1)
Title |
---|
See also references of EP2976073A4 |
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US11026929B2 (en) | 2016-04-19 | 2021-06-08 | Keto Patent Group, Inc. | Administration of berberine metabolites |
US11969411B2 (en) | 2016-04-19 | 2024-04-30 | Axcess Global Sciences, Llc | Administration of berberine metabolites |
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