WO2014138309A1 - Pansement pour plaies chroniques, possédant des tailles de pores variables - Google Patents
Pansement pour plaies chroniques, possédant des tailles de pores variables Download PDFInfo
- Publication number
- WO2014138309A1 WO2014138309A1 PCT/US2014/020924 US2014020924W WO2014138309A1 WO 2014138309 A1 WO2014138309 A1 WO 2014138309A1 US 2014020924 W US2014020924 W US 2014020924W WO 2014138309 A1 WO2014138309 A1 WO 2014138309A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- skin substitute
- slits
- layer
- wound
- porosity
- Prior art date
Links
- 230000001684 chronic effect Effects 0.000 title abstract description 15
- 239000011148 porous material Substances 0.000 title description 6
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 18
- 241001116389 Aloe Species 0.000 claims abstract description 9
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 9
- 239000000126 substance Substances 0.000 claims abstract 3
- 230000001225 therapeutic effect Effects 0.000 claims abstract 3
- 108010010803 Gelatin Proteins 0.000 claims description 8
- 229920000159 gelatin Polymers 0.000 claims description 8
- 239000008273 gelatin Substances 0.000 claims description 8
- 235000019322 gelatine Nutrition 0.000 claims description 8
- 235000011852 gelatine desserts Nutrition 0.000 claims description 8
- 230000000774 hypoallergenic effect Effects 0.000 claims description 4
- HKIKAXXIWJHWLY-ZIIYPAMZSA-N Aloesin Chemical compound C=12OC(CC(=O)C)=CC(=O)C2=C(C)C=C(O)C=1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HKIKAXXIWJHWLY-ZIIYPAMZSA-N 0.000 claims description 3
- HKIKAXXIWJHWLY-QEVGBQTESA-N Aloesin Natural products O=C(CC=1Oc2c([C@H]3[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)c(O)cc(C)c2C(=O)C=1)C HKIKAXXIWJHWLY-QEVGBQTESA-N 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims 1
- 239000002759 woven fabric Substances 0.000 claims 1
- 206010052428 Wound Diseases 0.000 abstract description 39
- 208000027418 Wounds and injury Diseases 0.000 abstract description 39
- 239000004677 Nylon Substances 0.000 abstract description 10
- 229920001778 nylon Polymers 0.000 abstract description 10
- 230000035876 healing Effects 0.000 abstract description 8
- 206010019909 Hernia Diseases 0.000 abstract description 7
- 239000004744 fabric Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229960000074 biopharmaceutical Drugs 0.000 description 7
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 description 4
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 description 4
- 210000000416 exudates and transudate Anatomy 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000003397 biobrane Substances 0.000 description 3
- 238000009581 negative-pressure wound therapy Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000037390 scarring Effects 0.000 description 2
- 102000007469 Actins Human genes 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 229920002567 Chondroitin Polymers 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- 206010056340 Diabetic ulcer Diseases 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 229920002529 medical grade silicone Polymers 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Classifications
-
- A61F13/01021—
-
- A61F13/01038—
Abstract
L'invention concerne un substitut de peau amélioré, qui comprend une couche de silicone renforcée d'une couche de tissu de Nylon tissé, la couche de silicone possédant un motif régulier de fentes qui permettent à la porosité du substitut de peau d'être ajustée par des cliniciens par application d'une tension sur le substitut de peau qui ouvre de façon différentielle les fentes. Diverses substances thérapeutiques peut être appliquées sur le substitut de peau pour favoriser la cicatrisation, dont des préparations d'aloès et d'autres préparations médicinales. Le substitut de peau est conçu pour le traitement de plaies chroniques et la réparation d'hernies.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2902387A CA2902387A1 (fr) | 2013-03-06 | 2014-03-05 | Pansement pour plaies chroniques, possedant des tailles de pores variables |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361773707P | 2013-03-06 | 2013-03-06 | |
| US61/773,707 | 2013-03-06 | ||
| US13/897,430 | 2013-05-19 | ||
| US13/897,430 US9017405B2 (en) | 2013-03-06 | 2013-05-19 | Skin substitute and wound dressing with variable pore sizes |
| US14/159,332 US20150202343A1 (en) | 2014-01-20 | 2014-01-20 | Chronic Wound Dressing with Variable Pore Sizes |
| US14/159,332 | 2014-01-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2014138309A1 true WO2014138309A1 (fr) | 2014-09-12 |
Family
ID=51491926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2014/020924 WO2014138309A1 (fr) | 2013-03-06 | 2014-03-05 | Pansement pour plaies chroniques, possédant des tailles de pores variables |
Country Status (2)
| Country | Link |
|---|---|
| CA (1) | CA2902387A1 (fr) |
| WO (1) | WO2014138309A1 (fr) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106039404A (zh) * | 2015-04-08 | 2016-10-26 | 上海宏创医疗科技有限公司 | 一种细胞外基质复合生物补片的制备方法 |
| WO2020231463A1 (fr) * | 2019-05-13 | 2020-11-19 | Woodroof E Aubrey | Amélioration de l'adhérence, de l'aptitude à l'étirage et de la compliance de substitut cutané pour substituts cutanés |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997006837A1 (fr) * | 1995-08-16 | 1997-02-27 | Integra Lifesciences Corporation | Greffes de peau artificielle perforee |
| US20090230592A1 (en) * | 2008-03-15 | 2009-09-17 | Aubrey Woodroof | Laser-Perforated Skin Substitute |
| US20090234305A1 (en) * | 2008-03-15 | 2009-09-17 | Ernest Aubrey Woodroof | Temporary skin substitute comprised of biological compounds of plant and animal origins |
| US20110305736A1 (en) * | 2010-06-10 | 2011-12-15 | Dr. Suwelack Skin & Health Care Ag | Stratiform Perforated Biomatrices |
-
2014
- 2014-03-05 WO PCT/US2014/020924 patent/WO2014138309A1/fr active Application Filing
- 2014-03-05 CA CA2902387A patent/CA2902387A1/fr not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997006837A1 (fr) * | 1995-08-16 | 1997-02-27 | Integra Lifesciences Corporation | Greffes de peau artificielle perforee |
| US20090230592A1 (en) * | 2008-03-15 | 2009-09-17 | Aubrey Woodroof | Laser-Perforated Skin Substitute |
| US20090234305A1 (en) * | 2008-03-15 | 2009-09-17 | Ernest Aubrey Woodroof | Temporary skin substitute comprised of biological compounds of plant and animal origins |
| US20110305736A1 (en) * | 2010-06-10 | 2011-12-15 | Dr. Suwelack Skin & Health Care Ag | Stratiform Perforated Biomatrices |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106039404A (zh) * | 2015-04-08 | 2016-10-26 | 上海宏创医疗科技有限公司 | 一种细胞外基质复合生物补片的制备方法 |
| WO2020231463A1 (fr) * | 2019-05-13 | 2020-11-19 | Woodroof E Aubrey | Amélioration de l'adhérence, de l'aptitude à l'étirage et de la compliance de substitut cutané pour substituts cutanés |
| JP7405866B2 (ja) | 2019-05-13 | 2023-12-26 | オーブリー ウッドルーフ、イー． | 皮膚代替物に対する接着性、伸縮性、及び適合性が向上した皮膚代替物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2902387A1 (fr) | 2014-09-12 |
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