WO2014107446A1 - Procédé et appareil intrabuccal de collecte de données d'eeg - Google Patents

Procédé et appareil intrabuccal de collecte de données d'eeg Download PDF

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Publication number
WO2014107446A1
WO2014107446A1 PCT/US2013/078443 US2013078443W WO2014107446A1 WO 2014107446 A1 WO2014107446 A1 WO 2014107446A1 US 2013078443 W US2013078443 W US 2013078443W WO 2014107446 A1 WO2014107446 A1 WO 2014107446A1
Authority
WO
WIPO (PCT)
Prior art keywords
eeg
oral appliance
electrode
electroencephalographic
appliance
Prior art date
Application number
PCT/US2013/078443
Other languages
English (en)
Inventor
Mark Steven COHEN
Original Assignee
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California filed Critical The Regents Of The University Of California
Publication of WO2014107446A1 publication Critical patent/WO2014107446A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/682—Mouth, e.g., oral cavity; tongue; Lips; Teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
    • A61B2560/0406—Constructional details of apparatus specially shaped apparatus housings

Definitions

  • aspects include an intra-oral (“intrabuccal”) pickup electrode that results in improved three-dimensional sensitivity to
  • EEG electroencephalography
  • Electroencephalography is the recording of electrical activity from the scalp. EEG measures voltage fluctuations that result from ionic current flows within the neurons of the brain.
  • EEG is recorded from multiple electrodes placed on the scalp for periods of minutes to days. Diagnostic applications include analysis of the spectral content of EEG, referring to the common presence of oscillatory signals, as well as observations of brief or extended electrical events that are pathognomonic of certain diseases or of brain and cognitive states.
  • EEG In neurology, the main diagnostic application of EEG is in the case of epilepsy, as epileptic activity can create clear abnormalities on a standard EEG study.
  • a secondary clinical use of EEG is in the diagnosis of coma, encephalopathies, and brain death.
  • a third clinical use of EEG is for studies of sleep and sleep disorders where recordings are typically done for one full night, sometimes more.
  • EEG has been a first-line method for the diagnosis of tumors, stroke and other focal brain disorders, but this use has decreased with the advent of anatomical imaging techniques with high ( ⁇ 1 mm) spatial resolution such as magnetic resonance imaging (MRI) and X-ray computed tomography (CT) .
  • MRI magnetic resonance imaging
  • CT X-ray computed tomography
  • EEG is used heavily in brain research applications on normal subjects. It offers unique information on the timing of the brain's responses to inputs, and in response variations associated with processes such as attention and perception.
  • EEG tomographic imaging by CT or MRI
  • CT or MRI tomographic imaging
  • EEG continues to be a valuable tool for research and diagnosis, especially when millisecond-range temporal resolution (not possible with CT or MRI) is required.
  • millisecond-range temporal resolution not possible with CT or MRI
  • the ability of EEG to identify the location at which electrical sources are generated is limited, which limits the utility of the method.
  • Embodiments include an oral appliance containing at least one electroencephalographic electrodes.
  • an oral appliance comprises a rigid support, at least one electroencephalographic electrode, and a wire.
  • the rigid support is configured to be fitted to a roof of a mouth.
  • the at least one electroencephalographic (EEG) electrode is coupled to the rigid support, and configured to detect electrical signals.
  • the wire is connected to the
  • electroencephalographic electrode and is configured to conduct the electrical signals.
  • an oral appliance comprises a flexible adhesive film, at least one electroencephalographic electrode, and a wire.
  • the adhesive film is configured to adhere to a roof of a mouth.
  • the at least one electroencephalographic electrode is coupled to the adhesive film, and is configured to detect electrical signals.
  • the wire is connected to the electroencephalographic electrode, and configured to conduct the electrical signals.
  • FIG. 1 illustrates an embodiment of a retainer-mounted EEG electrode device.
  • FIGS. 2A and 2B illustrate an alternate embodiment of an EEG electrode device incorporated into a flexible adhesive film.
  • FIGS. 3A and 3B shows recordings made from the
  • intrabuccal electrode includes periods in which the volunteer had his eyes open and when they were closed.
  • EEG electroencephalographic
  • Another aspect of the disclosure includes the understanding that while the scalp potentials are interesting in their own right, it frequently is highly desirable to determine the three-dimensional localization of the brain dipole sources that result in the scalp potentials. For example, in clinical evaluation of seizure disorders (epilepsy), the diagnostic team generally desires this information, as it can be used to help in planning for surgeries to remove diseased tissues. Such three dimensional localizations are of major interest to brain mapping researchers who seek to associate brain function with specific neural locations. [0017]
  • the problem of identifying the sources from distributions on the scalp is fundamentally under constrained, because an arbitrary topology of scalp potentials may result from an infinite number of different distributions of dipole sources within the head.
  • the community resolves this problem by constraining the possible dipole solutions to physiologically plausible locations, and by measuring the surface potentials with very dense recording arrays (many electrodes). Such tools are becoming accepted increasingly as the quality of the constraint methods improves steadily.
  • the geometry of the head creates further limitations.
  • the scalp electrodes cannot cover the surface of the head completely or uniformly, because the neck and body prevent the placement of electrodes below the brain.
  • electrodes can be placed on only about half of the spherical surface that surrounds the brain.
  • the lack of three-dimensional coverage introduces additional ambiguity into the localization of the brain sources that create the EEG.
  • the embodiments disclosed here resolve this problem in a straightforward manner by fitting a device into the mouth of the subject, and to the interior surfaces of the teeth, thereby allowing additional electrodes to be placed immediately below the brain.
  • This location is ideal in many respects. Not only is it approximately in the center of the least covered region of the head, but it is near to the mesial temporal lobes, which are the site of the epileptogenic tissue in a large fraction of seizure patients. It is also close to important brain structures such as the thalamus, brain stem and orbitofrontal cortex that are difficult to study by EEG.
  • FIG. 1 illustrates an embodiment of a retainer-mounted EEG electrode device, constructed and operative in accordance with an embodiment of the present disclosure. As shown in FIG. 1, in one embodiment, an
  • appliance 1000 similar to a dental retainer, includes a support 5, and one or more small wells carved into the appliance 1000; the wells receive an EEG electrode 2. As shown in this embodiment, contacts sit in wells set into support 5. Electrical leads (wires) 3 are carried to the front or side of the appliance 1000 and exit between the lips. As illustrated in FIG. 1, appliance 1000 has a four lead configuration, but other embodiments may be made with any number of leads.
  • electrodes 2 may be made of thin films of silver, silver-chloride, or the like.
  • Electrical leads 3 may be made of flexible copper wires or other electrical conducting material known in the art.
  • the top surface of the appliance may be covered in absorbent material (such as paper, chamois, or sponge dams) in such a manner that when the appliance 1000 is put in place, the surface of the palate is dried, improving the contact specificity.
  • the support 5 may be made of an insulating material, such as plastic resin, dental wax, or other material that may be used and placed into the mouth of a patient in dental appliances.
  • the appliance 1000 would be fitted to the individual subject in the same manner as dental retainers, by creating a mold and then casting the thermoplastic resin to it. This is an inexpensive and easy process, and the mold is adapted to include the wells that will receive the electrodes 2.
  • the bottom surface of the appliance 1000 is made smooth and such devices are easily tolerated by people.
  • FIGS. 2A-2B illustrate an alternate embodiment of an appliance 2000, constructed and operative in accordance with an embodiment of the present disclosure.
  • FIG. 2A illustrates the appliance 2000 assembled
  • FIG. 2B illustrates the appliance 2000 in an exploded view.
  • an intrabuccal appliance 2000 includes electrodes 2 placed on a flexible adhesive surface 4 and separated by flexible non-conductive material 1. Signals are conveyed from the appliance 2000 via flexible wires 3.
  • the adhesive surface, wires 3, electrodes 2, and flexible non-conductive material 1 are layered together in a thin "sandwich" configuration, exposing the adhesive materials 1 and the electrodes 2 to the upper surface.
  • support 4 would use a soft flexible material (such as silastic or rubber), which could be reusable after cleaning and sterilization.
  • the appliance 1000 may be similar to the devices used by hockey and football players to prevent jaw injuries, or by people during sleep to prevent grinding of the teeth. Small diameter wires 3 carry the EEG signal out of the mouth, as these are more easily tolerated, even for long periods, such as for sleep studies.
  • the electrodes 2 are placed onto an adhesive tape or film material that adheres lightly to the roof of the mouth. This configuration may be made very thin to minimize discomfort to the patient or subject.
  • non-conductive barriers may be added, if desired to isolate the electrode contacts from each other.
  • FIGS. 3A and 3B shows recordings made from the
  • intrabuccal electrode and includes periods in which the volunteer had his eyes open (FIG. 3A) and when they were closed (FIG. 3B), constructed and operative in accordance with an embodiment of the present disclosure. As shown in FIGS. 3A and 3B, clearly visible is an increase in signal energy in both the "alpha" (8- 14 Hz) and "beta” (14-30Hz) bands. This demonstrates that the intrabuccal electrode appliance 1000 and 2000 are able to detect brain electrical signals without introducing additional artifacts.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

L'invention concerne un appareil buccal contenant une électrode électroencéphalographique.
PCT/US2013/078443 2013-01-04 2013-12-31 Procédé et appareil intrabuccal de collecte de données d'eeg WO2014107446A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361749003P 2013-01-04 2013-01-04
US61/749,003 2013-01-04

Publications (1)

Publication Number Publication Date
WO2014107446A1 true WO2014107446A1 (fr) 2014-07-10

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Application Number Title Priority Date Filing Date
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Country Status (1)

Country Link
WO (1) WO2014107446A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11000405B2 (en) 2016-04-07 2021-05-11 Achaemenid, Llc Removable mandibular pharmaceutical delivery device
WO2021091583A1 (fr) * 2019-11-04 2021-05-14 Achaemenid, Llc Dispositif et procédé d'électro-encéphalographie intra-orale
US11033750B1 (en) 2020-02-17 2021-06-15 Achaemenid, Llc Intra-oral appliance with thermoelectric power source
US11191663B2 (en) 2016-04-07 2021-12-07 Achaemenid, Llc Oral appliance and kit for treatment of sleep apnea
US11234638B2 (en) 2016-04-07 2022-02-01 Achaemenid, Llc Intra-oral electroencephalography device and method
US11375951B2 (en) 2016-04-07 2022-07-05 Achaemenid, Llc Intra-oral electroencephalography device and method

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3599629A (en) * 1968-08-28 1971-08-17 Lexington Instr Oxidized surface biopotential skin electrode
US4629424A (en) * 1984-08-30 1986-12-16 Integrated Ionics, Inc. Intraoral ambient sensing device
US4777954A (en) * 1986-06-30 1988-10-18 Nepera Inc. Conductive adhesive medical electrode assemblies
US5212476A (en) * 1990-09-28 1993-05-18 Maloney Sean R Wireless intraoral controller disposed in oral cavity with electrodes to sense E.M.G. signals produced by contraction of the tongue
US5792067A (en) * 1995-11-21 1998-08-11 Karell; Manuel L. Apparatus and method for mitigating sleep and other disorders through electromuscular stimulation
US6598006B1 (en) * 1999-10-18 2003-07-22 Advanced Telecommunications Research Institute International Data input device using a palatal plate
US20090281433A1 (en) * 2008-05-07 2009-11-12 Sonitus Medical, Inc. Systems and methods for pulmonary monitoring and treatment
WO2012027648A2 (fr) * 2010-08-27 2012-03-01 The Johns Hopkins University Dispositif et système de détection de données médicales pertinentes émises par la bouche

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3599629A (en) * 1968-08-28 1971-08-17 Lexington Instr Oxidized surface biopotential skin electrode
US4629424A (en) * 1984-08-30 1986-12-16 Integrated Ionics, Inc. Intraoral ambient sensing device
US4777954A (en) * 1986-06-30 1988-10-18 Nepera Inc. Conductive adhesive medical electrode assemblies
US5212476A (en) * 1990-09-28 1993-05-18 Maloney Sean R Wireless intraoral controller disposed in oral cavity with electrodes to sense E.M.G. signals produced by contraction of the tongue
US5792067A (en) * 1995-11-21 1998-08-11 Karell; Manuel L. Apparatus and method for mitigating sleep and other disorders through electromuscular stimulation
US6598006B1 (en) * 1999-10-18 2003-07-22 Advanced Telecommunications Research Institute International Data input device using a palatal plate
US20090281433A1 (en) * 2008-05-07 2009-11-12 Sonitus Medical, Inc. Systems and methods for pulmonary monitoring and treatment
WO2012027648A2 (fr) * 2010-08-27 2012-03-01 The Johns Hopkins University Dispositif et système de détection de données médicales pertinentes émises par la bouche

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11000405B2 (en) 2016-04-07 2021-05-11 Achaemenid, Llc Removable mandibular pharmaceutical delivery device
US11191663B2 (en) 2016-04-07 2021-12-07 Achaemenid, Llc Oral appliance and kit for treatment of sleep apnea
US11234638B2 (en) 2016-04-07 2022-02-01 Achaemenid, Llc Intra-oral electroencephalography device and method
US11375951B2 (en) 2016-04-07 2022-07-05 Achaemenid, Llc Intra-oral electroencephalography device and method
US11786177B2 (en) 2016-04-07 2023-10-17 Achaemenid, Llc Oral appliance for the treatment of sleep apnea
WO2021091583A1 (fr) * 2019-11-04 2021-05-14 Achaemenid, Llc Dispositif et procédé d'électro-encéphalographie intra-orale
US11033750B1 (en) 2020-02-17 2021-06-15 Achaemenid, Llc Intra-oral appliance with thermoelectric power source

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