WO2014086177A1 - 一种肌松测量装置及监护设备 - Google Patents

一种肌松测量装置及监护设备 Download PDF

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Publication number
WO2014086177A1
WO2014086177A1 PCT/CN2013/083095 CN2013083095W WO2014086177A1 WO 2014086177 A1 WO2014086177 A1 WO 2014086177A1 CN 2013083095 W CN2013083095 W CN 2013083095W WO 2014086177 A1 WO2014086177 A1 WO 2014086177A1
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Prior art keywords
angular velocity
main processor
muscle relaxation
measuring device
detection module
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PCT/CN2013/083095
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English (en)
French (fr)
Inventor
王斌
岑建
张鹏
刘方
于辉
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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Priority to US14/649,874 priority Critical patent/US10893827B2/en
Publication of WO2014086177A1 publication Critical patent/WO2014086177A1/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
    • A61B5/1113—Local tracking of patients, e.g. in a hospital or private home
    • A61B5/1114—Tracking parts of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4519—Muscles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6825—Hand
    • A61B5/6826—Finger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/742—Details of notification to user or communication with user or patient; User input means using visual displays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0219—Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/22—Ergometry; Measuring muscular strength or the force of a muscular blow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes

Definitions

  • the present application relates to the field of medical devices, and in particular to a muscle relaxation measuring device and a monitoring device. Background technique
  • the muscle relaxation measurement is used to reflect the degree of blockage and recovery of neuromuscular transmission function caused by muscle relaxants in clinically anesthetized and critically ill patients.
  • a constant current stimulation of a certain current intensity and pulse width is applied to the corresponding nerve in the vicinity of the patient's wrist, in order to cause the contraction of the relevant muscle, and the depth of the anesthesia is reflected by the strength of the finger movement.
  • the existing muscle relaxation measuring device usually uses an acceleration sensor to sense and output motion information of the human body, that is, the acceleration sensor is attached to a portion to be measured, such as a thumb, and the acceleration sensor is considered to be in conformity with the motion state of the portion to be measured. Then, the acceleration sensor outputs single-axis, two-axis or three-axis acceleration information, and then the information is processed to reflect the human body's response to current stimulation.
  • the present application provides a muscle relaxation measuring device including a response signal detecting module and a control processing module.
  • the response signal detecting module is configured to detect motion information of the to-be-measured portion of the detected object under current stimulation, the response signal detecting module includes motion for sensing the portion to be measured, and output angular velocity information to the angular velocity sensor of the control processing module;
  • the module includes a connected main processor and a stimulation signal source, and the stimulation signal source applies a stimulation current to the detected object through the output terminal under the control of the main processor, and the main processor is connected to the response signal detection module, including wired or Wirelessly connecting, and processing motion information output by the response signal detecting module.
  • the present application also provides a monitoring apparatus comprising the above-described muscle relaxation measuring device, the monitoring device displaying the measurement result of the muscle relaxation measuring device.
  • the beneficial effects of the present application are as follows:
  • the muscle relaxation measuring device provided by the present application uses an angular velocity sensor to sense the motion of the measured portion, thereby obtaining a response of the portion to be measured under current stimulation.
  • FIG. 1 is a structural block diagram of a muscle relaxation measuring device according to an embodiment of the present application.
  • FIG. 2 is a schematic diagram of motion of a response signal detecting module in a two-dimensional plane according to an embodiment of the present application.
  • the muscle relaxation measuring device includes a response signal detecting module 20 , a control processing module 30 , and a display module 40 .
  • the control processing module 30 includes a main processor 301, a stimulation signal source 302, a second interface chip 303, and a third interface chip 304.
  • the main processor 301 is connected to the stimulation signal source 302, and the second interface chip 303 and the third interface chip 304 are connected to the main processor 301.
  • the stimulation signal source 302 applies a stimulation current to the object to be detected through the output terminal 101 under the control of the main processor 301.
  • the output terminal 101 is a pair of cables connected to the stimulation signal source 302, and the output terminal The end of 101 is connected to the electrode sheet 10 attached to the surface of the object to be inspected (the electrode sheet 10 is usually attached to the wrist of the human body), and the stimulation signal source 302 generates a stimulation current through the output terminal 101 and the electrode under the control of the main processor 301.
  • the sheet 10 is subjected to current stimulation of the object to be detected.
  • the output 101 of the stimulus signal source 302 is also coupled to the main processor 301, which feeds back the stimulus current back to the main processor 301.
  • the control of the stimulation signal source 302 by the main processor 301 is specifically as follows: On the one hand, the main processor 301 controls the stimulation signal source 302 to generate a constant current stimulation current required for muscle relaxation measurement, the magnitude of the stimulation current, and the pulse width within the allowable body impedance range. On the other hand, the stimulation signal source 302 feeds back the generated constant current stimulation current back to the main processor 301 for monitoring, determining whether the stimulation signal source 302 outputs the magnitude of the stimulation current, and whether the pulse width remains within the allowable body impedance range. To ensure the safety of patients.
  • the third interface chip 304 is connected to the display module 40 as the output end of the control processing module 30, and the main processor 301 acquires the motion information output by the response signal detecting module 20 and then performs the same.
  • the algorithm processes, and finally the processed data is transmitted to the display module 40 through the third interface chip 304 for corresponding display.
  • the second interface chip 303 is also connected to the response signal detection module 20.
  • the response signal detecting module 20 includes an angular velocity sensor 201, a slave processor 202, a memory 203, and a first interface chip 204.
  • the response signal detecting module 20 is fixedly placed on the detected object and has a motion state consistent with the portion to be detected of the detected object.
  • the angular velocity sensor 201 is coupled to the slave processor 202, and the angular velocity sensor 201 outputs angular velocity information of the motion of the portion to be detected to the slave processor 202 during movement with the portion to be detected.
  • the slave processor 202 is also used to configure and/or calibrate the parameters of the angular velocity sensor 201. For example, the measurement range, the filtering mode, the sampling rate, and the like of the angular velocity sensor 201 are configured from the processor 202.
  • the memory 203 is connected to the slave processor 202 for storing calibration information such as the zero offset of the angular velocity sensor 201, in order to facilitate future software and hardware upgrades.
  • the memory 203 also stores identity information such as the software and hardware version of the response signal detecting module 20.
  • the first interface chip 204 is connected to the slave processor 202 as an output end of the response signal detecting module 20.
  • the first interface chip 204 is also connected to the second interface chip 303, and the first interface chip 204 acquires the motion output from the processor 202.
  • the information is then sent to the second interface chip 303 by wire (such as cable) or wireless (such as Bluetooth), so that the control processing module 30 acquires the motion information output by the response signal detecting module 20.
  • the response signal detecting module 20 and the control processing module 30 may be separate, and the data is performed by the first interface chip 204 and the second interface chip 303.
  • the transmission may be integrated into the part to be measured of the object to be detected, the motion information of the part to be measured is detected, and the algorithm is processed, and then the processing result is directly output to the display module 40.
  • the slave processor 202 may not be provided in the response signal detecting module 20.
  • the memory set in the response signal detecting module 20 may also be disposed in the control processing module 30.
  • the memory is connected to the main processor 301 for storing configuration information for configuring the main processor 301 to the angular velocity sensor 201, calibration information, and/or identity information of the software and hardware version of the muscle relaxation measuring device.
  • the above memory may be a memory integrated in the main processor 301 or the slave processor 202, or may be a memory independent of the main processor 301 or the slave processor 202.
  • the acceleration degree information can be approximated by a certain assumption. That is, assuming that the portion to be measured is circularly moved around the fixed point, the angular velocity multiplied by the length of the portion to be measured can obtain the linear velocity, and the linear velocity can be obtained by deriving the time to obtain the acceleration information.
  • this method obtains accurate angular velocity information, it is still assumed that the obtained acceleration information still affects the accuracy of the muscle relaxation measurement results.
  • the response signal detecting module 20 further includes an acceleration sensor 205, and the acceleration sensor 205 is connected to the slave processor 202.
  • the acceleration sensor 205 outputs acceleration information of the motion of the portion to be detected to the slave processor 202 during movement with the portion to be detected.
  • the parameters of the acceleration sensor 201 are configured from the processor 202 to calibrate their detection operations.
  • the acceleration sensor 205 may be separate from the angular velocity sensor 201 or may be an integrated sensor chip.
  • the angular velocity sensor 201 can employ a gyro sensor.
  • other information such as a temperature sensor, a magnetic sensor, a proximity sensor, etc. can be integrated if other information about the portion to be measured is required during the measurement.
  • the slave processor 202 can also be coupled to the acceleration sensor 205 for configuring and/or calibrating the acceleration sensor 205.
  • the slave processor 202 can also be connected to the main processor 301 for outputting the motion information sensed by the angular velocity sensor 201 and the acceleration sensor 205 to the main processor 301, which can increase the transmission distance of the signal and the like.
  • the principle of the processing process of the acquired motion information by the main processor 301 is as follows:
  • the mass is m, m is a constant, and remains unchanged. During the entire movement, it is only subjected to the force of gravity mg and the elastic force of the sensor's triaxial polysilicon spring (which can be regarded as a resistance to the movement of the moving mass).
  • X g , Y g , Z g represent the components of the X, Y, and ⁇ axes of acceleration generated by gravity
  • X f , Y f , and Z f represent the components of the X, ⁇ , and ⁇ axes generated by the elastic force.
  • X F , Y F , Z F represent the components of the X, Y, and ⁇ axes of the acceleration generated by the resultant force F.
  • FIG. 1 is a schematic diagram of the movement of the response signal detecting module in a two-dimensional plane in the present embodiment, and considers that the motion mass is in a ⁇ - ⁇ plane motion (the ⁇ - ⁇ plane is parallel to the gravity direction).
  • Y F gcos (p + Y f
  • the size of the resultant force is:
  • the angle ⁇ in Equation 1 can be obtained by the acceleration sensor and the angular velocity sensor in the response signal detecting module.
  • the gravity direction of the motion state and the initial angle ⁇ of the X axis can be obtained by the inclination detection mechanism of the acceleration sensor;
  • the output of the angular velocity sensor is the angular velocity, and the angular change amount during the motion can be obtained by the angular velocity versus the time integration Get; you can find + ⁇ . Therefore, the resultant force IFI at any time only contains an unknown amount m.
  • the most widely used TOF (Training Four) in the measurement of muscle relaxation is the maxlF., I measurement mode.
  • the final result to be obtained is TOF, and max l F i! , where maxlFJ and maxlF 4 l represents the maximum resultant force of the 1st and 4th stimulations in a complete TOF measurement mode, respectively.
  • the result TOF is a ratio, the unknown amount m is eliminated; on the other hand, the maximum value of the resultant force generated by each stimulus can be obtained by the motion information outputted by the response signal detecting module. Therefore, the final result TOF can be obtained.
  • the motion of the part to be measured is a three-dimensional motion, so to fully reflect its motion, three-axis acceleration information and three-axis angular velocity information are required.
  • the combined force is: [F
  • the desired result of the actual muscle relaxation measurement can be obtained.
  • the main processor 301 can also directly configure the parameters of the angular velocity sensor 201 by the main processor 301 instead of the slave processor 202, and calibrate the detection work. And when the response signal detecting module 20 and the control processing module 30 are integrated and placed together in the to-be-measured portion of the detected object, the main processor 301 may not need to obtain the response through the first interface chip 204 and the second interface chip 303.
  • the function of the display module 40 is to facilitate the user to intuitively know the measurement results output by the muscle relaxation measuring device, and thus the presence of the display module 40 should not be construed as limiting the application.
  • the muscle relaxation measuring device uses an angular velocity sensor to sense the motion of the measured portion, thereby obtaining the reaction of the portion to be measured under current stimulation.
  • all the information of the muscle relaxation measurement can be obtained, which is actually measured by the sensor, which makes the muscle relaxation measurement more accurate.
  • the embodiment of the present application further provides a monitoring device, which comprises the muscle relaxation measuring device in the above embodiment, and the monitoring device displays the measurement result of the muscle relaxation measuring device.

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Abstract

本申请公开了一种肌松测量装置，包括响应信号检测模块（20）和控制处理模块（30）。响应信号检测模块（20）用于检测被检测对象在被电流刺激下的待测量部位的运动信息，响应信号检测模块（20）包括用于感应待测量部位的运动，输出角速度信息至控制处理模块（30）的角速度传感器（201）；控制处理模块（30）包括相连的主处理器（301）和刺激信号源（302），刺激信号源（302）在主处理器（301）的控制下通过输出端（101）将刺激电流施加到被检测对象上，主处理器（301）与响应信号检测模块（20）连接，对所述响应信号检测模块（20）输出的运动信息进行处理。本申请提供的肌松测量装置采用角速度传感器感应被测部位的运动情况，从而获取到待测量部位在电流刺激下的反应。

Description

一种肌松测量装置及监护设备 技术领域
本申请涉及医疗器械领域，具体涉及一种肌松测量装置及监护设备。 背景技术
肌松测量用于反映临床中麻醉和危重病人由肌松药引起的神经肌肉 传递功能的阻滞程度和恢复情况。 实际测量中通常在病人的腕部附近按 照不同的刺激模式给相应的神经施加一定电流强度和脉宽的恒流刺激， 以引起相关肌肉的收缩， 并通过手指运动的强弱来反映麻醉深度。
现有的肌松测量装置通常是采用加速度传感器感应并输出人体的运 动信息， 即将加速度传感器附着于待测量部位， 比如拇指， 并认为加速 度传感器与待测量部位的运动状态是一致的。 然后通过加速度传感器输 出单轴、 双轴或是三轴的加速度信息， 再对该信息进行算法处理来反映 人体对电流刺激的响应情况。
发明内容
本申请提供了一种肌松测量装置， 该装置包括响应信号检测模块和 控制处理模块。 响应信号检测模块用于检测被检测对象在被电流刺激下 的待测量部位的运动信息， 响应信号检测模块包括用于感应待测量部位 的运动， 输出角速度信息至控制处理模块的角速度传感器； 控制处理模 块包括相连的主处理器和刺激信号源， 所述刺激信号源在主处理器的控 制下通过输出端将刺激电流施加到被检测对象上， 主处理器与响应信号 检测模块连接， 包括有线或无线连接， 并对所述响应信号检测模块输出 的运动信息进行处理。
本申请还提供了一种监护设备， 包括上述肌松测量装置， 所述监护 设备显示肌松测量装置的测量结果。
本申请的有益效果是： 本申请提供的肌松测量装置采用角速度传感 器感应被测部位的运动情况， 从而获取到待测量部位在电流刺激下的反 应。
下面通过具体实施方式结合附图对本申请作进一步详细说明。
附图说明
图 1为本申请一种实施例中肌松测量装置的结构框图；
图 2为本申请一种实施例中响应信号检测模块在二维平面内的运动 示意图。
具体实施方式
请参考图 1 , 本实施例提供的肌松测量装置包括响应信号检测模块 20、 控制处理模块 30和显示模块 40。 控制处理模块 30包括主处理器 301、 刺激信号源 302、 第二接口芯 片 303和第三接口芯片 304。 主处理器 301与刺激信号源 302相连接， 第二接口芯片 303和第三接口芯片 304连接在主处理器 301上。 刺激信 号源 302在主处理器 301的控制下通过输出端 101将刺激电流施加到被 检测对象上， 在一具体实例中， 输出端 101为连接在刺激信号源 302上 的一对电缆， 输出端 101 末端连接在贴于被检测对象表面的电极片 10 上（电极片 10通常是贴于人体的手腕附近）， 刺激信号源 302在主处理 器 301的控制下产生刺激电流通过输出端 101和电极片 10对被检测对象 进行电流刺激。 为实现主处理器 301对刺激信号源 302的闭环控制， 刺 激信号源 302的输出端 101还连接到主处理器 301 , 将刺激电流反馈回 主处理器 301。 主处理器 301对刺激信号源 302的控制具体为： 一方面 主处理器 301控制刺激信号源 302产生肌松测量所需要的恒流刺激电流， 刺激电流的大小、 脉宽在允许的人体阻抗范围内可调； 另一方面， 刺激 信号源 302将产生的恒流刺激电流反馈回主处理器 301进行监测， 确定 刺激信号源 302输出刺激电流的大小、 脉宽是否保持在允许的人体阻抗 范围内， 以保证患者的安全。 为了方便用户获知肌松测量装置的测量结 果， 第三接口芯片 304作为控制处理模块 30的输出端与显示模块 40相 连，主处理器 301获取到响应信号检测模块 20输出的运动信息后对其进 行算法处理， 最后将处理后的数据经过第三接口芯片 304传输到显示模 块 40进行相应显示。第二接口芯片 303还连接到响应信号检测模块 20。
响应信号检测模块 20包括角速度传感器 201、 从处理器 202、 存储 器 203和第一接口芯片 204。响应信号检测模块 20固定放置在被检测对 象上， 并与被检测对象的待检测部位具有一致的运动状态。 角速度传感 器 201与从处理器 202连接， 角速度传感器 201在与待检测部位一起运 动的过程中输出待检测部位运动的角速度信息到从处理器 202。 从处理 器 202还用于对角速度传感器 201的参数进行配置和 /或对其检测工作进 行校准。 比如： 从处理器 202对角速度传感器 201的测量范围、 滤波方 式、 采样率等进行配置。 存储器 203与从处理器 202连接， 用于存储角 速度传感器 201的零点偏置等校准信息， 为了便于日后软硬件升级。 存 储器 203还存储响应信号检测模块 20的软硬件版本等身份信息。第一接 口芯片 204与从处理器 202连接， 作为响应信号检测模块 20的输出端， 第一接口芯片 204还与第二接口芯片 303连接， 第一接口芯片 204获取 到从处理器 202输出的运动信息后通过有线 （比如电缆） 或无线 （比如 蓝牙）方式将其发送给第二接口芯片 303 , 使得控制处理模块 30获取响 应信号检测模块 20输出的运动信息。
当然， 在具体实例中， 响应信号检测模块 20和控制处理模块 30可 以是分开的， 通过第一接口芯片 204和第二接口芯片 303来进行数据的 传输； 也可以是两者集成一体， 共同放置在被检测对象的待测量部位， 检测到待测量部位的运动信息后进行算法处理， 然后直接将处理结果输 出到显示模块 40。
另外，在具体实例中， 响应信号检测模块 20中也可以不设置从处理 器 202,上述响应信号检测模块 20中设置的存储器还可以设置在控制处 理模块 30 中。 此时， 存储器与主处理器 301连接， 用于存储主处理器 301对角速度传感器 201进行配置的配置信息、 校准信息和 /或肌松测量 装置软硬件版本的身份信息。
并且， 上述存储器也可以是集成在主处理器 301或从处理器 202内 部的存储器， 也可以是独立于主处理器 301或从处理器 202的存储器。
为获知能够得到肌松测量结果所必须的全部信息， 在角速度传感器 201 输出待测量部位的角速度信息后， 通过一定的假设可近似求得加速 度信息。 即假设待测量部位绕固定点做圓周运动， 角速度乘以待测量部 位的长度可求得线速度， 线速度再对时间求导即可得到加速度信息。 然 而此方法虽然获得了准确的角速度信息， 但通过假设求得的加速度信息 依然会影响肌松测量结果的准确性。优选的， 响应信号检测模块 20还包 括加速度传感器 205 , 加速度传感器 205与从处理器 202连接， 加速度 传感器 205在与待检测部位一起运动的过程中输出待检测部位运动的加 速度信息到从处理器 202。 从处理器 202对加速度传感器 201的参数进 行配置， 对其检测工作进行校准。 加速度传感器 205可以是与角速度传 感器 201分开的， 也可以是集成一体的传感器芯片。 在一具体实例中， 角速度传感器 201可以采用陀螺仪传感器， 当然， 在测量过程中如果还 需要获得待测量部位的其它信息， 还可以集成其它传感器， 比如温度传 感器、 磁传感器、 接近传感器等。
进一步地， 从处理器 202也可以与加速度传感器 205连接， 用于对 加速度传感器 205进行配置和 /或校准。 另外， 从处理器 202也可以与主 处理器 301连接， 用于将角速度传感器 201和加速度传感器 205感应到 的运动信息输出到主处理器 301 , 这样可以增加信号的传输距离等。 主处理器 301对获取的运动信息的处理过程的原理如下：
1.以响应信号检测模块 20 中传感器内部的运动质量块作为研究对 象， 设其质量为 m, m为一常量， 始终保持不变。 在整个运动过程中其 仅受到重力 mg和传感器三轴多晶硅弹簧的弹力 f (可视为是阻碍运动质 量块运动的阻力）。 重力 mg和弹力 f的合力为 F, 则运动质量块的实际 加速度 A=F/m。 以 Xg、 Yg、 Zg代表重力所产生的加速度在 X、 Y、 Ζ轴 的分量； 以 Xf、 Yf、 Zf代表因弹力所产生的加速度在 X、 Υ、 Ζ轴的分 量； 以 XF、 YF、 ZF代表合力 F产生的加速度在 X、 Y、 Ζ轴的分量。 由 加速度传感器的实现原理可知其输出的加速度信息为 Xf、 Yf、 zf, 而不 XF、 YF、 Ζρ0
请参考图 1 , 为本实施例中响应信号检测模块在二维平面内的运动 示意图，认为运动质量块在 Χ-Υ平面运动（Χ-Υ平面与重力方向平行）。 对于任意位置、 任意运动状态都有： XF =gcGs9+Xf 、 YF=gcos(p+Yf|和 zF=o+zf=o, 其中 Θ、 Ψ为运动过程中重力方向和运动质量块的 X 和 γ 轴的夹角。 由于是二维平面运动， 始终有 2 , 则 ½— i^mu ! ½ , 因此合加速度的大小为：
|A|=» YF 2+Z^ - (gcose+Xf)2+(gsine+Yf)2
合力的大小为：
|F|=^A|=m^/(gcos0+Xf)2+(gsM+Yf)2 ^
2.式①中的夹角 Θ可通过响应信号检测模块中的加速度传感器和角 速度传感器共同求得。 其中， 运动始态的重力方向与 X轴的初始角度 θο 可通过加速度传感器的倾角检测机制求得； 角速度传感器的输出量为角 速度， 运动过程中的角度改变量 Θ可以通过角速度对时间积分求得； 即可求得 + Δθ。 因此， 任意时刻的的合力大小 IFI仅包含未知量 m。
3.以肌松测量中应用最为广泛的 TOF ( Train of Four,四个成串刺激） maxlF., I 测量模式为例， 所要获得的最终结果为 TOF , 且 maxlFi! , 其中 maxlFJ和 maxlF4l分别表示一次完整的 TOF测量模式中第 1次和第 4次 刺激所产生的合力最大值。 一方面， 由于结果 TOF为一比值， 消除了未 知量 m; 另一方面， 每次刺激所产生的合力最大值可以通过响应信号检 测模块输出的运动信息得到。 因此， 可以求得最终结果 TOF。
4.在实际肌松测量中， 待测量部位的运动为三维空间运动， 因此要 完全反映其运动， 需要三轴加速度信息和三轴角速度信息。 其合力大小 为： [F |-m|A|-r (gcos0+Xf +(gcos(p+ Yf ) + (gcos5+Zf y 其中 Θ、 φ、 δ分别为重力与运动质量块在 x、 γ、 ζ轴的夹角， 再根据 上述原理即可求得实际肌松测量时所要的结果。
当然， 本实施例提供的肌松测量装置中， 主处理器 301也可以取代 从处理器 202, 直接由主处理器 301对角速度传感器 201的参数进行配 置，对其检测工作进行校准。并且当响应信号检测模块 20和控制处理模 块 30 者集成一体， 共同放置在被检测对象的待测量部位时， 主处理器 301可以不需要通过第一接口芯片 204和第二接口芯片 303来获取响应 信号检测模块 20输出的运动信息。 另外， 显示模块 40的作用在于方便 用户直观地获知肌松测量装置输出的测量结果，因此显示模块 40的存在 不应当理解为对本申请的限定。
本实施例提供的肌松测量装置采用角速度传感器感应被测部位的运 动情况， 从而获取到待测量部位在电流刺激下的反应。 另外， 结合加速 度传感器， 即可获得肌松测量的全部信息， 该信息由传感器实际测量得 到， 使肌松测量结果更加准确。
本申请实施例还提供了一种监护设备， 包括上述实施例中的肌松测 量装置， 监护设备显示肌松测量装置的测量结果。
以上内容是结合具体的实施方式对本申请所作的进一步详细说明， 不能认定本申请的具体实施只局限于这些说明。 对于本申请所属技术领 域的普通技术人员来说， 在不脱离本申请构思的前提下， 还可以做出若 干筒单推演或替换。

Claims

权 利 要 求
1、 一种肌松测量装置,包括：
响应信号检测模块， 用于检测被检测对象在被电流刺激下的待测量 部位的运动信息；
控制处理模块， 其包括相连的主处理器和刺激信号源， 所述刺激信 号源在主处理器的控制下通过输出端将刺激电流施加到被检测对象上， 主处理器与响应信号检测模块连接， 对所述响应信号检测模块输出的运 动信息进行处理；
其特征在于， 所述响应信号检测模块包括角速度传感器， 角速度传 感器用于感应待测量部位的运动， 输出角速度信息至控制处理模块。
2、 如权利要求 1所述的肌松测量装置， 其特征在于， 所述响应信号 检测模块还包括加速度传感器， 加速度传感器用于感应待测量部位的加 速度信息。
3、 如权利要求 1所述的肌松测量装置， 其特征在于， 还包括显示模 块， 显示模块与控制处理模块的输出端连接， 用于显示测量结果。
4、 如权利要求 1所述的肌松测量装置， 其特征在于， 所述响应信号 检测模块还包括从处理器， 所述从处理器与角速度传感器连接， 用于对 角速度传感器进行配置和 /或校准， 和 /或用于将角速度传感器感应到的 运动信息输出到主处理器。
5、 如权利要求 2所述的肌松测量装置， 其特征在于， 所述响应信号 检测模块还包括从处理器， 所述从处理器与角速度传感器和加速度传感 器分别连接， 用于对角速度传感器和加速度传感器进行配置和 /或校准， 和 /或用于将角速度传感器和加速度传感器感应到的运动信息输出到主 处理器。
6、 如权利要求 4或 5所述的几松测量装置， 其特征在于， 所述响应 信号检测模块还包括存储器， 所述存储器与从处理器或主处理器连接， 用于存储从处理器或主处理器对角速度传感器进行配置的配置信息、 校 准信息和 /或所述肌松测量装置软硬件版本的身份信息。
7、 如权利要求 4或 5所述的肌松测量装置， 其特征在于， 所述响应 信号检测模块还包括第一接口芯片，第一接口芯片与所述从处理器连接； 所述控制处理模块还包括第二接口芯片， 第二接口芯片与所述主处理器 连接； 所述第一接口芯片和所述第二接口芯片通过有线或无线方式进行 数据传输， 将从处理器输出的运动信息输出到主处理器。
8、 如权利要求 1或 2所述的肌松测量装置， 其特征在于， 所述刺激 信号源的输出端还连接到主处理器， 将所述刺激电流反馈给主处理器。
9、 一种监护设备， 其特征在于， 所述监护设备包括权利要求 1-8任 一项所述的肌松测量装置。
10、 如权利要求 9所述监护设备， 其特征在于， 所述监护设备显示 所述肌松测量装置的结果。
PCT/CN2013/083095 2012-12-05 2013-09-09 一种肌松测量装置及监护设备 Ceased WO2014086177A1 (zh)

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