WO2014080345A8 - Improved process for the preparation of pregabalin - Google Patents

Improved process for the preparation of pregabalin Download PDF

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Publication number
WO2014080345A8
WO2014080345A8 PCT/IB2013/060276 IB2013060276W WO2014080345A8 WO 2014080345 A8 WO2014080345 A8 WO 2014080345A8 IB 2013060276 W IB2013060276 W IB 2013060276W WO 2014080345 A8 WO2014080345 A8 WO 2014080345A8
Authority
WO
WIPO (PCT)
Prior art keywords
pregabalin
preparation
improved process
ash content
relates
Prior art date
Application number
PCT/IB2013/060276
Other languages
French (fr)
Other versions
WO2014080345A3 (en
WO2014080345A2 (en
Inventor
Bhuvaneswari SRIDHAR
Srimurugan SANKARESWARAN
Sathish Kumar Santhanampillai
Original Assignee
Shasun Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shasun Pharmaceuticals Limited filed Critical Shasun Pharmaceuticals Limited
Publication of WO2014080345A2 publication Critical patent/WO2014080345A2/en
Publication of WO2014080345A3 publication Critical patent/WO2014080345A3/en
Publication of WO2014080345A8 publication Critical patent/WO2014080345A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Disclosed is the process suitable for industrial synthesis of Pregabalin from (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic using sodium hypochlorite with low ash content by means of reverse addition. The invention relates to process for the preparation of Pregabalin with low ash content and the process is a reverse addition process. More specifically, the invention relates to process for the preparation of Pregabalin which is viable for large scale preparation.
PCT/IB2013/060276 2012-11-20 2013-11-20 Improved process for the preparation of pregabalin WO2014080345A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN4828/CHE/2012 2012-11-20
IN4828CH2012 2012-11-20

Publications (3)

Publication Number Publication Date
WO2014080345A2 WO2014080345A2 (en) 2014-05-30
WO2014080345A3 WO2014080345A3 (en) 2014-07-24
WO2014080345A8 true WO2014080345A8 (en) 2015-01-22

Family

ID=50776625

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2013/060276 WO2014080345A2 (en) 2012-11-20 2013-11-20 Improved process for the preparation of pregabalin

Country Status (1)

Country Link
WO (1) WO2014080345A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109678737B (en) * 2019-02-18 2021-12-24 常州制药厂有限公司 Preparation method of pregabalin
CN113801031B (en) * 2021-10-26 2023-12-26 浙江华海药业股份有限公司 Purification method of pregabalin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7241893B2 (en) * 2004-09-17 2007-07-10 Hoffman-La Roche Inc. Thiazolinone 2-substituted quinolines
WO2007035789A1 (en) * 2005-09-19 2007-03-29 Teva Pharmaceutical Industries Ltd. Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the new synthesis of (s)-pregabalin
ITMI20061297A1 (en) * 2006-07-04 2008-01-05 Laboratorio Chimico Int Spa PROCEDURE FOR THE PREPARATION OF ACID (R) - (-) - 3- (CARBAMYLMETHYL) -5-METHYLESANOIC AND PREGABALIN AND INTERMEDIATE OF SYNTHESIS
WO2009087650A2 (en) * 2007-10-15 2009-07-16 V.B. Medicare Pvt. Ltd. A novel process for synthesis of pregabalin from substituted cyclopropane intermediate and a process for enzymatic resolution of racemic pregabalin

Also Published As

Publication number Publication date
WO2014080345A3 (en) 2014-07-24
WO2014080345A2 (en) 2014-05-30

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