WO2014080345A8 - Improved process for the preparation of pregabalin - Google Patents
Improved process for the preparation of pregabalin Download PDFInfo
- Publication number
- WO2014080345A8 WO2014080345A8 PCT/IB2013/060276 IB2013060276W WO2014080345A8 WO 2014080345 A8 WO2014080345 A8 WO 2014080345A8 IB 2013060276 W IB2013060276 W IB 2013060276W WO 2014080345 A8 WO2014080345 A8 WO 2014080345A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pregabalin
- preparation
- improved process
- ash content
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
Abstract
Disclosed is the process suitable for industrial synthesis of Pregabalin from (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic using sodium hypochlorite with low ash content by means of reverse addition. The invention relates to process for the preparation of Pregabalin with low ash content and the process is a reverse addition process. More specifically, the invention relates to process for the preparation of Pregabalin which is viable for large scale preparation.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN4828/CHE/2012 | 2012-11-20 | ||
IN4828CH2012 | 2012-11-20 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2014080345A2 WO2014080345A2 (en) | 2014-05-30 |
WO2014080345A3 WO2014080345A3 (en) | 2014-07-24 |
WO2014080345A8 true WO2014080345A8 (en) | 2015-01-22 |
Family
ID=50776625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2013/060276 WO2014080345A2 (en) | 2012-11-20 | 2013-11-20 | Improved process for the preparation of pregabalin |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2014080345A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109678737B (en) * | 2019-02-18 | 2021-12-24 | 常州制药厂有限公司 | Preparation method of pregabalin |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7241893B2 (en) * | 2004-09-17 | 2007-07-10 | Hoffman-La Roche Inc. | Thiazolinone 2-substituted quinolines |
US7563923B2 (en) * | 2005-09-19 | 2009-07-21 | Teva Pharmaceutical Industries Ltd. | Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the synthesis of (S)-Pregabalin |
ITMI20061297A1 (en) * | 2006-07-04 | 2008-01-05 | Laboratorio Chimico Int Spa | PROCEDURE FOR THE PREPARATION OF ACID (R) - (-) - 3- (CARBAMYLMETHYL) -5-METHYLESANOIC AND PREGABALIN AND INTERMEDIATE OF SYNTHESIS |
WO2009087650A2 (en) * | 2007-10-15 | 2009-07-16 | V.B. Medicare Pvt. Ltd. | A novel process for synthesis of pregabalin from substituted cyclopropane intermediate and a process for enzymatic resolution of racemic pregabalin |
-
2013
- 2013-11-20 WO PCT/IB2013/060276 patent/WO2014080345A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2014080345A2 (en) | 2014-05-30 |
WO2014080345A3 (en) | 2014-07-24 |
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