WO2014076616A3 - Formulations de 5-azacytidine - Google Patents

Formulations de 5-azacytidine Download PDF

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Publication number
WO2014076616A3
WO2014076616A3 PCT/IB2013/059992 IB2013059992W WO2014076616A3 WO 2014076616 A3 WO2014076616 A3 WO 2014076616A3 IB 2013059992 W IB2013059992 W IB 2013059992W WO 2014076616 A3 WO2014076616 A3 WO 2014076616A3
Authority
WO
WIPO (PCT)
Prior art keywords
azacytidine
formulations
crystalline
lyophilized formulations
relates
Prior art date
Application number
PCT/IB2013/059992
Other languages
English (en)
Other versions
WO2014076616A2 (fr
Inventor
Pradeep SHIVAKUMAR
Nagaraju DASARI
Ravi KISHORE
Rizwan Ahmed
Akshaykant CHATURVEDI
Original Assignee
Shilpa Medicare Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shilpa Medicare Limited filed Critical Shilpa Medicare Limited
Priority to US14/441,517 priority Critical patent/US9765108B2/en
Publication of WO2014076616A2 publication Critical patent/WO2014076616A2/fr
Publication of WO2014076616A3 publication Critical patent/WO2014076616A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Cette invention concerne des formulations lyophilisées comprenant une 5-azacytidine cristalline et un procédé de préparation desdites formulations lyophilisées comprenant la 5-azacytidine cristalline.
PCT/IB2013/059992 2012-11-19 2013-11-08 Formulations de 5-azacytidine WO2014076616A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/441,517 US9765108B2 (en) 2012-11-19 2013-11-08 Formulation of 5-azacytidine

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN4801/CHE/2012 2012-11-19
INCH48012012 2012-11-19
IN2148/CHE/2013 2013-05-15
IN2148CH2013 2013-05-15

Publications (2)

Publication Number Publication Date
WO2014076616A2 WO2014076616A2 (fr) 2014-05-22
WO2014076616A3 true WO2014076616A3 (fr) 2014-07-10

Family

ID=50731788

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2013/059992 WO2014076616A2 (fr) 2012-11-19 2013-11-08 Formulations de 5-azacytidine

Country Status (1)

Country Link
WO (1) WO2014076616A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108295034A (zh) * 2018-03-29 2018-07-20 健进制药有限公司 一种注射用阿扎胞苷冻干粉针及其制备方法
KR20190136284A (ko) * 2018-05-30 2019-12-10 주식회사 삼양바이오팜 안정한 아자시티딘-함유 약제학적 조성물의 제조방법

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040186065A1 (en) * 2003-03-17 2004-09-23 Dumitru Ionescu Forms of 5-azacytidine
WO2004082822A2 (fr) * 2003-03-17 2004-09-30 Pharmion Corporation Procedes permettant d'isoler la forme i cristalline de la 5-azacytidine
US20080287378A1 (en) * 2007-01-11 2008-11-20 Ales Gavenda Solid state forms of 5-azacytidine and processes for preparation thereof
US20110042247A1 (en) * 2009-06-25 2011-02-24 Chandrasekhar Kocherlakota Formulations of azacitidine and its derivatives

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040186065A1 (en) * 2003-03-17 2004-09-23 Dumitru Ionescu Forms of 5-azacytidine
WO2004082822A2 (fr) * 2003-03-17 2004-09-30 Pharmion Corporation Procedes permettant d'isoler la forme i cristalline de la 5-azacytidine
EP2270023A1 (fr) * 2003-03-17 2011-01-05 Celgene International Sarl Nouvelle forme polymorphique de la 5-azacytidine
US20130059810A1 (en) * 2003-03-17 2013-03-07 Pharmion Llc Pharmaceutical compositions comprising forms of 5-azacytidine
US20080287378A1 (en) * 2007-01-11 2008-11-20 Ales Gavenda Solid state forms of 5-azacytidine and processes for preparation thereof
EP2644614A2 (fr) * 2007-01-11 2013-10-02 IVAX Pharmaceuticals s.r.o. Formes à l'état solide de 5-azacytidine et leurs procédés de préparation
US20110042247A1 (en) * 2009-06-25 2011-02-24 Chandrasekhar Kocherlakota Formulations of azacitidine and its derivatives

Also Published As

Publication number Publication date
WO2014076616A2 (fr) 2014-05-22

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