WO2014074501A1 - Marqueurs moléculaires permettant de diagnostiquer un rejet cellulaire aigu et une nécrose tubulaire aiguë - Google Patents

Marqueurs moléculaires permettant de diagnostiquer un rejet cellulaire aigu et une nécrose tubulaire aiguë Download PDF

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Publication number
WO2014074501A1
WO2014074501A1 PCT/US2013/068456 US2013068456W WO2014074501A1 WO 2014074501 A1 WO2014074501 A1 WO 2014074501A1 US 2013068456 W US2013068456 W US 2013068456W WO 2014074501 A1 WO2014074501 A1 WO 2014074501A1
Authority
WO
WIPO (PCT)
Prior art keywords
patient
sample
renal
rejection
suffering
Prior art date
Application number
PCT/US2013/068456
Other languages
English (en)
Inventor
Stanley J. NAIDES
Marian MIKULA, Jr.
Feras M. ABU HANTASH
Original Assignee
Quest Diagnostics Investments Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quest Diagnostics Investments Incorporated filed Critical Quest Diagnostics Investments Incorporated
Publication of WO2014074501A1 publication Critical patent/WO2014074501A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

Abstract

La présente invention concerne des méthodes permettant d'identifier un patient souffrant probablement d'un rejet de greffe de rein, lesdites méthodes comprenant de déterminer le niveau d'expression d'un ou plusieurs gènes sélectionnés dans le groupe comprenant ABL1, NK1, NK3, GZMB, PRF1, FOXP3 et CXCL10 dans un échantillon isolé d'un patient et d'identifier le patient comme souffrant probablement d'un rejet de greffe de rein si au moins un du ou des gènes est surexprimé dans l'échantillon. La présente invention concerne également des méthodes permettant de traiter le rejet lorsqu'un patient souffrant d'un rejet de greffe de rein est identifié.
PCT/US2013/068456 2012-11-06 2013-11-05 Marqueurs moléculaires permettant de diagnostiquer un rejet cellulaire aigu et une nécrose tubulaire aiguë WO2014074501A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261723299P 2012-11-06 2012-11-06
US61/723,299 2012-11-06
US201361779863P 2013-03-13 2013-03-13
US61/779,863 2013-03-13

Publications (1)

Publication Number Publication Date
WO2014074501A1 true WO2014074501A1 (fr) 2014-05-15

Family

ID=50685105

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/068456 WO2014074501A1 (fr) 2012-11-06 2013-11-05 Marqueurs moléculaires permettant de diagnostiquer un rejet cellulaire aigu et une nécrose tubulaire aiguë

Country Status (1)

Country Link
WO (1) WO2014074501A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016097259A1 (fr) * 2014-12-19 2016-06-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de prédiction d'altérations de greffes
US9752191B2 (en) 2009-07-09 2017-09-05 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
WO2020148358A1 (fr) * 2019-01-17 2020-07-23 Katholieke Universiteit Leuven Biomarqueurs à base d'arnm pour rejet de greffe à médiation par anticorps
EP3845665A1 (fr) * 2016-08-17 2021-07-07 The Regents Of The University Of California Nouvelle méthode basée sur une immunosonde, permettant d'évaluer un état de lésion organique par un dosage d'adn acellulaire (cfdna) à base de biofluide
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
EP3764877A4 (fr) * 2018-03-12 2021-12-15 The Regents of The University of California Évaluation du statut de rejet de greffe par analyse de la diversité de répertoire de sous-unités de récepteur de lymphocytes t

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187534B1 (en) * 1997-09-24 2001-02-13 Cornell Research Foundation, Inc. Methods of evaluating transplant rejection

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
US6187534B1 (en) * 1997-09-24 2001-02-13 Cornell Research Foundation, Inc. Methods of evaluating transplant rejection

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALFIERI, A ET AL.: "Role Of NK1 Receptors On Cisplatin-Induced Nephrotoxicity In The Rat. Naunyn-Schmeideberg's Arch.", PHARMACOL., vol. 361, 18 December 1999 (1999-12-18), pages 334 - 338 *
BROUARD, S ET AL.: "Identification Of A Peripheral Blood Transcriptional Biomarker Panel Associated With Operational Renal Allograft Tolerance.", PNAS., vol. 104, no. 39, 25 September 2007 (2007-09-25), pages 15448 - 15453 *
MEYER-MONARD, S ET AL.: "Broad Molecular Screening Of An Unclassifiable Myeloproliferative Disorder Reveals An Unexpected ETV6/ABL1 Fusion Transcript.", LEUKEMIA., vol. 19, 24 March 2005 (2005-03-24), pages 1096 - 1099 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9752191B2 (en) 2009-07-09 2017-09-05 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
US11821037B2 (en) 2009-07-09 2023-11-21 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
WO2016097259A1 (fr) * 2014-12-19 2016-06-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de prédiction d'altérations de greffes
US10961580B2 (en) 2014-12-19 2021-03-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting graft alterations
EP3845665A1 (fr) * 2016-08-17 2021-07-07 The Regents Of The University Of California Nouvelle méthode basée sur une immunosonde, permettant d'évaluer un état de lésion organique par un dosage d'adn acellulaire (cfdna) à base de biofluide
US11505822B2 (en) 2016-08-17 2022-11-22 The Regents Of The University Of California Reagents for detecting Alu elements in cell-free DNA (cfDNA)
US11753680B2 (en) 2016-08-17 2023-09-12 The Regents Of The University Of California Methods of preparing a biofluid sample for detection of kidney injury
US11926868B2 (en) 2016-08-17 2024-03-12 The Regents Of The University Of California Immunoprobe-based method to assess organ injury status through a biofluid-based cell-free DNA (cfDNA) assay
EP3764877A4 (fr) * 2018-03-12 2021-12-15 The Regents of The University of California Évaluation du statut de rejet de greffe par analyse de la diversité de répertoire de sous-unités de récepteur de lymphocytes t
WO2020148358A1 (fr) * 2019-01-17 2020-07-23 Katholieke Universiteit Leuven Biomarqueurs à base d'arnm pour rejet de greffe à médiation par anticorps

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