WO2014065622A1

WO2014065622A1 - Uv-curing resin injection device for aneurism treatment

Info

Publication number: WO2014065622A1
Application number: PCT/KR2013/009546
Authority: WO
Inventors: 김준원; 강동훈; 박재찬; 박우성
Original assignee: 포항공과대학교 산학협력단; 경북대학교 산학협력단
Priority date: 2012-10-24
Filing date: 2013-10-24
Publication date: 2014-05-01

Abstract

The UV-curing resin injection device for aneurism treatment according to the present invention comprises: a catheter; a light source which is disposed inside the catheter and transmits UV light; and a linking tube which is disposed separated from the light source on the inside of the catheter and transmits a UV-curing resin.

Description

UV Curing Resin Injector for Treatment of Aneurysms

The technical field to which the present invention pertains relates to a UV curable resin injector. Specifically, the present invention relates to a UV curable resin injector for treating aneurysms.

Cerebral aneurysm, a circulatory disease caused by an aneurysm, is a disease in which the weak part of the wall of the blood vessel is swollen in the shape of a cortex. subarachnoid hemorrhage).

Cerebral aneurysms can be treated in two ways: surgical and endovascular surgery. Surgical operation is mainly performed by opening the skull and snapping the aneurysm neck with a clip. Intravascular surgery is performed by inserting a catheter into an aneurysm and filling an embolic material into the aneurysm.

According to the 2002 International Subarachnoid Aneurysm Trial (ISAT) study, endovascular coil treatment during endovascular surgery reduces the risk of post-treatment patients and reduces post-treatment risk compared to surgical procedures in ruptured cerebral aneurysms. It has been announced as a safe treatment to increase independent survival.

Based on these findings, the most widely used intravascular aneurysm treatment method is using coils. First, a frame suitable for the size of an aneurysm is selected and inserted into the aneurysm through a catheter. The small coils are packed to block the inside of the aneurysm from blood flow.

However, if the neck of the aneurysm is very wide, the inserted coil may not be able to stay in the aneurysm and come out of the blood vessel.To prevent this problem, a balloon or stent may be used or two coils may be used at the same time. A variety of assistive procedures have been developed.

However, when the coil is used, it is difficult to completely fill the aneurysm and the coil compresses over time, causing the aneurysm to recur. Frequently used computed tomography (CT) and magnetic resonance imaging (MRI) ) Interference occurred during shooting, which made it difficult to use video equipment.

In order to solve the above problems, US Patent No. 6,576,000 discloses a technique of applying a UV curable resin to an inner space of an aneurysm and irradiating it with UV light. However, since the UV-transmitting tube and the UV-curable resin flow through the catheter in a ring shape, the UV-curable resin hardens by the UV light during the passage, so that the UV-curable resin does not fill the space inside the aneurysm well. There was a problem. In addition, the catheter should have a diameter small enough to be inserted into the blood vessel, and it is also a problem that it is not easy to manufacture a catheter formed in a circular shape with a tube and a UV curable resin that transmits UV light therein to a small diameter.

A UV curable resin injector for treating aneurysms according to the present invention aims to solve the following problems.

First, it is intended to provide an intravascular cerebral aneurysm treatment tool that can more effectively fill the space inside the aneurysm.

Second, to provide a therapeutic tool that can be applied to aneurysms other than cerebral aneurysms.

Third, to effectively block the inside of the aneurysm from the blood flow to prevent the recurrence of the aneurysm, and to further prevent problems that may occur through the simplification of the treatment step.

Fourthly, to provide a therapeutic tool that does not cause interference when photographing using radiation, non-radiological imaging equipment.

The problem of the present invention is not limited to those mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the following description.

A UV curable resin injector for treating aneurysms according to the present invention is a catheter, a light source disposed inside the catheter for transmitting UV light, and a connection pipe disposed to be spaced apart from the light source inside the catheter to deliver UV cured resin. And the light source is formed independently of the connector.

The light source of the UV curable resin injector for treating an aneurysm according to the present invention is formed of an optical fiber, one end of the light source is projected to one end of the catheter, the other end of the light source is preferably disposed UV light.

Inside the catheter of the UV curable resin injector for treating aneurysms according to the present invention is an optical fiber insertion groove is formed in communication with the light source, and the light source disposed in the optical fiber insertion groove is slidably disposed in the optical fiber insertion groove When pressing the light source toward the catheter, one end of the light source is preferably extended from one end of the catheter.

Preferably, the light source of the UV curable resin injector for treating an aneurysm is rotatably disposed in the optical fiber insertion groove.

A nozzle is formed at one end of the connecting tube of the UV curable resin injector for treating an aneurysm according to the present invention, and the other end of the connecting tube is preferably in communication with the UV resin supply unit.

UV resin supply portion of the UV curable resin injector for treating aneurysms according to the present invention is preferably a pump device.

UV barrier material is preferably coated on the outer surface of the connection tube or catheter of the UV curable resin injector for treating aneurysms according to the present invention.

It is preferable that a plurality of curable resin injection holes are formed at one end of the nozzle of the UV curable resin injector for treating an aneurysm according to the present invention.

It is preferable that each of the curable resin injection holes of the UV curable resin injector for treating an aneurysm according to the present invention has a different diameter.

The balloon is disposed on one side of the catheter of the UV curable resin injector for treating aneurysm according to the present invention, the liquid injection tube is in communication with the balloon to supply and expand the liquid between the one end and the other side of the catheter is disposed desirable.

One side of the catheter of the UV curable resin injector for treating an aneurysm according to the present invention is preferably arranged inside or outside the stent a plurality of corrugated modules to form a network shape.

It is preferable to further include a coupling member disposed between the light source and the connection tube of the UV curable resin injector for treating an aneurysm according to the present invention for coupling the light source and the connection tube.

It is preferable to further include a first blocking member disposed on the outer circumferential surface of the connecting tube of the UV curable resin injector for treating an aneurysm according to the present invention, and blocking the UV light irradiated to the connecting tube.

Preferably, the outer peripheral surface of one end of the connection pipe of the UV curable resin injection device for treating an aneurysm according to the present invention further includes a second blocking member for blocking UV light emitted from the connection pipe.

A reflective surface is formed at one end of the light source of the UV curable resin injector for treating an aneurysm according to the present invention, and the reflective surface is inclined such that UV light is reflected in a direction perpendicular to the longitudinal direction of the connection pipe.

The reflective surface of the UV curable resin injector for treating an aneurysm according to the present invention is preferably formed by a reflective coating.

It is preferable that a plurality of micro protrusions are formed on the end face and the outer circumferential surface of one end of the connection pipe of the UV curable resin injector for treating aneurysms according to the present invention.

The UV curable resin injector for treating aneurysms according to the present invention can be cured at the same time as ejecting the embolic material delivered to the affected part in a liquid state, thereby simplifying the surgical procedure, reducing the operating time, and improving the treatment precision. It can be effective.

In addition, the UV curable resin injector for treating aneurysm according to the present invention can be produced in a small size that can pass through small blood vessels while including a light source and a nozzle at the same time, thereby broadening the scope of treatment It works.

In addition, it can be applied to various shapes such as connection tube, light source, nozzle, etc. according to the structure and size of the aneurysm and the condition of the patient. The rate of filling the embolic material can be adjusted, and the time or degree of curing the UV curable resin can be controlled by controlling the intensity of the light source. Therefore, the UV curable resin injection device for treating aneurysms according to the present invention can be actively applied to various situations, and the above characteristics have the effect of greatly increasing the effect of the aneurysm treatment and are performed using a non-metallic material. There is an effect that does not generate interference.

The effects of the present invention are not limited to those mentioned above, and other effects that are not mentioned will be clearly understood by those skilled in the art from the following description.

1 is a front view of a UV curable resin injector for treating an aneurysm according to a first embodiment of the present invention.

FIG. 2 is a cross-sectional view taken along line II-II of FIG. 1.

3 is a side cross-sectional view of the catheter shown in FIG. 1.

4 is a plan view of the nozzle shown in FIG. 1.

5 is a front view of the UV curable resin injector for treating an aneurysm according to a second embodiment of the present invention.

FIG. 6 is a cross-sectional view taken along line VI-VI of FIG. 5.

Figure 7 is a partial perspective view of the UV curable resin injector for treating aneurysm according to a third embodiment of the present invention.

8 is a longitudinal sectional view of the catheter in the UV curable resin injector for treating an aneurysm according to a fourth embodiment of the present invention.

9 is a cross-sectional view of the catheter in the UV curable resin injector for treating an aneurysm according to a fourth embodiment of the present invention.

Hereinafter, with reference to the drawings will be described in detail with respect to the UV curable resin injector for treating aneurysm according to the present invention.

1 is a front view of the UV curable resin injector for treating aneurysm according to the present invention, Figure 2 is a cross-sectional view taken along the line II-II of Figure 1, Figure 3 is a side cross-sectional view of the catheter shown in Figure 1, Figure 4 Is a plan view of the nozzle shown in FIG. 1.

UV curable resin injector for treating aneurysms according to the present invention is used in the treatment for the treatment of cerebral aneurysms or aneurysms, as shown in Figure 1 is disposed inside the catheter 100, and the catheter 100 It includes a light source 200 for transmitting the UV light and the connection tube 320 is disposed spaced apart from the light source 200 in the catheter 100 to deliver the UV curable resin. In addition, the light source 200 is formed independently of the connection pipe 320.

Therefore, when one end of the catheter 100 is inserted into the aneurysm of the blood vessel, the UV curable resin is injected into the aneurysm through the connecting pipe 320, and the UV curable resin inside the aneurysm is cured when irradiated with ultraviolet light from the light source 200. It also treats an aneurysm by blocking the flow of blood into the aneurysm.

The light source 200 according to the present invention may be configured as a separate ultraviolet lamp when miniaturization is possible, but in the present embodiment, the light source 200 and the nozzle 300 may be inserted into a small catheter 100. It is preferable that it is composed of an optical fiber capable of total reflection so that it can be installed in, one end of the light source 200 can protrude to one end of the catheter, the other end of the light source 200 by placing a UV light generating unit 220 It is preferable to configure the UV light generating unit 220 disposed outside to be irradiated to one end of the light source 200 through the optical fiber.

1 and 3, the nozzle 300 described above is preferably in communication with the UV resin supply unit 340 through the connection pipe 320, and the UV resin supply unit 340 supplies the UV curable resin. It is desirable to be able to control the feed rate, flow rate of the UV curing resin. Therefore, in the case of the UV resin supply unit 340 may be composed of a precise small pump, etc., it may be composed of a syringe familiar to the doctor treating the aneurysm as shown in FIG.

The UV curable resin used herein is preferably a biocompatible UV curable resin suitable for human use, and the UV curable resin of the present embodiment is added with a photoinitiator to polyethylene glycol diacrylate (PEGDA). UV cured resin was used. In addition, it can be used in combination with a radiopaque material to confirm the location of the catheter 100 during the procedure, and nanoparticles clay to control the swelling, mechanical properties of the cured UV curable resin ) May be used by mixing UV curable resin.

Referring to Figure 2, the connector 320 according to the present invention is a connector having a circular cross section, but the shape of the connector 320 may be formed in various shapes according to the embodiment of the present invention Self-explanatory in the field

Inside the catheter 100 according to the present invention, as shown in Figure 3, one end and the other end of the catheter 100 is formed in communication with the optical fiber insertion groove 110 so that the optical fiber is projected, the optical fiber insertion groove 110 The light source 200 disposed in the) is slidably disposed in the optical fiber insertion groove 110 so that when the light source 200 is pressed in the direction of the catheter 100, one end of the light source 200 is separated from one end of the catheter 100. It is desirable to allow stretching.

Since the shape of the aneurysm may be formed in various ways, the UV curable resin injected into the aneurysm may be located in various forms. Therefore, in order to be able to effectively cure the UV curable resin located in various forms, it is preferable to allow one end of the light source 200 to extend from one end of the catheter 100.

Therefore, the optical fiber insertion groove 110 may be disposed in the catheter 100 so that the light source 200 may be slidably disposed.

In addition, according to the embodiment, the light source 200 disposed in the optical fiber insertion groove 110 may be rotatably disposed in the optical fiber insertion groove 110.

In addition, one end of the light source 200 may be variously processed according to the area of the ultraviolet light to be irradiated, and in some cases, a microlens may be attached.

The outer surface of the connection pipe 320 of the UV curable resin injector for treating aneurysm according to the present invention is preferably coated with a UV blocking material 321 to block the ultraviolet light emitted from the optical fiber 200, as shown in FIG. .

If ultraviolet rays are transmitted through the outer surface of the connector 320, the UV curable resin may be cured in the connector 320 to close the connector 320. Therefore, the outer surface of the connection tube 320 is preferably coated with a UV blocking material 321 to prevent the transmission of ultraviolet rays, UV blocking material 321 according to the embodiment is the catheter 100 in addition to the outer surface of the connection pipe 320. It can be coated on the outer surface of the.

Referring to FIG. 4, a plurality of curable resin injection holes 310 are formed at one end of the nozzle 300 to correspond to various shapes of the aneurysm.

The curable resin may be sprayed, and the curable resin injection hole 310 may be formed to have a different diameter as shown in FIGS. 4B and 4C. This may allow for treatment of various types such as abdominal aneurysms and cerebral aneurysms.

As described above, the UV curable resin injector for treating an aneurysm according to the first embodiment of the present invention is not coupled to the light source 200 and the connection tube 320, and is formed separately, and thus the ejection position of the UV curable resin and Since the direction and the position where the light source is focused can be adjusted during the procedure, the degree of freedom of the procedure can be increased.

Referring to FIG. 5, which is a front view of the UV curable resin injector for treating an aneurysm according to a second embodiment of the present invention, and FIG. 6 which is a cross-sectional view taken along line VI-VI of FIG. 5, one end of the catheter 100 includes a balloon ( 400 may be disposed.

If the neck is very wide in the aneurysm, the UV curable resin that is sprayed and cured to close the aneurysm may be discharged to the mother blood vessel through the wide neck.

Therefore, as shown in FIG. 5, the balloon 400 is disposed at one side of the catheter 100, and the UV curable resin is cured inside the aneurysm, and then the balloon is inflated to the wide neck to provide a space between the neck and the balloon 400. In this case, the cured UV curable resin in the aneurysm can be prevented from being discharged into the mother blood vessel.

Catheter 100 is preferably disposed through the balloon 400 as shown in FIG.

At this time, between the one end and the other side of the catheter 100 is in communication with the balloon 400 as shown in Figure 6 it is preferable that the liquid injection pipe 420 for supplying and expanding the liquid to the balloon 400 is disposed.

In addition, as shown in FIG. 7, which is a partial perspective view of the UV curable resin injector for treating an aneurysm according to a third embodiment of the present invention, one side of the catheter 100 has a plurality of corrugated modules inside the stent 500 forming a mesh shape. It may be disposed through, or may be disposed outside the stent 500.

In particular, when the neck is wide and not deep, the stent 500 is inserted into the aneurysm, the UV curable resin injection device for treating an aneurysm is inserted through the stent 500, and the neck is formed through the net formed on the stent 500. It is possible to spray UV curable resin.

In this case, the stent 500 may prevent the cured UV curable resin from being discharged inside the aneurysm when the neck is wide as described above.

In some embodiments, the stent 500 and the balloon 400 may be used together.

8 is a longitudinal cross-sectional view of the catheter 100 in the UV curable resin injector for treating aneurysm according to the fourth embodiment of the present invention, Figure 9 is a UV curable resin for treating aneurysm in accordance with a fourth embodiment of the present invention A cross sectional view of the catheter 100 in the device.

8 and 9, the UV curable resin injector for treating aneurysms according to the fourth embodiment of the present invention includes a catheter 100, a light source 200, a connector 320, and a coupling member 600. It includes.

The coupling member 600 is disposed between the light source 200 and the connection pipe 320 to perform the function of coupling the light source 200 and the connection pipe 320.

At this time, the coupling member 600 may be coupled to the entire side of the light source 200 and the connection pipe 320, may be able to couple only a portion as shown in FIG.

In addition, it will be possible to use an epoxy bond (Epoxy Bond) as the coupling member 600.

In particular, the UV curable resin injector for treating aneurysm according to the fourth embodiment of the present invention, unlike the UV curable resin injector for treating aneurysm according to the first embodiment of the present invention, the light source 200 is connected to the connector 320 Since the light source is focused to an unnecessary place during the procedure, there is no possibility that the liquid UV curable resin is not introduced into the body, and it can be provided to the operator because it only needs to be adjusted as a combined body.

Meanwhile, as illustrated in FIG. 9, a reflective surface 230 may be formed at one end of the light source 200.

The reflective surface 230 is inclined so that the UV light transmitted through the light source 200 is reflected in the direction perpendicular to the longitudinal direction of the connecting tube 320 and irradiated to the connecting tube 320. 230 may be formed by a reflective coating.

On the other hand, the UV curable resin injector for treating aneurysm according to the fourth embodiment of the present invention is arranged to be movable on the outer circumferential surface of the connection pipe 320, the first to block the UV light irradiated to the connection pipe 320 It is preferable to further include a blocking member 322.

In particular, when the reflective surface 230 is formed at one end of the light source 200 as described above, only the region of the connector 320 that is reflected by the reflective surface 230 and irradiated with UV light is opened, and the remaining portion is UV light may be blocked using the first blocking member 322.

In this case, the UV curable resin is not cured in the region of the connecting tube 320 blocked by the UV light by the first blocking member 322, the UV blocking is blocked because the first blocking member 322 is not disposed. Curing proceeds in the unheated region.

Therefore, as shown in FIG. 9, when the UV curable resin is irradiated only to the area immediately before the UV curable resin is sprayed using the first blocking member 322, the UV curable resin in the connection pipe 320 before the spraying. Since it can be cured to some extent, it is possible to completely cure the UV curable resin injected into the aneurysm in a shorter time.

However, in order to prevent the UV curing resin from being completely cured in the connection pipe 320 to block the connection pipe 320, the area blocking the UV light and the area not blocked by the first blocking member 322 are appropriate. Setting is required.

Therefore, in order to easily set the UV light blocking region by the first blocking member 322, the first blocking member 322 is preferably disposed to be movable on the outer circumferential surface of the connecting pipe 320. In particular, when setting the UV light blocking region, the type of the UV curing resin, the type of the light source 200, the intensity of the light source 200, and the like should be taken into consideration.

However, even when the UV light blocking region by the first blocking member 322 is appropriately set, there is a risk that the injection hole located at one end of the connecting pipe 320 may be blocked by curing of the UV curing resin. Smaller diameters of the jet can cause more serious problems.

In order to prevent such a problem, it is preferable to further include a second blocking member 323 on the outer circumferential surface of one end of the connection pipe 320 to block UV light emitted to the connection pipe 320.

On the other hand, after the injection and curing of the UV curable resin to the aneurysm when removing the UV curable resin injector treatment for aneurysm, it may be difficult to remove the injector is attached to the UV cured resin cured in the aneurysm .

In order to prevent this, a plurality of micro protrusions may be formed on the end surface and the outer circumferential surface of one end of the connection pipe 320.

In addition, it may be possible to chemically treat the end surface and the outer peripheral surface of one end so as not to be combined with the UV curing agent.

Such a chemical treatment method should be taken into account the material of the connector 320 and the UV curing agent, and further, the cross section of one end of the connector 320 to perform the role of the second blocking member 322 described above. And micro projections or chemical treatment on the outer circumferential surface.

In the case of the catheter 100 illustrated in FIGS. 1 to 9, only one catheter of one end and the other end of a straight form or one end is bent, but the shape of the catheter 100 is described in one embodiment for explaining the present invention. It can be formed in various shapes such as 'J' shape, 'S' shape according to the shape of the aneurysm.

The embodiments described in the present specification and the accompanying drawings merely illustrate some of the technical ideas included in the present invention. Therefore, since the embodiments disclosed herein are not intended to limit the technical spirit of the present invention but to explain, it is obvious that the scope of the technical spirit of the present invention is not limited by these embodiments. Modifications and specific embodiments that can be easily inferred by those skilled in the art within the scope of the technical idea included in the specification and drawings of the present invention should be construed as being included in the scope of the present invention.

Claims

Catheter 100;

A light source 200 disposed inside the catheter 100 to transmit UV light; And

It is disposed inside the catheter 100 and the light source 200 is spaced apart from the connection pipe 320 for delivering a UV curable resin,

The light source 200 is a UV curable resin injector for treating aneurysm is formed independently of the connecting pipe 320.
The method of claim 1,

The light source 200 is formed of an optical fiber,

One end of the light source 200 protrudes to one end of the catheter 100, UV light generating unit 220 is disposed on the other end of the light source 200 is UV curable resin injector treatment device.
The method of claim 2,

Inside the catheter 100, an optical fiber insertion groove 110 in which the light source 200 is disposed is formed in communication, and the light source 200 disposed in the optical fiber insertion groove 110 is in the optical fiber insertion groove 110. Is disposed so as to be slidable in the case of pressing the light source 200 toward the catheter 100, one end of the light source 200 is UV curable resin injector device for treating aneurysm is extended from one end of the catheter (100).
The method of claim 3, wherein

The light source 200 is a UV curable resin injector for treating aneurysm is rotatably disposed in the optical fiber insertion groove (110).
The method of claim 1,

One end of the connecting pipe 320, the nozzle 300 is formed,

The other end of the connection pipe 320 is UV curable resin injector for treating aneurysm in communication with the UV resin supply unit 340.
The method of claim 5,

The UV resin supply unit 340 is a UV curable resin injector for treating aneurysm pump device.
The method of claim 5,

One end of the nozzle 300 is a UV curable resin injector for treating aneurysm is formed a plurality of curable resin injection port 310.
The method of claim 1,

UV curable resin injector for treating aneurysm is coated on the outer surface of the connection pipe 320 or catheter 100, UV blocking material 321.
The method of claim 8,

Each of the curable resin injection port 310 is UV curable resin injector for treating aneurysm different diameter.
The method of claim 1,

One side of the catheter 100 is a balloon 400 is disposed,

Between the one end and the other side of the catheter 100, the liquid injection pipe 420 is disposed in communication with the balloon to supply and expand the liquid to the balloon 400 is UV curable resin injector for treatment.
The method of claim 1,

One side of the catheter 100 is a UV curable resin injector for treating aneurysm is disposed inside or outside the stent (500) in which a plurality of waveform modules to form a network shape.
The method of claim 1,

It is disposed between the light source 200 and the connection pipe 320 further comprises a coupling member 600 for coupling the light source 200 and the connection pipe 320 for curing aneurysm treatment UV curable resin.
The method of claim 1,

A reflective surface 230 is formed at one end of the light source 200,

The reflective surface 230 is a UV curable resin injector for treating aneurysm inclined so that the UV light is reflected in a direction perpendicular to the longitudinal direction of the connector 320 is irradiated to the connector 320.
The method of claim 13,

The reflective surface 230 is a UV curable resin injector for treating aneurysm is formed by a reflective coating.
The method of claim 1,

Arranged to be movable on the outer circumferential surface of the connection pipe 320, UV curable resin injection device for treating aneurysm further comprises a first blocking member (322) for blocking the UV light irradiated to the connection pipe (320).
The method of claim 1,

An outer circumferential surface of one end of the connection pipe 320 further includes a second blocking member 323 for blocking UV light emitted from the connection pipe 320.
The method of claim 1,

UV curing resin injector formed with a plurality of micro protrusions on the end surface and the outer circumferential surface of one end of the connection pipe (320).