WO2014058315A1 - Lentille intraoculaire multifocale accomodative à optique chirale - Google Patents

Lentille intraoculaire multifocale accomodative à optique chirale Download PDF

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Publication number
WO2014058315A1
WO2014058315A1 PCT/NL2013/050717 NL2013050717W WO2014058315A1 WO 2014058315 A1 WO2014058315 A1 WO 2014058315A1 NL 2013050717 W NL2013050717 W NL 2013050717W WO 2014058315 A1 WO2014058315 A1 WO 2014058315A1
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Prior art keywords
optical
lens
eye
lens construction
combination
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Application number
PCT/NL2013/050717
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English (en)
Inventor
Aleksey Nikolaevich Simonov
Michiel Christiaan Rombach
Original Assignee
Akkolens International B.V.
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Publication of WO2014058315A1 publication Critical patent/WO2014058315A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1632—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing radial position, i.e. perpendicularly to the visual axis when implanted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1616—Pseudo-accommodative, e.g. multifocal or enabling monovision
    • A61F2/1618—Multifocal lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1648—Multipart lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
    • A61F2002/1682—Intraocular lenses having supporting structure for lens, e.g. haptics having mechanical force transfer mechanism to the lens, e.g. for accommodating lenses

Definitions

  • monofocal intraocular lenses have fixed monofocal optics for fixed monofocality, meaning that the optics provide the retina of the eye with a single sharp image from an object in a single object plane and have a fixed position in the eye. So, additional optics, for example progressive spectacles are required to obtain sharp images from other object planes.
  • the second generation of intraocular lenses were developed in the 1990's, and comprise fixed multifocal optics for fixed multifocality, meaning that the optics provide the retina with two or three discrete and fixed sharp images of objects from corresponding object planes; the fixed multifocal optics thus provide a, perceived, larger depth of field, compared to monofocal lenses, however, at the cost of image quality, in particular significant decrease in image contrast, and, depending on the lens design, increase in glare.
  • Such lenses have a fixed position in the eye.
  • the third generation of intraocular lenses are the most recent type of intraocular lens and generally include variable monofocal optics for variable monofocality, meaning that the intraocular lens is a monofocal lens but that image plane, and consequently the object plane, is variable by shift of the lens, generally driven by the ciliary muscle of the eye, along the optical axis and that the lens can thus provide the retina with sharp images over a range of adjacent object planes; the lens provides accommodation to the eye.
  • the image quality at different object planes remains the image quality of fixed monofocal lenses.
  • the movement of the lens along the axis is smooth which provides smooth accommodation.
  • Accommodating lenses require mechanical driving, generally a type of 'pushing-and-pulling' by driving means in the eye to achieve either (a) by variable optics, a change in shape of the optics to change the focal power of the lens and thus shift the image plane, or, (b) by fixed optics, a change in position of the optics along the optical axis to shift the image plane and, consequently, the object plane.
  • Driving means can be, for example, the ciliary muscle of the eye which also drives accommodation of the natural lens of the eye, with the ciliary muscle being the driving means of preference in the context of the present document.
  • driving means are not restricted to the ciliary muscle only, because, for example, accommodation can also be driven by the sulcus, the iris and other
  • the present invention as described in this document relates to a fourth generation of intraocular lenses, namely accommodating intraocular lenses with variable multifocal optics (also: variable lenses, accommodating lenses, lenses).
  • the lenses comprise at least one multifocal optics, meaning a single optics adapted to provide multiple, at least two, fixed focal distances, fitted to at least one optical element, to focus, on the retina of the eye, multiple, at least two, variable image planes with each image plane covering a image range distinct from any other image range covered by any other variable image plane.
  • the advantage of such multifocal accommodating lens is that the accommodative range, the accommodative amplitude, of the eye is significantly extended compared to such range offered by an accommodative monofocal lens performing comparable
  • one image range can cover the distance of 1 meter up to 30 cm from the eye while the other range can cover the distance from 1 meter to 10 meters.
  • the present invention employs chiral optical surfaces to achieve multifocality and to provide variable multifocality, by movement along the optical axis of a combination of at least two chiral surfaces which surfaces are in fixed rotational position relative to each, and, alternatively, by relative rotation of at least two of such chiral optical surfaces in a plane perpendicular to the optical axis.
  • Chiral surfaces to be relatively rotated offer additional advantages because the distance of movement along the optical axis of optical elements is severely limited by constraints of dimensions in the eye which constraints do not apply to rotational movements of optical elements relative to each other in a plane perpendicular to the optical axis.
  • an optical function means a function adapted to provide any modulation of a light beam
  • mechanical function means any function adapted to provide positioning and anchoring the optics in the eye and to provide transfer movement from driving means in the eye to at least one of the optical elements
  • multifocal optics means optics which provide at least two distinct image planes including objects from at least two corresponding object planes
  • image plane means the plane along, and perpendicular to, the optical axis at which the object plane is sharp, in- focus
  • object plane means the plane along the optical axis which is in-focus at the corresponding image plane.
  • Figure 1 depicts a cross section an accommodating lens with multifocal optics with multiple fixed foci generated by one optical element.
  • This illustration shows a light beam 1, an optical axis 2, and a single optical element 3, in this example a bifocal element comprising two distinct optical sectors 4, 5, (and, for purpose of illustration, a lens of fixed optical power, 6, to correct refractive error of the eye, is added) which optical element can be moved 7, over a range along the optical axis which move corresponds to a move of focus from the one extreme 8, to the other extreme 9, of a range, resulting in two distinct focus ranges 10, 11.
  • the distance between the focus ranges 12 is exaggerated for illustrative purposes. In practice this distance 12, is small or, alternatively, the ranges can even largely overlap.
  • Figure 2 depicts a cross section an accommodating lens with multifocal optics with multiple fixed foci generated by two chiral optical elements.
  • This illustration shows a light beam 1, and optical axis 2, and two optical elements, in this example chiral optical surfaces of a parabolic screw type, with an anterior optical element 13, and a posterior optical element 14, (and, for purpose of illustration, a lens of fixed optical power 15, to correct refractive error of the eye, is added) which optical elements can be rotated, 16, 17, relative to the other element, in a plane perpendicular to the optical axis which rotation corresponds to a move of the two foci from the one extreme 8, to the other extreme 9, of a range, resulting in two distinct focus ranges 10, 11.
  • the distance between the focus ranges 12 is exaggerated for illustrative purposes. In practice this distance 12, is smaller or, alternatively, the ranges can even largely overlap.
  • Figure 3 depicts a front view of chiral optical elements for accommodating lens with elements rotating around a central axis.
  • Two optical elements with chiral optical surfaces 18, 19, form, in combination, a multifocal lens of variable multifocal power of which the degree of optical power depends on the degree of relative rotation of the optical elements, which optical elements, in this particular example, rotate 20, symmetrically around a central axis 21, which rotation is effectuated by, in this example, movement 22, of two haptics 23, 24, coupled to the optical elements at one end 25, and to driving means in the eye 26, which can be natural driving means such as the ciliary muscle, or, alternatively, artificial driving means such as a MEMS actuator, at the other end 27.
  • driving means in the eye 26 which can be natural driving means such as the ciliary muscle, or, alternatively, artificial driving means such as a MEMS actuator, at the other end 27.
  • Figure 4 depicts a front view of chiral optical elements for accommodating lens with elements rotating around an axis on the rim of the optical elements.
  • Two optical elements with chiral optical surfaces 18, 19, form, in combination, a multifocal lens of variable optical power of which the degree of optical power depends on the degree of relative fan-like rotation 28, of the optical elements, which optical elements, in this particular example, rotate around an axis 29, on the rim of the optical elements in a manner resembling a 'Chinese fan', which rotation is effectuated by movement 22, of two haptics 23, 24, coupled to the optical elements at one end 25, and to driving means in the eye 26, at the other end 27.
  • Such multifocal accommodating intraocular lens construction can comprise components for optical functions, meaning functions for modulation of light, for example a combination of at least two optical surfaces to provide at least one multifocal lens, meaning a lens adapted to provide at least two foci, with at least one such optical surface fitted to each of, at least two, optical elements included in the lens construction, and, at least one haptic adapted to provide the mechanical functions, meaning functions for positioning and driving of optical elements, for example positioning and anchoring of the optical elements in the eye.
  • the multifocal lens is a variable multifocal lens comprising at least one combination of optical surfaces to provide at least two variable foci such that the focal distances of each focus depends on the relative position, in a plane perpendicular to the optical axis, of optical surfaces relative to each other.
  • the haptic is adapted to provide translation of a degree of movement of driving means in the eye into a corresponding degree of movement, in a plane perpendicular to the optical axis, of at least one of the optical elements relative to at least one other optical element.
  • the lens construction can comprise at least one haptic adapted to provide the function of translation of a degree of movement of driving means in the eye into a corresponding degree of rotation, in a plane perpendicular to the optical axis, of at least one of the optical elements relative to at least one other optical element.
  • At least one haptic can be designed such that it provides a combination of functions, the function of positioning of said optical elements in the eye and the function of translation of a degree of movement of driving means into said a corresponding degree of rotation of at least one optical element relative to at least one other optical element.
  • the combination of at least two optical surfaces can be a combination of at least two chiral optical surfaces to provide at least two variable foci with the focal distance of each focus depending on the relative rotational position, in a plane perpendicular to the optical axis, of the chiral optical surfaces relative to each other, and, the combination of at least two chiral optical surfaces is a combination of parabolic screw surfaces can be shaped according to z - Ar 2 , but the shape of the chiral surfaces is not limited thereto.
  • An accommodating lens with each of the chiral free-form optical surfaces including at least one optical component which component is parabolic screw type surface according to z - Ar 2 can provide at least two distinct image ranges with the specific positions of the corresponding projected image planes within said image ranges depending on the specific rotational position of the optical elements, which surface represents a chiral free-form component.
  • the two chiral optical surfaces should be of opposite chirality, alternatively, right-handed or left-handed, but not necessarily of equal steepness.
  • the chiral optical surface includes a central point of origin and a radial transition zone which is not chiral. So, alternatively, a chiral optical surface can be composed which does not include said point of origin nor the transition zone.
  • An adapted cubic surface can be chiral optical surfaces to be included in lenses disclosed in the present document, or, alternatively, any other chiral surfaces can be chiral optical surfaces to be included in lenses disclosed in the present document. Note also that combinations of chiral optical surfaces with different degrees of steepness, of opposite sign, will provide combinations of discrete multifocality and of continuous multifocality, which combinations, albeit complex combinations, can be adapted to fit complex requirements of particular eyes.
  • More than two chiral surfaces distributed over at least two optical elements can be adapted to provide an adjustable continuous multifocal lens in which the dimensions of the range of sharpness, with sharpness meaning focused, can be varied in a fixed combination with the degree of sharpness, for example from a limited range in the direction of the optical axis in combination with a relative high degree of sharpness to an extended range along the optical axis in combination with a relative low degree of sharpness, or, in alternative terms, extension of range in the direction of the optical axis, the Z-direction will result in extension of range in the direction of the X or Y axis or in a direction of a combination thereof.
  • multifocal optics comprising two parabolic screw type surfaces distributed over two optical elements can provide multiple focal spots of which the positions along the optical axis depend on the relative position, for example the relative angle of rotation of the optical elements.
  • the multifocal lens can have multiple fixed foci combined on one single optical element, for example, a bifocal lens, a lens with two fixed focal spots, or, alternatively, a trifocal lens, with three fixed focal spots.
  • a variable multifocal accommodating intraocular lens can be provided by, for example, a combination of such multifocal lenses with haptics which allow movement of the optics over a range along the optical axis thus providing the eye with accommodation.
  • an accommodating lens can have a multifocal lens comprising one optical element which comprises at least two distinct optical sectors with each sector providing a fixed focal power, which power differs from the power provided by any other optical sector on the same optical element, with the multifocal lens providing at least two distinct image ranges corresponding to said optical sectors with the specific positions of the corresponding projected image planes within said ranges depending on the specific position of the multifocal optics along the optical axis.
  • the multifocal lens can be a combination of at least two optical elements which combination provides a continuous range of different optical powers at different relative positions of the optical elements by movement of at least one optical element relative to the other optical element.
  • Such movement can be a lateral shift, in which the degree of lateral shift corresponds to the degree of variable optical power, or, alternatively, a rotation, in which the degree of rotation corresponds to the degree of variable optical power, or, any other movement or combination of movements of at least one of the optical elements relative to the other optical element.
  • At least two free-form optical surfaces that are chiral free-form optical surfaces adapted can provide at least two distinct image ranges with the specific positions of the corresponding projected image planes within said image ranges depending on the specific rotational position of the optical elements with rotational position meaning the degree of rotation of the optical elements relative to each other in a plane perpendicular to the optical axis.
  • the rotational axis can be positioned in the centre of the optical elements for symmetrical rotation, at the rim of the optical elements, for 'Chinese fan-like' type of rotation, or outside the rim of the optical elements, for rotational shift, with pure shift resulting from positioning of the axis at infinity.
  • Such accommodating lens comprising said combination of at least one optics, for optical functions, and, at least one haptic, for mechanical functions can be positioned in the capsular bag of the eye or outside the bag, for example, in the sulcus of the eye or in the iris of the eye.
  • the haptic is coupled to driving means in the eye such that the haptic provides transfer of a degree of movement from the driving means to the variable multifocal optics, which driving means can be any driving means in the eye.
  • Accommodating lenses are, generally, driven by the ciliary muscle of the eye, either by the muscle directly or by the muscle via the capsular bag from which the natural lens was removed during, for example, cataract surgery, so the haptic can be coupled to the ciliary muscle of the eye such that the the haptic provides transfer of a degree of movement from the ciliary muscle to the variable multifocal optics.
  • the driving force can also be generated by artificial driving means, for example, an additional component of the lens construction, for example, a micro-electro-mechanical- system, MEMS, component.
  • Such component can, for example, amplify a relatively small movement of a natural component of the eye into a relatively large movement of at least one optical element, so, the haptic can also be coupled to a micro-electromechanical system in the eye such that the haptic provides transfer of a degree of movement from the micro-electro-mechanical system to the variable multifocal optics.
  • the accommodating intraocular lenses disclosed in the present document can include a lens of fixed optical power adapted to provide correction of the refractive error of the eye which results from the removal of the natural lens. Additional optical surfaces can be added to correct for any number of additional optical disorders of the eye including, for example, astigmatisms, trefoils and comas.
  • the loss of accommodation of the eye is a variable disorder of the eye and the lenses disclosed in the present document is mainly intended to restore the accommodation of the eye.
  • the lens construction comprises additional fixed optics for correction of at least one additional optical disorder, for example, additional fixed optics for refraction, meaning optics with fixed optical power adapted to provide correction of refraction of the eye, correcting the error which remains after surgical removal of the natural lens.
  • the lens can also include additional fixed optics for at least one additional optical disorder with additional optical disorder meaning any optical aberration of any order.
  • the lens includes a combination of variable multifocal optics, additional fixed optics for refraction and additional fixed optics for at least one additional optical disorder which combination is adapted to provide correction of any aberration of any optical order of the eye in combination with restoration of accommodation of the eye.
  • the lens construction can include a combination of optics including variable multifocal optics, additional fixed optics for correction refraction and additional fixed optics for at least one additional optical disorder which combination is adapted to provide restoration of accommodation of the eye and correction of at least one optical disorder with additional optical disorder meaning any optical aberration of any order.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne des lentilles intraoculaires multifocales accommodatives. Ces lentilles incluent au moins deux lentilles multifocales variables (13,14) de manière à fournir au moins deux foyers variables (8,9). Dans sa forme de réalisation préférée, cette lentille comprend deux surfaces optiques chirales qui sont décalées en rotation l'une par rapport à l'autre afin de produire une multifocalité variable.
PCT/NL2013/050717 2012-10-09 2013-10-09 Lentille intraoculaire multifocale accomodative à optique chirale WO2014058315A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL2009598 2012-10-09
NL2009598 2012-10-09

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Cited By (12)

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US10159562B2 (en) 2014-09-22 2018-12-25 Kevin J. Cady Intraocular pseudophakic contact lenses and related systems and methods
WO2019027936A1 (fr) * 2017-07-31 2019-02-07 Rxsight, Inc. Lentille intraoculaire biréfringente
US10299910B2 (en) 2014-09-22 2019-05-28 Kevin J. Cady Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
WO2020197386A1 (fr) 2019-03-25 2020-10-01 Akkolens International B.V. Combinaison de lentilles intraoculaires permettant la restauration de la réfraction et de l'accommodation
WO2020231260A1 (fr) 2019-05-15 2020-11-19 Akkolens International B.V. Lentilles intraoculaires d'accommodation avec combinaison de composants d'entraînement mécanique
WO2021034187A1 (fr) 2019-08-19 2021-02-25 Akkolens International B.V. Combinaison de lentille intraoculaire accommodative à sections de lentille à puissance fixe et variable indépendantes
US10945832B2 (en) 2014-09-22 2021-03-16 Onpoint Vision, Inc. Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
NL2027301A (en) 2020-01-13 2021-08-17 Akkolens Int B V Mechanical means for accommodative intraocular lens
US11109957B2 (en) 2014-09-22 2021-09-07 Onpoint Vision, Inc. Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
NL2028038A (en) 2020-05-11 2021-11-23 Akkolens Int B V Method to connect and distance hydrophilic intraocular lens elements
US11938018B2 (en) 2014-09-22 2024-03-26 Onpoint Vision, Inc. Intraocular pseudophakic contact lens (IOPCL) for treating age-related macular degeneration (AMD) or other eye disorders
US11963868B2 (en) 2020-06-01 2024-04-23 Ast Products, Inc. Double-sided aspheric diffractive multifocal lens, manufacture, and uses thereof

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Publication number Priority date Publication date Assignee Title
WO2011053143A1 (fr) * 2009-10-30 2011-05-05 Akkolens International B.V. Lentilles intraoculaires à focale variable
WO2011102719A1 (fr) * 2010-02-17 2011-08-25 Akkolens International B.V. Lentille ophtalmique chirale réglable
WO2012105843A1 (fr) * 2011-02-03 2012-08-09 Akkolens International B.V. Combinaisons haptiques permettant d'accommoder des lentilles intraoculaires

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2011053143A1 (fr) * 2009-10-30 2011-05-05 Akkolens International B.V. Lentilles intraoculaires à focale variable
WO2011102719A1 (fr) * 2010-02-17 2011-08-25 Akkolens International B.V. Lentille ophtalmique chirale réglable
WO2012105843A1 (fr) * 2011-02-03 2012-08-09 Akkolens International B.V. Combinaisons haptiques permettant d'accommoder des lentilles intraoculaires

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11109957B2 (en) 2014-09-22 2021-09-07 Onpoint Vision, Inc. Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
US11903818B2 (en) 2014-09-22 2024-02-20 Onpoint Vision, Inc. Intraocular pseudophakic contact lenses and related systems and methods
US10299910B2 (en) 2014-09-22 2019-05-28 Kevin J. Cady Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
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