WO2014029697A1 - Fungicidal ternary mixtures comprising fluazinam - Google Patents

Fungicidal ternary mixtures comprising fluazinam Download PDF

Info

Publication number
WO2014029697A1
WO2014029697A1 PCT/EP2013/067148 EP2013067148W WO2014029697A1 WO 2014029697 A1 WO2014029697 A1 WO 2014029697A1 EP 2013067148 W EP2013067148 W EP 2013067148W WO 2014029697 A1 WO2014029697 A1 WO 2014029697A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
fluazinam
pyraclostrobin
mixture
pyrazole
Prior art date
Application number
PCT/EP2013/067148
Other languages
French (fr)
Inventor
Rogerio Andrade DIACOV
Alexandre FRATESCHI
Fabio Eduardo Bueno OLIVEIRA
Marcelo ISMAEL
Sergio Zambon
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Priority to BR112015003688-0A priority Critical patent/BR112015003688B1/en
Publication of WO2014029697A1 publication Critical patent/WO2014029697A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/50—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids the nitrogen atom being doubly bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/88—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with three ring hetero atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/24—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing the groups, or; Thio analogues thereof

Definitions

  • the present invention relates to fungicidal ternary mixtures comprising at least one inhibitor of complex II and at least one inhibitor of complex III at Q 0 site as defined herein and fluazinam, to composition comprising said mixtures and to the use and to methods for combating phytopathogenic fungi.
  • the present invention also relates to seeds treated with at least one such mixture. Furthermore the invention relates to processes for preparing mixtures and compositions of such mixtures.
  • Binary mixtures of the inhibitor of complex II boscalid with one of the inhibitors of complex III at Qo site pyraclostrobin, azoxystrobin, fluoxastrobin or trifloxystrobin or with fluazinam have been mentioned in WO 98/08385 and WO 99/31981 , respectively. Further, WO 2007/017416 mentions inter alia binary fungicidal mixtures of the inhibitor of complex II fluxapyroxad with one of the inhibitors of complex III at Q 0 site pyraclostrobin, azoxystrobin, fluoxastrobin or trifloxystrobin or with fluazinam.
  • mixtures of more than two different active compounds are employed for controlling harmful fungi.
  • mixtures of more than two different active compounds are employed for controlling harmful fungi.
  • the invention also relates to a method for controlling phytopathogenic harmful fungi using mixtures of at least one inhibitor of complex II as defined herein and pyraclostrobin and fluazinam and to the use of a compound I and a compound II and fluazinam for preparing such mixtures, and to compositions comprising these mixtures and seed comprising these mixtures or coated with this this mixture.
  • the present invention relates to mixtures comprising, as active components
  • these ternary mixtures comprise the component 1 ), component 2) and component 3) in a synergistically effective amount.
  • the weight ratio of compound I (component 1 ) and compound II (component 2) depends from the properties of the active substances used, usually it is in the range of from 1 :50 to 50:1 , regularly in the range of from 1 :20 to 20:1 , preferably in the range of from 1 :10 to 10:1 , more preferably in the range of from 1 :4 to 4:1 and in particular in the range of from 1 :2 to 2:1 , and the weight ratio of compound I (component 1 ) and fluazinam (component 3) usually it is in the range of from 1 :50 to 50:1 , regularly in the range of from 1 :20 to 20:1 , preferably in the range of from 1 :10 to 10:1 , more preferably in the range of from 1 :4 to 4:1 and in particular in the range of from 1
  • the weight ratio of compound I (component 1 ) and compound II (component 2) depends from the properties of the active substances used, usually it is in the range of from 0.5:1 to 1 :5, regularly in the range of from 1 :1 to 1 :3, preferably in the range of from 1 :1 .5 to 1 :3, and in particular in the range of 1 :2, and the weight ratio of compound I (component 1 ) and fluazinam (component 3) usually it is in the range of from 1 :1 to 1 :50, regularly in the range of from 1 :5 to 1 :25, preferably in the range of from 1 :5 to 1 :15 and in particular in the range
  • any further active compounds are, if desired, added in a weight ratio of from 20:1 to 1 :20 to the compound I (component 1 ).
  • the compounds I and/or compounds II can be present in different crystal modifications, which may differ in biological activity.
  • the compound I is selected from fluxapyroxad, boscalid, benzovindiflupyr and sedaxane. According to another embodiment, in the inventive mixtures the compound I is selected from fluxapyroxad, boscalid and
  • the compound I is selected from fluxapyroxad and boscalid. According to a further embodiment, in the inventive mixtures the compound I is boscalid. According to a further embodiment, in the inventive mixtures the compound I is fluxapyroxad.
  • the compound II is selected from pyraclostrobin and azoxystrobin. According to another embodiment, in the inventive mixtures the compound II is pyraclostrobin.
  • mixtures and compositions thereof according to the invention can, in the use form as fungicides, also be present together with other active substances, e. g. with herbicides, insecticides, growth regulators, fungicides or else with fertilizers, as pre-mix or, if appropriate, not until immeadiately prior to use (tank mix).
  • active substances e. g. with herbicides, insecticides, growth regulators, fungicides or else with fertilizers, as pre-mix or, if appropriate, not until immeadiately prior to use (tank mix).
  • inventive ternary mixtures and the compositions comprising them, respectively, in the use form as fungicides with other fungicides results in many cases in an expansion of the fungicidal spectrum of activity being obtained or in a prevention of fungicide resistance develop- ment. Furthermore, in many cases, additional synergistic effects are obtained.
  • the mixtures comprise besides a compound I, a compound II and fluazinam a compound IV (component 4) a further active compound, preferably in a synergistically effective amount.
  • a compound IV is an active compound selected from groups A) to O):
  • active components e.g. active substances and biopesticides
  • active substances e.g. active substances and biopesticides
  • Inhibitors of complex III at Q 0 site e.g. strobilurins: azoxystrobin, coumethoxystrobin,
  • coumoxystrobin dimoxystrobin, enestroburin, fenaminstrobin, fenoxy- strobin/flufenoxystrobin, fluoxastrobin, kresoxim-methyl, mandestrobine, metominostrobin, orysastrobin, picoxystrobin, pyraclostrobin, pyrametostrobin, pyraoxystrobin, trifloxystrobin and 2-(2-(3-(2,6-dichlorophenyl)-1 -methyl-allylideneaminooxymethyl)-phenyl)-2- methoxyimino-N-methyl-acetamide, pyribencarb, triclopyricarb/chlorodincarb, famoxadone, fenamidone;
  • - inhibitors of complex II e. g. carboxamides: benodanil, benzovindiflupyr, bixafen, boscalid, carboxin, fenfuram, fluopyram, flutolanil, fluxapyroxad, furametpyr, isofetamid, isopyrazam, mepronil, oxycarboxin, penflufen, penthiopyrad, sedaxane, tecloftalam, thifluzamide, N-(4'- trifluoromethylthiobiphenyl-2-yl)-3-difluoromethyl-1-methyl-1 H-pyrazole-4-carboxamide, N-(2- (1 ,3,3-trimethyl-butyl)-phenyl)-1 ,3-dimethyl-5-fluoro-1 H-pyrazole-4-carboxamide,
  • complex II e. g. carboxamides: benodanil, benzovindiflupyr, bixafen,
  • respiration inhibitors e.g. complex I, uncouplers: diflumetorim, (5,8-difluoroquinazolin-
  • nitrophenyl derivates binapacryl, dinobuton, dinocap, fluazinam; ferimzone; organometal compounds: fentin salts, such as fentin-acetate, fentin chloride or fentin hydroxide; ametoctradin; and silthiofam;
  • DMI fungicides triazoles: azaconazole, bitertanol,
  • epoxiconazole fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, oxpoconazole, paclobutrazole, penconazole, propiconazole, prothioconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, uniconazole,
  • Delta14-reductase inhibitors aldimorph, dodemorph, dodemorph-acetate, fenpropimorph, tridemorph, fenpropidin, piperalin, spiroxamine;
  • phenylamides or acyl amino acid fungicides benalaxyl, benalaxyl-M, kiralaxyl, metalaxyl, metalaxyl-M (mefenoxam), ofurace, oxadixyl;
  • hymexazole hymexazole, octhilinone, oxolinic acid, bupirimate, 5-fluorocytosine, 5-fluoro-2-(p- tolylmethoxy)pyrimidin-4-amine, 5-fluoro-2-(4-fluorophenylmethoxy)pyrimidin-4-amine;
  • - tubulin inhibitors such as benzimidazoles, thiophanates: benomyl, carbendazim,
  • cell division inhibitors diethofencarb, ethaboxam, pencycuron, fluopicolide, zoxamide, metrafenone, pyriofenone;
  • - methionine synthesis inhibitors anilino-pyrimidines: cyprodinil, mepanipyrim, pyrimethanil; - protein synthesis inhibitors: blasticidin-S, kasugamycin, kasugamycin hydrochloride-hydrate, mildiomycin, streptomycin, oxytetracyclin, polyoxine, validamycin A;
  • MAP / histidine kinase inhibitors fluoroimid, iprodione, procymidone, vinclozolin, fenpiclonil, fludioxonil;
  • - Phospholipid biosynthesis inhibitors edifenphos, iprobenfos, pyrazophos, isoprothiolane;
  • lipid peroxidation dicloran, quintozene, tecnazene, tolclofos-methyl, biphenyl, chloroneb, etridiazole;
  • oxathiapiprolin oxathiapiprolin
  • organochlorine compounds e.g. phthalimides, sulfamides, chloronitriles: anilazine,
  • chlorothalonil captafol, captan, folpet, dichlofluanid, dichlorophen, hexachlorobenzene, pentachlorphenole and its salts, phthalide, tolylfluanid, N-(4-chloro-2-nitro-phenyl)-N-ethyl-4- methyl-benzenesulfonamide;
  • guanidine dodine, dodine free base, guazatine, guazatine-acetate, iminoctadine, iminoctadine-triacetate, iminoctadine-tris(albesilate), dithianon, 2,6-dimethyl- 1 H,5H-[1 ,4]dithiino[2,3-c:5,6-c']dipyrrole-1 ,3,5,7(2H,6H)-tetraone;
  • glucan synthesis inhibitors validamycin, polyoxin B; melanin synthesis inhibitors:
  • Microbial pesticides with fungicidal, bactericidal, viricidal and/or plant defense activator activity Ampelomyces quisqualis, Aspergillus flavus, Aureobasidium pullulans, Bacillus amyloliquefaciens, B. mojavensis, B. pumilus, B. simplex, B. solisalsi, B. subtilis, B. subtilis var. amyloliquefaciens, Candida oleophila, C. saitoana, Clavibacter
  • michiganensis (bacteriophages), Coniothyrium minitans, Cryphonectria parasitica, Cryptococcus albidus, Fusarium oxysporum, Clonostachys rosea f. catenulate (also named Gliocladium catenulatum), Gliocladium roseum, Metschnikowia fructicola, Microdochium dimerum, Paenibacillus polymyxa, Pantoea agglomerans, Phlebiopsis gigantea, Pseudozyma flocculosa, Pythium oligandrum, Sphaerodes mycoparasitica, Streptomyces lydicus, S.
  • T. violaceusniger also named Gliocladium virens
  • T. viride Typhula phacorrhiza, Ulocladium oudema, U. oudemansii,
  • Verticillium dahlia zucchini yellow mosaic virus (avirulent strain);
  • activator activity chitosan (hydrolysate), laminarin, Menhaden fish oil, natamycin, Plum pox virus coat protein, Reynoutria sachlinensis extract, salicylic acid, tea tree oil;
  • Agrobacterium radiobacter Bacillus firmus, B. thuringiensis ssp. israelensis, B. t. ssp. galleriae, B. t. ssp. kurstaki, Beauveria bassiana, Burkholderia sp., Chromobacterium subtsugae, Cydia pomonella granulosis virus, Isaria fumosorosea, Heterorhabditis bacteriophora, Lecanicillium longisporum, L. muscarium (formerly Verticillium lecanii), Metarhizium anisopliae, M. anisopliae var.
  • Microbial pesticides with plant stress reducing, plant growth regulator, plant growth promoting and/or yield enhancing activity Azospirillum amazonense A. brasilense, A. lipoferum, A. irakense, A. halopraeferens, Bradyrhizobium sp., B. elkanii, B. japonicum, B. liaoningense, B. lupini, Glomus intraradices, Mesorhizobium sp., Paenibacillus alvei, Penicillium bilaiae, Rhizobium leguminosarum bv. phaseolii, R. I. trifolii, R. I. bv. viciae P1 NP3Cst, Sinorhizobium meliloti;
  • Biochemical pesticides with plant stress reducing, plant growth regulator and/or plant yield enhancing activity abscisic acid, aluminium silicate (kaolin), 3-decen-2-one, homobrassinlide, humates, jasmonic acid or salts or derivatives thereof,
  • abscisic acid amidochlor, ancymidol, 6-benzylaminopurine, brassinolide, butralin, chlormequat (chlormequat chloride), choline chloride, cyclanilide, daminozide, dikegulac, dimethipin, 2,6- dimethylpuridine, ethephon, flumetralin, flurprimidol, fluthiacet, forchlorfenuron, gibberellic acid, inabenfide, indole-3-acetic acid , maleic hydrazide, mefluidide, mepiquat (mepiquat chloride), naphthaleneacetic acid, N-6-benzyladenine, paclobutrazol, prohexadione (prohexadione- calcium), prohydrojasmon, thidiazuron, triapenthenol, tributyl phosphorotrithioate,
  • acetochlor alachlor, butachlor, dimethachlor, dimethenamid, flufenacet,
  • mefenacet metolachlor, metazachlor, napropamide, naproanilide, pethoxamid, pretilachlor, propachlor, thenylchlor;
  • EPTC esprocarb, molinate, orbencarb, phenmedipham, prosulfocarb, pyributicarb, thiobencarb, triallate;
  • acifluorfen acifluorfen, aclonifen, bifenox, diclofop, ethoxyfen, fomesafen, lactofen, oxyfluorfen;
  • - pyridines aminopyralid, clopyralid, diflufenican, dithiopyr, fluridone, fluroxypyr, picloram, picolinafen, thiazopyr;
  • - sulfonyl ureas amidosulfuron, azimsulfuron, bensulfuron, chlorimuron-ethyl, chlorsulfuron, cinosulfuron, cyclosulfamuron, ethoxysulfuron, flazasulfuron, flucetosulfuron, flupyrsulfuron, foramsulfuron, halosulfuron, imazosulfuron, iodosulfuron, mesosulfuron, metazosulfuron, metsulfuron-methyl, nicosulfuron, oxasulfuron, primisulfuron, prosulfuron, pyrazosulfuron, rimsulfuron, sulfometuron, sulfosulfuron, thifensulfuron, triasulfuron, tribenuron,
  • - triazines ametryn, atrazine, cyanazine, dimethametryn, ethiozin, hexazinone, metamitron, metribuzin, prometryn, simazine, terbuthylazine, terbutryn, triaziflam;
  • ureas chlorotoluron, daimuron, diuron, fluometuron, isoproturon, linuron, metha- benzthiazuron,tebuthiuron; - other acetolactate synthase inhibitors: bispyribac-sodium, cloransulam-methyl, diclosulam, florasulam, flucarbazone, flumetsulam, metosulam, ortho-sulfamuron, penoxsulam, propoxycarbazone, pyribambenz-propyl, pyribenzoxim, pyriftalid, pyriminobac-methyl, pyrimisulfan, pyrithiobac, pyroxasulfone, pyroxsulam;
  • amicarbazone amicarbazone, aminotriazole, anilofos, beflubutamid, benazolin,
  • organo(thio)phosphates acephate, azamethiphos, azinphos-methyl, chlorpyrifos,
  • chlorpyrifos-methyl chlorfenvinphos, diazinon, dichlorvos, dicrotophos, dimethoate, disulfoton, ethion, fenitrothion, fenthion, isoxathion, malathion, methamidophos,
  • methidathion methidathion, methyl-parathion, mevinphos, monocrotophos, oxydemeton-methyl, paraoxon, parathion, phenthoate, phosalone, phosmet, phosphamidon, phorate, phoxim, pirimiphos- methyl, profenofos, prothiofos, sulprophos, tetrachlorvinphos, terbufos, triazophos, trichlorfon;
  • - pyrethroids allethrin, bifenthrin, cyfluthrin, cyhalothrin, cyphenothrin, cypermethrin, alpha- cypermethrin, beta-cypermethrin, zeta-cypermethrin, deltamethrin, esfenvalerate, etofenprox, fenpropathrin, fenvalerate, imiprothrin, lambda-cyhalothrin, permethrin, prallethrin, pyrethrin I and II, resmethrin, silafluofen, tau-fluvalinate, tefluthrin, tetramethrin, tralomethrin, transfluthrin, profluthrin, dimefluthrin;
  • - insect growth regulators a) chitin synthesis inhibitors: benzoylureas: chlorfluazuron,
  • cyramazin diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, teflubenzuron, triflumuron; buprofezin, diofenolan, hexythiazox, etoxazole, clofentazine; b) ecdysone antagonists: halofenozide, methoxyfenozide, tebufenozide, azadirachtin; c) juvenoids: pyriproxyfen, methoprene, fenoxycarb; d) lipid biosynthesis inhibitors:
  • spirodiclofen spiromesifen, spirotetramat
  • - nicotinic receptor agonists/antagonists compounds clothianidin, dinotefuran, flupyradifurone, imidacloprid, thiamethoxam, nitenpyram, acetamiprid, thiacloprid, 1 -2-chloro-thiazol-5- ylmethyl)-2-nitrimino-3,5-dimethyl-[1 ,3,5]triazinane;
  • - GABA antagonist compounds endosulfan, ethiprole, fipronil, vaniliprole, pyrafluprole,
  • - macrocyclic lactone insecticides abamectin, emamectin, milbemectin, lepimectin, spinosad, spinetoram;
  • oxidative phosphorylation inhibitors cyhexatin, diafenthiuron, fenbutatin oxide, propargite;
  • cryomazine cryomazine
  • biopesticides from group L their preparation and their biological activity e.g. against harmful fungi, pests are known (e-Pesticide Manual V 5.2 (ISBN 978 1 901396 85 0) (2008- 201 1 ); http://www.epa.gov/opp00001/biopesticides/, see product lists therein; http://www.omri.org/omri-lists, see lists therein; Bio-Pesticides Database BPDB http://sitem.herts.ac.uk/aeru/bpdb/, see A to Z link therein).
  • biopesticides are registered and/or are commercially available: aluminium silicate (SCREENTM DUO from Certis LLC, USA), Agrobacterium radiobacter K1026 (e.g.
  • AFLA-GUARD® from Syngenta, CH
  • Aureobasidium pullulans e.g. BOTECTOR® from bio-ferm GmbH, Germany
  • Azospirillum brasilense XOH e.g. AZOS from Xtreme Gardening, USA or RTI Reforestation Technologies International; USA
  • Bacillus amyloliquefaciens IT-45 CNCM I-3800, NCBI 1091041
  • NCBI 1091041 e.g. RHIZOCELL C from ITHEC, France
  • B. amyloliquefaciens subsp. plantarum MBI600 NRRL B-50595, deposited at United States Department of Agriculture
  • B. firmus 1-1582 (WO09/126473, WO09/124707, VOTIVO® from Bayer Crop Science LP, USA)
  • B. pumilus QST 2808 (NRRL Accession No. B-30087) (e.g. SONATA® and BALLAD® Plus from AgraQuest Inc., USA), B. subtilis GB03 (e.g. KODIAK from Gustafson, Inc., USA), B. subtilis GB07 (EPIC from Gustafson, Inc., USA), B. subtilis QST-713 (NRRL-No.
  • Bacillus thuringiensis ssp. kurstaki SB4 (NRRL B-50753; e.g. BETA PRO® from Becker Underwood, South Africa), Beauveria bassiana GHA (BOTANIGARD® 22WGP from Laverlam Int. Corp., USA), B. bassiana 12256 (e.g. BIOEXPERT® SC from Live Sytems Technology S.A., Colombia), B. bassiana PPRI 5339 (ARSEF number 5339 in the USDA ARS collection of entomopathogenic fungal cultures; NRRL 50757) (e.g. BROADBAND® from Becker
  • Bradyrhizobium sp. e.g. VAULT® from Becker Underwood, USA
  • B. japonicum e.g. VAULT® from Becker Underwood, USA
  • B. pumilus KFP9F NRRL B- 50754; e.g. in FUSION-P from Becker Underwood BioAg SA (Pty) Ltd., a BASF Company
  • Candida oleophila I-82 e.g. ASPIRE® from Ecogen Inc., USA
  • Candida saitoana e.g.
  • BIOCURE® in mixture with lysozyme
  • BIOCOAT® from Micro Flo Company, USA (BASF SE) and Arysta
  • Chitosan e.g. ARMOUR-ZEN from BotriZen Ltd., NZ
  • Clonostachys rosea f. catenulata also named Gliocladium catenulatum (e.g. isolate J 1446: PRESTOP® from Verdera, Finland), Coniothyrium minitans CON/M/91 -08 (e.g. Contans® WG from Prophyta, Germany), Cryphonectria parasitica (e.g. Endothia parasitica from CNICM, France), Cryptococcus albidus (e.g.
  • YIELD PLUS® from Anchor Bio-Technologies, South Africa Ecklonia maxima (kelp) extract (e.g. KELPAK SL from Kelp Products Ltd, South Africa), Fusarium oxysporum (e.g. BIOFOX® from S.I.A.P.A., Italy, FUSACLEAN® from Natural Plant Protection, France), Glomus intraradices (e.g. MYC 4000 from ITHEC, France), Glomus intraradices RTI-801 (e.g. MYKOS from Xtreme Gardening, USA or RTI Reforestation Technologies International; USA), grapefruit seeds and pulp extract (e.g. BC-1000 from Chemie S.A., Chile), Heterorhabditis bacteriophaga (e.g.
  • NEMASYS® G from Becker Underwood Ltd., UK
  • Isaria fumosorosea Apopka-97 (ATCC 20874) (PFR-97TM from Certis LLC, USA)
  • Lecanicillium muscarium (formerly Verticillium lecanii)
  • Lecanicillium longisporum KV42 and KV71 e.g. VERTALEC® from Koppert BV, Netherlands
  • Metarhizium anisopliae var. acridum IMI 330189 deposited in European Culture Collections CABI; NRRL 50758) (e.g. GREEN MUSCLE® from Becker Underwood, South Africa), M.
  • anisopliae FI-1045 e.g. BIOCANE® from Becker Underwood Pty Ltd, Australia
  • M. anisopliae var. acridum FI-985 e.g. GREEN GUARD® SC from Becker Underwood Pty Ltd, Australia
  • M. anisopliae F52 e.g. MET52® Novozymes Biologicals BioAg Group, Canada
  • M. anisopliae ICIPE 69 e.g. METATHRIPOL from ICIPE, Kenya
  • Metschnikowia fructicola e.g. SHEMER® from Agrogreen, Israel
  • Microdochium dimerum e.g. ANTIBOT® from Agrauxine, France
  • Neem oil e.g. TRILOGY®, TRIACT® 70 EC from Certis LLC, USA
  • Paecilomyces fumosoroseus strain FE 9901 e.g. NO FLYTM from Natural Industries, Inc., USA
  • P. Iilacinus DSM 15169 e.g. N EM ATA® SC from
  • P. Iilacinus BCP2 (NRRL 50756; e.g. PL GOLD from Becker Underwood BioAg SA Ltd, South Africa), mixture of Paenibacillus alvei NAS6G6 (NRRL B-50755) and Bacillus pumilus KFP9F (NRRL B-50754) (e.g. in BAC-UP or FUSION-P from Becker Underwood South Africa), Penicillium bilaiae (e.g. JUMP START® from Novozymes Biologicals BioAg Group, Canada), Phlebiopsis gigantea (e.g. ROTSTOP® from Verdera,
  • potassium silicate e.g. Sil-MATRIXTM from Certis LLC, USA
  • Pseudozyma flocculosa e.g. SPORODEX® from Plant Products Co. Ltd., Canada
  • Pythium oligandrum DV74 e.g. POLYVERSUM® from Remeslo SSRO, Biopreparaty, Czech Rep.
  • Reynoutria sachlinensis extract e.g. REGALIA® SC from Marrone Biolnnovations, Davis, CA, USA
  • Rhizobium leguminosarum bv. phaseolii e.g. RHIZO-STICK from Becker Underwood, USA
  • R. I. trifolii e.g.
  • viciae SU303 e.g. NODULAID Group E from Becker Underwood, Australia
  • R. I. bv. viciae WSM1455 e.g. NODULAID Group F from Becker Underwood, Australia
  • Sinorhizobium meliloti MSDJ0848 INRA, France
  • strain 201 1 or RCR201 1 e.g. DORMAL ALFALFA from Becker Underwood, USA; NITRAGIN® Gold from Novozymes Biologicals BioAg Group, Canada
  • Steinernema carpocapsae e.g.
  • Trichoderma asperellum SKT-1 e.g. ECO-HOPE® from Kumiai Chemical Industry Co., Ltd., Japan
  • T. atroviride LC52 e.g. SENTINEL® from Agrimm Technologies Ltd, NZ
  • T. fertile JM41 R NRRL 50759; e.g. RICHPLUSTM from Becker Underwood Bio Ag SA Ltd, South Africa
  • T. harzianum T-22 e.g. PLANTSHIELD® der Firma BioWorks Inc., USA
  • T. harzianum TH 35 e.g. ROOT PRO® from Mycontrol Ltd., Israel
  • T. harzianum T-39 e.g.
  • T. harzianum and T. viride e.g. TRICHOPEL from Agrimm Technologies Ltd, NZ
  • T. harzianum ICC012 and T. viride ICC080 e.g. REMEDIER® WP from Isagro Ricerca, Italy
  • T. polysporum and T. harzianum e.g. BINAB® from BINAB Bio-Innovation AB, Sweden
  • T. virens GL-21 also named Gliocladium virens
  • T. viride e.g. TRIECO® from Ecosense Labs. (India) Pvt. Ltd., Indien, BIO-CURE® F from T. Stanes & Co. Ltd., Indien
  • T. viride TV1 e.g. T. viride TV1 from Agribiotec srl, Italy
  • Ulocladium oudemansii HRU3 e.g. BOTRY-ZEN® from Botry-Zen Ltd, NZ.
  • Bacillus amyloliquefaciens AP-136 (NRRL B-50614), B. amyloliquefaciens AP-188 (NRRL B- 50615), B. amyloliquefaciens AP-218 (NRRL B-50618), B. amyloliquefaciens AP-219 (NRRL B- 50619), B. amyloliquefaciens AP-295 (NRRL B-50620), B. japonicum SEMIA 5079 (e.g. Gelfix 5 or Adhere 60 from Nitral Urbana Laoboratories, Brazil, a BASF Company), B. japonicum SEMIA 5080 (e.g. GELFIX 5 or ADHERE 60 from Nitral Urbana Laoboratories, Brazil, a BASF
  • B. mojavensis AP-209 No. NRRL B-50616
  • B. solisalsi AP-217 NRRL B-50617
  • B. pumilus strain INR-7 otherwise referred to as BU-F22 (NRRL B-50153) and BU-F33 (NRRL B-50185)
  • B. simplex ABU 288 NRRL B-50340
  • B. amyloliquefaciens subsp. plantarum MBI600 (NRRL B-50595) have been mentioned i.a. in US patent appl. 20120149571 , WO 2012/079073. Beauveria bassiana DSM 12256 is known from US200020031495.
  • Bradyrhizobium japonicum USDA is known from US patent 7,262,151. Sphaerodes
  • NRRL numbers refer to deposition numbers from strains deposited with the United States Department of Agriculture.
  • Bacillus amyloliquefaciens subsp. plantarum MBI600 having the accession number NRRL B- 50595 is deposited with the United States Department of Agriculture on Nov. 10, 201 1 under the strain designation Bacillus subtilis 1430. It has also been deposited at The National Collections of Industrial and Marine Bacteria Ltd. (NCIB), Torry Research Station, P.O. Box 31 , 135 Abbey Road, Aberdeen, AB9 8DG, Scotland under accession number 1237 on December 22, 1986.
  • Bacillus amyloliquefaciens MBI600 is known as plant growth-promoting rice seed treatment from Int. J. Microbiol. Res. ISSN 0975-5276, 3(2) (201 1 ), 120-130 and further described e.g.
  • strain MBI600 is commercially available as liquid formulation product Integral® (Becker-Underwood Inc., USA). Recently, the strain MBI 600 has been reclassified as Bacillus amyloliquefaciens subsp. plantarum based on polyphasic testing which combines classical microbiological methods relying on a mixture of traditional tools (such as culture-based methods) and molecular tools (such as genotyping and fatty acids analysis).
  • Bacillus subtilis MBI600 (or MBI 600 or MBI-600) is identical to Bacillus amyloliquefaciens subsp. plantarum MBI600, formerly Bacillus subtilis MBI600.
  • Metarhizium anisopliae IMI33 is commercially available from Becker Underwood as product Green Guard.
  • M. anisopliae var acridium strain IMI 330189 (NRRL-50758) is commercially available from Becker Underwood as product Green Muscle.
  • Bacillus subtilis strain FB17 was originally isolated from red beet roots in North America (System Appl. Microbiol 27 (2004) 372-379). This Bacillus subtilis strain promotes plant health (US 2010/0260735 A1 ; WO 201 1/109395 A2). B. subtilis FB17 has also been deposited at American Type Culture Collection (ATCC), Manassas, VA, USA, under accession number PTA- 1 1857 on April 26, 201 1 . Bacillus subtilis strain FB17 may also be referred to as UD1022 or UD10-22.
  • Bacillus amyloliquefaciens AP-136 (NRRL B-50614 and B-50330), B. amyloliquefaciens AP- 188 (NRRL B-50615 and B-50331 ), B. amyloliquefaciens AP-218 (NRRL B-50618), B. amyloliquefaciens AP-219 (NRRL B-50619 and B-50332), B. amyloliquefaciens AP-295 (NRRL B-50620 and B-50333), B. amyloliquefaciens subsp. plantarum MBI600 (NRRL B-50595), B. mojavensis AP-209 (No. NRRL B-50616), B.
  • pumilus INR-7 (otherwise referred to as BU-F22 (NRRL B-50153) and BU-F33 (NRRL B-50185)), B. simplex ABU 288 (NRRL B-50340), B. solisalsi AP-217 (NRRL B-50617) are known from US 8,445,255.
  • Jasmonic acid or salts (jasmonates) or derivatives include without limitation potassium jasmonate, sodium jasmonate, lithium jasmonate, ammonium jasmonate, dimethylammonium jasmonate, isopropylammonium jasmonate, diolammonium jasmonate,
  • Humates are humic and fulvic acids extracted from a form of lignite coal and clay, known as leonardite.
  • Humic acids are organic acids that occur in humus and other organically derived materials such as peat and certain soft coal. They have been shown to increase fertilizer efficiency in phosphate and micro-nutrient uptake by plants as well as aiding in the development of plant root systems.
  • the at least one biopesticide II is selected from the groups L1 ) to L6):
  • Microbial pesticides with fungicidal, bactericidal, viricidal and/or plant defense activator activity Ampelomyces quisqualis M-10, Aspergillus flavus NRRL 21882, Aureobasidium pullulans DSM 14940, A. pullulans DSM 14941 , Bacillus amyloliquefaciens AP-136
  • NRRL B-50614 B. amyloliquefaciens AP-188 (NRRL B-50615), B. amyloliquefaciens AP-218 (NRRL B-50618), B. amyloliquefaciens AP-219 (NRRL B-50619), B.
  • amyloliquefaciens AP-295 (NRRL B-50620), B. amyloliquefaciens IT-45 (CNCM I-3800, NCBI 1091041 ), B. amyloliquefaciens subsp. plantarum MBI600 (NRRL B-50595), B. mojavensis AP-209 (No. NRRL B-50616), B. pumilus INR-7 (otherwise referred to as BU-
  • B. pumilus KFP9F B. pumilus QST 2808 (NRRL B-30087), B. pumilus GHA 181 , B. simplex ABU 288 (NRRL B-50340), B. solisalsi AP-217 (NRRL B-50617), B. subtilis CX-9060, B. subtilis GB03, B. subtilis GB07, B. subtilis QST-713 (NRRL B-21661 ), B. subtilis var. amyloliquefaciens FZB23, B. subtilis var. amyloliquefaciens D747, Candida oleophila I-82, C. oleophila O, C. saitoana,
  • Pantoea agglomerans c91 Phlebiopsis gigantea, Pseudozyma flocculosa, Pythium oligandrum DV74, Sphaerodes mycoparasitica IDAC 301008-01 , Streptomyces lydicus WYEC 108, S. violaceusniger XL-2, S. violaceusniger YCED-9, Talaromyces flavus V1 17b, Trichoderma asperellum T34, T. asperellum SKT-1 , T. atroviride LC52, T. fertile JM41 R, T. gamsii, T. harmatum TH 382, T.
  • Biochemical pesticides with fungicidal, bactericidal, viricidal and/or plant defense activator activity chitosan (hydrolysate), laminarin, Menhaden fish oil, natamycin, Plum pox virus coat protein, Reynoutria sachlinensis extract, salicylic acid, tea tree oil;
  • nematicidal activity L-carvone, citral, (E,Z)-7,9-dodecadien-1 -yl acetate, ethyl formate, (E,Z)-2,4-ethyl decadienoate (pear ester), (Z,Z,E)-7,1 1 ,13-hexadecatrienal, heptyl butyrate, isopropyl myristate, lavanulyl senecioate, 2-methyl 1 -butanol, methyl eugenol, methyl jasmonate, (E,Z)-2,13-octadecadien-1 -ol, (E,Z)-2,13-octadecadien-1 -ol acetate, (E,Z)-3,13-octadecadien-1 -ol, R-1 -octen-3-ol, pentatermanone, potassium silicate, sorbito
  • BR 1 1002 A. Iipoferum BR 1 1646 (Sp31 ), A. irakense, A. halopraeferens, Bradyrhizobium sp. PNL01 , B. sp. (Arachis) CB1015, B. sp. (Arachis) USDA 3446, B. sp. (Arachis) SEMIA 6144, B. sp. (Arachis) SEMIA 6462, B. sp. (Arachis) SEMIA 6464, B. sp. (Vigna), B.
  • B. japonicum CPAC 15 B. japonicum E-109, B. japonicum G49, B. japonicum TA- 1 1 , B. japonicum USDA 3, B. japonicum USDA 31 , B. japonicum USDA 76, B. japonicum USDA 1 10, B. japonicum USDA 121 , B. japonicum USDA 123, B. japonicum USDA 136, B. japonicum SEMIA 566, B. japonicum SEMIA 5079, B. japonicum SEMIA 5080, B.
  • Biochemical pesticides with plant stress reducing, plant growth regulator and/or plant yield enhancing activity abscisic acid, aluminium silicate (kaolin), 3-decen-2-one,
  • homobrassinlide humates, methyl jasmonate, cis-jasmone, lysophosphatidyl ethanlamine, polymeric polyhydroxy acid, salicylic acid, Ascophyllum nodosum (Norwegian kelp, Brown kelp) extract and Ecklonia maxima (kelp) extract.
  • the mixtures comprise as component 4) fungicidal compounds that are independently of each other selected from the groups A), B), C), D), E), F), G), H), I), J), K) and L).
  • mixtures comprise as compound IV (component 4) a herbicidal compound that is selected from the group N), in particular glyphosate.
  • mixtures comprise as compound IV (component 4) an insecticidal compound that is selected from the group O).
  • mixtures comprise ascompound IV (component 4) at least one active substance selected from group A) and particularly selected from dimoxystrobin, kresoxim- methyl, orysastrobin, picoxystrobin, pyraclostrobin; famoxadone, fenamidone; benzovindiflupyr, bixafen, fluopyram, isopyrazam, penflufen, penthiopyrad, sedaxane; ametoctradin, cyazofamid, fentin salts, such as fentin acetate.
  • mixtures comprise as compound IV (component 4) at least one active substance selected from group B) and particularly selected from cyproconazole, difenoconazole, epoxiconazole, fluquinconazole, flusilazole, flutriafol, metconazole,
  • myclobutanil penconazole, propiconazole, prothioconazole, triadimefon, triadimenol, tebuconazole, tetraconazole, triticonazole, prochloraz, fenarimol, triforine; dodemorph, fenpropimorph, tridemorph, fenpropidin, spiroxamine; fenhexamid.
  • mixtures comprise as compound IV (component 4) at least one active substance selected from group C) and particularly selected from metalaxyl, (metalaxyl-M) mefenoxam, ofurace.
  • mixtures comprise as compound IV (component 4) at least one active substance selected from group D) and particularly selected from benomyl, carbendazim, thiophanate-methyl, ethaboxam, fluopicolide, zoxamide, metrafenone, pyriofenone.
  • mixtures comprise as compound IV (component 4) at least one active substance selected from group E) and particularly selected from cyprodinil, mepanipyrim, pyrimethanil.
  • mixtures comprise as compound IV (component 4) at least one active substance selected from group F) and particularly selected from iprodione, fludioxonil, vinclozolin, quinoxyfen.
  • mixtures comprise as compound IV (component 4) at least one active substance selected from group G) and particularly selected from dimethomorph, flumorph, iprovalicarb, benthiavalicarb, mandipropamid, propamocarb.
  • mixtures comprise as component 4) at least one active substance selected from group H) and particularly selected from copper acetate, copper hydroxide, copper oxychloride, copper sulfate, sulfur, mancozeb, metiram, propineb, thiram, captafol, folpet, chlorothalonil, dichlofluanid, dithianon.
  • mixtures comprise as compound IV (component 4) at least one active substance selected from group I) and particularly selected from carpropamid and fenoxanil.
  • mixtures comprise as compound IV (component 4) at least one active substance selected from group J) and particularly selected from acibenzolar-S-methyl, probenazole, tiadinil, fosetyl, fosetyl-aluminium, H3PO3 and salts thereof.
  • mixtures comprise as compound IV (component 4) at least one active substance selected from group K) and particularly selected from cymoxanil, proquinazid and A/-methyl-2- ⁇ 1 -[(5-methyl-3-trifluoromethyl-1 H-pyrazol-1 -yl)-acetyl]-piperidin-4-yl ⁇ -A/-[(1 R)- 1 ,2,3,4-tetrahydronaphthalen-1 -yl]-4-thiazolecarboxamide.
  • the present invention furthermore relates to agrochemical compositions comprising a mixture comprising as component 4) at least one biopesticide selected from the group L), in particular at least one further fungicidal biopesticide selected from the groups L1 ) and L2), as described above, and if desired at least one suitable auxiliary.
  • mixtures comprise as biopesticide IV (component 4) a
  • biopesticide from group L1 preferably selected from Bacillus amyloliquefaciens AP-136 (NRRL B-50614 and B-50330), B. amyloliquefaciens AP-188 (NRRL B-50615 and B-50331 ), B.
  • amyloliquefaciens AP-218 (NRRL B-50618), B. amyloliquefaciens AP-219 (NRRL B-50619 and B-50332), B. amyloliquefaciens AP-295 (NRRL B-50620 and B-50333), B. amyloliquefaciens IT- 45 (CNCM I-3800, NCBI 1091041 ), B. amyloliquefaciens subsp. plantarum MBI600 (NRRL B- 50595), B. mojavensis AP-209 (No. NRRL B-50616), B.
  • pumilus INR-7 (otherwise referred to as BU-F22 (NRRL B-50153) and BU-F33 (NRRL B-50185)), B. pumilus KFP9F, B. pumilus QST 2808 (NRRL B-30087), B. pumilus GHA 181 , B. simplex ABU 288 (NRRL B-50340), B. solisalsi AP-217 (NRRL B-50617), B. subtilis CX-9060, B. subtilis GB03, B. subtilis GB07, B. subtilis QST-713 (NRRL B-21661 ), B. subtilis var. amyloliquefaciens FZB23, B. subtilis var.
  • amyloliquefaciens AP-188 (NRRL B-50615), B. amyloliquefaciens AP-218 (NRRL B-50618), B. amyloliquefaciens AP-219 (NRRL B-50619), B. amyloliquefaciens AP-295 (NRRL B-50620), B. amyloliquefaciens IT-45 (CNCM I-3800, NCBI 1091041 ), B. mojavensis AP-209 (No. NRRL B- 50616), B. pumilus INR-7 (otherwise referred to as BU-F22 (NRRL B-50153) and BU-F33 (NRRL B-50185)), B.
  • pumilus QST 2808 (NRRL B-30087), B. simplex ABU 288 (NRRL B- 50340), B. subtilis QST-713 (NRRL B-21661 ), B. subtilis MBI600 (NRRL B-50595),
  • Paenibacillus alvei NAS6G6 Sphaerodes mycoparasitica IDAC 301008-01 and Trichoderma fertile J M41 R.
  • biopesticide IV component 4
  • a biopesticide from group L2 preferably selected from chitosan (hydrolysate), methyl-jasmonate, cis-jasmone, laminarin, Reynoutria sachlinensis extract and tea tree oil.
  • biopesticide II component 3 a biopesticide from group L3), preferably selected from Agrobacterium radiobacter K1026, Bacillus firmus I- 1582, Bacillus thuringiensis ssp. kurstaki SB4, Beauveria bassiana GHA, B. bassiana H 123, B. bassiana DSM 12256, B. bassiana PPRI 5339, Metarhizium anisopliae var. acridum IMI 330189, M. anisopliae FI-985, M. anisopliae FI-1045, M. anisopliae F52, M.
  • mixtures comprise as biopesticide II (component 2) a biopesticide from group L4), preferably selected from methyl jasmonate, Acacia negra extract, extract of grapefruit seeds and pulp, Catnip oil, Neem oil, Quillay extract and Tagetes oil.
  • mixtures comprise as biopesticide IV (component 4) a
  • biopesticide from group L5) preferably selected from Azospirillum amazonense BR 1 1 140 (SpY2T), A. brasilense XOH, A. brasilense BR 1 1005 (Sp245), A. brasilense BR 1 1002, A. lipoferum BR 1 1646 (Sp31 ), A. irakense, A. halopraeferens, Bacillus amyloliquefaciens AP-136 (NRRL B-50614), Bradyrhizobium sp. (Vigna), B. japonicum USDA 3, B. japonicum USDA 31 , B. japonicum USDA 76, B. japonicum USDA 1 10, B. japonicum USDA 121 , Glomus intraradices RTI-801 , Paenibacillus alvei NAS6G6, Penicillium bilaiae, Rhizobium leguminosarum bv.
  • phaseolii R. I. trifolii, R. I. bv. viciae, and Sinorhizobium meliloti, more preferably selected from Azospirillum brasilense BR 1 1005 (Sp245), Bradyrhizobium sp. (Vigna), B. japonicum USDA 3, B. japonicum USDA 31 , B. japonicum USDA 76, B. japonicum USDA 1 10, B. japonicum USDA 121 , Rhizobium leguminosarum bv. phaseolii, R. I. trifolii, R. I. bv. viciae SU303, R. I. bv. viciae WSM1455, and Sinorhizobium meliloti.
  • mixtures comprise as biopesticide IV (component 4) a
  • biopesticide from group L6 preferably selected from abscisic acid, aluminium silicate (kaolin), humates, Ascophyllum nodosum (Norwegian kelp, Brown kelp) extract and Ecklonia maxima (kelp) extract.
  • inventive mixtures comprising as biopesticide IV a microbial pesticide from groups L1 ), L3) and L5) may be formulated as an inoculant for a plant.
  • inoculant means a preparation that includes an isolated culture of a microbial pesticide and optionally a carrier, which may include a biologically acceptable medium.
  • mixtures and compositions according to the invention are suitable as fungicides. They are distinguished by an outstanding effectiveness against a broad spectrum of phytopathogenic fungi, including soil-borne fungi, which derive especially from the classes of the
  • Some are systemically effective and they can be used in crop protection as foliar fungicides, fungicides for seed dressing and soil fungicides. Moreover, they are suitable for controlling harmful fungi, which inter alia occur in wood or roots of plants.
  • the mixtures and compositions according to the invention are particularly important in the control of a multitude of phytopathogenic fungi on various cultivated plants, such as cereals, e. g. wheat, rye, barley, triticale, oats or rice; beet, e. g. sugar beet or fodder beet; fruits, such as pomes, stone fruits or soft fruits, e. g.
  • cereals e. g. wheat, rye, barley, triticale, oats or rice
  • beet e. g. sugar beet or fodder beet
  • fruits such as pomes, stone fruits or soft fruits, e. g.
  • inventive mixtures and compositions are used for controlling a multitude of fungi on field crops, such as potatoes sugar beets, tobacco, wheat, rye, barley, oats, rice, corn, cotton, soybeans, rape, legumes, sunflowers, coffee or sugar cane; fruits; vines; ornamentals; or vegetables, such as cucumbers, tomatoes, beans or squashes. Even more preferably the inventive mixtures and compositions are used for controlling a multitude of fungi on soybean.
  • field crops such as potatoes sugar beets, tobacco, wheat, rye, barley, oats, rice, corn, cotton, soybeans, rape, legumes, sunflowers, coffee or sugar cane; fruits; vines; ornamentals; or vegetables, such as cucumbers, tomatoes, beans or squashes.
  • inventive mixtures and compositions are used for controlling a multitude of fungi on soybean.
  • plant propagation material is to be understood to denote all the generative parts of the plant such as seeds and vegetative plant material such as cuttings and tubers (e. g.
  • potatoes which can be used for the multiplication of the plant. This includes seeds, roots, fruits, tubers, bulbs, rhizomes, shoots, sprouts and other parts of plants, including seedlings and young plants, which are to be transplanted after germination or after emergence from soil.
  • These young plants may also be protected before transplantation by a total or partial treatment by immersion or pouring.
  • treatment of plant propagation materials with the inventive combination of compound I, compound II and fluazinam as defined herein and compositions thereof, respectively, is used for controlling a multitude of fungi on cereals, such as wheat, rye, barley and oats; rice, corn, cotton and soybeans.
  • cultiva plants is to be understood as including plants which have been modified by breeding, mutagenesis or genetic engineering including but not limiting to agricultural biotech products on the market or in development (cf. http://cera-gmc.org/, see GM crop database therein).
  • Genetically modified plants are plants, which genetic material has been so modified by the use of recombinant DNA techniques that under natural circumstances cannot readily be obtained by cross breeding, mutations or natural recombination.
  • one or more genes have been integrated into the genetic material of a genetically modified plant in order to improve certain properties of the plant.
  • Such genetic modifications also include but are not limited to targeted post-transtional modification of protein(s), oligo- or polypeptides e. g. by glycosylation or polymer additions such as prenylated, acetylated or farnesylated moieties or PEG moieties.
  • inventive mixtures and compositions are particularly suitable for controlling the following plant diseases:
  • Albugo spp. white rust
  • vegetables e. g. A. Candida
  • sunflowers e. g. A. tragopogonis
  • Altemaria spp. Alternaria leaf spot) on vegetables, rape (A. brassicola or brassicae), sugar beets (A. tenuis), fruits, rice, soybeans, potatoes (e. g. A. solani or A.
  • alternata tomatoes (e. g. A. solani or A. alternata) and wheat; Aphanomyces spp. on sugar beets and vegetables; Ascochyta spp. on cereals and vegetables, e. g. A. tritici (anthracnose) on wheat and A. hordei on barley; Bipolaris and Drechslera spp. (teleomorph: Cochliobolus spp.) on corn (e. g. D. maydis), cereals (e. g. B. sorokiniana: spot blotch), rice (e. g. B.
  • Ceratocystis (syn. Ophiostoma) spp. (rot or wilt) on broad-leaved trees and evergreens, e. g. C. ulmi (Dutch elm disease) on elms; Cercospora spp. (Cercospora leaf spots) on corn, rice, sugar beets (e. g. C. beticola), sugar cane, vegetables, coffee, soybeans (e. g. C. sojina or C. kikuchii) and rice; Cladosporium spp. on tomatoes (e. g. C. fulvum: leaf mold) and cereals, e. g. C. herbarum (black ear) on wheat; Claviceps purpurea (ergot) on cereals; Cochliobolus
  • anamorph Helminthosporium of Bipolaris
  • spp. leaf spots
  • corn C. carbonum
  • cereals e. g. C. sativus, anamorph: B. sorokiniana
  • rice e. g. C. miyabeanus, anamorph: H.
  • teleomorph Nectria or Neonectria spp.
  • fruit trees canker or young vine decline
  • teleomorph Nectria or Neonectria spp.
  • fruit trees canker or young vine decline
  • teleomorph Nectria or Neonectria spp.
  • vines e. g. C. liriodendri, teleomorph: Neonectria liriodendri: Black Foot Disease
  • Dematophora teleomorph: Rosellinia necatrix (root and stem rot) on soybeans
  • Diaporthe spp. e. g. D. phaseolorum (damping off) on soybeans
  • Drechslera sertraolorum
  • Phaeomoniella chlamydospora (earlier Phaeoacremonium chlamydosporum)
  • fujikuroi Bakanae disease
  • G. gossypii Gossypii on cotton
  • Grainstaining complex on rice Guignardia bidwellii (black rot) on vines
  • Helminthosporium spp. (syn. Drechslera, teleomorph: Cochliobolus) on corn, cereals and rice; Hemileia spp., e. g. H.
  • Monilinia spp. e. g. M. laxa, M. fructicola and M. fructigena (bloom and twig blight, brown rot) on stone fruits and other rosaceous plants; Mycosphaerella spp. on cereals, bananas, soft fruits and ground nuts, such as e. g. M. graminicola (anamorph: Septoria tritici, Septoria blotch) on wheat or M. fijiensis (black Sigatoka disease) on bananas; Peronospora spp. (downy mildew) on cabbage (e. g. P. brassicae), rape (e. g. P. parasitica), onions (e. g. P.
  • soybeans e. g. P. gregata: stem rot
  • Phoma lingam root and stem rot
  • P. betae root rot, leaf spot and damping-off
  • sugar beets e. g. P. viticola: can and leaf spot
  • soybeans e. g. stem rot: P.
  • phaseoli, teleomorph Diaporthe phaseolorum
  • Physoderma maydis brown spots
  • Phytophthora spp. wilt, root, leaf, fruit and stem root
  • various plants such as paprika and cucurbits (e. g. P. capsici), soybeans (e. g. P. megasperma, syn. P. sojae), potatoes and tomatoes (e. g. P. infestans: late blight) and broad-leaved trees (e. g. P. ramorum: sudden oak death); Plasmodiophora brassicae (club root) on cabbage, rape, radish and other plants;
  • Plasmopara spp. e. g. P. viticola (grapevine downy mildew) on vines and P. halstedii on sunflowers; Podosphaera spp. (powdery mildew) on rosaceous plants, hop, pome and soft fruits, e. g. P. leucotricha on apples; Polymyxa spp., e. g. on cereals, such as barley and wheat (P. graminis) and sugar beets (P. betae) and thereby transmitted viral diseases;
  • Pseudocercosporella herpotrichoides eyespot, teleomorph: Tapesia yallundae
  • cereals e. g. wheat or barley
  • Pseudoperonospora downy mildew
  • Pseudopezicula tracheiphila red fire disease or .rotbrenner', anamorph: Phialophora
  • Puccinia spp. rusts
  • striiformis stripe or yellow rust
  • P. hordei dwarf rust
  • P. graminis seed or black rust
  • P. recondita brown or leaf rust
  • cereals such as e. g. wheat, barley or rye, and asparagus (e. g. P. asparagi); Pyrenophora (anamorph: Drechslera) tritici-repentis (tan spot) on wheat or P. feres (net blotch) on barley; Pyricularia spp., e. g. P. oryzae (teleomorph: Magnaporthe grisea, rice blast) on rice and P. grisea on turf and cereals; Pythium spp.
  • solani (sheath blight) on rice or R. cerealis (Rhizoctonia spring blight) on wheat or barley; Rhizopus stolonifer (black mold, soft rot) on strawberries, carrots, cabbage, vines and tomatoes;
  • Rhynchosporium secalis (scald) on barley, rye and triticale; Sarocladium oryzae and S.
  • Attenuatum (sheath rot) on rice; Sclerotinia spp. (stem rot or white mold) on vegetables and field crops, such as rape, sunflowers (e. g. S. sclerotiorum) and soybeans (e. g. S. rolfsii or S.
  • Septoria spp. on various plants, e. g. S. glycines (brown spot) on soybeans, S. tritici (Septoria blotch) on wheat and S. (syn. Stagonospora) nodorum (Stagonospora blotch) on cereals; Uncinula (syn. Erysiphe) necator (powdery mildew, anamorph: Oidium tuckeri) on vines; Setospaeria spp. (leaf blight) on corn (e. g. S. turcicum, syn.
  • Sphacelotheca spp. (smut) on corn, (e. g. S. reiliana: head smut), sorghum und sugar cane; Sphaerotheca fuliginea (powdery mildew) on cucurbits; Spongospora subterranea (powdery scab) on potatoes and thereby transmitted viral diseases; Stagonospora spp. on cereals, e. g. S. nodorum (Stagonospora blotch, teleomorph: Leptosphaeria [syn.
  • Taphrina spp. e. g. T. deformans (leaf curl disease) on peaches and T. pruni (plum pocket) on plums
  • Thielaviopsis spp. black root rot
  • controversa dwarf bunt
  • Typhula incarnata grey snow mold
  • Urocystis spp. e. g. U. occulta (stem smut) on rye
  • Uromyces spp. rust on vegetables, such as beans (e. g. U. appendiculatus, syn. U. phaseoli) and sugar beets (e. g. U. betae)
  • Ustilago spp. loose smut) on cereals (e. g. U. nuda and U. avaenae), corn (e. g. U. maydis: corn smut) and sugar cane; Venturia spp.
  • the inventive mixtures and compositions are used for controlling Sclerotinia spp. (stem rot or white mold) on apples (e. g. V. inaequalis) and pears; and Verticillium spp. (wilt) on various plants, such as fruits and ornamentals, vines, soft fruits, vegetables and field crops, e. g. V. dahliae on strawberries, rape, potatoes and tomatoes.
  • the inventive mixtures and compositions are used for controlling Sclerotinia spp. (stem rot or white mold) on
  • vegetables and field crops such as rape, sunflowers (e. g. S. sclerotiorum) and soybeans (e. g. S. rolfsii or S. sclerotiorum). More preferably, the inventive mixtures and compositions are used for controlling Sclerotinia sclerotiorum (white mold) on vegetables and field crops, such as rape, sunflowers and soybeans; in particular on soybeans.
  • Plant propagation materials may be treated with the mixtures and compositions of the invention prophylactically either at or before planting or transplanting.
  • the invention also relates to agrochemical compositions comprising an auxiliary and at least one inhibitor of complex II, pyraclostrobin and fluazinam according to the invention.
  • An agrochemical composition comprises a fungicidally effective amount of an inhibitor of complex II, pyraclostrobin and fluazinam.
  • effective amount denotes an amount of the composition or of the mixtures according to the invention, which is sufficient for controlling harmful fungi on cultivated plants or in the protection of materials and which does not result in a substantial damage to the treated plants. Such an amount can vary in a broad range and is dependent on various factors, such as the fungal species to be controlled, the treated cultivated plant or material, the climatic conditions and the specific mixture used.
  • the components 1 ), 2) and 3) can be converted into customary types of agrochemical compositions, e. g. solutions, emulsions, suspensions, dusts, powders, pastes, granules, pressings, capsules, and mixtures thereof.
  • agrochemical compositions e.g. solutions, emulsions, suspensions, dusts, powders, pastes, granules, pressings, capsules, and mixtures thereof.
  • composition types are suspensions (e.g. SC, OD, FS), emulsifiable concentrates (e.g. EC), emulsions (e.g. EW, EO, ES, ME), capsules (e.g. CS, ZC), pastes, pastilles, wettable powders or dusts (e.g. WP, SP, WS, DP, DS), pressings (e.g.
  • compositions types are defined in the "Catalogue of pesticide formulation types and international coding system", Technical Monograph No. 2, 6 th Ed. May 2008, CropLife International.
  • compositions are prepared in a known manner, such as described by Mollet and Grubemann, Formulation technology, Wiley VCH, Weinheim, 2001 ; or Knowles, New
  • Suitable auxiliaries are solvents, liquid carriers, solid carriers or fillers, surfactants, dispersants, emulsifiers, wetters, adjuvants, solubilizers, penetration enhancers, protective colloids, adhesion agents, thickeners, humectants, repellents, attractants, feeding stimulants, compatibilizers, bactericides, anti-freezing agents, anti-foaming agents, colorants, tackifiers and binders.
  • Suitable solvents and liquid carriers are water and organic solvents, such as mineral oil fractions of medium to high boiling point, e.g. kerosene, diesel oil; oils of vegetable or animal origin; aliphatic, cyclic and aromatic hydrocarbons, e. g. toluene, paraffin,
  • tetrahydronaphthalene alkylated naphthalenes
  • alcohols e.g. ethanol, propanol, butanol, benzylalcohol, cyclohexanol
  • glycols DMSO
  • ketones e.g. cyclohexanone
  • esters e.g. lactates, carbonates, fatty acid esters, gamma-butyrolactone
  • fatty acids phosphonates
  • amines amides, e.g. N-methylpyrrolidone, fatty acid dimethylamides; and mixtures thereof.
  • Suitable solid carriers or fillers are mineral earths, e.g. silicates, silica gels, talc, kaolins, limestone, lime, chalk, clays, dolomite, diatomaceous earth, bentonite, calcium sulfate, magnesium sulfate, magnesium oxide; polysaccharides, e.g. cellulose, starch; fertilizers, e.g. ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas; products of vegetable origin, e.g. cereal meal, tree bark meal, wood meal, nutshell meal, and mixtures thereof.
  • mineral earths e.g. silicates, silica gels, talc, kaolins, limestone, lime, chalk, clays, dolomite, diatomaceous earth, bentonite, calcium sulfate, magnesium sulfate, magnesium oxide
  • polysaccharides e.g. cellulose, starch
  • fertilizers
  • Suitable surfactants are surface-active compounds, such as anionic, cationic, nonionic and amphoteric surfactants, block polymers, polyelectrolytes, and mixtures thereof. Such surfactants can be used as emusifier, dispersant, solubilizer, wetter, penetration enhancer, protective colloid, or adjuvant. Examples of surfactants are listed in McCutcheon's, Vol.1 : Emulsifiers & Detergents, McCutcheon's Directories, Glen Rock, USA, 2008 (International Ed. or North American Ed.).
  • Suitable anionic surfactants are alkali, alkaline earth or ammonium salts of sulfonates, sulfates, phosphates, carboxylates, and mixtures thereof.
  • sulfonates are alkylarylsulfonates, diphenylsulfonates, alpha-olefin sulfonates, lignine sulfonates, sulfonates of fatty acids and oils, sulfonates of ethoxylated alkylphenols, sulfonates of alkoxylated
  • tridecylbenzenes sulfonates of naphthalenes and alkylnaphthalenes, sulfosuccinates or sulfosuccinamates.
  • sulfates are sulfates of fatty acids and oils, of ethoxylated alkylphenols, of alcohols, of ethoxylated alcohols, or of fatty acid esters.
  • phosphates are phosphate esters.
  • carboxylates are alkyl carboxylates, and carboxylated alcohol or alkylphenol ethoxylates.
  • Suitable nonionic surfactants are alkoxylates, N-subsituted fatty acid amides, amine oxides, esters, sugar-based surfactants, polymeric surfactants, and mixtures thereof.
  • alkoxylates are compounds such as alcohols, alkylphenols, amines, amides, arylphenols, fatty acids or fatty acid esters which have been alkoxylated with 1 to 50 equivalents.
  • Ethylene oxide and/or propylene oxide may be employed for the alkoxylation, preferably ethylene oxide.
  • N-subsititued fatty acid amides are fatty acid glucamides or fatty acid
  • esters are fatty acid esters, glycerol esters or monoglycerides.
  • sugar-based surfactants are sorbitans, ethoxylated sorbitans, sucrose and glucose esters or alkylpolyglucosides.
  • polymeric surfactants are home- or copolymers of vinylpyrrolidone, vinylalcohols, or vinylacetate.
  • Suitable cationic surfactants are quaternary surfactants, for example quaternary ammonium compounds with one or two hydrophobic groups, or salts of long-chain primary amines.
  • Suitable amphoteric surfactants are alkylbetains and imidazolines.
  • Suitable block polymers are block polymers of the A-B or A-B-A type comprising blocks of polyethylene oxide and polypropylene oxide, or of the A-B-C type comprising alkanol, polyethylene oxide and polypropylene oxide.
  • Suitable polyelectrolytes are polyacids or polybases.
  • polyacids are alkali salts of polyacrylic acid or polyacid comb polymers.
  • polybases are polyvinylamines or polyethyleneamines.
  • Suitable adjuvants are compounds, which have a neglectable or even no pesticidal activity themselves, and which improve the biological performance of the mixture on the target.
  • Suitable thickeners are polysaccharides (e.g. xanthan gum, carboxymethylcellulose), anorganic clays (organically modified or unmodified), polycarboxylates, and silicates.
  • Suitable bactericides are bronopol and isothiazolinone derivatives such as alkyliso- thiazolinones and benzisothiazolinones.
  • Suitable anti-freezing agents are ethylene glycol, propylene glycol, urea and glycerin.
  • Suitable anti-foaming agents are silicones, long chain alcohols, and salts of fatty acids.
  • Suitable colorants are pigments of low water solubility and water- soluble dyes.
  • examples are inorganic colorants (e.g. iron oxide, titan oxide, iron
  • organic colorants e.g. alizarin-, azo- and phthalocyanine colorants.
  • Suitable tackifiers or binders are polyvinylpyrrolidone, polyvinylacetates, polyvinyl alcohols, polyacrylates, biological or synthetic waxes, and cellulose ethers.
  • the agrochemical compositions generally comprise between 0.01 and 95%, preferably between 0.1 and 90%, and in particular between 0.5 and 75%, by weight of active substances.
  • the active substances are employed in a purity of from 90% to 100%, preferably from 95% to 100% (according to NMR spectrum).
  • Solutions for seed treatmenr (LS), Suspoemulsions (SE), flowable concentrates (FS), powders for dry treatment (DS), water-dispersible powders for slurry treatment (WS), water- soluble powders (SS), emulsions (ES), emulsifiable concentrates (EC) and gels (GF) are usually employed for the purposes of treatment of plant propagation materials, particularly seeds.
  • the compositions in question give, after two-to-tenfold dilution, active substance concentrations of from 0.01 to 60% by weight, preferably from 0.1 to 40%, in the ready-to-use preparations.
  • Methods for applying or treating the fungicidal mixtures and compositions thereof, respectively, on to plant propagation material, especially seeds include dressing, coating, pelleting, dusting, soaking and in-furrow application methods of the propagation material.
  • the fungicidal mixtures or the compositions thereof, respectively are applied on to the plant propagation material by a method such that germination is not induced, e. g. by seed dressing, pelleting, coating and dusting.
  • the amounts of active substances are, depending on the kind of effect desired, usually from 0.001 to 2 kg per ha, preferably from 0.005 to 2 kg per ha, more preferably from 0.05 to 0.9 kg per ha, even more preferably from 0.1 to 0.8 kg per ha, and in particular from 0.25 to 0.75 kg per ha.
  • amounts of active substance of from 0.1 to 1000 g, preferably from 1 to 1000 g, more preferably from 1 to 100 g and most preferably from 5 to 100 g, per 100 kilogram of plant propagation material (preferably seed) are generally required.
  • the amount of active substance applied depends on the kind of application area and on the desired effect. Amounts customarily applied in the protection of materials are 0.001 g to 2 kg, preferably 0.005 g to 1 kg, of active substance per cubic meter of treated material.
  • oils, wetters, adjuvants, fertilizer, or micronutrients may be added to the active substances or the compositions comprising them as premix or, if
  • compositions according to the invention can be admixed with the compositions according to the invention in a weight ratio of 1 :100 to 100:1 , preferably 1 :10 to 10:1 .
  • Biopesticides are typically created by growing and concentrating naturally occurring organisms and/or their metabolites including bacteria and other microbes, fungi, viruses, nematodes, proteins, etc. They are often considered to be important components of integrated pest management (IPM) programmes.
  • IPM integrated pest management
  • Biopesticides fall into two major classes, microbial and biochemical pesticides:
  • Microbial pesticides consist of bacteria, fungi or viruses (and often include the
  • Entomopathogenic nematodes are also classed as microbial pesticides, even though they are multi-cellular.
  • Biochemical pesticides are naturally occurring substances that control pests or provide other crop protection uses as defined below, but are relatively non-toxic to mammals.
  • composition according to the invention such as parts of a kit or parts of a binary or ternary mixture may be mixed by the user himself in a spray tank or any other kind of vessel used for applications (e.g seed treater drums, seed pelleting machinery, knapsack sprayer) and further auxiliaries may be added, if appropriate.
  • a spray tank or any other kind of vessel used for applications (e.g seed treater drums, seed pelleting machinery, knapsack sprayer) and further auxiliaries may be added, if appropriate.
  • one embodiment of the invention is a kit for preparing a usable pesticidal composition, the kit compring a) a composition comprising component 1 ) as defined herein and at least one auxiliary; and b) a composition comprising component 2) as defined herein and at least one auxiliary; c) a composition comprising component 3) as defined herein and at least one auxiliary; and optionally d) a composition comprising a component 4) as defined herein and at least one auxiliary.
  • the user applies the composition according to the invention usually from a predosage device, a knapsack sprayer, a spray tank, a spray plane, or an irrigation system.
  • the agrochemical composition is made up with water, buffer, and/or further auxiliaries to the desired application concentration and the ready-to-use spray liquor or the agrochemical composition according to the invention is thus obtained.
  • 20 to 2000 liters, preferably 50 to 400 liters, of the ready-to-use spray liquor are applied per hectare of agricultural useful area.
  • the mixtures comprising at least one compound I and at least one biochemical pesticide selected from groups L2), L4) and L6) as defined herein can be prepared as compositions comprising besides the active ingredients at least one inert ingredient (auxiliary) by usual means, e. g. by the means given for the compositions of compounds I. Concerning usual ingredients of such compositions reference is made to the explanations given for the
  • compositions containing compounds I are provided.
  • the microbial pesticides selected from groups L1 ), L3) and L5) embrace not only the isolated, pure cultures of the respective micro-organism as defined herein, but also its cell-free extract, its suspensions in a whole broth culture or as a metabolite- containing supernatant or a purified metabolite obtained from a whole broth culture of the microorganism or microorganism strain.
  • the microbial pesticides selected from groups L1 ), L3 and L5) embraces not only the isolated, pure cultures of the respective micro-organism as defined herein, but also a cell-free extract thereof or at least one metabolite thereof, and/or a mutant of the respective micro-organism having all the identifying characteristics thereof and also a cell-free extract or at least one metabolite of the mutant.
  • Whole broth culture refers to a liquid culture containing both cells and media.
  • Supernatant refers to the liquid broth remaining when cells grown in broth are removed by centrifugation, filtration, sedimentation, or other means well known in the art.
  • cell-free extract refers to an extract of the vegetative cells, spores and/or the whole culture broth of a microorganism comprising cellular metabolites produced by the respective microorganism obtainable by cell disruption methods known in the art such as solvent-based (e.g. organic solvents such as alcohols sometimesin combination with suitable salts), temperature-based, application of shear forces, cell disrupotion with an ultrasonicator.
  • solvent-based e.g. organic solvents such as alcohols sometimesin combination with suitable salts
  • temperature-based e.g. temperature-based
  • shear forces e.g. cell disrupotion with an ultrasonicator.
  • the desired extract may be concentrated by conventional concentration techniques such as drying, evaporation, centrifugation or alike. Certain washing steps using organic solents and/or water-based media may also be applied to the crude extract preferably prior to use.
  • metabolite refers to any compound, substance or byproduct produced by a microorganism (such as fungi and bacteria) that has improves plant growth, water use efficiency of the plant, plant health, plant appearance, or the population of beneficial microorganisms in the soil around the plant activity.
  • a microorganism such as fungi and bacteria
  • mutant refers a microorganism obtained by direct mutant selection but also includes microorganisms that have been further mutagenized or otherwise manipulated (e.g., via the introduction of a plasmid). Accordingly, embodiments include mutants, variants, and or derivatives of the respective microorganism, both naturally occurring and artificially induced mutants. For example, mutants may be induced by subjecting the microorganism to known mutagens, such as N-methyl-nitrosoguanidine, using conventional methods.
  • compositions comprising cell-free extracts and/or metabolites of microbial pesticides selected from groups L1 ), L3) and L5) as defined herein can be prepared as compositions comprising besides the active ingredients at least one inert ingredient by usual means, e. g. by the means given for the compositions of compounds I. Concerning usual ingredients of such compositions reference is made to the explanations given for the compositions containing compounds I.
  • the mixtures comprising at least one compound I and cells, spores and/or whole broth culture of at least one microbial pesticide selected from groups L1 ), L3) and L5) as defined herein can be prepared as compositions comprising besides the active ingredients at least one inert ingredient (auxiliary) by usual means (see e.g. H.D. Burges: Formulation of Micobial
  • compositions of compounds I e.g. by the means given for the compositions of compounds I.
  • suitable customary types of such compositions are suspensions, dusts, powders, pastes, granules, pressings, capsules, and mixtures thereof.
  • composition types are suspensions (e.g. SC, OD, FS), capsules (e.g. CS, ZC), pastes, pastilles, wettable powders or dusts (e.g. WP, SP, WS, DP, DS), pressings (e.g. BR, TB, DT), granules (e.g. WG, SG, GR,
  • FG, GG, MG insecticidal articles
  • LN insecticidal articles
  • gel formulations for the treatment of plant propagation materials such as seeds (e.g. GF).
  • the compound ratios e. g. compound l/compound ll/fluazinam ratio
  • the compound ratios are advantageously chosen so as to produce a synergistic effect.
  • the components can be used individually or already partially or completely mixed with one another to prepare the composition according to the invention. It is also possible for them to be packaged and used as combination such as a kit of parts.
  • compositions according to the invention can be shown by the tests described below.
  • the active compounds are prepared as a stock solution comprising 25 mg of active compound which is made up to 10 ml using a mixture of acetone and/or DMSO and the emulsifier Uniperol ® EL (wetting agent having an emulsifying and dispersing action based on ethoxylated alkylphenols) in a ratio by volume of solvent/emulsifier of 99:1 .
  • the mixture is then made up to 100 ml with water. This stock solution is diluted with the
  • the visually determined percentages of infected leaf areas are converted into efficacies in % of the untreated control.
  • the efficacy (E) is calculated as follows using Abbot's formula:
  • a corresponds to the fungicidal infection of the treated plants in %
  • ⁇ corresponds to the fungicidal infection of the untreated (control) plants in %
  • An efficacy of 0 means that the infection level of the treated plants corresponds to that of the untreated control plants; an efficacy of 100 means that the treated plants were not infected.
  • Colby's formula can also be extended to be directly applied to 3-way mixtures (Colby, S.R. "Calculating synergistic and antagonistic responses of herbicide combinations", Weeds, 1J5, pp. 20-22, 1967):
  • the active compounds were formulated separately as a stock solution having a
  • the product orysastrobin was used as commercial finished formulation and diluted with water to the stated concentration of the active compound.
  • the stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations.
  • MTP micro titer plate
  • a spore suspension of the respective pathogen in the respective nutrient medium was then added.
  • the plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation.
  • the measured parameters were compared to the growth of the active compound-free control variant (100%) and the fungus-free and active compound-free blank value to determine the relative growth in % of the pathogens in the respective active compounds. These percentages were converted into efficacies. Colby's formula for 3-way and 2-way mixtures were applied as described in Weeds, 15, pp. 20-22, 1967.
  • Boscalid 1 16 1 40 39 Pyraclostrobin 0.063
  • Boscalid 1 63 1 15 13 Pyraclostrobin 0.016
  • Boscalid 4 16 1 75 72 Pyraclostrobin 0.25
  • Boscalid 4 63 1 8 4 Fluazinam 0.063
  • Boscalid 4 63 1 58 39 Pyraclostrobin 0.063
  • Boscalid 4 63 1 8 4 Fluazinam 0.063 Calculated
  • Boscalid 1 4 1 75 72

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The present invention relates to fungicidal ternary mixtures comprising at least one inhibitor of complex II and at least one inhibitor of complex III at Qo site as defined herein and fluazinam, to composition comprising said mixtures and to the use and to methods for combating phytopathogenic fungi. The present invention also relates to seeds treated with at least one such mixture. Furthermore the invention relates to processes for preparing mixtures and compositions of such mixtures.

Description

FUNGICIDAL TERNARY MIXTURES COMPRISING FLUAZINAM
Description The present invention relates to fungicidal ternary mixtures comprising at least one inhibitor of complex II and at least one inhibitor of complex III at Q0 site as defined herein and fluazinam, to composition comprising said mixtures and to the use and to methods for combating phytopathogenic fungi. The present invention also relates to seeds treated with at least one such mixture. Furthermore the invention relates to processes for preparing mixtures and compositions of such mixtures.
Binary mixtures of the inhibitor of complex II boscalid with one of the inhibitors of complex III at Qo site pyraclostrobin, azoxystrobin, fluoxastrobin or trifloxystrobin or with fluazinam have been mentioned in WO 98/08385 and WO 99/31981 , respectively. Further, WO 2007/017416 mentions inter alia binary fungicidal mixtures of the inhibitor of complex II fluxapyroxad with one of the inhibitors of complex III at Q0 site pyraclostrobin, azoxystrobin, fluoxastrobin or trifloxystrobin or with fluazinam.
Practical agricultural experience has shown that the repeated and exclusive application of an individual active compound or a binary mixture in the control of harmful fungi leads in many cases to a rapid selection of those fungus strains which have developed natural or adapted resistance against the active compound in question. Effective control of these fungi with the active compound and/or binary mixture in question is then no longer possible.
To reduce the risk of the selection of resistant fungus strains, mixtures of more than two different active compounds are employed for controlling harmful fungi. By combining at least three active compounds having different mechanisms of action, it is possible to ensure successful control over a relatively long period of time.
It is an object of the present invention to provide, with a view to effective resistance management and effective control of phytopathogenic harmful fungi, at application rates which are as low as possible, compositions which, at a reduced total amount of active compounds applied, have improved activity against the harmful fungi (synergistic mixtures) and a broadened activty spectrum, in particular for certain indications.
We have accordingly found that this object is achieved by the mixtures and compositions, defined herein, comprising at least one compound I as defined herein, at least one compound II as defined herein and fluazinam.
Moreover, we have found that simultaneous, that is joint or separate, application of a compound I, a compound II and fluazinam or successive application of a compound I, a compound II and fluazinam allows better control of harmful fungi than is possible with the binary mixtures or the individual compounds alone (synergistic mixtures).
The invention also relates to a method for controlling phytopathogenic harmful fungi using mixtures of at least one inhibitor of complex II as defined herein and pyraclostrobin and fluazinam and to the use of a compound I and a compound II and fluazinam for preparing such mixtures, and to compositions comprising these mixtures and seed comprising these mixtures or coated with this this mixture. Thus, the present invention relates to mixtures comprising, as active components
1 ) at least one compound I selected from:
fluxapyroxad, boscalid, benzovindiflupyr, bixafen, fluopyram, furametpyr, isopyrazam, penflufen, penthiopyrad, sedaxane, thifluzamide, N-(4'-trifluoromethylthiobiphenyl-2-yl)-
3- difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxamide, N-(2-(1 ,3,3-trimethyl-butyl)- phenyl)-1 ,3-dimethyl-5-fluoro-1 H-pyrazole-4-carboxamide, 3-(difluoromethyl)-1 -methyl- N-(1 ,1 ,3-trimethylindan-4-yl)pyrazole-4-carboxamide, 3-(trifluoromethyl)-1 -methyl-N-
(1 ,1 ,3-trimethylindan-4-yl)pyrazole-4-carboxamide, 1 ,3-dimethyl-N-(1 ,1 ,3-trimethylindan- 4-yl)pyrazole-4-carboxamide, 3-(trifluoromethyl)-1 ,5-dimethyl-N-(1 ,1 ,3-trimethylindan-
4- yl)pyrazole-4-carboxamide, 3-(difluoromethyl)-1 ,5-dimethyl-N-(1 ,1 ,3-trimethylindan- 4-yl)pyrazole-4-carboxamide and 1 ,3,5-trimethyl-N-(1 ,1 ,3-trimethylindan-4-yl)pyrazole-4- carboxamide;
and
2) at least one compound II selected from:
pyraclostrobin, azoxystrobin, fluoxastrobin and trifloxystrobin; and
3) fluazinam.
According to one embodiment, these ternary mixtures comprise the component 1 ), component 2) and component 3) in a synergistically effective amount.
In the ternary mixtures according to the invention, i.e. compositions comprising one compound I (component 1 ) and one compound II (component 2) and fluazinam (component 3), the weight ratio of compound I (component 1 ) and compound II (component 2) depends from the properties of the active substances used, usually it is in the range of from 1 :50 to 50:1 , regularly in the range of from 1 :20 to 20:1 , preferably in the range of from 1 :10 to 10:1 , more preferably in the range of from 1 :4 to 4:1 and in particular in the range of from 1 :2 to 2:1 , and the weight ratio of compound I (component 1 ) and fluazinam (component 3) usually it is in the range of from 1 :50 to 50:1 , regularly in the range of from 1 :20 to 20:1 , preferably in the range of from 1 :10 to 10:1 , more preferably in the range of from 1 :4 to 4:1 and in particular in the range of from 1 :2 to 2:1. According to a further embodiment, the weight ratio of component 1 ) and component 2) is in the range of from 20:1 to 1 :20 and the weight ratio of component 1 ) and component 3) is in the range of from 1 :1 to 1 :50.
In the ternary mixtures according to the invention, i.e. compositions comprising one compound I selected from boscalid, fluxapyroxad and benzovindiflupyr (as component 1 ) and one compound II selected from pyraclostrobin and azoxystrobin (component 2) and fluazinam (component 3), the weight ratio of compound I (component 1 ) and compound II (component 2) depends from the properties of the active substances used, usually it is in the range of from 0.5:1 to 1 :5, regularly in the range of from 1 :1 to 1 :3, preferably in the range of from 1 :1 .5 to 1 :3, and in particular in the range of 1 :2, and the weight ratio of compound I (component 1 ) and fluazinam (component 3) usually it is in the range of from 1 :1 to 1 :50, regularly in the range of from 1 :5 to 1 :25, preferably in the range of from 1 :5 to 1 :15 and in particular in the range of 1 :10.
Any further active compounds (components 4) are, if desired, added in a weight ratio of from 20:1 to 1 :20 to the compound I (component 1 ).
The compounds I and/or compounds II can be present in different crystal modifications, which may differ in biological activity.
According to one embodiment, in the inventive mixtures the compound I is selected from fluxapyroxad, boscalid, benzovindiflupyr and sedaxane. According to another embodiment, in the inventive mixtures the compound I is selected from fluxapyroxad, boscalid and
benzovindiflupyr. According to a further embodiment, in the inventive mixtures the compound I is selected from fluxapyroxad and boscalid. According to a further embodiment, in the inventive mixtures the compound I is boscalid. According to a further embodiment, in the inventive mixtures the compound I is fluxapyroxad.
According to one embodiment, in the inventive mixtures the compound II is selected from pyraclostrobin and azoxystrobin. According to another embodiment, in the inventive mixtures the compound II is pyraclostrobin.
The mixtures and compositions thereof according to the invention can, in the use form as fungicides, also be present together with other active substances, e. g. with herbicides, insecticides, growth regulators, fungicides or else with fertilizers, as pre-mix or, if appropriate, not until immeadiately prior to use (tank mix).
Mixing the inventive ternary mixtures and the compositions comprising them, respectively, in the use form as fungicides with other fungicides results in many cases in an expansion of the fungicidal spectrum of activity being obtained or in a prevention of fungicide resistance develop- ment. Furthermore, in many cases, additional synergistic effects are obtained.
According to the present invention, it may be preferred that the mixtures comprise besides a compound I, a compound II and fluazinam a compound IV (component 4) a further active compound, preferably in a synergistically effective amount. Another embodiment relates to mixtures wherein the compound IV (component 4) is an active compound selected from groups A) to O):
The following list of active components (e.g. active substances and biopesticides), in conjunction with which the compounds I can be used, is intended to illustrate the possible combinations but does not limit them:
A) Respiration inhibitors
- Inhibitors of complex III at Q0 site (e.g. strobilurins): azoxystrobin, coumethoxystrobin,
coumoxystrobin, dimoxystrobin, enestroburin, fenaminstrobin, fenoxy- strobin/flufenoxystrobin, fluoxastrobin, kresoxim-methyl, mandestrobine, metominostrobin, orysastrobin, picoxystrobin, pyraclostrobin, pyrametostrobin, pyraoxystrobin, trifloxystrobin and 2-(2-(3-(2,6-dichlorophenyl)-1 -methyl-allylideneaminooxymethyl)-phenyl)-2- methoxyimino-N-methyl-acetamide, pyribencarb, triclopyricarb/chlorodincarb, famoxadone, fenamidone;
- inhibitors of complex III at Q, site: cyazofamid, amisulbrom, [(3S,6S,7R,8R)-8-benzyl-3-[(3- acetoxy-4-methoxy-pyridine-2-carbonyl)amino]-6-methyl-4,9-dioxo-1 ,5-dioxonan-7-yl] 2-methylpropanoate, [(3S,6S,7R,8R)-8-benzyl-3-[[3-(acetoxymethoxy)-4-methoxy-pyridine-
2- carbonyl]amino]-6-methyl-4,9-dioxo-1 ,5-dioxonan-7-yl] 2-methylpropanoate,
[(3S,6S,7R,8R)-8-benzyl-3-[(3-isobutoxycarbonyloxy-4-methoxy-pyridine-2-carbonyl)amino]- 6-methyl-4,9-dioxo-1 ,5-dioxonan-7-yl] 2-methylpropanoate, [(3S,6S,7R,8R)-8-benzyl-3-[[3- (1 ,3-benzodioxol-5-ylmethoxy)-4-methoxy-pyridine-2-carbonyl]amino]-6-methyl-4,9-dioxo- 1 ,5-dioxonan-7-yl] 2-methylpropanoate; (3S,6S,7R,8R)-3-[[(3-hydroxy-4-methoxy-2- pyridinyl)carbonyl]amino]-6-methyl-4,9-dioxo-8-(phenylmethyl)-1 ,5-dioxonan-7-yl 2- methylpropanoate
- inhibitors of complex II (e. g. carboxamides): benodanil, benzovindiflupyr, bixafen, boscalid, carboxin, fenfuram, fluopyram, flutolanil, fluxapyroxad, furametpyr, isofetamid, isopyrazam, mepronil, oxycarboxin, penflufen, penthiopyrad, sedaxane, tecloftalam, thifluzamide, N-(4'- trifluoromethylthiobiphenyl-2-yl)-3-difluoromethyl-1-methyl-1 H-pyrazole-4-carboxamide, N-(2- (1 ,3,3-trimethyl-butyl)-phenyl)-1 ,3-dimethyl-5-fluoro-1 H-pyrazole-4-carboxamide,
3- (difluoromethyl)-1 -methyl-N-(1 ,1 ,3-trimethylindan-4-yl)pyrazole-4-carboxamide,
3-(trifluoromethyl)-1 -methyl-N-(1 ,1 ,3-trimethylindan-4-yl)pyrazole-4-carboxamide, 1 ,3- dimethyl-N-(1 ,1 ,3-trimethylindan-4-yl)pyrazole-4-carboxamide, 3-(trifluoromethyl)-1 ,5- dimethyl-N-(1 ,1 ,3-trimethylindan-4-yl)pyrazole-4-carboxamide, 1 ,3,5-trimethyl-N-(1 ,1 ,3- trimethylindan-4-yl)pyrazole-4-carboxamide, N-(7-fluoro-1 ,1 ,3-trimethyl-indan-4-yl)-1 ,3- dimethyl-pyrazole-4-carboxamide, N-[2-(2,4-dichlorophenyl)-2-methoxy-1 -methyl-ethyl]-3- (difluoromethyl)-l -methyl-pyrazole-4-carboxamide;
- other respiration inhibitors (e.g. complex I, uncouplers): diflumetorim, (5,8-difluoroquinazolin-
4- yl)-{2-[2-fluoro-4-(4-trifluoromethylpyridin-2-yloxy)-phenyl]-ethyl}-amine; nitrophenyl derivates: binapacryl, dinobuton, dinocap, fluazinam; ferimzone; organometal compounds: fentin salts, such as fentin-acetate, fentin chloride or fentin hydroxide; ametoctradin; and silthiofam;
B) Sterol biosynthesis inhibitors (SBI fungicides)
- C14 demethylase inhibitors (DMI fungicides): triazoles: azaconazole, bitertanol,
bromuconazole, cyproconazole, difenoconazole, diniconazole, diniconazole-M,
epoxiconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, oxpoconazole, paclobutrazole, penconazole, propiconazole, prothioconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, uniconazole,
1 - [re/-(2S;3R)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)-oxiranylmethyl]-5-thiocyanato-1 H- [1 ,2,4]triazole, 2-[re/-(2S;3R)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)-oxiranylmethyl]- 2H-[1 ,2,4]triazole-3-thiol, 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1 -(1 ,2,4-triazol-1 -yl)pentan-
2- ol, 1 -[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1 -cyclopropyl-2-(1 ,2,4-triazol-1 - yl)ethanol, 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1 -(1 ,2,4-triazol-1 -yl)butan-2-ol, 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1 -(1 ,2,4-triazol-1 -yl)butan-2-ol, 2-[4-(4- chlorophenoxy)-2-(trifluoromethyl)phenyl]-3-methyl-1 -(1 ,2,4-triazol-1 -yl)butan-2-ol, 2-[4-(4- chlorophenoxy)-2-(trifluoromethyl)phenyl]-1 -(1 ,2,4-triazol-1 -yl)propan-2-ol, 2-[2-chloro-4-(4- chlorophenoxy)phenyl]-3-methyl-1 -(1 ,2,4-triazol-1 -yl)butan-2-ol, 2-[4-(4-chlorophenoxy)-2- (trifluoromethyl)phenyl]-1 -(1 ,2,4-triazol-1 -yl)pentan-2-ol, 2-[4-(4-fluorophenoxy)-2- (trifluoromethyl)phenyl]-1 -(1 ,2,4-triazol-1 -yl)propan-2-ol; imidazoles: imazalil, pefurazoate, prochloraz, triflumizol; pyrimidines, pyridines and piperazines: fenarimol, nuarimol, pyrifenox, triforine, [3-(4-chloro-2-fluoro-phenyl)-5-(2,4-difluorophenyl)isoxazol-4-yl]-(3- pyridyl)methanol;
- Delta14-reductase inhibitors: aldimorph, dodemorph, dodemorph-acetate, fenpropimorph, tridemorph, fenpropidin, piperalin, spiroxamine;
- Inhibitors of 3-keto reductase: fenhexamid;
C) Nucleic acid synthesis inhibitors
- phenylamides or acyl amino acid fungicides: benalaxyl, benalaxyl-M, kiralaxyl, metalaxyl, metalaxyl-M (mefenoxam), ofurace, oxadixyl;
- others: hymexazole, octhilinone, oxolinic acid, bupirimate, 5-fluorocytosine, 5-fluoro-2-(p- tolylmethoxy)pyrimidin-4-amine, 5-fluoro-2-(4-fluorophenylmethoxy)pyrimidin-4-amine;
D) Inhibitors of cell division and cytoskeleton
- tubulin inhibitors, such as benzimidazoles, thiophanates: benomyl, carbendazim,
fuberidazole, thiabendazole, thiophanate-methyl; triazolopyrimidines: 5-chloro-7-(4-methyl- piperidin-1 -yl)-6-(2,4,6-trifluorophenyl)-[1 ,2,4]triazolo[1 ,5-a]pyrimidine
- other cell division inhibitors: diethofencarb, ethaboxam, pencycuron, fluopicolide, zoxamide, metrafenone, pyriofenone;
E) Inhibitors of amino acid and protein synthesis
- methionine synthesis inhibitors (anilino-pyrimidines): cyprodinil, mepanipyrim, pyrimethanil; - protein synthesis inhibitors: blasticidin-S, kasugamycin, kasugamycin hydrochloride-hydrate, mildiomycin, streptomycin, oxytetracyclin, polyoxine, validamycin A;
F) Signal transduction inhibitors
- MAP / histidine kinase inhibitors: fluoroimid, iprodione, procymidone, vinclozolin, fenpiclonil, fludioxonil;
- G protein inhibitors: quinoxyfen;
G) Lipid and membrane synthesis inhibitors
- Phospholipid biosynthesis inhibitors: edifenphos, iprobenfos, pyrazophos, isoprothiolane;
- lipid peroxidation: dicloran, quintozene, tecnazene, tolclofos-methyl, biphenyl, chloroneb, etridiazole;
- phospholipid biosynthesis and cell wall deposition: dimethomorph, flumorph,
mandipropamid, pyrimorph, benthiavalicarb, iprovalicarb, valifenalate and N-(1 -(1 -(4-cyano- phenyl)ethanesulfonyl)-but-2-yl) carbamic acid-(4-fluorophenyl) ester;
- compounds affecting cell membrane permeability and fatty acides: propamocarb, propamo- carb-hydrochlorid
- fatty acid amide hydrolase inhibitors: oxathiapiprolin;
H) Inhibitors with Multi Site Action
- inorganic active substances: Bordeaux mixture, copper acetate, copper hydroxide, copper oxychloride, basic copper sulfate, sulfur;
- thio- and dithiocarbamates: ferbam, mancozeb, maneb, metam, metiram, propineb, thiram, zineb, ziram;
- organochlorine compounds (e.g. phthalimides, sulfamides, chloronitriles): anilazine,
chlorothalonil, captafol, captan, folpet, dichlofluanid, dichlorophen, hexachlorobenzene, pentachlorphenole and its salts, phthalide, tolylfluanid, N-(4-chloro-2-nitro-phenyl)-N-ethyl-4- methyl-benzenesulfonamide;
- guanidines and others: guanidine, dodine, dodine free base, guazatine, guazatine-acetate, iminoctadine, iminoctadine-triacetate, iminoctadine-tris(albesilate), dithianon, 2,6-dimethyl- 1 H,5H-[1 ,4]dithiino[2,3-c:5,6-c']dipyrrole-1 ,3,5,7(2H,6H)-tetraone;
I) Cell wall synthesis inhibitors
- inhibitors of glucan synthesis: validamycin, polyoxin B; melanin synthesis inhibitors:
pyroquilon, tricyclazole, carpropamid, dicyclomet, fenoxanil;
J) Plant defence inducers
- acibenzolar-S-methyl, probenazole, isotianil, tiadinil, prohexadione-calcium; phosphonates: fosetyl, fosetyl-aluminum, phosphorous acid and its salts;
K) Unknown mode of action
- bronopol, chinomethionat, cyflufenamid, cymoxanil, dazomet, debacarb, diclomezine,
difenzoquat, difenzoquat-methylsulfate, diphenylamin, fenpyrazamine, flumetover, flusulfamide, flutianil, methasulfocarb, nitrapyrin, nitrothal-isopropyl, oxathiapiprolin, tolprocarb, 2-[3,5-bis(difluoromethyl)-1 H-pyrazol-1 -yl]-1 -[4-(4-{5-[2-(prop-2-yn-1 - yloxy)phenyl]-4,5-dihydro-1 ,2-oxazol-3-yl}-1 ,3-thiazol-2-yl)piperidin-1 -yl]ethanone, 2-[3,5- bis(difluoromethyl)-1 H-pyrazol-1 -yl]-1 -[4-(4-{5-[2-fluoro-6-(prop-2-yn-1 -yloxy)phenyl]-4,5- dihydro-1 ,2-oxazol-3-yl}-1 ,3-thiazol-2-yl)piperidin-1 -yl]ethanone, 2-[3,5-bis(difluoromethyl)- 1 H-pyrazol-1 -yl]-1 -[4-(4-{5-[2-chloro-6-(prop-2-yn-1 -yloxy)phenyl]-4,5-dihydro-1 ,2-oxazol-3- yl}-1 ,3-thiazol-2-yl)piperidin-1 -yl]ethanone, oxin-copper, proquinazid, tebufloquin, tecloftalam, triazoxide, 2-butoxy-6-iodo-3-propylchromen-4-one, N-(cyclo- propylmethoxyimino-(6-difluoro-methoxy-2,3-difluoro-phenyl)-methyl)-2-phenyl acetamide, N'-(4-(4-chloro-3-trifluoromethyl-phenoxy)-2,5-dimethyl-phenyl)-N-ethyl-N-methyl formamidine, N'-(4-(4-fluoro-3-trifluoromethyl-phenoxy)-2,5-dimethyl-phenyl)-N-ethyl-N- methyl formamidine, N'-(2-methyl-5-trifluoromethyl-4-(3-trimethylsilanyl-propoxy)-phenyl)-N- ethyl-N-methyl formamidine, N'-(5-difluoromethyl-2-methyl-4-(3-trimethylsilanyl-propoxy)- phenyl)-N-ethyl-N-methyl formamidine, methoxy-acetic acid 6-tert-butyl-8-fluoro-2,3- dimethyl-quinolin-4-yl ester, 3-[5-(4-methylphenyl)-2,3-dimethyl-isoxazolidin-3-yl]-pyridine, 3-[5-(4-chloro-phenyl)-2,3-dimethyl-isoxazolidin-3-yl]-pyridine (pyrisoxazole),
N-(6-methoxy-pyridin-3-yl) cyclopropanecarboxylic acid amide, 5-chloro-1 -(4,6-dimethoxy- pyrimidin-2-yl)-2-methyl-1 H-benzoimidazole, 2-(4-chloro-phenyl)-
N-[4-(3,4-dimethoxy-phenyl)-isoxazol-5-yl]-2-prop-2-ynyloxy-acetamide, ethyl (Z)-3-amino-2- cyano-3-phenyl-prop-2-enoate, tert-butyl N-[6-[[(Z)-[(1 -methyltetrazol-5-yl)-phenyl- methylene]amino]oxymethyl]-2-pyridyl]carbamate, pentyl N-[6-[[(Z)-[(1 -methyltetrazol-5-yl)- phenyl-methylene]amino]oxymethyl]-2-pyridyl]carbamate, 2-[2-[(7,8-difluoro-2-methyl-3- quinolyl)oxy]-6-fluoro-phenyl]propan-2-ol, 2-[2-fluoro-6-[(8-fluoro-2-methyl-3- quinolyl)oxy]phenyl]propan-2-ol, 3-(5-fluoro-3,3,4,4-tetramethyl-3,4-dihydroisoquinolin-1 - yl)quinoline, 3-(4,4-difluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1 -yl)quinoline, 3-(4,4,5- trifluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1 -yl)quinoline;
L) Biopesticides
L1 ) Microbial pesticides with fungicidal, bactericidal, viricidal and/or plant defense activator activity: Ampelomyces quisqualis, Aspergillus flavus, Aureobasidium pullulans, Bacillus amyloliquefaciens, B. mojavensis, B. pumilus, B. simplex, B. solisalsi, B. subtilis, B. subtilis var. amyloliquefaciens, Candida oleophila, C. saitoana, Clavibacter
michiganensis (bacteriophages), Coniothyrium minitans, Cryphonectria parasitica, Cryptococcus albidus, Fusarium oxysporum, Clonostachys rosea f. catenulate (also named Gliocladium catenulatum), Gliocladium roseum, Metschnikowia fructicola, Microdochium dimerum, Paenibacillus polymyxa, Pantoea agglomerans, Phlebiopsis gigantea, Pseudozyma flocculosa, Pythium oligandrum, Sphaerodes mycoparasitica, Streptomyces lydicus, S. violaceusniger, Talaromyces flavus, Trichoderma asperellum, T. atroviride, T. fertile, T. gamsii, T. harmatum; mixture of T. harzianum and T. viride; mixture of T. polysporum and T. harzianum; T. stromaticum, T. virens (also named Gliocladium virens), T. viride, Typhula phacorrhiza, Ulocladium oudema, U. oudemansii,
Verticillium dahlia, zucchini yellow mosaic virus (avirulent strain);
L2) Biochemical pesticides with fungicidal, bactericidal, viricidal and/or plant defense
activator activity: chitosan (hydrolysate), laminarin, Menhaden fish oil, natamycin, Plum pox virus coat protein, Reynoutria sachlinensis extract, salicylic acid, tea tree oil;
L3) Microbial pesticides with insecticidal, acaricidal, molluscidal and/or nematicidal activity:
Agrobacterium radiobacter, Bacillus firmus, B. thuringiensis ssp. israelensis, B. t. ssp. galleriae, B. t. ssp. kurstaki, Beauveria bassiana, Burkholderia sp., Chromobacterium subtsugae, Cydia pomonella granulosis virus, Isaria fumosorosea, Heterorhabditis bacteriophora, Lecanicillium longisporum, L. muscarium (formerly Verticillium lecanii), Metarhizium anisopliae, M. anisopliae var. acridum, Paecilomyces fumosoroseus, P. lilacinus, Paenibacillus poppiliae, Pasteuria spp., P. nishizawae, P. reneformis, P.
usagae, Pseudomonas fluorescens, Steinernema carpocapsae, S. feltiae, S. kraussei, Streptomces galbus;
L4) Biochemical pesticides with insecticidal, acaricidal, molluscidal, pheromone and/or nematicidal activity: L-carvone, citral, (E,Z)-7,9-dodecadien-1 -yl acetate, ethyl formate,
(E,Z)-2,4-ethyl decadienoate (pear ester), (Z,Z,E)-7,1 1 ,13-hexadecatrienal, heptyl butyrate, isopropyl myristate, lavanulyl senecioate, 2-methyl 1 -butanol, methyl eugenol, methyl jasmonate, (E,Z)-2,13-octadecadien-1 -ol, (E,Z)-2,13-octadecadien-1 -ol acetate, (E,Z)-3,13-octadecadien-1 -ol, R-1 -octen-3-ol, pentatermanone, potassium silicate, sorbitol actanoate, (E,Z,Z)-3,8,1 1 -tetradecatrienyl acetate, (Z,E)-9,12-tetradecadien-1 -yl acetate, Z-7-tetradecen-2-one, Z-9-tetradecen-1 -yl acetate, Z-1 1 -tetradecenal, Z-1 1 - tetradecen-1 -ol, Acacia negra extract, extract of grapefruit seeds and pulp, extract of Chenopodium ambrosiodae, Catnip oil, Neem oil, Quillay extract, Tagetes oil;
L5) Microbial pesticides with plant stress reducing, plant growth regulator, plant growth promoting and/or yield enhancing activity: Azospirillum amazonense A. brasilense, A. lipoferum, A. irakense, A. halopraeferens, Bradyrhizobium sp., B. elkanii, B. japonicum, B. liaoningense, B. lupini, Glomus intraradices, Mesorhizobium sp., Paenibacillus alvei, Penicillium bilaiae, Rhizobium leguminosarum bv. phaseolii, R. I. trifolii, R. I. bv. viciae P1 NP3Cst, Sinorhizobium meliloti;
L6) Biochemical pesticides with plant stress reducing, plant growth regulator and/or plant yield enhancing activity: abscisic acid, aluminium silicate (kaolin), 3-decen-2-one, homobrassinlide, humates, jasmonic acid or salts or derivatives thereof,
lysophosphatidyl ethanolamine, polymeric polyhydroxy acid, Ascophyllum nodosum (Norwegian kelp, Brown kelp) extract and Ecklonia maxima (kelp) extract. M) Growth regulators
abscisic acid, amidochlor, ancymidol, 6-benzylaminopurine, brassinolide, butralin, chlormequat (chlormequat chloride), choline chloride, cyclanilide, daminozide, dikegulac, dimethipin, 2,6- dimethylpuridine, ethephon, flumetralin, flurprimidol, fluthiacet, forchlorfenuron, gibberellic acid, inabenfide, indole-3-acetic acid , maleic hydrazide, mefluidide, mepiquat (mepiquat chloride), naphthaleneacetic acid, N-6-benzyladenine, paclobutrazol, prohexadione (prohexadione- calcium), prohydrojasmon, thidiazuron, triapenthenol, tributyl phosphorotrithioate,
2,3,5-tri-iodobenzoic acid , trinexapac-ethyl and uniconazole;
N) Herbicides
- acetamides: acetochlor, alachlor, butachlor, dimethachlor, dimethenamid, flufenacet,
mefenacet, metolachlor, metazachlor, napropamide, naproanilide, pethoxamid, pretilachlor, propachlor, thenylchlor;
- amino acid derivatives: bilanafos, glyphosate, glufosinate, sulfosate;
- aryloxyphenoxypropionat.es: clodinafop, cyhalofop-butyl, fenoxaprop, fluazifop, haloxyfop, metamifop, propaquizafop, quizalofop, quizalofop-P-tefuryl;
- Bipyridyls: diquat, paraquat;
- (thio)carbamates: asulam, butylate, carbetamide, desmedipham, dimepiperate, eptam
(EPTC), esprocarb, molinate, orbencarb, phenmedipham, prosulfocarb, pyributicarb, thiobencarb, triallate;
- cyclohexanediones: butroxydim, clethodim, cycloxydim, profoxydim, sethoxydim,
tepraloxydim, tralkoxydim;
- dinitroanilines: benfluralin, ethalfluralin, oryzalin, pendimethalin, prodiamine, trifluralin;
- diphenyl ethers: acifluorfen, aclonifen, bifenox, diclofop, ethoxyfen, fomesafen, lactofen, oxyfluorfen;
- hydroxybenzonitriles: bomoxynil, dichlobenil, ioxynil;
- imidazolinones: imazamethabenz, imazamox, imazapic, imazapyr, imazaquin, imazethapyr;
- phenoxy acetic acids: clomeprop, 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4-DB,
dichlorprop, MCPA, MCPA-thioethyl, MCPB, Mecoprop;
- pyrazines: chloridazon, flufenpyr-ethyl, fluthiacet, norflurazon, pyridate;
- pyridines: aminopyralid, clopyralid, diflufenican, dithiopyr, fluridone, fluroxypyr, picloram, picolinafen, thiazopyr;
- sulfonyl ureas: amidosulfuron, azimsulfuron, bensulfuron, chlorimuron-ethyl, chlorsulfuron, cinosulfuron, cyclosulfamuron, ethoxysulfuron, flazasulfuron, flucetosulfuron, flupyrsulfuron, foramsulfuron, halosulfuron, imazosulfuron, iodosulfuron, mesosulfuron, metazosulfuron, metsulfuron-methyl, nicosulfuron, oxasulfuron, primisulfuron, prosulfuron, pyrazosulfuron, rimsulfuron, sulfometuron, sulfosulfuron, thifensulfuron, triasulfuron, tribenuron,
trifloxysulfuron, triflusulfuron, tritosulfuron, 1 -((2-chloro-6-propyl-imidazo[1 ,2-b]pyridazin-3- yl)sulfonyl)-3-(4,6-dimethoxy-pyrimidin-2-yl)urea;
- triazines: ametryn, atrazine, cyanazine, dimethametryn, ethiozin, hexazinone, metamitron, metribuzin, prometryn, simazine, terbuthylazine, terbutryn, triaziflam;
- ureas: chlorotoluron, daimuron, diuron, fluometuron, isoproturon, linuron, metha- benzthiazuron,tebuthiuron; - other acetolactate synthase inhibitors: bispyribac-sodium, cloransulam-methyl, diclosulam, florasulam, flucarbazone, flumetsulam, metosulam, ortho-sulfamuron, penoxsulam, propoxycarbazone, pyribambenz-propyl, pyribenzoxim, pyriftalid, pyriminobac-methyl, pyrimisulfan, pyrithiobac, pyroxasulfone, pyroxsulam;
- others: amicarbazone, aminotriazole, anilofos, beflubutamid, benazolin,
bencarbazone,benfluresate, benzofenap, bentazone, benzobicyclon, bicyclopyrone, bromacil, bromobutide, butafenacil, butamifos, cafenstrole, carfentrazone, cinidon-ethyl, chlorthal, cinmethylin, clomazone, cumyluron, cyprosulfamide, dicamba, difenzoquat, diflufenzopyr, Drechslera monoceras, endothal, ethofumesate, etobenzanid, fenoxasulfone, fentrazamide, flumiclorac-pentyl, flumioxazin, flupoxam, flurochloridone, flurtamone, indanofan, isoxaben, isoxaflutole, lenacil, propanil, propyzamide, quinclorac, quinmerac, mesotrione, methyl arsonic acid, naptalam, oxadiargyl, oxadiazon, oxaziclomefone, pentoxazone, pinoxaden, pyraclonil, pyraflufen-ethyl, pyrasulfotole, pyrazoxyfen,
pyrazolynate, quinoclamine, saflufenacil, sulcotrione, sulfentrazone, terbacil, tefuryltrione, tembotrione, thiencarbazone, topramezone, (3-[2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4- trifluoromethyl-3,6-dihydro-2H-pyrimidin-1 -yl)-phenoxy]-pyridin-2-yloxy)-acetic acid ethyl ester, 6-amino-5-chloro-2-cyclopropyl-pyrimidine-4-carboxylic acid methyl ester, 6-chloro-3- (2-cyclopropyl-6-methyl-phenoxy)-pyridazin-4-ol, 4-amino-3-chloro-6-(4-chloro-phenyl)-5- fluoro-pyridine-2-carboxylic acid, 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxy-phenyl)- pyridine-2-carboxylic acid methyl ester, and 4-amino-3-chloro-6-(4-chloro-3-dimethylamino- 2-fluoro-phenyl)-pyridine-2-carboxylic acid methyl ester.
O) Insecticides
- organo(thio)phosphates: acephate, azamethiphos, azinphos-methyl, chlorpyrifos,
chlorpyrifos-methyl, chlorfenvinphos, diazinon, dichlorvos, dicrotophos, dimethoate, disulfoton, ethion, fenitrothion, fenthion, isoxathion, malathion, methamidophos,
methidathion, methyl-parathion, mevinphos, monocrotophos, oxydemeton-methyl, paraoxon, parathion, phenthoate, phosalone, phosmet, phosphamidon, phorate, phoxim, pirimiphos- methyl, profenofos, prothiofos, sulprophos, tetrachlorvinphos, terbufos, triazophos, trichlorfon;
- carbamates: alanycarb, aldicarb, bendiocarb, benfuracarb, carbaryl, carbofuran,
carbosulfan, fenoxycarb, furathiocarb, methiocarb, methomyl, oxamyl, pirimicarb, propoxur, thiodicarb, triazamate;
- pyrethroids: allethrin, bifenthrin, cyfluthrin, cyhalothrin, cyphenothrin, cypermethrin, alpha- cypermethrin, beta-cypermethrin, zeta-cypermethrin, deltamethrin, esfenvalerate, etofenprox, fenpropathrin, fenvalerate, imiprothrin, lambda-cyhalothrin, permethrin, prallethrin, pyrethrin I and II, resmethrin, silafluofen, tau-fluvalinate, tefluthrin, tetramethrin, tralomethrin, transfluthrin, profluthrin, dimefluthrin;
- insect growth regulators: a) chitin synthesis inhibitors: benzoylureas: chlorfluazuron,
cyramazin, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, teflubenzuron, triflumuron; buprofezin, diofenolan, hexythiazox, etoxazole, clofentazine; b) ecdysone antagonists: halofenozide, methoxyfenozide, tebufenozide, azadirachtin; c) juvenoids: pyriproxyfen, methoprene, fenoxycarb; d) lipid biosynthesis inhibitors:
spirodiclofen, spiromesifen, spirotetramat; - nicotinic receptor agonists/antagonists compounds: clothianidin, dinotefuran, flupyradifurone, imidacloprid, thiamethoxam, nitenpyram, acetamiprid, thiacloprid, 1 -2-chloro-thiazol-5- ylmethyl)-2-nitrimino-3,5-dimethyl-[1 ,3,5]triazinane;
- GABA antagonist compounds: endosulfan, ethiprole, fipronil, vaniliprole, pyrafluprole,
pyriprole, 5-amino-1 -(2,6-dichloro-4-methyl-phenyl)-4-sulfinamoyl-1 H-pyrazole-3-carbothioic acid amide;
- macrocyclic lactone insecticides: abamectin, emamectin, milbemectin, lepimectin, spinosad, spinetoram;
- mitochondrial electron transport inhibitor (METI) I acaricides: fenazaquin, pyridaben,
tebufenpyrad, tolfenpyrad, flufenerim;
- METI II and III compounds: acequinocyl, fluacyprim, hydramethylnon;
- Uncouplers: chlorfenapyr;
- oxidative phosphorylation inhibitors: cyhexatin, diafenthiuron, fenbutatin oxide, propargite;
- moulting disruptor compounds: cryomazine;
- mixed function oxidase inhibitors: piperonyl butoxide;
- sodium channel blockers: indoxacarb, metaflumizone;
- ryanodine receptor inhibitors: chlorantraniliprole, cyantraniliprole, flubendiamide, N-[4,6- dichloro-2-[(diethyl-lambda-4-sulfanylidene)carbamoyl]-phenyl]-2-(3-chloro-2-pyridyl)-5- (trifluoromethyl)pyrazole-3-carboxamide; N-[4-chloro-2-[(diethyl-lambda-4- sulfanylidene)carbamoyl]-6-methyl-phenyl]-2-(3-chloro-2-pyridyl)-5-(trifluoromethyl)pyrazole- 3-carboxamide; N-[4-chloro-2-[(di-2-propyl-lambda-4-sulfanylidene)carbamoyl]-6-methyl- phenyl]-2-(3-chloro-2-pyridyl)-5-(trifluoromethyl)pyrazole-3-carboxamide; N-[4,6-dichloro- 2-[(di-2-propyl-lambda-4-sulfanylidene)carbamoyl]-phenyl]-2-(3-chloro-2-pyridyl)- 5-(trifluoromethyl)pyrazole-3-carboxamide; N-[4,6-dichloro-2-[(diethyl-lambda- 4-sulfanylidene)carbamoyl]-phenyl]-2-(3-chloro-2-pyridyl)-5-(difluoromethyl)pyrazole-3- carboxamide; N-[4,6-dibromo-2-[(di-2-propyl-lambda-4-sulfanylidene)carbamoyl]-phenyl]-2- (3-chloro-2-pyridyl)-5-(trifluoromethyl)pyrazole-3-carboxamide; N-[4-chloro-2-[(di-2-propyl- lambda-4-sulfanylidene)carbamoyl]-6-cyano-phenyl]-2-(3-chloro-2-pyridyl)-5- (trifluoromethyl)pyrazole-3-carboxamide; N-[4,6-dibromo-2-[(diethyl-lambda-4- sulfanylidene)carbamoyl]-phenyl]-2-(3-chloro-2-pyridyl)-5-(trifluoromethyl)pyrazole-3- carboxamide;
- others: benclothiaz, bifenazate, cartap, flonicamid, pyridalyl, pymetrozine, sulfur, thiocyclam, cyenopyrafen, flupyrazofos, cyflumetofen, amidoflumet, imicyafos, bistrifluron,
pyrifluquinazon and 1 , 1 '-[(3S,4R,4aR,6S,6aS, 12R, 12aS, 12bS)-4-[[(2- cyclopropylacetyl)oxy]methyl]-1 ,3,4,4a,5,6,6a,12,12a,12b-decahydro-12-hydroxy-4,6a,12b- trimethyl-1 1 -oxo-9-(3-pyridinyl)-2H,1 1 H-naphtho[2,1 -b]pyrano[3,4-e]pyran-3,6-diyl] cyclopropaneacetic acid ester.
The biopesticides from group L), their preparation and their biological activity e.g. against harmful fungi, pests are known (e-Pesticide Manual V 5.2 (ISBN 978 1 901396 85 0) (2008- 201 1 ); http://www.epa.gov/opp00001/biopesticides/, see product lists therein; http://www.omri.org/omri-lists, see lists therein; Bio-Pesticides Database BPDB http://sitem.herts.ac.uk/aeru/bpdb/, see A to Z link therein).
Many of these biopesticides are registered and/or are commercially available: aluminium silicate (SCREEN™ DUO from Certis LLC, USA), Agrobacterium radiobacter K1026 (e.g.
NOGALL from Becker Underwood Pty Ltd., Australia), A. radiobacter K84 (Tate et al., 1979; Nature 280, 697-699; e.g. GALLTROL from AG Biochem, Inc., C, USA), Ampelomyces quisqualis M-10 (e.g. AQ 10® from Intrachem Bio GmbH & Co. KG, Germany), Ascophyllum nodosum (Norwegian kelp, Brown kelp) extract (e.g. ORKA GOLD from Becker Underwood, South Africa), Aspergillus flavus accession no. from USDA NRRL 21882 isolated from a peanut in Georgia in 1991 by the United States Department of Agriculture (USDA), National Peanut Research Laboratory (e.g. in AFLA-GUARD® from Syngenta, CH), Aureobasidium pullulans (e.g. BOTECTOR® from bio-ferm GmbH, Germany), Azospirillum brasilense XOH (e.g. AZOS from Xtreme Gardening, USA or RTI Reforestation Technologies International; USA), Bacillus amyloliquefaciens IT-45 (CNCM I-3800, NCBI 1091041 ) (e.g. RHIZOCELL C from ITHEC, France), B. amyloliquefaciens subsp. plantarum MBI600 (NRRL B-50595, deposited at United States Department of Agriculture) (e.g. INTEGRAL®, CLARITY, SUBTILEX NG from Becker Underwood, USA), B. firmus 1-1582 (WO09/126473, WO09/124707, VOTIVO® from Bayer Crop Science LP, USA), B. pumilus QST 2808 (NRRL Accession No. B-30087) (e.g. SONATA® and BALLAD® Plus from AgraQuest Inc., USA), B. subtilis GB03 (e.g. KODIAK from Gustafson, Inc., USA), B. subtilis GB07 (EPIC from Gustafson, Inc., USA), B. subtilis QST-713 (NRRL-No. B-21661 in RHAPSODY®, SERENADE® MAX and SERENADE® ASO from AgraQuest Inc., USA), B. subtilis var. amyloliquefaciens FZB24 (e.g. TAEGRO® from Novozyme Biologicals, Inc., USA), B. subtilis var. amyloliquefaciens D747 (e.g. Double Nickel 55 from Certis LLC,
USA), Bacillus thuringiensis ssp. kurstaki SB4 (NRRL B-50753; e.g. BETA PRO® from Becker Underwood, South Africa), Beauveria bassiana GHA (BOTANIGARD® 22WGP from Laverlam Int. Corp., USA), B. bassiana 12256 (e.g. BIOEXPERT® SC from Live Sytems Technology S.A., Colombia), B. bassiana PPRI 5339 (ARSEF number 5339 in the USDA ARS collection of entomopathogenic fungal cultures; NRRL 50757) (e.g. BROADBAND® from Becker
Underwood, South Africa), Bradyrhizobium sp. (e.g. VAULT® from Becker Underwood, USA), B. japonicum (e.g. VAULT® from Becker Underwood, USA), B. pumilus KFP9F (NRRL B- 50754; e.g. in FUSION-P from Becker Underwood BioAg SA (Pty) Ltd., a BASF Company), (Candida oleophila I-82 (e.g. ASPIRE® from Ecogen Inc., USA), Candida saitoana (e.g.
BIOCURE® (in mixture with lysozyme) and BIOCOAT® from Micro Flo Company, USA (BASF SE) and Arysta), Chitosan (e.g. ARMOUR-ZEN from BotriZen Ltd., NZ), Clonostachys rosea f. catenulata, also named Gliocladium catenulatum (e.g. isolate J 1446: PRESTOP® from Verdera, Finland), Coniothyrium minitans CON/M/91 -08 (e.g. Contans® WG from Prophyta, Germany), Cryphonectria parasitica (e.g. Endothia parasitica from CNICM, France), Cryptococcus albidus (e.g. YIELD PLUS® from Anchor Bio-Technologies, South Africa), Ecklonia maxima (kelp) extract (e.g. KELPAK SL from Kelp Products Ltd, South Africa), Fusarium oxysporum (e.g. BIOFOX® from S.I.A.P.A., Italy, FUSACLEAN® from Natural Plant Protection, France), Glomus intraradices (e.g. MYC 4000 from ITHEC, France), Glomus intraradices RTI-801 (e.g. MYKOS from Xtreme Gardening, USA or RTI Reforestation Technologies International; USA), grapefruit seeds and pulp extract (e.g. BC-1000 from Chemie S.A., Chile), Heterorhabditis bacteriophaga (e.g. NEMASYS® G from Becker Underwood Ltd., UK), Isaria fumosorosea Apopka-97 (ATCC 20874) (PFR-97™ from Certis LLC, USA), Lecanicillium muscarium (formerly Verticillium lecanii) (e.g. MYCOTAL from Koppert BV, Netherlands), Lecanicillium longisporum KV42 and KV71 (e.g. VERTALEC® from Koppert BV, Netherlands), Metarhizium anisopliae var. acridum IMI 330189 (deposited in European Culture Collections CABI; NRRL 50758) (e.g. GREEN MUSCLE® from Becker Underwood, South Africa), M. anisopliae FI-1045 (e.g. BIOCANE® from Becker Underwood Pty Ltd, Australia), M. anisopliae var. acridum FI-985 (e.g. GREEN GUARD® SC from Becker Underwood Pty Ltd, Australia), M. anisopliae F52 (e.g. MET52® Novozymes Biologicals BioAg Group, Canada), M. anisopliae ICIPE 69 (e.g. METATHRIPOL from ICIPE, Kenya), Metschnikowia fructicola (e.g. SHEMER® from Agrogreen, Israel),
Microdochium dimerum (e.g. ANTIBOT® from Agrauxine, France), Neem oil (e.g. TRILOGY®, TRIACT® 70 EC from Certis LLC, USA), Paecilomyces fumosoroseus strain FE 9901 (e.g. NO FLY™ from Natural Industries, Inc., USA), P. Iilacinus DSM 15169 (e.g. N EM ATA® SC from
Live Systems Technology S.A., Colombia), P. Iilacinus BCP2 (NRRL 50756; e.g. PL GOLD from Becker Underwood BioAg SA Ltd, South Africa), mixture of Paenibacillus alvei NAS6G6 (NRRL B-50755) and Bacillus pumilus KFP9F (NRRL B-50754) (e.g. in BAC-UP or FUSION-P from Becker Underwood South Africa), Penicillium bilaiae (e.g. JUMP START® from Novozymes Biologicals BioAg Group, Canada), Phlebiopsis gigantea (e.g. ROTSTOP® from Verdera,
Finland), potassium silicate (e.g. Sil-MATRIX™ from Certis LLC, USA), Pseudozyma flocculosa (e.g. SPORODEX® from Plant Products Co. Ltd., Canada), Pythium oligandrum DV74 (e.g. POLYVERSUM® from Remeslo SSRO, Biopreparaty, Czech Rep.), Reynoutria sachlinensis extract (e.g. REGALIA® SC from Marrone Biolnnovations, Davis, CA, USA), Rhizobium leguminosarum bv. phaseolii (e.g. RHIZO-STICK from Becker Underwood, USA), R. I. trifolii (e.g. DORMAL from Becker Underwood, USA), R. I. bv. viciae P1 NP3Cst (also referred to as 1435; New Phytol 179(1 ), 224-235, 2008; e.g. in NODULATOR PL Peat Granule from Becker Underwood, USA; or in NODULATOR XL PL bfrom Becker Underwood, Canada), R. I. bv.
viciae SU303 (e.g. NODULAID Group E from Becker Underwood, Australia), R. I. bv. viciae WSM1455 (e.g. NODULAID Group F from Becker Underwood, Australia), Sinorhizobium meliloti MSDJ0848 (INRA, France) also referred to as strain 201 1 or RCR201 1 (Mol Gen Genomics (2004) 272: 1-17; e.g. DORMAL ALFALFA from Becker Underwood, USA; NITRAGIN® Gold from Novozymes Biologicals BioAg Group, Canada), Steinernema carpocapsae (e.g.
MILLENIUM® from Becker Underwood Ltd., UK), S. feltiae (NEMASHIELD® from BioWorks, Inc., USA; NEMASYS® from Becker Underwood Ltd., UK), S. kraussei L137 (NEMASYS® L from Becker Underwood Ltd., UK), Streptomyces lydicus WYEC 108 (e.g. Actinovate® from Natural Industries, Inc., USA, US 5,403,584), S. violaceusniger YCED-9 (e.g. DT-9® from Natural Industries, Inc., USA, US 5,968,503), Talaromyces flavus V1 17b (e.g. PROTUS® from Prophyta, Germany), Trichoderma asperellum SKT-1 (e.g. ECO-HOPE® from Kumiai Chemical Industry Co., Ltd., Japan), T. atroviride LC52 (e.g. SENTINEL® from Agrimm Technologies Ltd, NZ), T. fertile JM41 R (NRRL 50759; e.g. RICHPLUS™ from Becker Underwood Bio Ag SA Ltd, South Africa), T. harzianum T-22 (e.g. PLANTSHIELD® der Firma BioWorks Inc., USA), T. harzianum TH 35 (e.g. ROOT PRO® from Mycontrol Ltd., Israel), T. harzianum T-39 (e.g.
TRICHODEX® and TRICHODERMA 2000® from Mycontrol Ltd., Israel and Makhteshim Ltd., Israel), T. harzianum and T. viride (e.g. TRICHOPEL from Agrimm Technologies Ltd, NZ), T. harzianum ICC012 and T. viride ICC080 (e.g. REMEDIER® WP from Isagro Ricerca, Italy), T. polysporum and T. harzianum (e.g. BINAB® from BINAB Bio-Innovation AB, Sweden), T.
stromaticum (e.g. TRICOVAB® from C.E.P.L.A.C., Brazil), T. virens GL-21 (also named Gliocladium virens) (e.g. SOILGARD® from Certis LLC, USA), T. viride (e.g. TRIECO® from Ecosense Labs. (India) Pvt. Ltd., Indien, BIO-CURE® F from T. Stanes & Co. Ltd., Indien), T. viride TV1 (e.g. T. viride TV1 from Agribiotec srl, Italy) and Ulocladium oudemansii HRU3 (e.g. BOTRY-ZEN® from Botry-Zen Ltd, NZ).
Bacillus amyloliquefaciens AP-136 (NRRL B-50614), B. amyloliquefaciens AP-188 (NRRL B- 50615), B. amyloliquefaciens AP-218 (NRRL B-50618), B. amyloliquefaciens AP-219 (NRRL B- 50619), B. amyloliquefaciens AP-295 (NRRL B-50620), B. japonicum SEMIA 5079 (e.g. Gelfix 5 or Adhere 60 from Nitral Urbana Laoboratories, Brazil, a BASF Company), B. japonicum SEMIA 5080 (e.g. GELFIX 5 or ADHERE 60 from Nitral Urbana Laoboratories, Brazil, a BASF
Company), B. mojavensis AP-209 (No. NRRL B-50616), B. solisalsi AP-217 (NRRL B-50617), B. pumilus strain INR-7 (otherwise referred to as BU-F22 (NRRL B-50153) and BU-F33 (NRRL B-50185)), B. simplex ABU 288 (NRRL B-50340) and B. amyloliquefaciens subsp. plantarum MBI600 (NRRL B-50595) have been mentioned i.a. in US patent appl. 20120149571 , WO 2012/079073. Beauveria bassiana DSM 12256 is known from US200020031495.
Bradyrhizobium japonicum USDA is known from US patent 7,262,151. Sphaerodes
mycoparasitica IDAC 301008-01 (IDAC = International Depositary Authority of Canada
Collection) is known from WO 201 1/022809. NRRL numbers refer to deposition numbers from strains deposited with the United States Department of Agriculture.
Bacillus amyloliquefaciens subsp. plantarum MBI600 having the accession number NRRL B- 50595 is deposited with the United States Department of Agriculture on Nov. 10, 201 1 under the strain designation Bacillus subtilis 1430. It has also been deposited at The National Collections of Industrial and Marine Bacteria Ltd. (NCIB), Torry Research Station, P.O. Box 31 , 135 Abbey Road, Aberdeen, AB9 8DG, Scotland under accession number 1237 on December 22, 1986. Bacillus amyloliquefaciens MBI600 is known as plant growth-promoting rice seed treatment from Int. J. Microbiol. Res. ISSN 0975-5276, 3(2) (201 1 ), 120-130 and further described e.g. in US 2012/0149571 A1 . This strain MBI600 is commercially available as liquid formulation product Integral® (Becker-Underwood Inc., USA). Recently, the strain MBI 600 has been reclassified as Bacillus amyloliquefaciens subsp. plantarum based on polyphasic testing which combines classical microbiological methods relying on a mixture of traditional tools (such as culture-based methods) and molecular tools (such as genotyping and fatty acids analysis).
Thus, Bacillus subtilis MBI600 (or MBI 600 or MBI-600) is identical to Bacillus amyloliquefaciens subsp. plantarum MBI600, formerly Bacillus subtilis MBI600.
Metarhizium anisopliae IMI33 is commercially available from Becker Underwood as product Green Guard. M. anisopliae var acridium strain IMI 330189 (NRRL-50758) is commercially available from Becker Underwood as product Green Muscle.
Bacillus subtilis strain FB17 was originally isolated from red beet roots in North America (System Appl. Microbiol 27 (2004) 372-379). This Bacillus subtilis strain promotes plant health (US 2010/0260735 A1 ; WO 201 1/109395 A2). B. subtilis FB17 has also been deposited at American Type Culture Collection (ATCC), Manassas, VA, USA, under accession number PTA- 1 1857 on April 26, 201 1 . Bacillus subtilis strain FB17 may also be referred to as UD1022 or UD10-22.
Bacillus amyloliquefaciens AP-136 (NRRL B-50614 and B-50330), B. amyloliquefaciens AP- 188 (NRRL B-50615 and B-50331 ), B. amyloliquefaciens AP-218 (NRRL B-50618), B. amyloliquefaciens AP-219 (NRRL B-50619 and B-50332), B. amyloliquefaciens AP-295 (NRRL B-50620 and B-50333), B. amyloliquefaciens subsp. plantarum MBI600 (NRRL B-50595), B. mojavensis AP-209 (No. NRRL B-50616), B. pumilus INR-7 (otherwise referred to as BU-F22 (NRRL B-50153) and BU-F33 (NRRL B-50185)), B. simplex ABU 288 (NRRL B-50340), B. solisalsi AP-217 (NRRL B-50617) are known from US 8,445,255.
Jasmonic acid or salts (jasmonates) or derivatives include without limitation potassium jasmonate, sodium jasmonate, lithium jasmonate, ammonium jasmonate, dimethylammonium jasmonate, isopropylammonium jasmonate, diolammonium jasmonate,
diethtriethanolammonium jasmonate, jasmonic acid methyl ester, jasmonic acid amide, jasmonic acid methylamide, jasmonic acid-L-amino acid (amide-linked) conjugates (e.g., conjugates with L-isoleucine, L-valine, L-leucine, or L-phenylalanine), 12-oxo-phytodienoic acid, coronatine, coronafacoyl-L-serine, coronafacoyl-L-threonine, methyl esters of 1 -oxo-indanoyl- isoleucine, methyl esters of 1 -oxo-indanoyl-leucine, coronalon (2-[(6-ethyl-l-oxo-indane-4- carbonyl) -amino]-3-methyl -pentanoic acid methyl ester), linoleic acid or derivatives thereof and cis-jasmone, or combinations of any of the above.
Humates are humic and fulvic acids extracted from a form of lignite coal and clay, known as leonardite. Humic acids are organic acids that occur in humus and other organically derived materials such as peat and certain soft coal. They have been shown to increase fertilizer efficiency in phosphate and micro-nutrient uptake by plants as well as aiding in the development of plant root systems.
According to one embodiment of the inventive mixtures, the at least one biopesticide II is selected from the groups L1 ) to L6):
L1 ) Microbial pesticides with fungicidal, bactericidal, viricidal and/or plant defense activator activity: Ampelomyces quisqualis M-10, Aspergillus flavus NRRL 21882, Aureobasidium pullulans DSM 14940, A. pullulans DSM 14941 , Bacillus amyloliquefaciens AP-136
(NRRL B-50614), B. amyloliquefaciens AP-188 (NRRL B-50615), B. amyloliquefaciens AP-218 (NRRL B-50618), B. amyloliquefaciens AP-219 (NRRL B-50619), B.
amyloliquefaciens AP-295 (NRRL B-50620), B. amyloliquefaciens IT-45 (CNCM I-3800, NCBI 1091041 ), B. amyloliquefaciens subsp. plantarum MBI600 (NRRL B-50595), B. mojavensis AP-209 (No. NRRL B-50616), B. pumilus INR-7 (otherwise referred to as BU-
F22 (NRRL B-50153) and BU-F33 (NRRL B-50185)), B. pumilus KFP9F, B. pumilus QST 2808 (NRRL B-30087), B. pumilus GHA 181 , B. simplex ABU 288 (NRRL B-50340), B. solisalsi AP-217 (NRRL B-50617), B. subtilis CX-9060, B. subtilis GB03, B. subtilis GB07, B. subtilis QST-713 (NRRL B-21661 ), B. subtilis var. amyloliquefaciens FZB23, B. subtilis var. amyloliquefaciens D747, Candida oleophila I-82, C. oleophila O, C. saitoana,
Clavibacter michiganensis (bacteriophages), Coniothyrium minitans CON/M/91 -08, Cryphonectria parasitica, Cryptococcus albidus, Fusarium oxysporum, Clonostachys rosea f. catenulata J1446 (also named Gliocladium catenulatum), Gliocladium roseum 321 U, Metschnikowia fructicola, Microdochium dimerum, Paenibacillus polymyxa PKB1 (ATCC No. 202127), Pantoea agglomerans c91 , Phlebiopsis gigantea, Pseudozyma flocculosa, Pythium oligandrum DV74, Sphaerodes mycoparasitica IDAC 301008-01 , Streptomyces lydicus WYEC 108, S. violaceusniger XL-2, S. violaceusniger YCED-9, Talaromyces flavus V1 17b, Trichoderma asperellum T34, T. asperellum SKT-1 , T. atroviride LC52, T. fertile JM41 R, T. gamsii, T. harmatum TH 382, T. harzianum TH-35, T. harzianum T-22, T. harzianum T-39, ; mixture of T. harzianum ICC012 and T. viride ICC080; mixture of T. polysporum and T. harzianum; T. stromaticum, T. virens (also named Gliocladium virens) GL-21 , T. virens G41 , T. viride TV1 , Typhula phacorrhiza 94671 , Ulocladium oudema, U. oudemansii HRU3, Verticillium dahlia, zucchini yellow mosaic virus (avirulent strain);
L2) Biochemical pesticides with fungicidal, bactericidal, viricidal and/or plant defense activator activity: chitosan (hydrolysate), laminarin, Menhaden fish oil, natamycin, Plum pox virus coat protein, Reynoutria sachlinensis extract, salicylic acid, tea tree oil;
L3) Microbial pesticides with insecticidal, acaricidal, molluscidal and/or nematicidal activity:
Agrobacterium radiobacter K1026, A radiobacter K84, Bacillus firmus 1-1582, B. thurin- giensis ssp. israelensis SUM-6218, B. t. ssp. galleriae SDS-502, B. t. ssp. kurstaki SB4, Beauveria bassiana GHA, B. bassiana H123, B. bassiana DSM 12256, B. bassiana PPRI 5339, Burkholderia sp. A396, Chromobacterium subtsugae PRAA4-1 T, Cydia pomonella granulosis virus isolate V22, Isaria fumosorosea Apopka-97, Lecanicillium longisporum
KV42, L. longisporum KV71 , L. muscarium (formerly Verticillium lecanii), Metarhizium anisopliae FI-985, M. anisopliae FI-1045, M. anisopliae F52, M. anisopliae ICIPE 69, M. anisopliae var. acridum IMI 330189, Paecilomyces fumosoroseus FE 9901 , P. lilacinus DSM 15169, P. lilacinus BCP2, Paenibacillus poppiliae Dutky-1940 (NRRL B-2309 = ATCC 14706), P. poppiliae KLN 3, P. poppiliae Dutky 1 , Pasteuria spp. Ph3, P.
nishizawae PN-1 , P. reneformis Pr-3, P. usagae, Pseudomonas fluorescens CL 145A, Steinernema carpocapsae, S. feltiae, S. kraussei L137, Streptomces galbus;
L4) Biochemical pesticides with insecticidal, acaricidal, molluscidal, pheromone and/or
nematicidal activity: L-carvone, citral, (E,Z)-7,9-dodecadien-1 -yl acetate, ethyl formate, (E,Z)-2,4-ethyl decadienoate (pear ester), (Z,Z,E)-7,1 1 ,13-hexadecatrienal, heptyl butyrate, isopropyl myristate, lavanulyl senecioate, 2-methyl 1 -butanol, methyl eugenol, methyl jasmonate, (E,Z)-2,13-octadecadien-1 -ol, (E,Z)-2,13-octadecadien-1 -ol acetate, (E,Z)-3,13-octadecadien-1 -ol, R-1 -octen-3-ol, pentatermanone, potassium silicate, sorbitol actanoate, (E,Z,Z)-3,8,1 1 -tetradecatrienyl acetate, (Z,E)-9,12-tetradecadien-1 -yl acetate, Z-7-tetradecen-2-one, Z-9-tetradecen-1 -yl acetate, Z-1 1 -tetradecenal, Z-1 1 -tetradecen-1 - ol, Acacia negra extract, extract of grapefruit seeds and pulp, extract of Chenopodium ambrosiodae, Catnip oil, Neem oil, Quillay extract, Tagetes oil;
L5) Microbial pesticides with plant stress reducing, plant growth regulator, plant growth
promoting and/or yield enhancing activity: Azospirillum amazonense BR 1 1 140 (SpY2T), A. brasilense AZ39, A. brasilense XOH, A. brasilense BR 1 1005 (Sp245), A. brasilense
BR 1 1002, A. Iipoferum BR 1 1646 (Sp31 ), A. irakense, A. halopraeferens, Bradyrhizobium sp. PNL01 , B. sp. (Arachis) CB1015, B. sp. (Arachis) USDA 3446, B. sp. (Arachis) SEMIA 6144, B. sp. (Arachis) SEMIA 6462, B. sp. (Arachis) SEMIA 6464, B. sp. (Vigna), B.
elkanii SEMIA 587, B. elkanii SEMIA 5019, B. elkanii U-1301 , B. elkanii U-1302, B. elkanii USDA 74, B. elkanii USDA 76, B. elkanii USDA 94, B. elkanii USDA 3254, B. japonicum
532c, B. japonicum CPAC 15, B. japonicum E-109, B. japonicum G49, B. japonicum TA- 1 1 , B. japonicum USDA 3, B. japonicum USDA 31 , B. japonicum USDA 76, B. japonicum USDA 1 10, B. japonicum USDA 121 , B. japonicum USDA 123, B. japonicum USDA 136, B. japonicum SEMIA 566, B. japonicum SEMIA 5079, B. japonicum SEMIA 5080, B.
liaoningense, B. lupini LL13, B. lupini WU425, B. lupini WSM471 , B. lupini WSM4024, Glomus intraradices RTI-801 , Mesorhizobium sp. WSM1271 , M. sp. WSM1497, M. ciceri CC1 192, M. huakii, M. loti CC829, M. loti SU343, Paenibacillus alvei NAS6G6, Penicillium bilaiae, Rhizobium leguminosarum bv. phaseolii, R. I. trifolii, R. I. bv. viciae SU303, R. I. bv. viciae WSM1455, Sinorhizobium meliloti MSDJ0848 (INRA, France);
L6) Biochemical pesticides with plant stress reducing, plant growth regulator and/or plant yield enhancing activity: abscisic acid, aluminium silicate (kaolin), 3-decen-2-one,
homobrassinlide, humates, methyl jasmonate, cis-jasmone, lysophosphatidyl ethanlamine, polymeric polyhydroxy acid, salicylic acid, Ascophyllum nodosum (Norwegian kelp, Brown kelp) extract and Ecklonia maxima (kelp) extract.
It is preferred that the mixtures comprise as component 4) fungicidal compounds that are independently of each other selected from the groups A), B), C), D), E), F), G), H), I), J), K) and L).
According to another embodiment of the invention, mixtures comprise as compound IV (component 4) a herbicidal compound that is selected from the group N), in particular glyphosate.
According to a further embodiment, mixtures comprise as compound IV (component 4) an insecticidal compound that is selected from the group O).
Preference is also given to mixtures comprise ascompound IV (component 4) at least one active substance selected from group A) and particularly selected from dimoxystrobin, kresoxim- methyl, orysastrobin, picoxystrobin, pyraclostrobin; famoxadone, fenamidone; benzovindiflupyr, bixafen, fluopyram, isopyrazam, penflufen, penthiopyrad, sedaxane; ametoctradin, cyazofamid, fentin salts, such as fentin acetate.
Preference is also given to mixtures comprise as compound IV (component 4) at least one active substance selected from group B) and particularly selected from cyproconazole, difenoconazole, epoxiconazole, fluquinconazole, flusilazole, flutriafol, metconazole,
myclobutanil, penconazole, propiconazole, prothioconazole, triadimefon, triadimenol, tebuconazole, tetraconazole, triticonazole, prochloraz, fenarimol, triforine; dodemorph, fenpropimorph, tridemorph, fenpropidin, spiroxamine; fenhexamid.
Preference is also given to mixtures comprise as compound IV (component 4) at least one active substance selected from group C) and particularly selected from metalaxyl, (metalaxyl-M) mefenoxam, ofurace.
Preference is also given to mixtures comprise as compound IV (component 4) at least one active substance selected from group D) and particularly selected from benomyl, carbendazim, thiophanate-methyl, ethaboxam, fluopicolide, zoxamide, metrafenone, pyriofenone.
Preference is also given to mixtures comprise as compound IV (component 4) at least one active substance selected from group E) and particularly selected from cyprodinil, mepanipyrim, pyrimethanil.
Preference is also given to mixtures comprise as compound IV (component 4) at least one active substance selected from group F) and particularly selected from iprodione, fludioxonil, vinclozolin, quinoxyfen.
Preference is also given to mixtures comprise as compound IV (component 4) at least one active substance selected from group G) and particularly selected from dimethomorph, flumorph, iprovalicarb, benthiavalicarb, mandipropamid, propamocarb.
Preference is also given to mixtures comprise as component 4) at least one active substance selected from group H) and particularly selected from copper acetate, copper hydroxide, copper oxychloride, copper sulfate, sulfur, mancozeb, metiram, propineb, thiram, captafol, folpet, chlorothalonil, dichlofluanid, dithianon.
Preference is also given to mixtures comprise as compound IV (component 4) at least one active substance selected from group I) and particularly selected from carpropamid and fenoxanil.
Preference is also given to mixtures comprise as compound IV (component 4) at least one active substance selected from group J) and particularly selected from acibenzolar-S-methyl, probenazole, tiadinil, fosetyl, fosetyl-aluminium, H3PO3 and salts thereof.
Preference is also given to mixtures comprise as compound IV (component 4) at least one active substance selected from group K) and particularly selected from cymoxanil, proquinazid and A/-methyl-2-{1 -[(5-methyl-3-trifluoromethyl-1 H-pyrazol-1 -yl)-acetyl]-piperidin-4-yl}-A/-[(1 R)- 1 ,2,3,4-tetrahydronaphthalen-1 -yl]-4-thiazolecarboxamide.
The present invention furthermore relates to agrochemical compositions comprising a mixture comprising as component 4) at least one biopesticide selected from the group L), in particular at least one further fungicidal biopesticide selected from the groups L1 ) and L2), as described above, and if desired at least one suitable auxiliary.
Preference is also given to mixtures comprise as biopesticide IV (component 4) a
biopesticide from group L1 ), preferably selected from Bacillus amyloliquefaciens AP-136 (NRRL B-50614 and B-50330), B. amyloliquefaciens AP-188 (NRRL B-50615 and B-50331 ), B.
amyloliquefaciens AP-218 (NRRL B-50618), B. amyloliquefaciens AP-219 (NRRL B-50619 and B-50332), B. amyloliquefaciens AP-295 (NRRL B-50620 and B-50333), B. amyloliquefaciens IT- 45 (CNCM I-3800, NCBI 1091041 ), B. amyloliquefaciens subsp. plantarum MBI600 (NRRL B- 50595), B. mojavensis AP-209 (No. NRRL B-50616), B. pumilus INR-7 (otherwise referred to as BU-F22 (NRRL B-50153) and BU-F33 (NRRL B-50185)), B. pumilus KFP9F, B. pumilus QST 2808 (NRRL B-30087), B. pumilus GHA 181 , B. simplex ABU 288 (NRRL B-50340), B. solisalsi AP-217 (NRRL B-50617), B. subtilis CX-9060, B. subtilis GB03, B. subtilis GB07, B. subtilis QST-713 (NRRL B-21661 ), B. subtilis var. amyloliquefaciens FZB23, B. subtilis var.
amyloliquefaciens D747, Paenibacillus alvei NAS6G6, Paenibacillus polymyxa PKB1 (ATCC No. 202127), Sphaerodes mycoparasitica IDAC 301008-01 and Trichoderma fertile JM41 R, even more preferably from Bacillus amyloliquefaciens AP-136 (NRRL B-50614), B.
amyloliquefaciens AP-188 (NRRL B-50615), B. amyloliquefaciens AP-218 (NRRL B-50618), B. amyloliquefaciens AP-219 (NRRL B-50619), B. amyloliquefaciens AP-295 (NRRL B-50620), B. amyloliquefaciens IT-45 (CNCM I-3800, NCBI 1091041 ), B. mojavensis AP-209 (No. NRRL B- 50616), B. pumilus INR-7 (otherwise referred to as BU-F22 (NRRL B-50153) and BU-F33 (NRRL B-50185)), B. pumilus QST 2808 (NRRL B-30087), B. simplex ABU 288 (NRRL B- 50340), B. subtilis QST-713 (NRRL B-21661 ), B. subtilis MBI600 (NRRL B-50595),
Paenibacillus alvei NAS6G6, Sphaerodes mycoparasitica IDAC 301008-01 and Trichoderma fertile J M41 R.
Preference is also given to mixtures comprise as biopesticide IV (component 4) a biopesticide from group L2), preferably selected from chitosan (hydrolysate), methyl-jasmonate, cis-jasmone, laminarin, Reynoutria sachlinensis extract and tea tree oil.
Preference is also given to mixtures comprise as biopesticide II (component 3) a biopesticide from group L3), preferably selected from Agrobacterium radiobacter K1026, Bacillus firmus I- 1582, Bacillus thuringiensis ssp. kurstaki SB4, Beauveria bassiana GHA, B. bassiana H 123, B. bassiana DSM 12256, B. bassiana PPRI 5339, Metarhizium anisopliae var. acridum IMI 330189, M. anisopliae FI-985, M. anisopliae FI-1045, M. anisopliae F52, M. anisopliae ICIPE 69, Paecilomyces lilacinus DSM 15169, P. lilacinus BCP2, Paenibacillus poppiliae Dutky-1940 (NRRL B-2309 = ATCC 14706), P. poppiliae KLN 3 and P. poppiliae Dutky 1 , even more preferably from Bacillus thuringiensis ssp. kurstaki SB4, B. bassiana DSM 12256, B. bassiana PPRI 5339, Metarhizium anisopliae var. acridum IMI 330189, M. anisopliae FI-985, M.
anisopliae FI-1045, Paecilomyces lilacinus DSM 15169, P. lilacinus BCP2, Paenibacillus poppiliae Dutky-1940 (NRRL B-2309 = ATCC 14706), P. poppiliae KLN 3 and P. poppiliae Dutky 1 .
Preference is also given to mixtures comprise as biopesticide II (component 2) a biopesticide from group L4), preferably selected from methyl jasmonate, Acacia negra extract, extract of grapefruit seeds and pulp, Catnip oil, Neem oil, Quillay extract and Tagetes oil.
Preference is also given to mixtures comprise as biopesticide IV (component 4) a
biopesticide from group L5), preferably selected from Azospirillum amazonense BR 1 1 140 (SpY2T), A. brasilense XOH, A. brasilense BR 1 1005 (Sp245), A. brasilense BR 1 1002, A. lipoferum BR 1 1646 (Sp31 ), A. irakense, A. halopraeferens, Bacillus amyloliquefaciens AP-136 (NRRL B-50614), Bradyrhizobium sp. (Vigna), B. japonicum USDA 3, B. japonicum USDA 31 , B. japonicum USDA 76, B. japonicum USDA 1 10, B. japonicum USDA 121 , Glomus intraradices RTI-801 , Paenibacillus alvei NAS6G6, Penicillium bilaiae, Rhizobium leguminosarum bv.
phaseolii, R. I. trifolii, R. I. bv. viciae, and Sinorhizobium meliloti, more preferably selected from Azospirillum brasilense BR 1 1005 (Sp245), Bradyrhizobium sp. (Vigna), B. japonicum USDA 3, B. japonicum USDA 31 , B. japonicum USDA 76, B. japonicum USDA 1 10, B. japonicum USDA 121 , Rhizobium leguminosarum bv. phaseolii, R. I. trifolii, R. I. bv. viciae SU303, R. I. bv. viciae WSM1455, and Sinorhizobium meliloti.
Preference is also given to mixtures comprise as biopesticide IV (component 4) a
biopesticide from group L6), preferably selected from abscisic acid, aluminium silicate (kaolin), humates, Ascophyllum nodosum (Norwegian kelp, Brown kelp) extract and Ecklonia maxima (kelp) extract.
The inventive mixtures comprising as biopesticide IV a microbial pesticide from groups L1 ), L3) and L5) may be formulated as an inoculant for a plant. The term "inoculant" means a preparation that includes an isolated culture of a microbial pesticide and optionally a carrier, which may include a biologically acceptable medium.
The mixtures and compositions according to the invention are suitable as fungicides. They are distinguished by an outstanding effectiveness against a broad spectrum of phytopathogenic fungi, including soil-borne fungi, which derive especially from the classes of the
Plasmodiophoromycetes, Peronosporomycetes (syn. Oomycetes), Chytridiomycetes,
Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes (syn. Fungi imperfecti).
Some are systemically effective and they can be used in crop protection as foliar fungicides, fungicides for seed dressing and soil fungicides. Moreover, they are suitable for controlling harmful fungi, which inter alia occur in wood or roots of plants.
The mixtures and compositions according to the invention are particularly important in the control of a multitude of phytopathogenic fungi on various cultivated plants, such as cereals, e. g. wheat, rye, barley, triticale, oats or rice; beet, e. g. sugar beet or fodder beet; fruits, such as pomes, stone fruits or soft fruits, e. g. apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries, blackberries or gooseberries; leguminous plants, such as lentils, peas, alfalfa or soybeans; oil plants, such as rape, mustard, olives, sunflowers, coconut, cocoa beans, castor oil plants, oil palms, ground nuts or soybeans; cucurbits, such as squashes, cucumber or melons; fiber plants, such as cotton, flax, hemp or jute; citrus fruit, such as oranges, lemons, grapefruits or mandarins; vegetables, such as spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes, cucurbits or paprika; lauraceous plants, such as avocados, cinnamon or camphor; energy and raw material plants, such as corn, soybean, rape, sugar cane or oil palm; corn; tobacco; nuts; coffee; tea; bananas; vines (table grapes and grape juice grape vines); hop; turf; natural rubber plants or ornamental and forestry plants, such as flowers, shrubs, broad-leaved trees or evergreens, e. g. conifers; and on the plant propagation material, such as seeds, and the crop material of these plants.
Preferably the inventive mixtures and compositions are used for controlling a multitude of fungi on field crops, such as potatoes sugar beets, tobacco, wheat, rye, barley, oats, rice, corn, cotton, soybeans, rape, legumes, sunflowers, coffee or sugar cane; fruits; vines; ornamentals; or vegetables, such as cucumbers, tomatoes, beans or squashes. Even more preferably the inventive mixtures and compositions are used for controlling a multitude of fungi on soybean.
The term "plant propagation material" is to be understood to denote all the generative parts of the plant such as seeds and vegetative plant material such as cuttings and tubers (e. g.
potatoes), which can be used for the multiplication of the plant. This includes seeds, roots, fruits, tubers, bulbs, rhizomes, shoots, sprouts and other parts of plants, including seedlings and young plants, which are to be transplanted after germination or after emergence from soil.
These young plants may also be protected before transplantation by a total or partial treatment by immersion or pouring.
Preferably, treatment of plant propagation materials with the inventive combination of compound I, compound II and fluazinam as defined herein and compositions thereof, respectively, is used for controlling a multitude of fungi on cereals, such as wheat, rye, barley and oats; rice, corn, cotton and soybeans.
The term "cultivated plants" is to be understood as including plants which have been modified by breeding, mutagenesis or genetic engineering including but not limiting to agricultural biotech products on the market or in development (cf. http://cera-gmc.org/, see GM crop database therein). Genetically modified plants are plants, which genetic material has been so modified by the use of recombinant DNA techniques that under natural circumstances cannot readily be obtained by cross breeding, mutations or natural recombination. Typically, one or more genes have been integrated into the genetic material of a genetically modified plant in order to improve certain properties of the plant. Such genetic modifications also include but are not limited to targeted post-transtional modification of protein(s), oligo- or polypeptides e. g. by glycosylation or polymer additions such as prenylated, acetylated or farnesylated moieties or PEG moieties.
The inventive mixtures and compositions are particularly suitable for controlling the following plant diseases:
Albugo spp. (white rust) on ornamentals, vegetables (e. g. A. Candida) and sunflowers (e. g. A. tragopogonis); Altemaria spp. (Alternaria leaf spot) on vegetables, rape (A. brassicola or brassicae), sugar beets (A. tenuis), fruits, rice, soybeans, potatoes (e. g. A. solani or A.
alternata), tomatoes (e. g. A. solani or A. alternata) and wheat; Aphanomyces spp. on sugar beets and vegetables; Ascochyta spp. on cereals and vegetables, e. g. A. tritici (anthracnose) on wheat and A. hordei on barley; Bipolaris and Drechslera spp. (teleomorph: Cochliobolus spp.) on corn (e. g. D. maydis), cereals (e. g. B. sorokiniana: spot blotch), rice (e. g. B. oryzae) and turfs; Blumeria (formerly Erysiphe) graminis (powdery mildew) on cereals (e. g. on wheat or barley); Botrytis cinerea (teleomorph: Botryotinia fuckeliana: grey mold) on fruits and berries (e. g. strawberries), vegetables (e. g. lettuce, carrots, celery and cabbages), rape, flowers, vines, forestry plants and wheat; Bremia lactucae (downy mildew) on lettuce;
Ceratocystis (syn. Ophiostoma) spp. (rot or wilt) on broad-leaved trees and evergreens, e. g. C. ulmi (Dutch elm disease) on elms; Cercospora spp. (Cercospora leaf spots) on corn, rice, sugar beets (e. g. C. beticola), sugar cane, vegetables, coffee, soybeans (e. g. C. sojina or C. kikuchii) and rice; Cladosporium spp. on tomatoes (e. g. C. fulvum: leaf mold) and cereals, e. g. C. herbarum (black ear) on wheat; Claviceps purpurea (ergot) on cereals; Cochliobolus
(anamorph: Helminthosporium of Bipolaris) spp. (leaf spots) on corn (C. carbonum), cereals (e. g. C. sativus, anamorph: B. sorokiniana) and rice (e. g. C. miyabeanus, anamorph: H.
oryzae); Colletotrichum (teleomorph: Glomerella) spp. (anthracnose) on cotton (e. g. C.
gossypii), corn (e. g. C. graminicola), soft fruits, potatoes (e. g. C. coccodes: black dot), beans (e. g. C. lindemuthianum) and soybeans (e. g. C. truncatum or C. gloeosporioides); Corticium spp., e. g. C. sasakii (sheath blight) on rice; Corynespora cassiicola (leaf spots) on soybeans and ornamentals; Cycloconium spp., e. g. C. oleaginum on olive trees; Cylindrocarpon spp. (e. g. fruit tree canker or young vine decline, teleomorph: Nectria or Neonectria spp.) on fruit trees, vines (e. g. C. liriodendri, teleomorph: Neonectria liriodendri: Black Foot Disease) and ornamentals; Dematophora (teleomorph: Rosellinia) necatrix (root and stem rot) on soybeans; Diaporthe spp., e. g. D. phaseolorum (damping off) on soybeans; Drechslera (syn.
Helminthosporium, teleomorph: Pyrenophora) spp. on corn, cereals, such as barley (e. g. D. teres, net blotch) and wheat (e. g. D. tritici-repentis: tan spot), rice and turf; Esca (dieback, apoplexy) on vines, caused by Formitiporia (syn. Phellinus) punctata, F. mediterranea,
Phaeomoniella chlamydospora (earlier Phaeoacremonium chlamydosporum),
Phaeoacremonium aleophilum and/or Botryosphaeria obtusa; Elsinoe spp. on pome fruits (£. pyri), soft fruits (£. veneta: anthracnose) and vines (£. ampelina: anthracnose); Entyloma oryzae (leaf smut) on rice; Epicoccum spp. (black mold) on wheat; Erysiphe spp. (powdery mildew) on sugar beets (£. betae), vegetables (e. g. E. pisi), such as cucurbits (e. g. E.
cichoracearum), cabbages, rape (e. g. E. cruciferarum); Eutypa lata (Eutypa canker or dieback, anamorph: Cytosporina lata, syn. Libertella blepharis) on fruit trees, vines and ornamental woods; Exserohilum (syn. Helminthosporium) spp. on corn (e. g. E. turcicum); Fusarium
(teleomorph: Gibberella) spp. (wilt, root or stem rot) on various plants, such as F. graminearum or F. culmorum (root rot, scab or head blight) on cereals (e. g. wheat or barley), F. oxysporum on tomatoes, F. solani on soybeans and F. verticillioides on corn; Gaeumannomyces graminis (take-all) on cereals (e. g. wheat or barley) and corn; Gibberella spp. on cereals (e. g. G. zeae) and rice (e. g. G. fujikuroi: Bakanae disease); Glomerella cingulata on vines, pome fruits and other plants and G. gossypii on cotton; Grainstaining complex on rice; Guignardia bidwellii (black rot) on vines; Gymnosporangium spp. on rosaceous plants and junipers, e. g. G. sabinae (rust) on pears; Helminthosporium spp. (syn. Drechslera, teleomorph: Cochliobolus) on corn, cereals and rice; Hemileia spp., e. g. H. vastatrix (coffee leaf rust) on coffee; Isariopsis clavispora (syn. Cladosporium vitis) on vines; Macrophomina phaseolina (syn. phaseoli) (root and stem rot) on soybeans and cotton; Microdochium (syn. Fusarium) nivale (pink snow mold) on cereals (e. g. wheat or barley); Microsphaera diffusa (powdery mildew) on soybeans;
Monilinia spp., e. g. M. laxa, M. fructicola and M. fructigena (bloom and twig blight, brown rot) on stone fruits and other rosaceous plants; Mycosphaerella spp. on cereals, bananas, soft fruits and ground nuts, such as e. g. M. graminicola (anamorph: Septoria tritici, Septoria blotch) on wheat or M. fijiensis (black Sigatoka disease) on bananas; Peronospora spp. (downy mildew) on cabbage (e. g. P. brassicae), rape (e. g. P. parasitica), onions (e. g. P. destructor), tobacco (P. tabacina) and soybeans (e. g. P. manshurica); Phakopsora pachyrhizi and P. meibomiae (soybean rust) on soybeans; Phialophora spp. e. g. on vines (e. g. P. tracheiphila and P.
tetraspora) and soybeans (e. g. P. gregata: stem rot); Phoma lingam (root and stem rot) on rape and cabbage and P. betae (root rot, leaf spot and damping-off) on sugar beets; Phomopsis spp. on sunflowers, vines (e. g. P. viticola: can and leaf spot) and soybeans (e. g. stem rot: P.
phaseoli, teleomorph: Diaporthe phaseolorum); Physoderma maydis (brown spots) on corn; Phytophthora spp. (wilt, root, leaf, fruit and stem root) on various plants, such as paprika and cucurbits (e. g. P. capsici), soybeans (e. g. P. megasperma, syn. P. sojae), potatoes and tomatoes (e. g. P. infestans: late blight) and broad-leaved trees (e. g. P. ramorum: sudden oak death); Plasmodiophora brassicae (club root) on cabbage, rape, radish and other plants;
Plasmopara spp., e. g. P. viticola (grapevine downy mildew) on vines and P. halstedii on sunflowers; Podosphaera spp. (powdery mildew) on rosaceous plants, hop, pome and soft fruits, e. g. P. leucotricha on apples; Polymyxa spp., e. g. on cereals, such as barley and wheat (P. graminis) and sugar beets (P. betae) and thereby transmitted viral diseases;
Pseudocercosporella herpotrichoides (eyespot, teleomorph: Tapesia yallundae) on cereals, e. g. wheat or barley; Pseudoperonospora (downy mildew) on various plants, e. g. P. cubensis on cucurbits or P. humili on hop; Pseudopezicula tracheiphila (red fire disease or .rotbrenner', anamorph: Phialophora) on vines; Puccinia spp. (rusts) on various plants, e. g. P. triticina (brown or leaf rust), P. striiformis (stripe or yellow rust), P. hordei (dwarf rust), P. graminis (stem or black rust) or P. recondita (brown or leaf rust) on cereals, such as e. g. wheat, barley or rye, and asparagus (e. g. P. asparagi); Pyrenophora (anamorph: Drechslera) tritici-repentis (tan spot) on wheat or P. feres (net blotch) on barley; Pyricularia spp., e. g. P. oryzae (teleomorph: Magnaporthe grisea, rice blast) on rice and P. grisea on turf and cereals; Pythium spp.
(damping-off) on turf, rice, corn, wheat, cotton, rape, sunflowers, soybeans, sugar beets, vegetables and various other plants (e. g. P. ultimum or P. aphanidermatum); Ramularia spp., e. g. R. collo-cygni (Ramularia leaf spots, Physiological leaf spots) on barley and R. beticola on sugar beets; Rhizoctonia spp. on cotton, rice, potatoes, turf, corn, rape, potatoes, sugar beets, vegetables and various other plants, e. g. R. solani (root and stem rot) on soybeans, R. solani (sheath blight) on rice or R. cerealis (Rhizoctonia spring blight) on wheat or barley; Rhizopus stolonifer (black mold, soft rot) on strawberries, carrots, cabbage, vines and tomatoes;
Rhynchosporium secalis (scald) on barley, rye and triticale; Sarocladium oryzae and S.
attenuatum (sheath rot) on rice; Sclerotinia spp. (stem rot or white mold) on vegetables and field crops, such as rape, sunflowers (e. g. S. sclerotiorum) and soybeans (e. g. S. rolfsii or S.
sclerotiorum); Septoria spp. on various plants, e. g. S. glycines (brown spot) on soybeans, S. tritici (Septoria blotch) on wheat and S. (syn. Stagonospora) nodorum (Stagonospora blotch) on cereals; Uncinula (syn. Erysiphe) necator (powdery mildew, anamorph: Oidium tuckeri) on vines; Setospaeria spp. (leaf blight) on corn (e. g. S. turcicum, syn. Helminthosporium turcicum) and turf; Sphacelotheca spp. (smut) on corn, (e. g. S. reiliana: head smut), sorghum und sugar cane; Sphaerotheca fuliginea (powdery mildew) on cucurbits; Spongospora subterranea (powdery scab) on potatoes and thereby transmitted viral diseases; Stagonospora spp. on cereals, e. g. S. nodorum (Stagonospora blotch, teleomorph: Leptosphaeria [syn.
Phaeosphaeria] nodorum) on wheat; Synchytrium endobioticum on potatoes (potato wart disease); Taphrina spp., e. g. T. deformans (leaf curl disease) on peaches and T. pruni (plum pocket) on plums; Thielaviopsis spp. (black root rot) on tobacco, pome fruits, vegetables, soybeans and cotton, e. g. T. basicola (syn. Chalara elegans); Tilletia spp. (common bunt or stinking smut) on cereals, such as e. g. T. tritici (syn. T. caries, wheat bunt) and T. controversa (dwarf bunt) on wheat; Typhula incarnata (grey snow mold) on barley or wheat; Urocystis spp., e. g. U. occulta (stem smut) on rye; Uromyces spp. (rust) on vegetables, such as beans (e. g. U. appendiculatus, syn. U. phaseoli) and sugar beets (e. g. U. betae); Ustilago spp. (loose smut) on cereals (e. g. U. nuda and U. avaenae), corn (e. g. U. maydis: corn smut) and sugar cane; Venturia spp. (scab) on apples (e. g. V. inaequalis) and pears; and Verticillium spp. (wilt) on various plants, such as fruits and ornamentals, vines, soft fruits, vegetables and field crops, e. g. V. dahliae on strawberries, rape, potatoes and tomatoes. Preferably, the inventive mixtures and compositions are used for controlling Sclerotinia spp. (stem rot or white mold) on
vegetables and field crops, such as rape, sunflowers (e. g. S. sclerotiorum) and soybeans (e. g. S. rolfsii or S. sclerotiorum). More preferably, the inventive mixtures and compositions are used for controlling Sclerotinia sclerotiorum (white mold) on vegetables and field crops, such as rape, sunflowers and soybeans; in particular on soybeans.
Plant propagation materials may be treated with the mixtures and compositions of the invention prophylactically either at or before planting or transplanting.
The invention also relates to agrochemical compositions comprising an auxiliary and at least one inhibitor of complex II, pyraclostrobin and fluazinam according to the invention.
An agrochemical composition comprises a fungicidally effective amount of an inhibitor of complex II, pyraclostrobin and fluazinam. The term "effective amount" denotes an amount of the composition or of the mixtures according to the invention, which is sufficient for controlling harmful fungi on cultivated plants or in the protection of materials and which does not result in a substantial damage to the treated plants. Such an amount can vary in a broad range and is dependent on various factors, such as the fungal species to be controlled, the treated cultivated plant or material, the climatic conditions and the specific mixture used.
The components 1 ), 2) and 3) can be converted into customary types of agrochemical compositions, e. g. solutions, emulsions, suspensions, dusts, powders, pastes, granules, pressings, capsules, and mixtures thereof. Examples for composition types are suspensions (e.g. SC, OD, FS), emulsifiable concentrates (e.g. EC), emulsions (e.g. EW, EO, ES, ME), capsules (e.g. CS, ZC), pastes, pastilles, wettable powders or dusts (e.g. WP, SP, WS, DP, DS), pressings (e.g. BR, TB, DT), granules (e.g. WG, SG, GR, FG, GG, MG), insecticidal articles (e.g. LN), as well as gel formulations for the treatment of plant propagation materials such as seeds (e.g. GF). These and further compositions types are defined in the "Catalogue of pesticide formulation types and international coding system", Technical Monograph No. 2, 6th Ed. May 2008, CropLife International.
The compositions are prepared in a known manner, such as described by Mollet and Grubemann, Formulation technology, Wiley VCH, Weinheim, 2001 ; or Knowles, New
developments in crop protection product formulation, Agrow Reports DS243, T&F Informa, London, 2005.
Suitable auxiliaries are solvents, liquid carriers, solid carriers or fillers, surfactants, dispersants, emulsifiers, wetters, adjuvants, solubilizers, penetration enhancers, protective colloids, adhesion agents, thickeners, humectants, repellents, attractants, feeding stimulants, compatibilizers, bactericides, anti-freezing agents, anti-foaming agents, colorants, tackifiers and binders.
Suitable solvents and liquid carriers are water and organic solvents, such as mineral oil fractions of medium to high boiling point, e.g. kerosene, diesel oil; oils of vegetable or animal origin; aliphatic, cyclic and aromatic hydrocarbons, e. g. toluene, paraffin,
tetrahydronaphthalene, alkylated naphthalenes; alcohols, e.g. ethanol, propanol, butanol, benzylalcohol, cyclohexanol; glycols; DMSO; ketones, e.g. cyclohexanone; esters, e.g. lactates, carbonates, fatty acid esters, gamma-butyrolactone; fatty acids; phosphonates; amines; amides, e.g. N-methylpyrrolidone, fatty acid dimethylamides; and mixtures thereof.
Suitable solid carriers or fillers are mineral earths, e.g. silicates, silica gels, talc, kaolins, limestone, lime, chalk, clays, dolomite, diatomaceous earth, bentonite, calcium sulfate, magnesium sulfate, magnesium oxide; polysaccharides, e.g. cellulose, starch; fertilizers, e.g. ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas; products of vegetable origin, e.g. cereal meal, tree bark meal, wood meal, nutshell meal, and mixtures thereof.
Suitable surfactants are surface-active compounds, such as anionic, cationic, nonionic and amphoteric surfactants, block polymers, polyelectrolytes, and mixtures thereof. Such surfactants can be used as emusifier, dispersant, solubilizer, wetter, penetration enhancer, protective colloid, or adjuvant. Examples of surfactants are listed in McCutcheon's, Vol.1 : Emulsifiers & Detergents, McCutcheon's Directories, Glen Rock, USA, 2008 (International Ed. or North American Ed.).
Suitable anionic surfactants are alkali, alkaline earth or ammonium salts of sulfonates, sulfates, phosphates, carboxylates, and mixtures thereof. Examples of sulfonates are alkylarylsulfonates, diphenylsulfonates, alpha-olefin sulfonates, lignine sulfonates, sulfonates of fatty acids and oils, sulfonates of ethoxylated alkylphenols, sulfonates of alkoxylated
arylphenols, sulfonates of condensed naphthalenes, sulfonates of dodecyl- and
tridecylbenzenes, sulfonates of naphthalenes and alkylnaphthalenes, sulfosuccinates or sulfosuccinamates. Examples of sulfates are sulfates of fatty acids and oils, of ethoxylated alkylphenols, of alcohols, of ethoxylated alcohols, or of fatty acid esters. Examples of phosphates are phosphate esters. Examples of carboxylates are alkyl carboxylates, and carboxylated alcohol or alkylphenol ethoxylates.
Suitable nonionic surfactants are alkoxylates, N-subsituted fatty acid amides, amine oxides, esters, sugar-based surfactants, polymeric surfactants, and mixtures thereof. Examples of alkoxylates are compounds such as alcohols, alkylphenols, amines, amides, arylphenols, fatty acids or fatty acid esters which have been alkoxylated with 1 to 50 equivalents. Ethylene oxide and/or propylene oxide may be employed for the alkoxylation, preferably ethylene oxide.
Examples of N-subsititued fatty acid amides are fatty acid glucamides or fatty acid
alkanolamides. Examples of esters are fatty acid esters, glycerol esters or monoglycerides. Examples of sugar-based surfactants are sorbitans, ethoxylated sorbitans, sucrose and glucose esters or alkylpolyglucosides. Examples of polymeric surfactants are home- or copolymers of vinylpyrrolidone, vinylalcohols, or vinylacetate.
Suitable cationic surfactants are quaternary surfactants, for example quaternary ammonium compounds with one or two hydrophobic groups, or salts of long-chain primary amines. Suitable amphoteric surfactants are alkylbetains and imidazolines. Suitable block polymers are block polymers of the A-B or A-B-A type comprising blocks of polyethylene oxide and polypropylene oxide, or of the A-B-C type comprising alkanol, polyethylene oxide and polypropylene oxide.
Suitable polyelectrolytes are polyacids or polybases. Examples of polyacids are alkali salts of polyacrylic acid or polyacid comb polymers. Examples of polybases are polyvinylamines or polyethyleneamines.
Suitable adjuvants are compounds, which have a neglectable or even no pesticidal activity themselves, and which improve the biological performance of the mixture on the target.
Examples are surfactants, mineral or vegetable oils, and other auxilaries. Further examples are listed by Knowles, Adjuvants and additives, Agrow Reports DS256, T&F Informa UK, 2006, chapter 5.
Suitable thickeners are polysaccharides (e.g. xanthan gum, carboxymethylcellulose), anorganic clays (organically modified or unmodified), polycarboxylates, and silicates.
Suitable bactericides are bronopol and isothiazolinone derivatives such as alkyliso- thiazolinones and benzisothiazolinones.
Suitable anti-freezing agents are ethylene glycol, propylene glycol, urea and glycerin.
Suitable anti-foaming agents are silicones, long chain alcohols, and salts of fatty acids.
Suitable colorants (e.g. in red, blue, or green) are pigments of low water solubility and water- soluble dyes. Examples are inorganic colorants (e.g. iron oxide, titan oxide, iron
hexacyanoferrate) and organic colorants (e.g. alizarin-, azo- and phthalocyanine colorants).
Suitable tackifiers or binders are polyvinylpyrrolidone, polyvinylacetates, polyvinyl alcohols, polyacrylates, biological or synthetic waxes, and cellulose ethers.
The agrochemical compositions generally comprise between 0.01 and 95%, preferably between 0.1 and 90%, and in particular between 0.5 and 75%, by weight of active substances. The active substances are employed in a purity of from 90% to 100%, preferably from 95% to 100% (according to NMR spectrum).
Solutions for seed treatmenr (LS), Suspoemulsions (SE), flowable concentrates (FS), powders for dry treatment (DS), water-dispersible powders for slurry treatment (WS), water- soluble powders (SS), emulsions (ES), emulsifiable concentrates (EC) and gels (GF) are usually employed for the purposes of treatment of plant propagation materials, particularly seeds. The compositions in question give, after two-to-tenfold dilution, active substance concentrations of from 0.01 to 60% by weight, preferably from 0.1 to 40%, in the ready-to-use preparations.
Application can be carried out before or during sowing. Methods for applying or treating the fungicidal mixtures and compositions thereof, respectively, on to plant propagation material, especially seeds include dressing, coating, pelleting, dusting, soaking and in-furrow application methods of the propagation material. Preferably, the fungicidal mixtures or the compositions thereof, respectively, are applied on to the plant propagation material by a method such that germination is not induced, e. g. by seed dressing, pelleting, coating and dusting.
When employed in plant protection, the amounts of active substances (the sum of all active substances in the composition e.g the components 1 ) to 3)) applied are, depending on the kind of effect desired, usually from 0.001 to 2 kg per ha, preferably from 0.005 to 2 kg per ha, more preferably from 0.05 to 0.9 kg per ha, even more preferably from 0.1 to 0.8 kg per ha, and in particular from 0.25 to 0.75 kg per ha.
In treatment of plant propagation materials such as seeds, e. g. by dusting, coating or drenching seed, amounts of active substance of from 0.1 to 1000 g, preferably from 1 to 1000 g, more preferably from 1 to 100 g and most preferably from 5 to 100 g, per 100 kilogram of plant propagation material (preferably seed) are generally required.
When used in the protection of materials or stored products, the amount of active substance applied depends on the kind of application area and on the desired effect. Amounts customarily applied in the protection of materials are 0.001 g to 2 kg, preferably 0.005 g to 1 kg, of active substance per cubic meter of treated material.
Various types of oils, wetters, adjuvants, fertilizer, or micronutrients, and further pesticides (e.g. herbicides, insecticides, fungicides, growth regulators, safeners, biopesticides) may be added to the active substances or the compositions comprising them as premix or, if
appropriate not until immediately prior to use (tank mix). These agents can be admixed with the compositions according to the invention in a weight ratio of 1 :100 to 100:1 , preferably 1 :10 to 10:1 .
Biopesticides are typically created by growing and concentrating naturally occurring organisms and/or their metabolites including bacteria and other microbes, fungi, viruses, nematodes, proteins, etc. They are often considered to be important components of integrated pest management (IPM) programmes.
Biopesticides fall into two major classes, microbial and biochemical pesticides:
(1 ) Microbial pesticides consist of bacteria, fungi or viruses (and often include the
metabolites that bacteria and fungi produce). Entomopathogenic nematodes are also classed as microbial pesticides, even though they are multi-cellular.
(2) Biochemical pesticides are naturally occurring substances that control pests or provide other crop protection uses as defined below, but are relatively non-toxic to mammals.
According to one embodiment, individual components of the composition according to the invention such as parts of a kit or parts of a binary or ternary mixture may be mixed by the user himself in a spray tank or any other kind of vessel used for applications (e.g seed treater drums, seed pelleting machinery, knapsack sprayer) and further auxiliaries may be added, if appropriate. Consequently, one embodiment of the invention is a kit for preparing a usable pesticidal composition, the kit compring a) a composition comprising component 1 ) as defined herein and at least one auxiliary; and b) a composition comprising component 2) as defined herein and at least one auxiliary; c) a composition comprising component 3) as defined herein and at least one auxiliary; and optionally d) a composition comprising a component 4) as defined herein and at least one auxiliary.
The user applies the composition according to the invention usually from a predosage device, a knapsack sprayer, a spray tank, a spray plane, or an irrigation system. Usually, the agrochemical composition is made up with water, buffer, and/or further auxiliaries to the desired application concentration and the ready-to-use spray liquor or the agrochemical composition according to the invention is thus obtained. Usually, 20 to 2000 liters, preferably 50 to 400 liters, of the ready-to-use spray liquor are applied per hectare of agricultural useful area.
The mixtures comprising at least one compound I and at least one biochemical pesticide selected from groups L2), L4) and L6) as defined herein can be prepared as compositions comprising besides the active ingredients at least one inert ingredient (auxiliary) by usual means, e. g. by the means given for the compositions of compounds I. Concerning usual ingredients of such compositions reference is made to the explanations given for the
compositions containing compounds I.
According to one embodiment, the microbial pesticides selected from groups L1 ), L3) and L5) embrace not only the isolated, pure cultures of the respective micro-organism as defined herein, but also its cell-free extract, its suspensions in a whole broth culture or as a metabolite- containing supernatant or a purified metabolite obtained from a whole broth culture of the microorganism or microorganism strain.
According to a further embodiment, the microbial pesticides selected from groups L1 ), L3 and L5) embraces not only the isolated, pure cultures of the respective micro-organism as defined herein, but also a cell-free extract thereof or at least one metabolite thereof, and/or a mutant of the respective micro-organism having all the identifying characteristics thereof and also a cell-free extract or at least one metabolite of the mutant.
"Whole broth culture" refers to a liquid culture containing both cells and media.
"Supernatant" refers to the liquid broth remaining when cells grown in broth are removed by centrifugation, filtration, sedimentation, or other means well known in the art.
The term "cell-free extract" refers to an extract of the vegetative cells, spores and/or the whole culture broth of a microorganism comprising cellular metabolites produced by the respective microorganism obtainable by cell disruption methods known in the art such as solvent-based (e.g. organic solvents such as alcohols sometimesin combination with suitable salts), temperature-based, application of shear forces, cell disrupotion with an ultrasonicator. The desired extract may be concentrated by conventional concentration techniques such as drying, evaporation, centrifugation or alike. Certain washing steps using organic solents and/or water-based media may also be applied to the crude extract preferably prior to use.
The term "metabolite" refers to any compound, substance or byproduct produced by a microorganism (such as fungi and bacteria) that has improves plant growth, water use efficiency of the plant, plant health, plant appearance, or the population of beneficial microorganisms in the soil around the plant activity.
The term "mutant" refers a microorganism obtained by direct mutant selection but also includes microorganisms that have been further mutagenized or otherwise manipulated (e.g., via the introduction of a plasmid). Accordingly, embodiments include mutants, variants, and or derivatives of the respective microorganism, both naturally occurring and artificially induced mutants. For example, mutants may be induced by subjecting the microorganism to known mutagens, such as N-methyl-nitrosoguanidine, using conventional methods.
The mixtures comprising cell-free extracts and/or metabolites of microbial pesticides selected from groups L1 ), L3) and L5) as defined herein can be prepared as compositions comprising besides the active ingredients at least one inert ingredient by usual means, e. g. by the means given for the compositions of compounds I. Concerning usual ingredients of such compositions reference is made to the explanations given for the compositions containing compounds I.
The mixtures comprising at least one compound I and cells, spores and/or whole broth culture of at least one microbial pesticide selected from groups L1 ), L3) and L5) as defined herein can be prepared as compositions comprising besides the active ingredients at least one inert ingredient (auxiliary) by usual means (see e.g. H.D. Burges: Formulation of Micobial
Biopestcides, Springer, 1998, ), e. g. by the means given for the compositions of compounds I. Suitable customary types of such compositions are suspensions, dusts, powders, pastes, granules, pressings, capsules, and mixtures thereof. Examples for composition types are suspensions (e.g. SC, OD, FS), capsules (e.g. CS, ZC), pastes, pastilles, wettable powders or dusts (e.g. WP, SP, WS, DP, DS), pressings (e.g. BR, TB, DT), granules (e.g. WG, SG, GR,
FG, GG, MG), insecticidal articles (e.g. LN), as well as gel formulations for the treatment of plant propagation materials such as seeds (e.g. GF).
In the mixtures and compositions, the compound ratios (e. g. compound l/compound ll/fluazinam ratio) are advantageously chosen so as to produce a synergistic effect.
The term "synergstic effect" is understood to refer in particular to that defined by Colby's formula (Colby, S. R., "Calculating synergistic and antagonistic responses of herbicide combinations", Weeds, 15, pp. 20-22, 1967).
The term "synergistic effect" is also understood to refer to that defined by application of the Tammes method, (Tammes, P. M. L, "Isoboles, a graphic representation of synergism in pesticides", Netherl. J. Plant Pathol. 70, 1964).
The components can be used individually or already partially or completely mixed with one another to prepare the composition according to the invention. It is also possible for them to be packaged and used as combination such as a kit of parts.
The fungicidal action of the compositions according to the invention can be shown by the tests described below.
The active compounds, separately or jointly, are prepared as a stock solution comprising 25 mg of active compound which is made up to 10 ml using a mixture of acetone and/or DMSO and the emulsifier Uniperol® EL (wetting agent having an emulsifying and dispersing action based on ethoxylated alkylphenols) in a ratio by volume of solvent/emulsifier of 99:1 . The mixture is then made up to 100 ml with water. This stock solution is diluted with the
solvent/emulsifier/water mixture described to give the concentration of active compound stated below.
The visually determined percentages of infected leaf areas are converted into efficacies in % of the untreated control.
The efficacy (E) is calculated as follows using Abbot's formula:
E = (1 - α/β) ■ 100
a corresponds to the fungicidal infection of the treated plants in % and
β corresponds to the fungicidal infection of the untreated (control) plants in %
An efficacy of 0 means that the infection level of the treated plants corresponds to that of the untreated control plants; an efficacy of 100 means that the treated plants were not infected.
The expected efficacies of two way active compound combinations were determined according to Colby's formula (Colby, S.R. "Calculating synergistic and antagonistic responses of herbicide combinations", Weeds, 1J5, pp. 20-22, 1967) and compared with the observed efficacies.
Colby's formula: E = x + y - x »y/100
E expected efficacy, expressed in % of the untreated control, when using the mixture of the active compounds A and B at the concentrations a and b
x efficacy, expressed in % of the untreated control, when using the active compound A at the concentration a
y efficacy, expressed in % of the untreated control, when using the active compound C at the concentration c.
Colby's formula can also be extended to be directly applied to 3-way mixtures (Colby, S.R. "Calculating synergistic and antagonistic responses of herbicide combinations", Weeds, 1J5, pp. 20-22, 1967):
Colby's formula for 3-way mixtures:
E = x + y + z - (x»y + x»y + χ·ζ/ + yz)/100 - x»yz/10000
E expected efficacy, expressed in % of the untreated control, when using the mixture of the active compounds A and B and C at the concentrations a and b and c
x efficacy, expressed in % of the untreated control, when using the active compound A at the concentration a
y efficacy, expressed in % of the untreated control, when using the mixture of active
compound B at the concentration b and active compound C at the concentration c.
z efficacy, expressed in % of the untreated control, when using the active compound C at the concentration c.
Microtests
The active compounds were formulated separately as a stock solution having a
concentration of 10000 ppm in dimethyl sulfoxide.
The product orysastrobin was used as commercial finished formulation and diluted with water to the stated concentration of the active compound. The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of the respective pathogen in the respective nutrient medium was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation.
The measured parameters were compared to the growth of the active compound-free control variant (100%) and the fungus-free and active compound-free blank value to determine the relative growth in % of the pathogens in the respective active compounds. These percentages were converted into efficacies. Colby's formula for 3-way and 2-way mixtures were applied as described in Weeds, 15, pp. 20-22, 1967.
Use example 1. Activity against the late blight pathogen Phytophthora infestans
In this test, a spore suspension of Phytophtora infestans containing a pea juice-based aqueous nutrient medium or DDC medium was used. Results are shown here:
Boscalid + Pyraclostrobin + Fluazinam
Figure imgf000030_0001
Use example 2. Activity against Leptosphaeria nodorum causing wheat leaf spots
In this test, a spore suspension of Leptosphaeria nodorum in an aqueous biomalt or yeast- bactopeptone-glycerine solution was used. Results are shown here:
Fluxapyroxad + Pyraclostrobin + Fluazinam
Calculated
Active compound Observed
Cone, (ppm) Mixture efficacy acc. to
/ active mixture efficacy (%)
Colby (%)
Fluxapyroxad 0.25 - 31
Pyraclostrobin 0.063 - 56
Fluazinam 0.063 - 23
Fluxapyroxad 0.25 4 : 1 52 47
Fluazinam 0.063
Fluxapyroxad 0.25 4 : 1 : 1 100 77 Calculated
Active compound Observed
Cone, (ppm) Mixture efficacy acc. to
/ active mixture efficacy (%)
Colby (%)
Pyraclostrobin 0.063
Fluazinam 0.063
Boscalid + Pyraclostrobin + Fluazinam
Figure imgf000031_0001
Use example 3. Activity against Rhizoctonia solani causing potato stem canker
In this test, a spore suspension of Rhizoctonia solani in an aqueous biomalt or yeast- bactopeptone-glycerine solution was used. Results are shown here:
Fluxapyroxad + Pyraclostrobin + Fluazinam
Calculated
Active compound Observed
Cone, (ppm) Mixture efficacy acc. to
/ active mixture efficacy (%)
Colby (%)
Fluxapyroxad 0.016 0
0.004 - 0
0.001 0
Pyraclostrobin 0.016 - 48
Fluazinam 0.016 - 0
0.004 0
Pyraclostrobin 0.016 1 : 1 72 48
Fluazinam 0.016
Fluxapyroxad 0.004 1 : 4 10 0
Fluazinam 0.016
Fluxapyroxad 0.004 1 : 4 : 4 84 48
Pyraclostrobin 0.016
Fluazinam 0.016 Calculated
Active compound Observed
Cone, (ppm) Mixture efficacy acc. to / active mixture efficacy (%)
Colby (%)
Fluxapyroxad 0.001 1 : 16 54 48 Pyraclostrobin 0.016
Pyraclostrobin 0.016 1 : 1 72 48 Fluazinam 0.016
Fluxapyroxad 0.001 1 : 16 : 16 79 48
Pyraclostrobin 0.016
Fluazinam 0.016
Fluxapyroxad 0.016 1 : 1 77 48 Pyraclostrobin 0.016
Pyraclostrobin 0.016 4 : 1 61 48 Fluazinam 0.004
Fluxapyroxad 0.016 4 : 4 : 1 85 48
Pyraclostrobin 0.016
Fluazinam 0.004
Fluxapyroxad 0.001 1 : 16 54 48 Pyraclostrobin 0.016
Pyraclostrobin 0.016 4 : 1 61 48 Fluazinam 0.004
Fluxapyroxad 0.001 1 : 16 : 4 74 48
Pyraclostrobin 0.016
Fluazinam 0.004
Boscalid + Pyraclostrobin + Fluazinam
Calculated
Active compound Observed
Cone, (ppm) Mixture efficacy acc. to / active mixture efficacy (%)
Colby (%)
Boscalid 0.25 - 0
0.063 0
Pyraclostrobin 0.016 - 48
Fluazinam 0.016 - 0
0.004 0
Pyraclostrobin 0.016 1 : 1 72 48 Fluazinam 0.016
Boscalid 0.25 16 : 1 : 1 88 48
Pyraclostrobin 0.016
Fluazinam 0.016
Pyraclostrobin 0.016 1 : 1 72 48 Fluazinam 0.016 Calculated
Active compound Observed
Cone, (ppm) Mixture efficacy acc. to
/ active mixture efficacy (%)
Colby (%)
Boscalid 0.063 4 : 1 4 0
Fluazinam 0.016
Boscalid 0.063 4 : 1 : 1 79 48
Pyraclostrobin 0.016
Fluazinam 0.016
Pyraclostrobin 0.016 4 : 1 61 52
Fluazinam 0.004
Boscalid 0.25 63 : 4 : 1 89 48
Pyraclostrobin 0.016
Fluazinam 0.004
Use example 4. Activity against Colletotrichum truncatum causing soybean anthracnose
In this test, a spore suspension of Colletotrichum truncatum in an aqueous biomalt or yeast- bactopeptone-glycerine solution was then added. Results are shown here:
Fluxapyroxad + Pyraclostrobin + Fluazinam
Calculated
Active compound Observed
Cone, (ppm) Mixture efficacy acc. to
/ active mixture efficacy (%)
Colby (%)
Fluxapyroxad 0.25 3
0.063 - 0
0.016 0
0.004 1
Pyraclostrobin 0.25 71
0.063 - 37
0.016 10
Fluazinam 0.063 - 0
Fluxapyroxad 0.063 1 : 1 40 37
Pyraclostrobin 0.063
Fluxapyroxad 0.063 1 : 1 2 0
Fluazinam 0.063
Fluxapyroxad 0.063 1 : 1 : 1 77 37
Pyraclostrobin 0.063
Fluazinam 0.063
Fluxapyroxad 0.016 1 : 4 45 36
Pyraclostrobin 0.063
Fluxapyroxad 0.016 1 : 4 : 4 66 37 Calculated
Active compound Observed
Cone, (ppm) Mixture efficacy acc. to / active mixture efficacy (%)
Colby (%)
Pyraclostrobin 0.063
Fluazinam 0.063
Pyraclostrobin 0.063 1 : 1 40 37 Fluazinam 0.063
Fluxapyroxad 0.004 1 : 16 : 16 79 37
Pyraclostrobin 0.063
Fluazinam 0.063
Fluxapyroxad 0.25 1 : 1 75 72 Pyraclostrobin 0.25
Fluxapyroxad 0.25 4 : 1 5 3 Fluazinam 0.063
Fluxapyroxad 0.25 4 : 4 : 1 100 72
Pyraclostrobin 0.25
Fluazinam 0.063
Fluxapyroxad 0.25 4 : 1 68 38 Pyraclostrobin 0.063
Fluxapyroxad 0.25 4 : 1 5 3 Fluazinam 0.063
Fluxapyroxad 0.25 4 : 1 : 1 100 38
Pyraclostrobin 0.063
Fluazinam 0.063
Fluxapyroxad 0.25 16 : 1 31 13 Pyraclostrobin 0.016
Pyraclostrobin 0.016 1 : 4 44 10 Fluazinam 0.063
Fluxapyroxad 0.25 4 : 1 5 3 Fluazinam 0.063
Fluxapyroxad 0.25 16 : 1 : 4 86 13
Pyraclostrobin 0.016
Fluazinam 0.063
Fluxapyroxad 0.063 1 : 4 76 71 Pyraclostrobin 0.25
Fluxapyroxad 0.063 1 : 1 2 0 Fluazinam 0.063
Fluxapyroxad 0.063 1 : 4 : 1 100 71
Pyraclostrobin 0.25
Fluazinam 0.063
Fluxapyroxad 0.016 1 : 16 74 71 Calculated
Active compound Observed
Cone, (ppm) Mixture efficacy acc. to / active mixture efficacy (%)
Colby (%)
Pyraclostrobin 0.25
Fluxapyroxad 0.016 1 : 16 : 4 100 71
Pyraclostrobin 0.25
Fluazinam 0.063
Boscalid + Pyraclostrobin + Fluazinam
Calculated
Active compound Observed
Cone, (ppm) Mixture efficacy acc. to / active mixture efficacy (%)
Colby (%)
Boscalid 4 - 4
1 4
Pyraclostrobin 0.25 71
0.063 - 37
0.016 10
Fluazinam 0.063 - 0
Boscalid 1 16 : 1 40 39 Pyraclostrobin 0.063
Boscalid 1 16 : 1 : 1 72 39
Pyraclostrobin 0.063
Fluazinam 0.063
Boscalid 1 63 : 1 15 13 Pyraclostrobin 0.016
Boscalid 1 63 : 1 : 4 43 13
Pyraclostrobin 0.016
Fluazinam 0.063
Boscalid 4 16 : 1 75 72 Pyraclostrobin 0.25
Boscalid 4 63 : 1 8 4 Fluazinam 0.063
Boscalid 4 63 : 4 : 1 100 72
Pyraclostrobin 0.25
Fluazinam 0.063
Boscalid 4 63 : 1 58 39 Pyraclostrobin 0.063
Pyraclostrobin 0.063 1 : 1 83 37 Fluazinam 0.063
Boscalid 4 63 : 1 8 4 Fluazinam 0.063 Calculated
Active compound Observed
Cone, (ppm) Mixture efficacy acc. to
/ active mixture efficacy (%)
Colby (%)
Boscalid 4 63 : 1 : 1 93 39
Pyraclostrobin 0.063
Fluazinam 0.063
Boscalid 4 250 : 1 25 13
Pyraclostrobin 0.016
Pyraclostrobin 0.016 1 : 4 44 10
Fluazinam 0.063
Boscalid 4 250 : 1 : 4 67 13
Pyraclostrobin 0.016
Fluazinam 0.063
Boscalid 4 63 : 1 8 4
Fluazinam 0.063
Boscalid 1 4 : 1 75 72
Pyraclostrobin 0.25
Boscalid 1 16 : 4 : 1 100 72
Pyraclostrobin 0.25
Fluazinam 0.063
Use example 5. Activity against Corynespora cassiicola causing soybean leaf spot
In this test, a spore suspension of Corynespora cassiicola in an aqueous biomalt or yeast- bactopeptone-glycerine solution was then added. Results are shown here:
Fluxapyroxad + Pyraclostrobin + Fluazinam
Calculated
Active compound Observed
Cone, (ppm) Mixture efficacy acc. to
/ active mixture efficacy (%)
Colby (%)
Fluxapyroxad 0.25 - 54
Pyraclostrobin 0.063 - 39
0.016 9
Fluazinam 0.25 - 51
0.063 12
Fluxapyroxad 0.25 16 : 1 64 58
Pyraclostrobin 0.016
Fluxapyroxad 0.25 16 : 1 : 16 100 79
Pyraclostrobin 0.016
Fluazinam 0.25
Pyraclostrobin 0.063 1 : 1 52 46
Fluazinam 0.063 Calculated
Active compound Observed
Cone, (ppm) Mixture efficacy acc. to / active mixture efficacy (%)
Colby (%)
Fluxapyroxad 0.25 4: 1 : 1 98 75
Pyraclostrobin 0.063
Fluazinam 0.063
Fluxapyroxad 0.25 16 : 1 64 58
Pyraclostrobin 0.016
Pyraclostrobin 0.016 1 : 4 29 19
Fluazinam 0.063
Fluxapyroxad 0.25 16: 1 :4 87 63
Pyraclostrobin 0.016
Fluazinam 0.063

Claims

Claims
A mixture, comprising as active compounds
1 ) at least one compound I selected from:
fluxapyroxad, boscalid, benzovindiflupyr, bixafen, fluopyram, furametpyr, iso- pyrazam, penflufen, penthiopyrad, sedaxane, thifluzamide, N-(4'-trifluoromethyl- thiobiphenyl-2-yl)-3-difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxamide, N-(2-(1 ,3,3-trimethyl-butyl)-phenyl)-1 ,3-dimethyl-5-fluoro-1 H-pyrazole-4-carbox- amide, 3-(difluoromethyl)-1 -methyl-N-(1 ,1 ,3-trimethylindan-4-yl)pyrazole-4-car- boxamide, 3-(trifluoromethyl)-1 -methyl-N-(1 , 1 ,3-trimethylindan-4-yl)pyrazole- 4-carboxamide, 1 ,3-dimethyl-N-(1 ,1 ,3-trimethylindan-4-yl)pyrazole-4-carboxamide,
3- (trifluoromethyl)-1 ,5-dimethyl-N-(1 ,1 ,3-trimethylindan-4-yl)pyrazole-
4- carboxamide, 3-(difluoromethyl)-1 ,5-dimethyl-N-(1 ,1 ,3-trimethylindan-4-yl)- pyrazole-4-carboxamide and 1 ,3,5-trimethyl-N-(1 ,1 ,3-trimethylindan-4-yl)pyrazole-4- carboxamide; and
2) at least one compound II selected from:
pyraclostrobin, azoxystrobin, fluoxastrobin and trifloxystrobin; and
3) fluazinam.
The mixture according to claim 1 , comprising at least one compound I and at least one compound II and fluazinam in a synergistically effective amount.
The mixture according to any of claims 1 and 2, wherein the weight ratio of component 1 ) and component 2) is in the range of from 20:1 to 1 :20 and the weight ratio of component 1 ) and component 3) is in the range of from 1 :1 to 1 :50.
The mixture according to any of the claims 1 to 3, wherein the compound I is selected from fluxapyroxad, boscalid and benzovindiflupyr.
The mixture according to claim 4, wherein the compound I is fluoxapyroxad.
The mixture according to any of the claims 1 to 5, wherein the compound II is selected from pyraclostrobin and azoxystrobin.
7. The mixture according to claim 6, wherein the compound II is pyraclostrobin.
8. The mixture according to any of the claims 1 to 7, comprising at least one further active compound as compound IV (component 4).
9. An agrochemical composition, comprising an auxiliary and the mixture according to any of claims 1 to 8.
10. Seed coated with the mixture according to any one of claims 1 to 8 or the composition according to claim 9 in an amount of from 1 g to 1000 g per 100 kg of seed.
1 1 . Use of the mixture as defined in any one of claims 1 to 8 or of the composition as defined in claim 9 for combating phytopathogenic harmful fungi.
12. The use according to claim 10 wherein the phytopathogenic fungi are selected from
Sclerotinia spp. .
13. A method for controlling phytopathogenic harmful fungi, comprising treating the fungi, their habitat or the seed, the soil or the plants to be protected against fungal attack with an effective amount of the mixture as defined in any one of claims 1 to 8 or of the
composition as defined in claim 9.
14. The method according to claim 13, comprising treating soybean plants to be protected against fungal attack with an effective amount of the mixture as defined in any one of claims 1 to 8 or of the composition as defined in claim 9 and wherein the phytopathogenic harmful fungi are selected from Sclerotinia spp. .
15. A method for improving plant health, comprising treating a plant, its propagation material, the locus where the plant is growing or is to grow with an effective amount of the mixture as defined in any one of claims 1 to 8 or of the composition as defined in claim 9.
PCT/EP2013/067148 2012-08-22 2013-08-16 Fungicidal ternary mixtures comprising fluazinam WO2014029697A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR112015003688-0A BR112015003688B1 (en) 2012-08-22 2013-08-16 MIXTURE, AGRICULTURAL COMPOSITION, SEED, USE OF THE MIXTURE AND METHOD FOR THE CONTROL OF PHYTOPATHOGEN HARMFUL FUNGI

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12181312 2012-08-22
EP12181312.5 2012-08-22

Publications (1)

Publication Number Publication Date
WO2014029697A1 true WO2014029697A1 (en) 2014-02-27

Family

ID=46826252

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/067148 WO2014029697A1 (en) 2012-08-22 2013-08-16 Fungicidal ternary mixtures comprising fluazinam

Country Status (2)

Country Link
BR (1) BR112015003688B1 (en)
WO (1) WO2014029697A1 (en)

Cited By (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104798786A (en) * 2015-05-07 2015-07-29 深圳诺普信农化股份有限公司 Sterilization composition containing benzovindiflupyr and application thereof
CN104839165A (en) * 2014-09-09 2015-08-19 陕西美邦农药有限公司 Benzovindiflupyr sterilization composition
US20150313241A1 (en) * 2012-11-22 2015-11-05 Basf Corporation Pesticidal Mixtures
US20150327556A1 (en) * 2012-11-22 2015-11-19 Basf Corporation Pesticidal Mixtures
WO2015177021A1 (en) * 2014-05-23 2015-11-26 Basf Se Mixtures comprising a bacillus strain and a pesticide
EP2952507A1 (en) 2014-06-06 2015-12-09 Basf Se Substituted [1,2,4]triazole compounds
EP2952506A1 (en) 2014-06-06 2015-12-09 Basf Se Substituted [1,2,4]triazole and imidazole compounds
EP2952512A1 (en) 2014-06-06 2015-12-09 Basf Se Substituted [1,2,4]triazole compounds
EP2962568A1 (en) 2014-07-01 2016-01-06 Basf Se Mixtures comprising a bacillus amyliquefaciens ssp. plantarum strain and a pesticide
EP2962567A1 (en) 2014-07-01 2016-01-06 Basf Se Ternary mixtures comprising biopesticides and at least two chemical insecticides
CN105409965A (en) * 2014-09-12 2016-03-23 陕西美邦农药有限公司 Sterilization composition containing benzovindiflupyr
WO2016142456A1 (en) 2015-03-11 2016-09-15 BASF Agro B.V. Pesticidal mixture comprising a carboxamide compound and a biopesticide
CN106070248A (en) * 2016-08-09 2016-11-09 李祥英 A kind of containing benzo alkene fluorine bacterium azoles and the bactericidal composition of fluoxastrobin
WO2016204160A1 (en) * 2015-06-15 2016-12-22 石原産業株式会社 Soybean disease control composition and soybean disease control method
WO2016202656A1 (en) 2015-06-16 2016-12-22 Basf Agrochemical Products B.V. Method for managing flea beetles of the family chrysomelidae in brassica crops
EP3111763A1 (en) 2015-07-02 2017-01-04 BASF Agro B.V. Pesticidal compositions comprising a triazole compound
WO2017093163A1 (en) 2015-11-30 2017-06-08 Basf Se Mixtures of cis-jasmone and bacillus amyloliquefaciens
US20170188584A1 (en) * 2014-05-23 2017-07-06 Basf Se Mixtures Comprising a Bacillus Strain and a Pesticide
EP3205209A1 (en) 2016-02-09 2017-08-16 Basf Se Mixtures and compositions comprising paenibacillus strains or metabolites thereof and other biopesticides
WO2017144231A1 (en) * 2016-02-26 2017-08-31 Basf Se Fungicidal mixtures comprising fluxapyroxad
WO2018050421A1 (en) 2016-09-13 2018-03-22 Basf Se Fungicidal mixtures i comprising quinoline fungicides
WO2018149754A1 (en) 2017-02-16 2018-08-23 Basf Se Pyridine compounds
WO2018184882A1 (en) 2017-04-06 2018-10-11 Basf Se Pyridine compounds
WO2018197466A1 (en) 2017-04-26 2018-11-01 Basf Se Substituted succinimide derivatives as pesticides
WO2018206479A1 (en) 2017-05-10 2018-11-15 Basf Se Bicyclic pesticidal compounds
EP3305072A4 (en) * 2015-05-29 2018-12-05 Ishihara Sangyo Kaisha, Ltd. Fungicidal composition and method for controlling plant diseases
WO2018219725A1 (en) 2017-05-30 2018-12-06 Basf Se Pyridine and pyrazine compounds
WO2018229202A1 (en) 2017-06-16 2018-12-20 Basf Se Mesoionic imidazolium compounds and derivatives for combating animal pests
WO2018234202A1 (en) 2017-06-19 2018-12-27 Basf Se Substituted pyrimidinium compounds and derivatives for combating animal pests
WO2018234488A1 (en) 2017-06-23 2018-12-27 Basf Se Substituted cyclopropyl derivatives
EP3453706A1 (en) 2017-09-08 2019-03-13 Basf Se Pesticidal imidazole compounds
WO2019057660A1 (en) 2017-09-25 2019-03-28 Basf Se Indole and azaindole compounds with substituted 6-membered aryl and heteroaryl rings as agrochemical fungicides
WO2019072906A1 (en) 2017-10-13 2019-04-18 Basf Se Imidazolidine pyrimidinium compounds for combating animal pests
WO2019121143A1 (en) 2017-12-20 2019-06-27 Basf Se Substituted cyclopropyl derivatives
WO2019121159A1 (en) 2017-12-21 2019-06-27 Basf Se Pesticidal compounds
WO2019137995A1 (en) 2018-01-11 2019-07-18 Basf Se Novel pyridazine compounds for controlling invertebrate pests
WO2019145140A1 (en) 2018-01-09 2019-08-01 Basf Se Silylethynyl hetaryl compounds as nitrification inhibitors
WO2019166561A1 (en) 2018-02-28 2019-09-06 Basf Se Use of alkoxypyrazoles as nitrification inhibitors
WO2019166560A1 (en) 2018-02-28 2019-09-06 Basf Se Use of n-functionalized alkoxy pyrazole compounds as nitrification inhibitors
WO2019166558A1 (en) 2018-02-28 2019-09-06 Basf Se Use of pyrazole propargyl ethers as nitrification inhibitors
WO2019175713A1 (en) 2018-03-14 2019-09-19 Basf Corporation New catechol molecules and their use as inhibitors to p450 related metabolic pathways
WO2019175712A1 (en) 2018-03-14 2019-09-19 Basf Corporation New uses for catechol molecules as inhibitors to glutathione s-transferase metabolic pathways
US10433768B2 (en) 2015-12-21 2019-10-08 Amer Sports Digital Services Oy Activity intensity level determination
WO2019224092A1 (en) 2018-05-22 2019-11-28 Basf Se Pesticidally active c15-derivatives of ginkgolides
WO2020002472A1 (en) 2018-06-28 2020-01-02 Basf Se Use of alkynylthiophenes as nitrification inhibitors
WO2020020777A1 (en) 2018-07-23 2020-01-30 Basf Se Use of substituted 2-thiazolines as nitrification inhibitors
WO2020020765A1 (en) 2018-07-23 2020-01-30 Basf Se Use of a substituted thiazolidine compound as nitrification inhibitor
EP3613736A1 (en) 2018-08-22 2020-02-26 Basf Se Substituted glutarimide derivatives
EP3628158A1 (en) 2018-09-28 2020-04-01 Basf Se Pesticidal mixture comprising a mesoionic compound and a biopesticide
EP3643705A1 (en) 2018-10-24 2020-04-29 Basf Se Pesticidal compounds
EP3670501A1 (en) 2018-12-17 2020-06-24 Basf Se Substituted [1,2,4]triazole compounds as fungicides
WO2020126591A1 (en) 2018-12-18 2020-06-25 Basf Se Substituted pyrimidinium compounds for combating animal pests
EP3696177A1 (en) 2019-02-12 2020-08-19 Basf Se Heterocyclic compounds for the control of invertebrate pests
US10779536B2 (en) 2014-11-07 2020-09-22 Basf Se Pesticidal mixtures
EP3730489A1 (en) 2019-04-25 2020-10-28 Basf Se Heteroaryl compounds as agrochemical fungicides
WO2020239517A1 (en) 2019-05-29 2020-12-03 Basf Se Mesoionic imidazolium compounds and derivatives for combating animal pests
EP3766879A1 (en) 2019-07-19 2021-01-20 Basf Se Pesticidal pyrazole derivatives
US10899932B2 (en) 2014-10-24 2021-01-26 Basf Se Non-amphoteric, quaternisable and water-soluble polymers for modifying the surface charge of solid particles
EP3769623A1 (en) 2019-07-22 2021-01-27 Basf Se Mesoionic imidazolium compounds and derivatives for combating animal pests
US10905122B2 (en) 2016-03-16 2021-02-02 Basf Se Use of tetrazolinones for combating resistant phytopathogenic fungi on cereals
WO2021170463A1 (en) 2020-02-28 2021-09-02 BASF Agro B.V. Methods and uses of a mixture comprising alpha-cypermethrin and dinotefuran for controlling invertebrate pests in turf
EP3903582A1 (en) 2020-04-28 2021-11-03 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors ii
EP3903584A1 (en) 2020-04-28 2021-11-03 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors iv
EP3903581A1 (en) 2020-04-28 2021-11-03 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors i
EP3903583A1 (en) 2020-04-28 2021-11-03 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors iii
WO2021219513A1 (en) 2020-04-28 2021-11-04 Basf Se Pesticidal compounds
EP3909950A1 (en) 2020-05-13 2021-11-17 Basf Se Heterocyclic compounds for the control of invertebrate pests
WO2021249800A1 (en) 2020-06-10 2021-12-16 Basf Se Substituted [1,2,4]triazole compounds as fungicides
US11219211B2 (en) 2015-03-11 2022-01-11 Basf Agrochemical Products B.V. Pesticidal mixture comprising a carboxamide compound and a biopesticide
EP3939961A1 (en) 2020-07-16 2022-01-19 Basf Se Strobilurin type compounds and their use for combating phytopathogenic fungi
WO2022017836A1 (en) 2020-07-20 2022-01-27 BASF Agro B.V. Fungicidal compositions comprising (r)-2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1- (1,2,4-triazol-1-yl)propan-2-ol
EP3945089A1 (en) 2020-07-31 2022-02-02 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors v
US11241012B2 (en) 2016-03-16 2022-02-08 Basf Se Use of tetrazolinones for combating resistant phytopathogenic fungi on soybean
EP3970494A1 (en) 2020-09-21 2022-03-23 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors viii
WO2022090069A1 (en) 2020-11-02 2022-05-05 Basf Se Compositions comprising mefenpyr-diethyl
WO2022089969A1 (en) 2020-10-27 2022-05-05 BASF Agro B.V. Compositions comprising mefentrifluconazole
WO2022106304A1 (en) 2020-11-23 2022-05-27 BASF Agro B.V. Compositions comprising mefentrifluconazole
EP4011208A1 (en) 2020-12-08 2022-06-15 BASF Corporation Microparticle compositions comprising fluopyram
WO2022128812A1 (en) 2020-12-17 2022-06-23 Basf Se Spore compositions, production and uses thereof
WO2022167488A1 (en) 2021-02-02 2022-08-11 Basf Se Synergistic action of dcd and alkoxypyrazoles as nitrification inhibitors
EP4043444A1 (en) 2021-02-11 2022-08-17 Basf Se Substituted isoxazoline derivatives
US11425909B2 (en) 2016-03-16 2022-08-30 Basf Se Use of tetrazolinones for combating resistant phytopathogenic fungi on fruits
WO2022243109A1 (en) 2021-05-18 2022-11-24 Basf Se New substituted quinolines as fungicides
WO2022243111A1 (en) 2021-05-18 2022-11-24 Basf Se New substituted pyridines as fungicides
WO2022243107A1 (en) 2021-05-18 2022-11-24 Basf Se New substituted pyridines as fungicides
WO2022243521A1 (en) 2021-05-21 2022-11-24 Basf Se Use of ethynylpyridine compounds as nitrification inhibitors
WO2022243523A1 (en) 2021-05-21 2022-11-24 Basf Se Use of an n-functionalized alkoxy pyrazole compound as nitrification inhibitor
WO2022268810A1 (en) 2021-06-21 2022-12-29 Basf Se Metal-organic frameworks with pyrazole-based building blocks
EP4119547A1 (en) 2021-07-12 2023-01-18 Basf Se Triazole compounds for the control of invertebrate pests
WO2023011957A1 (en) 2021-08-02 2023-02-09 Basf Se (3-quinolyl)-quinazoline
WO2023011958A1 (en) 2021-08-02 2023-02-09 Basf Se (3-pirydyl)-quinazoline
EP4140986A1 (en) 2021-08-23 2023-03-01 Basf Se Pyrazine compounds for the control of invertebrate pests
EP4140995A1 (en) 2021-08-27 2023-03-01 Basf Se Pyrazine compounds for the control of invertebrate pests
EP4151631A1 (en) 2021-09-20 2023-03-22 Basf Se Heterocyclic compounds for the control of invertebrate pests
WO2023072671A1 (en) 2021-10-28 2023-05-04 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors ix
WO2023072670A1 (en) 2021-10-28 2023-05-04 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors x
EP4194453A1 (en) 2021-12-08 2023-06-14 Basf Se Pyrazine compounds for the control of invertebrate pests
EP4198023A1 (en) 2021-12-16 2023-06-21 Basf Se Pesticidally active thiosemicarbazone compounds
EP4198033A1 (en) 2021-12-14 2023-06-21 Basf Se Heterocyclic compounds for the control of invertebrate pests
WO2023127767A1 (en) * 2021-12-27 2023-07-06 バイエルクロップサイエンス株式会社 Disease control agent and disease control method
EP4238971A1 (en) 2022-03-02 2023-09-06 Basf Se Substituted isoxazoline derivatives
WO2023203066A1 (en) 2022-04-21 2023-10-26 Basf Se Synergistic action as nitrification inhibitors of dcd oligomers with alkoxypyrazole and its oligomers
WO2024028243A1 (en) 2022-08-02 2024-02-08 Basf Se Pyrazolo pesticidal compounds
EP4342885A1 (en) 2022-09-20 2024-03-27 Basf Se N-(3-(aminomethyl)-phenyl)-5-(4-phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-amine derivatives and similar compounds as pesticides
EP4361126A1 (en) 2022-10-24 2024-05-01 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors xv
WO2024104815A1 (en) 2022-11-16 2024-05-23 Basf Se Substituted benzodiazepines as fungicides
WO2024104823A1 (en) 2022-11-16 2024-05-23 Basf Se New substituted tetrahydrobenzoxazepine
WO2024104818A1 (en) 2022-11-16 2024-05-23 Basf Se Substituted benzodiazepines as fungicides
WO2024104822A1 (en) 2022-11-16 2024-05-23 Basf Se Substituted tetrahydrobenzodiazepine as fungicides
EP4389210A1 (en) 2022-12-21 2024-06-26 Basf Se Heteroaryl compounds for the control of invertebrate pests

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998054965A1 (en) * 1997-06-06 1998-12-10 Basf Aktiengesellschaft Fungicidal mixtures
WO1999031981A2 (en) * 1997-12-18 1999-07-01 Basf Aktiengesellschaft Fungicide mixtures based on pyridine carboxamides_________________________________________
DE102004049761A1 (en) * 2004-10-12 2006-04-13 Bayer Cropscience Ag Fungicidal drug combinations
WO2006069699A1 (en) * 2004-12-23 2006-07-06 Basf Aktiengesellschaft Fungicidal mixtures
WO2007017416A2 (en) * 2005-08-05 2007-02-15 Basf Se Fungicidal mixtures containing substituted 1-methyl pyrazol-4-yl carboxylic acid anilides
WO2009098223A2 (en) * 2008-02-05 2009-08-13 Basf Se Plant health composition
WO2010139410A2 (en) * 2009-06-02 2010-12-09 Bayer Cropscience Ag Use of succinate dehydrogenase inhibitors for controlling sclerotinia ssp.
CN101984817A (en) * 2010-07-15 2011-03-16 江阴苏利科技有限公司 Bactericidal composition containing azoxystrobin and fluazinam and use thereof
CN102119689A (en) * 2010-01-08 2011-07-13 南京华洲药业有限公司 Bactericidal composition containing fluazinam and azoxystrobin and application of same

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998054965A1 (en) * 1997-06-06 1998-12-10 Basf Aktiengesellschaft Fungicidal mixtures
WO1999031981A2 (en) * 1997-12-18 1999-07-01 Basf Aktiengesellschaft Fungicide mixtures based on pyridine carboxamides_________________________________________
DE102004049761A1 (en) * 2004-10-12 2006-04-13 Bayer Cropscience Ag Fungicidal drug combinations
WO2006040123A2 (en) * 2004-10-12 2006-04-20 Bayer Cropscience Ag Fungicidal active ingredient combinations containing fluoxastrobin
WO2006069699A1 (en) * 2004-12-23 2006-07-06 Basf Aktiengesellschaft Fungicidal mixtures
WO2007017416A2 (en) * 2005-08-05 2007-02-15 Basf Se Fungicidal mixtures containing substituted 1-methyl pyrazol-4-yl carboxylic acid anilides
WO2009098223A2 (en) * 2008-02-05 2009-08-13 Basf Se Plant health composition
WO2010139410A2 (en) * 2009-06-02 2010-12-09 Bayer Cropscience Ag Use of succinate dehydrogenase inhibitors for controlling sclerotinia ssp.
CN102119689A (en) * 2010-01-08 2011-07-13 南京华洲药业有限公司 Bactericidal composition containing fluazinam and azoxystrobin and application of same
CN101984817A (en) * 2010-07-15 2011-03-16 江阴苏利科技有限公司 Bactericidal composition containing azoxystrobin and fluazinam and use thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BRADLEY C A ET AL: "Efficacy of fungicides for control of Sclerotinia stem rot of canola", PLANT DISEASE, THE AMERICAN PHYTOPATHOLOGICAL SOCIETY, vol. 90, no. 9, 1 September 2006 (2006-09-01), pages 1129 - 1134, XP008091141, ISSN: 0191-2917, DOI: 10.1094/PD-90-1129 *
DATABASE WPI Week 201137, Derwent World Patents Index; AN 2011-E47169, XP002686081 *
DATABASE WPI Week 201218, Derwent World Patents Index; AN 2011-K06587, XP002686082 *
DISCLOSED ANONYMOUSLY: "Fluazinam compositions", RESEARCH DISCLOSURES, MASON PUBLICATIONS, HAMPSHIRE, GB, vol. 438, no. 047, October 2004 (2004-10-01), Mason Publications, XP002686080, ISSN: 0374-4353 *
G. M. MARTENS, T.E. KRAUS, W.R. BARTON: "A new broad spectrum fungicide for use on lentil, field pea, and chickenpea crops", PHYTOPATHOLOGY, vol. 101:S115, 6 August 2011 (2011-08-06), XP002712171, Retrieved from the Internet <URL:http://www.apsnet.org/meetings/Documents/2011_Meeting_Abstracts/a11ma670.htm> [retrieved on 20130903] *
KOMYOJI T ET AL: "BIOLOGICAL PROPERTIES OF A NEW FUNGICIDE, FLUAZINAM", JOURNAL OF PESTICIDE SCIENCE - NIPPON NOYAKU GAKKAISHI, NIPPON NOYAKU GAKKAI, TOKYO, JP, vol. 20, no. 2, 1 January 1995 (1995-01-01), pages 129 - 135, XP008043158, ISSN: 0385-1559 *
SMITH ET AL: "Evaluation of application timing and efficacy of the fungicides fluazinam and boscalid for control of Sclerotinia blight of peanut", CROP PROTECTION, ELSEVIER SCIENCE, GB, vol. 27, no. 3-5, 21 December 2007 (2007-12-21), pages 823 - 833, XP022460370, ISSN: 0261-2194 *

Cited By (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10076119B2 (en) 2012-11-22 2018-09-18 Basf Corporation Pesticidal mixtures
US20150313241A1 (en) * 2012-11-22 2015-11-05 Basf Corporation Pesticidal Mixtures
US20150327556A1 (en) * 2012-11-22 2015-11-19 Basf Corporation Pesticidal Mixtures
US11284623B2 (en) 2012-11-22 2022-03-29 Basf Corporation Pesticidal mixtures
US20170188584A1 (en) * 2014-05-23 2017-07-06 Basf Se Mixtures Comprising a Bacillus Strain and a Pesticide
WO2015177021A1 (en) * 2014-05-23 2015-11-26 Basf Se Mixtures comprising a bacillus strain and a pesticide
US11083202B2 (en) 2014-05-23 2021-08-10 Basf Se Mixtures comprising a bacillus strain and a pesticide
US10251400B2 (en) 2014-05-23 2019-04-09 Basf Se Mixtures comprising a Bacillus strain and a pesticide
EP2952506A1 (en) 2014-06-06 2015-12-09 Basf Se Substituted [1,2,4]triazole and imidazole compounds
EP2952512A1 (en) 2014-06-06 2015-12-09 Basf Se Substituted [1,2,4]triazole compounds
EP2952507A1 (en) 2014-06-06 2015-12-09 Basf Se Substituted [1,2,4]triazole compounds
EP2962567A1 (en) 2014-07-01 2016-01-06 Basf Se Ternary mixtures comprising biopesticides and at least two chemical insecticides
EP2962568A1 (en) 2014-07-01 2016-01-06 Basf Se Mixtures comprising a bacillus amyliquefaciens ssp. plantarum strain and a pesticide
CN104839165A (en) * 2014-09-09 2015-08-19 陕西美邦农药有限公司 Benzovindiflupyr sterilization composition
CN105409965A (en) * 2014-09-12 2016-03-23 陕西美邦农药有限公司 Sterilization composition containing benzovindiflupyr
US10899932B2 (en) 2014-10-24 2021-01-26 Basf Se Non-amphoteric, quaternisable and water-soluble polymers for modifying the surface charge of solid particles
US10779536B2 (en) 2014-11-07 2020-09-22 Basf Se Pesticidal mixtures
US11882830B2 (en) 2015-03-11 2024-01-30 Basf Agrochemical Products B.V. Pesticidal mixture comprising a carboxamide compound and a biopesticide
WO2016142456A1 (en) 2015-03-11 2016-09-15 BASF Agro B.V. Pesticidal mixture comprising a carboxamide compound and a biopesticide
US11219211B2 (en) 2015-03-11 2022-01-11 Basf Agrochemical Products B.V. Pesticidal mixture comprising a carboxamide compound and a biopesticide
CN104798786A (en) * 2015-05-07 2015-07-29 深圳诺普信农化股份有限公司 Sterilization composition containing benzovindiflupyr and application thereof
CN104798786B (en) * 2015-05-07 2016-07-06 深圳诺普信农化股份有限公司 A kind of bactericidal composition containing benzo alkene fluorine bacterium azoles and application thereof
US10172357B2 (en) 2015-05-29 2019-01-08 Ishihara Sangyo Kaisha, Ltd. Fungicidal composition and method for controlling plant diseases
EP3305072A4 (en) * 2015-05-29 2018-12-05 Ishihara Sangyo Kaisha, Ltd. Fungicidal composition and method for controlling plant diseases
US20180168156A1 (en) 2015-06-15 2018-06-21 Ishihara Sangyo Kaisha, Ltd. Soybean disease control composition and soybean disease control method
US10791737B2 (en) 2015-06-15 2020-10-06 Ishihara Sangyo Kaisha, Ltd. Soybean disease control composition and soybean disease control method
WO2016204160A1 (en) * 2015-06-15 2016-12-22 石原産業株式会社 Soybean disease control composition and soybean disease control method
US11317627B2 (en) 2015-06-15 2022-05-03 Ishihara Sangyo Kaisha, Ltd. Soybean disease control composition and soybean disease control method
WO2016202656A1 (en) 2015-06-16 2016-12-22 Basf Agrochemical Products B.V. Method for managing flea beetles of the family chrysomelidae in brassica crops
EP3111763A1 (en) 2015-07-02 2017-01-04 BASF Agro B.V. Pesticidal compositions comprising a triazole compound
WO2017093163A1 (en) 2015-11-30 2017-06-08 Basf Se Mixtures of cis-jasmone and bacillus amyloliquefaciens
US10433768B2 (en) 2015-12-21 2019-10-08 Amer Sports Digital Services Oy Activity intensity level determination
EP3205209A1 (en) 2016-02-09 2017-08-16 Basf Se Mixtures and compositions comprising paenibacillus strains or metabolites thereof and other biopesticides
WO2017144231A1 (en) * 2016-02-26 2017-08-31 Basf Se Fungicidal mixtures comprising fluxapyroxad
US11241012B2 (en) 2016-03-16 2022-02-08 Basf Se Use of tetrazolinones for combating resistant phytopathogenic fungi on soybean
US10905122B2 (en) 2016-03-16 2021-02-02 Basf Se Use of tetrazolinones for combating resistant phytopathogenic fungi on cereals
US11425909B2 (en) 2016-03-16 2022-08-30 Basf Se Use of tetrazolinones for combating resistant phytopathogenic fungi on fruits
CN106070248A (en) * 2016-08-09 2016-11-09 李祥英 A kind of containing benzo alkene fluorine bacterium azoles and the bactericidal composition of fluoxastrobin
WO2018050421A1 (en) 2016-09-13 2018-03-22 Basf Se Fungicidal mixtures i comprising quinoline fungicides
WO2018149754A1 (en) 2017-02-16 2018-08-23 Basf Se Pyridine compounds
WO2018184882A1 (en) 2017-04-06 2018-10-11 Basf Se Pyridine compounds
WO2018197466A1 (en) 2017-04-26 2018-11-01 Basf Se Substituted succinimide derivatives as pesticides
WO2018206479A1 (en) 2017-05-10 2018-11-15 Basf Se Bicyclic pesticidal compounds
WO2018219725A1 (en) 2017-05-30 2018-12-06 Basf Se Pyridine and pyrazine compounds
WO2018229202A1 (en) 2017-06-16 2018-12-20 Basf Se Mesoionic imidazolium compounds and derivatives for combating animal pests
WO2018234202A1 (en) 2017-06-19 2018-12-27 Basf Se Substituted pyrimidinium compounds and derivatives for combating animal pests
WO2018234488A1 (en) 2017-06-23 2018-12-27 Basf Se Substituted cyclopropyl derivatives
EP3453706A1 (en) 2017-09-08 2019-03-13 Basf Se Pesticidal imidazole compounds
WO2019057660A1 (en) 2017-09-25 2019-03-28 Basf Se Indole and azaindole compounds with substituted 6-membered aryl and heteroaryl rings as agrochemical fungicides
WO2019072906A1 (en) 2017-10-13 2019-04-18 Basf Se Imidazolidine pyrimidinium compounds for combating animal pests
WO2019121143A1 (en) 2017-12-20 2019-06-27 Basf Se Substituted cyclopropyl derivatives
WO2019121159A1 (en) 2017-12-21 2019-06-27 Basf Se Pesticidal compounds
WO2019145140A1 (en) 2018-01-09 2019-08-01 Basf Se Silylethynyl hetaryl compounds as nitrification inhibitors
WO2019137995A1 (en) 2018-01-11 2019-07-18 Basf Se Novel pyridazine compounds for controlling invertebrate pests
WO2019166560A1 (en) 2018-02-28 2019-09-06 Basf Se Use of n-functionalized alkoxy pyrazole compounds as nitrification inhibitors
WO2019166558A1 (en) 2018-02-28 2019-09-06 Basf Se Use of pyrazole propargyl ethers as nitrification inhibitors
WO2019166561A1 (en) 2018-02-28 2019-09-06 Basf Se Use of alkoxypyrazoles as nitrification inhibitors
WO2019175712A1 (en) 2018-03-14 2019-09-19 Basf Corporation New uses for catechol molecules as inhibitors to glutathione s-transferase metabolic pathways
WO2019175713A1 (en) 2018-03-14 2019-09-19 Basf Corporation New catechol molecules and their use as inhibitors to p450 related metabolic pathways
WO2019224092A1 (en) 2018-05-22 2019-11-28 Basf Se Pesticidally active c15-derivatives of ginkgolides
WO2020002472A1 (en) 2018-06-28 2020-01-02 Basf Se Use of alkynylthiophenes as nitrification inhibitors
WO2020020765A1 (en) 2018-07-23 2020-01-30 Basf Se Use of a substituted thiazolidine compound as nitrification inhibitor
WO2020020777A1 (en) 2018-07-23 2020-01-30 Basf Se Use of substituted 2-thiazolines as nitrification inhibitors
EP3613736A1 (en) 2018-08-22 2020-02-26 Basf Se Substituted glutarimide derivatives
EP3628158A1 (en) 2018-09-28 2020-04-01 Basf Se Pesticidal mixture comprising a mesoionic compound and a biopesticide
WO2020064480A1 (en) 2018-09-28 2020-04-02 Basf Se Pesticidal mixture comprising a mesoionic compound and a biopesticide
WO2020083733A1 (en) 2018-10-24 2020-04-30 Basf Se Pesticidal compounds
EP3643705A1 (en) 2018-10-24 2020-04-29 Basf Se Pesticidal compounds
EP3670501A1 (en) 2018-12-17 2020-06-24 Basf Se Substituted [1,2,4]triazole compounds as fungicides
WO2020126591A1 (en) 2018-12-18 2020-06-25 Basf Se Substituted pyrimidinium compounds for combating animal pests
EP3696177A1 (en) 2019-02-12 2020-08-19 Basf Se Heterocyclic compounds for the control of invertebrate pests
EP3730489A1 (en) 2019-04-25 2020-10-28 Basf Se Heteroaryl compounds as agrochemical fungicides
WO2020239517A1 (en) 2019-05-29 2020-12-03 Basf Se Mesoionic imidazolium compounds and derivatives for combating animal pests
EP3766879A1 (en) 2019-07-19 2021-01-20 Basf Se Pesticidal pyrazole derivatives
WO2021013561A1 (en) 2019-07-19 2021-01-28 Basf Se Pesticidal pyrazole and triazole derivatives
EP3769623A1 (en) 2019-07-22 2021-01-27 Basf Se Mesoionic imidazolium compounds and derivatives for combating animal pests
WO2021170463A1 (en) 2020-02-28 2021-09-02 BASF Agro B.V. Methods and uses of a mixture comprising alpha-cypermethrin and dinotefuran for controlling invertebrate pests in turf
WO2021219513A1 (en) 2020-04-28 2021-11-04 Basf Se Pesticidal compounds
EP3903583A1 (en) 2020-04-28 2021-11-03 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors iii
EP3903582A1 (en) 2020-04-28 2021-11-03 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors ii
EP3903581A1 (en) 2020-04-28 2021-11-03 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors i
EP3903584A1 (en) 2020-04-28 2021-11-03 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors iv
EP3909950A1 (en) 2020-05-13 2021-11-17 Basf Se Heterocyclic compounds for the control of invertebrate pests
WO2021249800A1 (en) 2020-06-10 2021-12-16 Basf Se Substituted [1,2,4]triazole compounds as fungicides
EP3939961A1 (en) 2020-07-16 2022-01-19 Basf Se Strobilurin type compounds and their use for combating phytopathogenic fungi
WO2022017836A1 (en) 2020-07-20 2022-01-27 BASF Agro B.V. Fungicidal compositions comprising (r)-2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1- (1,2,4-triazol-1-yl)propan-2-ol
EP3945089A1 (en) 2020-07-31 2022-02-02 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors v
EP3970494A1 (en) 2020-09-21 2022-03-23 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors viii
WO2022089969A1 (en) 2020-10-27 2022-05-05 BASF Agro B.V. Compositions comprising mefentrifluconazole
WO2022090069A1 (en) 2020-11-02 2022-05-05 Basf Se Compositions comprising mefenpyr-diethyl
WO2022106304A1 (en) 2020-11-23 2022-05-27 BASF Agro B.V. Compositions comprising mefentrifluconazole
EP4011208A1 (en) 2020-12-08 2022-06-15 BASF Corporation Microparticle compositions comprising fluopyram
WO2022128812A1 (en) 2020-12-17 2022-06-23 Basf Se Spore compositions, production and uses thereof
WO2022167488A1 (en) 2021-02-02 2022-08-11 Basf Se Synergistic action of dcd and alkoxypyrazoles as nitrification inhibitors
EP4043444A1 (en) 2021-02-11 2022-08-17 Basf Se Substituted isoxazoline derivatives
WO2022243109A1 (en) 2021-05-18 2022-11-24 Basf Se New substituted quinolines as fungicides
WO2022243111A1 (en) 2021-05-18 2022-11-24 Basf Se New substituted pyridines as fungicides
WO2022243107A1 (en) 2021-05-18 2022-11-24 Basf Se New substituted pyridines as fungicides
WO2022243523A1 (en) 2021-05-21 2022-11-24 Basf Se Use of an n-functionalized alkoxy pyrazole compound as nitrification inhibitor
WO2022243521A1 (en) 2021-05-21 2022-11-24 Basf Se Use of ethynylpyridine compounds as nitrification inhibitors
WO2022268810A1 (en) 2021-06-21 2022-12-29 Basf Se Metal-organic frameworks with pyrazole-based building blocks
EP4119547A1 (en) 2021-07-12 2023-01-18 Basf Se Triazole compounds for the control of invertebrate pests
WO2023011957A1 (en) 2021-08-02 2023-02-09 Basf Se (3-quinolyl)-quinazoline
WO2023011958A1 (en) 2021-08-02 2023-02-09 Basf Se (3-pirydyl)-quinazoline
EP4140986A1 (en) 2021-08-23 2023-03-01 Basf Se Pyrazine compounds for the control of invertebrate pests
EP4140995A1 (en) 2021-08-27 2023-03-01 Basf Se Pyrazine compounds for the control of invertebrate pests
EP4151631A1 (en) 2021-09-20 2023-03-22 Basf Se Heterocyclic compounds for the control of invertebrate pests
WO2023072670A1 (en) 2021-10-28 2023-05-04 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors x
WO2023072671A1 (en) 2021-10-28 2023-05-04 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors ix
EP4194453A1 (en) 2021-12-08 2023-06-14 Basf Se Pyrazine compounds for the control of invertebrate pests
EP4198033A1 (en) 2021-12-14 2023-06-21 Basf Se Heterocyclic compounds for the control of invertebrate pests
EP4198023A1 (en) 2021-12-16 2023-06-21 Basf Se Pesticidally active thiosemicarbazone compounds
WO2023127767A1 (en) * 2021-12-27 2023-07-06 バイエルクロップサイエンス株式会社 Disease control agent and disease control method
EP4238971A1 (en) 2022-03-02 2023-09-06 Basf Se Substituted isoxazoline derivatives
WO2023203066A1 (en) 2022-04-21 2023-10-26 Basf Se Synergistic action as nitrification inhibitors of dcd oligomers with alkoxypyrazole and its oligomers
WO2024028243A1 (en) 2022-08-02 2024-02-08 Basf Se Pyrazolo pesticidal compounds
EP4342885A1 (en) 2022-09-20 2024-03-27 Basf Se N-(3-(aminomethyl)-phenyl)-5-(4-phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-amine derivatives and similar compounds as pesticides
EP4361126A1 (en) 2022-10-24 2024-05-01 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors xv
WO2024088792A1 (en) 2022-10-24 2024-05-02 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors xv
WO2024104815A1 (en) 2022-11-16 2024-05-23 Basf Se Substituted benzodiazepines as fungicides
WO2024104823A1 (en) 2022-11-16 2024-05-23 Basf Se New substituted tetrahydrobenzoxazepine
WO2024104818A1 (en) 2022-11-16 2024-05-23 Basf Se Substituted benzodiazepines as fungicides
WO2024104822A1 (en) 2022-11-16 2024-05-23 Basf Se Substituted tetrahydrobenzodiazepine as fungicides
EP4389210A1 (en) 2022-12-21 2024-06-26 Basf Se Heteroaryl compounds for the control of invertebrate pests

Also Published As

Publication number Publication date
BR112015003688A2 (en) 2017-07-04
BR112015003688B1 (en) 2020-09-24

Similar Documents

Publication Publication Date Title
US11083202B2 (en) Mixtures comprising a bacillus strain and a pesticide
WO2014029697A1 (en) Fungicidal ternary mixtures comprising fluazinam
EP3019013B1 (en) Compositions comprising a triazole compound and a biopesticide
EP3010344B1 (en) Fungicidal mixtures i comprising strobilurin-type fungicides
EP3068890B1 (en) Antifungal penicillium strains, fungicidal extrolites thereof, and their use
AU2014233858C1 (en) Synergistic compositions comprising a Bacillus subtilis strain and a pesticide
EP2815650B1 (en) Fungicidal mixtures II comprising strobilurin-type fungicides
WO2014086850A1 (en) Compositions comprising a quillay extract and a fungicidal inhibitor of respiratory complex ii
EP3080092B1 (en) Substituted [1,2,4]triazole and imidazole compounds
WO2014086856A1 (en) Compositions comprising a quillay extract and a biopesticide
WO2014086853A1 (en) Compositions comprising a quillay extract and a fungicidal compound
WO2015011615A1 (en) Mixtures comprising a trichoderma strain and a pesticide
EP2962568A1 (en) Mixtures comprising a bacillus amyliquefaciens ssp. plantarum strain and a pesticide
EP2975940A1 (en) Synergistic compositions comprising a bacillus subtilis strain and a biopesticide
WO2014086851A1 (en) Compositions comprising a quillay extract and a fungicidal inhibitor of respiratory complex iii at qo site
WO2015177021A1 (en) Mixtures comprising a bacillus strain and a pesticide
EP2839745A1 (en) Agrochemical formulations comprising a 2-ethyl-hexanol alkoxylate
WO2015044039A1 (en) Synergistic fungicidal compositions containing khc03
CN105377813A (en) Strobilurin type compounds for combating phytopathogenic fungi
EP2751085A1 (en) Co-crystals of cyprodinil and dithianon
EP2952507A1 (en) Substituted [1,2,4]triazole compounds
EP3145315A1 (en) Mixtures comprising a bacillus strain and a pesticide
EP2952506A1 (en) Substituted [1,2,4]triazole and imidazole compounds
EP2949216A1 (en) Fungicidal substituted alkynyl [1,2,4]triazole and imidazole compounds
EP2924027A1 (en) Substituted [1,2,4]triazole and imidazole fungicidal compounds

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13750078

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 13750078

Country of ref document: EP

Kind code of ref document: A1

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112015003688

Country of ref document: BR

ENP Entry into the national phase

Ref document number: 112015003688

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20150220