WO2014018294A1 - Moniteur de pression - Google Patents

Moniteur de pression Download PDF

Info

Publication number
WO2014018294A1
WO2014018294A1 PCT/US2013/050515 US2013050515W WO2014018294A1 WO 2014018294 A1 WO2014018294 A1 WO 2014018294A1 US 2013050515 W US2013050515 W US 2013050515W WO 2014018294 A1 WO2014018294 A1 WO 2014018294A1
Authority
WO
WIPO (PCT)
Prior art keywords
sensor
sclera
conjunctiva
eye
micro
Prior art date
Application number
PCT/US2013/050515
Other languages
English (en)
Inventor
Timothy J. Ehrecke
Original Assignee
Ehrecke Timothy J
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/549,862 external-priority patent/US20120289810A1/en
Application filed by Ehrecke Timothy J filed Critical Ehrecke Timothy J
Publication of WO2014018294A1 publication Critical patent/WO2014018294A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/16—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers

Definitions

  • the present invention relates to a system and method for measuring physiological parameters in organisms, and is particularly directed to a system and method for measuring intraocular pressure in the eye.
  • Glaucoma patients and post-operative patients of eye surgery require regular monitoring of the intraocular pressure (IOP) of their eyes in order to diagnose degenerative conditions that may lead to degraded sight and/or blindness without immediate medical treatment. Accordingly, such patients must make frequent trips to their ophthalmologist's office for this regular monitoring of their IOP with conventional mechanical impact type tonometers. This becomes a nuisance to the patient after a time, leading to patient resistance to compliance.
  • the only measurement of the patient's IOP that the doctor may use for diagnosis is the pressure that exists at the time of the office visit. Therefore, if the pressure is normal at the time of the visit, but becomes high thereafter, the patient's actual risk of blindness may be misdiagnosed. Also, if the pressure measured at the time of the office visit is high for reasons other than eye degeneration, the patient may be falsely diagnosed and be required to undergo therapy or take medication that may not be needed.
  • Intraocular pressure has been known to fluctuate widely during any given period of time and thus, should be monitored many times during the period of a day in order to gain an average or representative IOP, which in turn may be tracked for diagnosis. Attempts have been made to permit glaucoma patients to monitor their IOP at home many times during the period of a day with a self-tonometry portable instrument. Reference is made to the paper "Self-Tonometry to Manage Patients with Glaucoma and Apparently Controlled Intraocular Pressure", Jacob T. Wilensky et al., published in Arch Opthalmol, Vol. 105, August 1987 for more details of such a device.
  • This paper describes a portable tonometer instrument consisting of a pneumatically driven plunger fitted with an elastic membrane that slowly comes forward and applanates the cornea. Applanation is detected by an internal optic sensor and the pressure necessary to achieve applanation is registered and displayed automatically. The patient is able to prepare the eye and self-tonometer and activate the instrument for taking the measurement.
  • the device proposed is relatively large and bulky and not conducive to convenient transport with the patient during normal daily routine in order to measure IOP.
  • the proposed technique requires special eye preparation by instilling a topical anesthetic in the eye prior to tonometric measurements.
  • the AT was mounted in the lower part of the scleral haptic so that it applanated the inferior sclera under the lower lid.
  • the whole haptic ring was placed in the conjunctival formix.
  • Intraocular pressure was monitored from the AT with an automatic continual frequency monitor (ACFM) attached by adhesive and elastic bands to the exterior of the lower eye lid.
  • the ACFM induced in the AT electromagnetic oscillations at varying radio frequencies via a magnetic coupling of inductive coils and monitored for its resonant frequency, which is representative of IOP.
  • This device is clearly uncomfortable and bulky, minimizing expected patient compliance.
  • the device measures IOP by applanation of the sclera, which is a rather unconventional method of measuring IOP.
  • the applanation sensor of this new instrument comprises a micro-machined plunger and pressure sensing electronics on three electrically insulated levels of a silicon substrate resulting in a modified Mackay-Marg tonometer in which the radius of the flattened area and the distance between the periphery of the applanation and the pressure center can be measured to render a more accurate pressure area measurement.
  • the researchers did not actually propose a pressure sensor or transducer.
  • a tonometer system uses a contact device shaped to match the outer surface of the cornea and having a hole through which a movable central piece is slidably disposed for flattening or indenting a portion of the cornea.
  • a magnetic field controls the movement of the central piece against the eye surface to achieve a predetermined amount of applanation.
  • a sophisticated optical arrangement is used to detect when the predetermined amount of applanation has been achieved to measure IOP, and a calculation unit determines the IOP based on the amount of force the contact device must apply against the cornea in order to achieve the predetermined amount of applanation.
  • a sensor including: a bottom surface with an adhesion surface including a plurality of micro-protrusions, or an adhesive adhered to the bottom surface; a pressure monitoring device configured to measure intraocular pressure of an eye and generate a signal representing the measured pressure; and a transmitter configured to transmit the signal.
  • the bottom surface is arranged to secure the sensor to: an outer surface of a conjunctiva for the eye without penetrating the conjunctiva; or an outer surface of a sclera for the eye without penetrating the sclera.
  • a sensor including: an adhesion surface with a plurality of micro-protrusions; a pressure monitoring device configured to measure intraocular pressure of an eye and generate a signal representing the measured pressure; and a transmitter configured to transmit the signal.
  • the adhesion surface is arranged to secure the sensor to an outer surface of a conjunctiva for the eye without penetrating the conjunctiva.
  • a method for measuring intraocular pressure using a sensor including a bottom surface with an adhesion surface with a plurality of micro-protrusions or an adhesive adhered to the bottom surface, a pressure monitoring device, and a transmitter, the method including: securing, with the bottom surface, the sensor to: an outer surface of a conjunctiva for an eye without penetrating the conjunctiva; or an outer surface of a sclera for an eye without penetrating the sclera; measuring, using the pressure monitoring device, intraocular pressure in the eye; generating a signal representing the measured pressure; and transmitting, using the transmitter, the signal.
  • Fig. 1 is a front view of an exemplary embodiment of the sensor adhered to the sclera of a human eye;
  • Fig. 2 is a perspective view of an exemplary embodiment of the sensor
  • Fig. 3 is a top view of an exemplary embodiment of the sensor
  • Fig. 4 is a simplified schematic diagram of some of the components of an exemplary embodiment of the sensor
  • Fig. 5 is a simplified schematic diagram of some of the components of another exemplary embodiment of the sensor.
  • Fig. 6 is a simplified schematic diagram of some of the components of a third exemplary embodiment of the sensor.
  • Fig. 7 is a simplified schematic diagram of some of the components of an exemplary embodiment of a base unit for communication with the sensor;
  • Fig. 8 is a side view of a portion of an embodiment of a pressuring monitoring device having a variable capacitance and a variable inductance resonant circuit;
  • Figure 9 is a perspective top view of a pressure monitor
  • Figure 10 is a perspective bottom view of the pressure monitor shown in Figure 9;
  • Figure 1 1 is a schematic representation of micro-protrusions;
  • Figure 12 is a perspective view of the pressure monitor shown in Figure 9 adhered to a human eye;
  • Figure 13 is a cross-sectional view generally along line 13-12/13-12 in Figure 12;
  • Figure 13 is a cross-sectional view generally along line 13- 12/13-12 in Figure 12.
  • FIG. 1 illustrates a first exemplary embodiment of a sensor 10 adhered to the sclera 4 of a human eye 2.
  • the sensor 10 is shown with a smoothed hour-glass shape.
  • the particular shape of the sensor 10 is in no way limiting, and therefore the sensor 10 may have any shape that is suitable for the particular application for that specific sensor 10.
  • the sensor 10 may be adhered to the sclera 4 in a position on the eye 2 above the cornea 6.
  • the sensor 10 may be adhered to other parts of the sclera 4 as well, although only a position above the cornea 6 is shown herein.
  • the sensor 10 includes a body 15, which is the medium to which all other components of the sensor 10 are affixed or embedded, as shown in FIGS. 2 and 3. At least a portion of the body 15 that abuts the sclera 4 includes an adhesion substrate 15a.
  • the adhesion substrate 15a may take several embodiments depending on the application for the sensor 10 and/or materials used.
  • the adhesion substrate 15a may be a patch of biologically safe adhesive integrated into a portion of the body 15.
  • the adhesion substrate 15 a may be manufactured separately from the sensor 10 and/or body 15, in which case the adhesion substrate 15a may be placed on the sclera 4 prior to the placement of the sensor 10. In this embodiment, the adhesion substrate 15a would be applied to the portion of the sclera 4 where the sensor 10 is desired. After the adhesion substrate 15a is applied, the sensor 10 may then be positioned on the sclera 4 over the adhesion substrate 15a. In this embodiment, the adhesion substrate 15a must be a material that is both adhesive to the surface of the eye 2 and to the portion of the body 15 of the sensor 10 adjacent the eye 2.
  • the adhesion substrate 15a and material used to construct the body 15 are ideally biologically inert and should not be chemically active on the surface of the eye 2. Furthermore, the adhesion substrate 15a should be reversibly adhesive. Certain biologically safe adhesives that may be used as an adhesive substrate 15a and/or for use in construction of the body 15 include but are not limited to silicones, hydrogels, polymer hydrogels, or poly-methyl methacrylates.
  • sensor MPU 12 is embedded in the body 15 of the sensor 10.
  • the sensor MPU 12 controls the operation of the sensor 10 and the various components thereof.
  • the sensor MPU 12 may be any type of micro controller/processor, such as a programmable logic controller or other circuitry known to those skilled in the art that is capable of directing, communicating with, or controlling electromechanical devices.
  • the embodiment shown in FIG. 4 does not include a battery 16 to power the sensor 10. Instead, a sensor antenna 1 1 configured as an inductive coil is in electronic communication with a diode 34 and power capacitor 36 that is sized to provide enough power to the sensor 10 for one interrogation cycle.
  • the power capacitor 36 is in electronic communication with the sensor MPU 12 and is the power source therefor.
  • a pressure monitoring device is comprised of a strain array 17.
  • the strain array 17 is positioned on the body 15 such that when the sensor 10 is adhered to the eye 2, the strain array 17 abuts a portion of the sclera 4.
  • the strain array 17 shown in FIG. 4 is comprised of a first, second, third, and fourth resistor 19a, 19b, 19c, 19d that have variable resistance values.
  • the first and third resistors 19a, 19c are connected in series, as are the second and fourth resistors 19b, 19d.
  • the pair of first and third resistors 19a, 19c are connected in parallel with the pair of second and fourth resistors 19b, 19d.
  • the electrical lead between the first and third resistors 19a, 19c is electronically connected to the sensor MPU 12 as is the electrical lead between the second and fourth resistors 19b, 19d.
  • the strain array 17 also includes a ground 13. As the shape of the portion of the sclera 4 to which the sensor 10 is adhered changes, the resistance of the strain array 17 changes.
  • the sensor MPU 12 may be programmed to detect the difference in resistance of the pair of first and third resistors 19a, 19c as compared to the resistance of the second and fourth resistors 19b, 19d, which is indicated strain array first output 18a and strain array second output 18b, respectively. This value may be stored in a flash memory
  • flash memory 14 electronically connected to the sensor MPU 12, which flash memory 14 is affixed to and/or embedded in the body 15, or it may be transmitted to a base unit 40 as described in detail below.
  • a media for storing data other than flash memory 14 is used. Accordingly, the type of media used for storing the data in no way limits the scope of the present disclosure.
  • the sensor antenna 11 may also enable transmitting/receiving data to/from the sensor 10.
  • a transmitter 30 and a receiver 32 are affixed to and/or embedded in the body
  • the sensor antenna 1 1 in combination with the receiver 32 may facilitate programming of the sensor MPU 12 through remote communication, such as electromagnetic energy.
  • the sensor antenna 1 1 in combination with the transmitter 30 may facilitate downloading the data in the flash memory 14 if the sensor 10 is so equipped, or transmitting the instantaneous value recorded by the strain array 17 via electromagnetic energy, both of which are described in more detail below.
  • FIG. 7 A simplified schematic diagram of one embodiment of a base unit 40 is shown in FIG. 7. As shown in FIG. 7, the base unit 40 includes a battery 16, flash memory 14, base MPU 44, transmitter 30, receiver 32, and base antenna 42, all of which are ultimately controlled by the base MPU 44.
  • the base unit 40 may also include a USB interface 46 for communication with a computer (not shown). Other types of communication devices and/or methods may be used to enable data transmission between the base unit 40 and a computer (not shown).
  • the present disclosure is in no way limited by the type of communication and/or data transmission between the base unit 40 and a computer (not shown) or other electronic equipment.
  • the base unit 40 may be small enough to be attached to the body of the user of the sensor 10, such as through a headband, eye patch, or biologically safe adhesive, or it may be affixed to a pair of eyeglasses or other apparel.
  • the base unit 40 may be constructed as a hand held device that is not affixed to or worn by the user.
  • the base unit 40 may be programmed so that the base MPU 44 will send an electromagnetic pulse to the base antenna 42 at a known frequency, which it is contemplated will be a relatively low frequency.
  • the sensor antenna 1 1 will be configured such that the electromagnetic pulse will cause the sensor antenna 1 1 to charge the power capacitor 36 with sufficient energy to power the components of the sensor 10 for one interrogation cycle. What constitutes an interrogation cycle will depend on the specific application of the sensor 10 as well as the type of pressure monitoring device employed therewith. For the embodiment shown in FIG.
  • an interrogation cycle comprises the sensor MPU 12 supplying energy to the strain array 17, comparing the resistance between the two pairs of resistors, and transmitting that information back to the base unit 40 through the cooperative interaction between the transmitter 30 in the sensor 10 and the sensor antenna 1 1, and between the receiver 32 in the base unit 40 and the base antenna 42.
  • the base unit 40 may then store the data it received from the sensor 10 in the flash memory 14 of the base unit 40. After a predetermined number of interrogation cycles, the information in the flash memory 14 of the base unit 40 may be transferred to a computer (not shown) through the USB interface 46. Alternatively, the information could be wirelessly transferred to another piece of equipment, such as a computer.
  • the sensor antenna 1 1 may also serve as a communication link between the sensor
  • the sensor MPU 12 may be configured so that when the sensor antenna 1 1 and receiver 32 in the sensor 10 receive electromagnetic energy having certain characteristics (i.e., frequency, wavelength, duration, digital code, etc.), the sensor MPU 12 changes the interrogation cycle, downloads the information stored in the flash memory 14 of the sensor 10 (if so equipped), uploads a new program, performs a self-diagnostic, or performs some other function advantageous to the application for which the sensor 10 is used. Other methods may be used to program, reprogram, and/or control the sensor MPU 12 without limitation.
  • the sensor MPU 12 may be configured to digitize the information it receives from the pressure monitoring device, in which case the sensor antenna 1 1 would transmit a digitized signal to the base unit 40.
  • the base unit 40 and/or sensor 10 may require other circuitry components, such as amplifiers, resistors, capacitors, etc. for proper configuration for the specific application. Such modifications are within the purview of one of ordinary skill in the art and therefore will not be described in detail herein for purposes of clarity.
  • FIG. 5 functions in a manner similar to that in which the embodiment shown in FIG. 4 functions.
  • the embodiment shown in FIG. 5 includes a battery 16 for a power source, wherein the embodiment shown in FIG. 4 utilizes an external power source.
  • the battery 16 may be affixed to or embedded in the body 15 of the sensor, and is electronically connected to the sensor MPU 12.
  • the sensor 10 shown in FIG. 5 includes an internal power source, it is often referred to as an active sensor 10.
  • the sensor 10 preferably includes flash memory 14 and functions as a data logger. That is, the sensor MPU 12 is programmed to perform interrogation cycles at predetermined time intervals.
  • Each interrogation cycle produces a data point from the strain array 17, which is proportional to IOP at the time the interrogation cycle was performed.
  • the sensor MPU 12 is programmed to store each data point in the flash memory 14. After a predetermined amount of time, the sensor antenna 1 1 receives electromagnetic energy with certain characteristics that causes the receiver 32 in the sensor 10 and sensor MPU 12 to transmit the data in the flash memory 14 to the transmitter 30 in the sensor 10 and the sensor antenna 1 1 , which data may be received by a base unit 40 or other electrical equipment, such as a computer (not shown).
  • the strain array 17 that is used as a pressure monitoring device in the embodiments of the sensor 10 shown in FIGS. 4 and 5 is comprised of four resistors 19a, 19b, 19c, 19d that have a resistance that varies based on deformation of the resistor 19a, 19b, 19c, 19d.
  • other strain arrays 17 may be used with the sensor 10 without departing from the spirit or scope of the present disclosure. Accordingly, any strain array 17 known to those skilled in the art that is suitable for the particular application of the sensor 10 may be used without limitation.
  • any pressure monitoring device that changes an electrical property in response to IOP may be used without limitation.
  • the pressure monitoring device is comprised of a plurality of pressure sensitive resistors that are electronically connected to the sensor MPU 12.
  • the voltage drop across the plurality of pressure sensitive resistors may be correlated to IOP.
  • FIG. 6 Another embodiment of a sensor 10 is shown in FIG. 6.
  • the pressure monitoring device is comprised of a resonant circuit 20.
  • the resonant circuit 20 is comprised of an inductor 24, variable capacitor 22 (which also may be a fixed capacitor in other embodiments), and a ground 13.
  • An MPU resistor 38 is electronically connected to both the sensor MPU 12 and the resonant circuit 20.
  • embodiments of the sensor 10 using a resonant circuit 20 as a pressure monitoring device may include a internal power source such as a battery 16, or the sensor 10 may be powered through an external signal through the sensor antenna 1 1.
  • the resonant circuit 20 is configured so that the resonant frequency varies proportionally to IOP.
  • IOP the resonant frequency
  • the variable capacitor 22 is comprised of two dielectric plates, wherein one plate abuts the sclera 4, as the capacitance of the variable capacitor 22 increases, the resonant frequency increases, which frequency may then be correlated to IOP.
  • the resonant frequency is the quantity that may be correlated to IOP.
  • the sensor MPU 12 is programmed to subject the resonant circuit 20 to energy of varying frequencies using the sensor MPU 12 in a continuous, preferably sinusoidal manner an monitor the output from the resonant circuit 20.
  • the sensor MPU 12 will detect the resonant frequency of the resonant circuit 20 and either record the data point in flash memory 14 (if equipped) or transmit the data point to a base unit 40 in a manner similar to that described above.
  • a resonant circuit 20 may be used as the pressure monitoring device whether the sensor 10 includes an internal or external power source.
  • a variable capacitance resonant circuit 20 such as the one described above may also include a variable resistance element, such as a pressure sensitive resistor to increase the accuracy and/or precision of the resonant circuit 20.
  • the resonant circuit includes a variable capacitor 22 and a variable inductor 24.
  • the variable inductor 24 consists of an inductive coil having a ferrous member 26 positioned therein. As the position of the ferrous member 26 changes with respect to the inductive coil, the inductance of the inductor 24 changes.
  • the ferrous member 26 may be mechanically connected to one of the plates of the variable capacitor 22 such that the change in capacitance and the change in inductance of the resonant circuit 20 are coupled.
  • one type of variable capacitor 22 that may be used with the embodiment shown in FIG.
  • variable capacitor 8 is comprised of two plates separated by a dielectric, which type of variable capacitor is well known to those skilled in the art and therefore will not be described in detail herein. Accordingly, a change in IOP would produce both a change in capacitance and a change in inductance, which together would have a greater effect on the resonant frequency than a change in either variable alone would have. This is true because an increase in capacitance yields a decrease in resonant frequency, and an increase in inductance yields a decrease in resonant frequency.
  • Other combinations and/or configurations of electrical components known to those skilled in the art may be used to correlate a change in resonant frequency with a value for IOP without departing from the spirit and scope of the present disclosure. Accordingly, all embodiments pictured and described herein are for exemplary purposes only and are in no way meant to be limiting.
  • ⁇ monitoring devices may be used with the sensor 10 other than a strain array 17 and a resonant circuit 20 as pictured and described herein.
  • piezoelectric pressure transducers may be used, as well as thermistors, piezo-resistive transducers, silicon strain gauges, semiconductor devices and the like may be used as the pressure monitoring device.
  • any electrical component that responds in a detectable manner in proportion to IOP may be used with any embodiment of the sensor 10 without limitation.
  • any of the embodiments of the sensor 10 as disclosed and described herein that include a sensor MPU 12 may also be used without a sensor MPU 12.
  • the sensor 10 would not be a smart sensor 10.
  • a sensor 10 without a sensor MPU 12 would only measure IOP when directed to do so by an external source.
  • a sensor 10 with a resonant circuit 20 for a pressure monitoring device and no sensor MPU 12 may be interrogated with a grid dip meter (not shown) to find the resonant frequency.
  • the resonant frequency may then be correlated to IOP, the manner of which is dependent upon the configuration of the resonant circuit 20 (i.e., variable capacitance, variable resistance, variable inductance, or combinations thereof).
  • the sensor 10 should be placed within the periphery of a substantially circular interrogation device (e.g., grid dip meter, electromagnetic field generator, etc.) so that the effect the distance between the sensor 10 and the interrogation device has on the resonant frequency is nullified.
  • the interrogation device is disposed in the frame of a pair of eyeglasses wherein an inductive coil is positioned around the periphery of each lens.
  • the senor 10 may be used to deliver a predetermined amount of medication upon a given value of IOP.
  • the sensor 10 would further comprise a delivery switch that would function to cause a predetermined amount of medication to be delivered to a specific location from a medication storage area.
  • both the delivery switch and the medication storage area may be affixed to or embedded in the body 15 of the sensor 10.
  • the delivery switch and the medication storage area may be external to the sensor 10 and in remote communication therewith.
  • the medication storage area may be configured as a bladder.
  • the delivery switch may be configured as a valve between the medication storage area and the eye 2.
  • the sensor MPU 12 may be programmed to direct the delivery switch to open, thereby releasing a predetermined amount of medication to the eye.
  • the medication storage area and delivery switch are external to the sensor 10, they may be in communication with an intra venous (IV) system.
  • IV intra venous
  • the medication storage area may be configured as an IV bag plumbed to a typical IV system and the delivery switch may be configured as a valve affixed to the IV bag.
  • the valve would be in communication, most likely wirelessly, with the sensor 10 so that the valve would open upon certain instructions transmitted from the sensor 10.
  • the medication storage area may be configured is a punctual insert that is in direct communication with the sensor 10 such that the punctual insert releases a predetermined amount of medication based on direction from the sensor 10. Any of the embodiments described herein for medication delivery would allow for instantaneous medication treatment of elevated IOP.
  • the materials used to construct the sensor 10 and various electrical components thereof may be any suitable material known to those skilled in the art that is suitable for the particular application of the sensor 10.
  • the sensor MPU 12 may be constructed of a fiberglass substrate with copper or gold traces. Accordingly, the materials of construction for the sensor 10 or the various components thereof in no way limit the scope of the present disclosure.
  • Figure 9 is a perspective top view of sensor 100.
  • Figure 10 is a perspective bottom view of sensor 100 shown in Figure 9.
  • Figure 1 1 is a schematic representation of micro-protrusions.
  • Figure 12 is a perspective view of sensor 100 shown in Figure 9 adhered to a human eye.
  • Figure 13 is a cross-sectional view generally along line 13- 14/13-14 in Figure 12.
  • Figure 14 is a cross-sectional view generally along line 13- 14/13-14 in Figure 12.
  • Sensor 100 includes body 102, pressure monitoring device 104, and transmitter 106.
  • the pressure monitoring device is configured to measure intraocular pressure of an eye and generate signal 108 representing the measured pressure.
  • the transmitter is configured to transmit the signal.
  • the body includes bottom surface 110 with adhesion surface 112 with a plurality of micro-protrusions 114.
  • the micro-protrusions are made of patterned silicone.
  • the sensor includes bottom surface 110 with adhesive 116 adhered to bottom surface 110.
  • the bottom surface for example, surface 112 and the plurality of micro-protrusions or adhesive 116, is arranged to secure the sensor, for example, body 102, to outer surface OSC of conjunctiva 118 for the eye without penetrating OCS or sclera 120 for the eye, for example as shown in Figure 13.
  • the sensor for example, body 102
  • outer surface OSC of conjunctiva 118 for the eye without penetrating OCS or sclera 120 for the eye, for example as shown in Figure 13.
  • no portion of sensor 100 penetrates OSC and thus, no portion of sensor 100 penetrates the conjunctiva or the sclera.
  • the bottom surface for example, surface 112 and the plurality of micro-protrusions or adhesive 116, is arranged to secure the sensor, for example, body 102, to outer surface OSS of the sclera without penetrating the sclera, for example as shown in Figure 14.
  • the sensor for example, body 102
  • outer surface OSS of the sclera without penetrating the sclera, for example as shown in Figure 14.
  • no portion of sensor 100 penetrates OSS and thus, no portion of sensor 100 penetrates the sclera.
  • Sensor 100 does not contact the cornea of the eye.
  • Body 102 includes top surface 122 and in an example embodiment, the pressure monitoring device and the transmitter are secured to surface 122 by any means known in the art.
  • top surface 122 including device 104 and the transmitter is smooth.
  • the bottom surface includes both the adhesion surface and the adhesive and the plurality of micro-protrusions and the adhesive are arranged to secure the sensor to outer surface OSC without penetrating the conjunctiva or the sclera, or to secure the sensor to outer surface OSS without penetrating the sclera.
  • An adhesive attraction between the adhesion surface and the eye for example,
  • OSC or OSS is dependent upon a height H of each micro-protrusion in the plurality of micro- protrusions and a spacing S of micro-protrusions in the plurality of micro-protrusions.
  • H is from 3 to 40 microns
  • spacing S is from 3 to 40 microns. It should be understood that other respective values of H and S are possible.
  • Adhesive 116 can be any medical grade, or biologically safe adhesive known in the art.
  • the adhesive is reversible, that is, the sensor can be removed from the conjunctiva or the sclera without damaging the conjunctiva or sclera.
  • Adhesive 116 can include, but is not limited to silicones, hydrogels, polymer hydrogels, and poly-methyl methacrylates.
  • Body 102 can be made of or can be encased in any biologically safe material known in the art, including, but not limited to materials used for constructing contact lenses, silicones, hydrogels, polymer hydrogels, and poly-methyl methacrylates.
  • the pressure monitoring device and the transmitter can be any pressure monitoring device and transmitter, respectively, known in the art. Any type of material known in the art, including, but not limited to silicone, can be used for surface 112 and micro-protrusions 114.
  • the size, shape, and configuration of micro-protrusions can be any applicable size, shape, and configuration known in the art.
  • the present disclosure also includes a method for measuring intraocular pressure using sensor 100.
  • One step secures, with the bottom surface, the sensor to: the outer surface of the conjunctiva of an eye without penetrating the conjunctiva or a sclera for the eye; or the outer surface of a sclera for an eye without penetrating the sclera.
  • Another step measures, using the pressure monitoring device, intraocular pressure in the eye.
  • a further step generates a signal representing the measured pressure.
  • Yet another step transmits, using the transmitter, the signal.
  • the adhesive is separately formed from the body as an adhesion substrate and is separately adhered to the conjunctiva or sclera. After the adhesion substrate is applied, the remainder of sensor 100 is positioned on and adhered to the substrate.
  • sensor 100 includes MPU 12 and the discussion regarding sensor 10 and MPU 12 is applicable to sensor 100.
  • sensor 100 includes the embodiment shown in Fig. 4 and the discussion regarding sensor 10 and Fig. 4 is applicable to sensor 100.
  • sensor 100 includes strain array 17 and the discussion regarding Figs. 4 and 5, sensor 10 and strain array 17 is applicable to sensor 100.
  • sensor 100 is usable with base unit 40 and the discussion of base unit 40 and sensor 10 is applicable to base unit 40 and sensor 100.
  • sensor 100 includes antenna 11 and the discussion regarding sensor 10 and antenna 11 is applicable to sensor 100.
  • sensor 100 includes resonant circuit 20 and the discussion regarding Figs. 6 and/or 8, sensor 10 and resonant circuit 20 is applicable to sensor 100.
  • the discussion regarding Figs. 6, sensor 10 and an interrogation cycle is applicable to sensor 100.
  • the pressure monitoring device can include, but is not limited to, a piezoelectric pressure transducer, a thermistor, a piezo-resistive transducer, a silicon strain gauge, and a semiconductor device. In general, any electrical component that responds in a detectable manner in proportion to IOP may be used with sensor 100.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Eye Examination Apparatus (AREA)

Abstract

L'invention concerne une surface inférieure ayant une surface d'adhérence comprenant une pluralité de micro-saillies, ou un adhésif amené à adhérer à la surface inférieure ; un dispositif de surveillance de pression configuré pour mesurer la pression intra-oculaire d'un œil et générer un signal représentant la pression mesurée ; et un émetteur configuré pour émettre le signal. La surface inférieure est agencée pour fixer le capteur à : une surface externe d'une conjonctive de l'œil sans pénétrer dans la conjonctive ; ou une surface externe d'une sclérotique de l'œil sans pénétrer dans la sclérotique.
PCT/US2013/050515 2012-07-16 2013-07-15 Moniteur de pression WO2014018294A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/549,862 2012-07-16
US13/549,862 US20120289810A1 (en) 2008-12-30 2012-07-16 Pressure monitor

Publications (1)

Publication Number Publication Date
WO2014018294A1 true WO2014018294A1 (fr) 2014-01-30

Family

ID=49997734

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/050515 WO2014018294A1 (fr) 2012-07-16 2013-07-15 Moniteur de pression

Country Status (1)

Country Link
WO (1) WO2014018294A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11358852B2 (en) 2016-07-05 2022-06-14 Heineken Supply Chain B.V. Beverage dispensing assembly and beverage container
US11591202B2 (en) 2017-05-19 2023-02-28 Heineken Supply Chain B.V. Beverage dispensing assembly and beverage container
US11724930B2 (en) 2017-05-19 2023-08-15 Heineken Supply Chain B.V. Beverage dispensing assembly and beverage container

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002067688A1 (fr) * 2001-02-23 2002-09-06 Marcio Marc Abreu Mesure non effractive de substances chimiques
US20090203985A1 (en) * 2005-10-14 2009-08-13 Ehrecke Timothy J Pressure Monitor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002067688A1 (fr) * 2001-02-23 2002-09-06 Marcio Marc Abreu Mesure non effractive de substances chimiques
US20090203985A1 (en) * 2005-10-14 2009-08-13 Ehrecke Timothy J Pressure Monitor

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11358852B2 (en) 2016-07-05 2022-06-14 Heineken Supply Chain B.V. Beverage dispensing assembly and beverage container
US11565928B2 (en) 2016-07-05 2023-01-31 Heineken Supply Chain B.V. Beverage dispensing assembly and beverage container
US11591202B2 (en) 2017-05-19 2023-02-28 Heineken Supply Chain B.V. Beverage dispensing assembly and beverage container
US11724930B2 (en) 2017-05-19 2023-08-15 Heineken Supply Chain B.V. Beverage dispensing assembly and beverage container

Similar Documents

Publication Publication Date Title
US20090203985A1 (en) Pressure Monitor
US20120289810A1 (en) Pressure monitor
Katuri et al. Intraocular pressure monitoring sensors
US5830139A (en) Tonometer system for measuring intraocular pressure by applanation and/or indentation
US7131945B2 (en) Optically powered and optically data-transmitting wireless intraocular pressure sensor device
CA2424529C (fr) Systeme de mesure de la pression intraoculaire d'un oeil et capteur mem a utiliser avec ledit systeme
KR101850019B1 (ko) 안압 모니터링 기구
US6749568B2 (en) Intraocular pressure measurement system including a sensor mounted in a contact lens
EP2876487A1 (fr) Lentille ophtalmique avec système de surveillance de la pression intraoculaire
US20110288395A1 (en) Pressure Measurement Device
JP2017527329A (ja) 垂直積層構造を備える、気密封止したインプラントセンサ
CN103458775A (zh) 用于检测眼科疾病和/或脑部疾病的设备和方法
KR20150016968A (ko) 관성 센서를 포함하는 안압 측정 또는 모니터링 시스템
KR20140005138A (ko) Iop 모니터링을 위한 소프트 컨택트 렌즈에서 통합된 유연한 수동 센서
WO2007136993A1 (fr) Surveillance de la pression intra-oculaire
Piso et al. Modern monitoring intraocular pressure sensing devices based on application specific integrated circuits
Kakaday et al. Advances in telemetric continuous intraocular pressure assessment
WO2014018294A1 (fr) Moniteur de pression
CN220876746U (zh) 一种眼内压测量装置
AU758525B2 (en) A tonometer system for measuring intraocular pressure by applanation and/or indentation
JP2022545174A (ja) 眼の生体力学的特性の測定および監視装置
CN117017206A (zh) 一种眼内压测量装置
CN113331785A (zh) 一种无线压平式眼压监测系统
Tang et al. The novel research of intraocular pressure tonometer by using inductance sensor
MXPA99002157A (en) A tonometer system for measuring intraocular pressure by applanation and/or indentation

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13822191

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 13822191

Country of ref document: EP

Kind code of ref document: A1