WO2014014389A3 - Composition in gel form for the prophylaxis and treatment of periodontal diseases - Google Patents

Composition in gel form for the prophylaxis and treatment of periodontal diseases Download PDF

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Publication number
WO2014014389A3
WO2014014389A3 PCT/RU2013/000604 RU2013000604W WO2014014389A3 WO 2014014389 A3 WO2014014389 A3 WO 2014014389A3 RU 2013000604 W RU2013000604 W RU 2013000604W WO 2014014389 A3 WO2014014389 A3 WO 2014014389A3
Authority
WO
WIPO (PCT)
Prior art keywords
prophylaxis
treatment
pharmaceutical composition
periodontal diseases
lending
Prior art date
Application number
PCT/RU2013/000604
Other languages
French (fr)
Russian (ru)
Other versions
WO2014014389A2 (en
Inventor
Илья Александрович МАРКОВ
Елена Алексеевна МАРКОВА
Полина Петровна ГАПОНЮК
Инна Николаевна МАРКОВА
Petr Yakovlevich Gaponyuk (Гапонюк, Петр Яковлевич)
Original Assignee
Markov Iliya Aleksandrovich
Markova Elena Alekseevna
Gaponyuk Polina Petrovna
Markova Inna Nikolaevna
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Markov Iliya Aleksandrovich, Markova Elena Alekseevna, Gaponyuk Polina Petrovna, Markova Inna Nikolaevna filed Critical Markov Iliya Aleksandrovich
Publication of WO2014014389A2 publication Critical patent/WO2014014389A2/en
Publication of WO2014014389A3 publication Critical patent/WO2014014389A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

The invention relates to medicine, specifically to dentistry, and concerns medicinal agents for the prophylaxis and treatment of infectious and inflammatory periodontal diseases, particularly medicinal agents for the prophylaxis and treatment of periodontosis. Essence of the invention: A pharmaceutical composition in the form of a gel for the prophylaxis and treatment of periodontal diseases, containing metronidazole benzoate and chlorhexidine gluconate as the active agent, carbomer and hydroxypropyl methylcellulose as the gelling agent, menthol as the flavoring agent, a sweetener, EDTA disodium salt as an auxiliary component, and a base for lending consistency. The pharmaceutical composition additionally contains, as an active agent, components chosen from the following group: a recombinant alpha, beta or gamma interferon, lysine, proline, choline salicylate. The sweetener is saccharin or sorbitol. The pharmaceutical composition may additionally contain, as an auxiliary component, triethanolamine in the amount of 0.5-5.0 mass percent. The base for lending consistency is in the form of components chosen from the following group: glycerin, polyethylene glycol 400, polyethylene glycol 4000, propylene glycol, glycerin, and purified water.
PCT/RU2013/000604 2012-07-18 2013-07-15 "dentoferon" pharmaceutical composition in the form of a gel for the prophylaxis and treatment of periodontal diseases WO2014014389A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2012130338 2012-07-18
RU2012130338/15A RU2490006C1 (en) 2012-07-18 2012-07-18 Pharmaceutical composition dentoferon in form of gel for preventing and treating periodontal diseases

Publications (2)

Publication Number Publication Date
WO2014014389A2 WO2014014389A2 (en) 2014-01-23
WO2014014389A3 true WO2014014389A3 (en) 2014-03-20

Family

ID=49162715

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2013/000604 WO2014014389A2 (en) 2012-07-18 2013-07-15 "dentoferon" pharmaceutical composition in the form of a gel for the prophylaxis and treatment of periodontal diseases

Country Status (2)

Country Link
RU (1) RU2490006C1 (en)
WO (1) WO2014014389A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2624866C1 (en) * 2016-06-15 2017-07-07 федеральное государственное бюджетное образовательное учреждение высшего образования "Башкирский государственный медицинский университет" Министерства здравоохранения Российской Федерации Gel with oximethyluracyl, chlorohexidin and lidocaine for diagnostic and treatment endourethral procedures
CN109819650A (en) 2017-09-25 2019-05-28 春布里泽·格奥尔基·格奥尔基耶维奇 With antiviral and antibacterial activity thermostable composite and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2003106444A (en) * 2003-03-11 2004-09-10 Общество с ограниченной ответственностью фирма "Фермент" IMMUNOMODULATING, ANTI-MICROBIAL, ANTIOXIDANT AND REGENERATIVE AGENT (ITS OPTIONS)
RU2242963C2 (en) * 2002-06-19 2004-12-27 Дж.Б.Кемикалс Энд Фармасьютикалс Лтд. Mucoadhesive composition for treating stomatological diseases and method for its obtaining
RU2349339C1 (en) * 2007-07-12 2009-03-20 Валентина Васильевна Малиновская Medicine with immune modifying, antivirus, antibacterial antioxidising, membrane stabilising, cartilage and connective tissue growth stimulating effect
RU2360664C2 (en) * 2004-08-12 2009-07-10 Дзе Проктер Энд Гэмбл Компани Oral compositions and systems
US20120014884A1 (en) * 2009-04-01 2012-01-19 Colgate-Palmolive Company Menthol-derivative compounds and use thereof as oral and systemic active agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2255760C2 (en) * 2003-03-11 2005-07-10 Общество с ограниченной ответственностью фирма "Фермент" Agent eliciting immunomodulating, antibacterial, antioxidant and regenerating effect (variants)

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2242963C2 (en) * 2002-06-19 2004-12-27 Дж.Б.Кемикалс Энд Фармасьютикалс Лтд. Mucoadhesive composition for treating stomatological diseases and method for its obtaining
RU2003106444A (en) * 2003-03-11 2004-09-10 Общество с ограниченной ответственностью фирма "Фермент" IMMUNOMODULATING, ANTI-MICROBIAL, ANTIOXIDANT AND REGENERATIVE AGENT (ITS OPTIONS)
RU2360664C2 (en) * 2004-08-12 2009-07-10 Дзе Проктер Энд Гэмбл Компани Oral compositions and systems
RU2349339C1 (en) * 2007-07-12 2009-03-20 Валентина Васильевна Малиновская Medicine with immune modifying, antivirus, antibacterial antioxidising, membrane stabilising, cartilage and connective tissue growth stimulating effect
US20120014884A1 (en) * 2009-04-01 2012-01-19 Colgate-Palmolive Company Menthol-derivative compounds and use thereof as oral and systemic active agents

Also Published As

Publication number Publication date
RU2490006C1 (en) 2013-08-20
WO2014014389A2 (en) 2014-01-23

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