WO2014008426A3 - Diagnostic du lupus érythémateux systémique - Google Patents

Diagnostic du lupus érythémateux systémique Download PDF

Info

Publication number
WO2014008426A3
WO2014008426A3 PCT/US2013/049371 US2013049371W WO2014008426A3 WO 2014008426 A3 WO2014008426 A3 WO 2014008426A3 US 2013049371 W US2013049371 W US 2013049371W WO 2014008426 A3 WO2014008426 A3 WO 2014008426A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnosis
lupus erythematosus
systemic lupus
sle
loci
Prior art date
Application number
PCT/US2013/049371
Other languages
English (en)
Other versions
WO2014008426A2 (fr
Inventor
Jonathan Lim
Robert Shoemaker
Louis Bookbinder
David Anderson
Original Assignee
Ignyta, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ignyta, Inc. filed Critical Ignyta, Inc.
Publication of WO2014008426A2 publication Critical patent/WO2014008426A2/fr
Publication of WO2014008426A3 publication Critical patent/WO2014008426A3/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne des locus ayant des sites de méthylation pertinents pour le diagnostic du LES, ainsi que des procédés et des réactifs associés.
PCT/US2013/049371 2012-07-06 2013-07-03 Diagnostic du lupus érythémateux systémique WO2014008426A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261668939P 2012-07-06 2012-07-06
US61/668,939 2012-07-06

Publications (2)

Publication Number Publication Date
WO2014008426A2 WO2014008426A2 (fr) 2014-01-09
WO2014008426A3 true WO2014008426A3 (fr) 2014-04-17

Family

ID=49882616

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/049371 WO2014008426A2 (fr) 2012-07-06 2013-07-03 Diagnostic du lupus érythémateux systémique

Country Status (1)

Country Link
WO (1) WO2014008426A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10174375B2 (en) * 2013-09-20 2019-01-08 The Chinese University Of Hong Kong Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases
GB201609951D0 (en) * 2016-06-07 2016-07-20 Immunovia Ab Biomarkers signatures and uses thereof
KR102109105B1 (ko) * 2018-05-09 2020-05-12 아주대학교산학협력단 Smyd3 자가항체를 이용한 전신홍반성루푸스 진단방법
CN110512000A (zh) * 2018-05-22 2019-11-29 广州市康立明生物科技有限责任公司 肿瘤标志物、甲基化试剂、试剂盒及其应用
WO2021041931A1 (fr) * 2019-08-28 2021-03-04 The Regents Of The University Of California Procédés de production de profils de méthylation de l'adn
CN117230186B (zh) * 2023-11-14 2024-01-26 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) 谷氨酰胺转运体ASCT2作为靶点在制备治疗Tfh相关自身免疫性疾病药物中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070238094A1 (en) * 2005-12-09 2007-10-11 Baylor Research Institute Diagnosis, prognosis and monitoring of disease progression of systemic lupus erythematosus through blood leukocyte microarray analysis
US20090246768A1 (en) * 2008-02-15 2009-10-01 Sawalha Amr H Predicting and Diagnosing Patients With Autoimmune Disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070238094A1 (en) * 2005-12-09 2007-10-11 Baylor Research Institute Diagnosis, prognosis and monitoring of disease progression of systemic lupus erythematosus through blood leukocyte microarray analysis
US20090246768A1 (en) * 2008-02-15 2009-10-01 Sawalha Amr H Predicting and Diagnosing Patients With Autoimmune Disease

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANTOSHECHKIN, A ET AL.: "Analysis Of Effects Of The Herbal Preparation Circulat On Gene Expression Levels In Cultured Human Fibroblasts.", PHYTOTHERAPY RESEARCH, vol. 21, 18 May 2007 (2007-05-18), pages 777 - 789 *
JAVIERRE, BM ET AL.: "Change In The Pattern of DNA Methylation Associate With Twin Discordance In Systemic Lupus Erythematosus.", GENOME RES., vol. 20, no. 2, 22 December 2009 (2009-12-22), pages 170 - 179 *
SHOEMAKER, R ET AL.: "Mediators And Dynamics Of DNA Methylation.", WILEY INTERDISCIP REV SYST BLOL MED., vol. 3, 28 September 2010 (2010-09-28), pages 281 - 298 *

Also Published As

Publication number Publication date
WO2014008426A2 (fr) 2014-01-09

Similar Documents

Publication Publication Date Title
IL264555B (en) Specific primers for nucleic acid amplification
EP3443092A4 (fr) Compositions de conjugués d'acides nucléiques ciblés
EP3065540A4 (fr) Loci optimaux de maïs
EP3066110A4 (fr) Loci optimaux de maïs
EP3035936A4 (fr) Entités chimiques, compositions et méthodes particulières
EP3258517A4 (fr) Module de batterie à structure de fixation améliorée
EP3080289A4 (fr) Molécules d'acides nucléiques modifiés et leurs utilisations
EP2943590A4 (fr) Procédés et compositions pour la pcr à l'aide d'amorces bloquées et universelles
EP2997276A4 (fr) Ensemble dispositif de désolidarisation de différentiel de véhicule
WO2014028429A3 (fr) Enzymes et polymérases destinées à la synthèse d'arn
EP2971123A4 (fr) Amplification d'acide nucléique
EP3481430A4 (fr) Conjugués de type acide nucléique et leurs utilisations
WO2014008426A3 (fr) Diagnostic du lupus érythémateux systémique
WO2012099930A3 (fr) Compositions de flavonol
EP3377658A4 (fr) Réactifs nucléotidiques modifiés
EP3084051A4 (fr) Sondes d'hybridation d'acide nucléique ultra-spécifiques finement reglées
EP3458600A4 (fr) Essai amélioré avec un fragment à base de synaptobrévine
EP3071713A4 (fr) Amplification des acides nucléiques
WO2014031523A3 (fr) Procédé de préparation de dispositif microfluidique ayant une hauteur de canal réduite
WO2012034041A3 (fr) Détection de la structure de la chromatine
EP3074526A4 (fr) Test d'activité enzymatique multiplex à l'aide d'une analyse élémentaire
EP3003298A4 (fr) Composés antifibrosants, méthodes et utilisations associées
EP3087132A4 (fr) Résistance supérieure aux chocs à basse température résultant de la conception du caoutchouc
WO2012004073A3 (fr) UTILISATION DE β-ISOPHORONE COMME SOLVANT
EP3411387A4 (fr) Molécules signal utiles en tant qu'agents de pénétration cellulaire

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13813224

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 13813224

Country of ref document: EP

Kind code of ref document: A2