WO2014003241A1

WO2014003241A1 - Skin temperature sensitive hydrogel composition and preparation method thereof

Info

Publication number: WO2014003241A1
Application number: PCT/KR2012/007657
Authority: WO
Inventors: 이준배; 박천호; 유희창
Original assignee: 코스맥스 주식회사; 코스맥스 (중국)화장품 유한공사
Priority date: 2012-06-27
Filing date: 2012-09-24
Publication date: 2014-01-03
Also published as: KR101462390B1; KR20140006172A

Abstract

The present invention relates to a preparation of a skin temperature sensitive hydrogel, and a hydrogel composition providing a cool feeling, moisture, and various active ingredients to the skin by using a contracting property which responds to skin temperature through a use thereof. The hydrogel of the present invention is obtained by adding a double bond to both ends of Pluronic, which is a temperature sensitive polymer, and chemically cross-linking the same through UV radiation. The hydrogel obtained thereby responds to skin temperature so as to show a contraction property, and thereby can provide water collected inside, a moisturizing ingredient, and various active ingredients to the skin. In addition, elasticity is provided to the skin and adhesion of the hydrogel to the skin is increased by the contracting property of the hydrogel.

Description

【Specification】

[Name of invention]

Skin temperature sensitive hydrogel composition and preparation method thereof

Technical Field

The present invention relates to a cosmetic composition having a skin temperature sensitizing hydrogel to more quickly and uniformly deliver the water-soluble beauty agent contained in the hydrogel into the skin through shrinkage according to the temperature of the hydrogel in response to the skin temperature. This shrinkage can also help the hydrogel adhere to the skin more tightly. Background Art

Hydrogel is a material having a polymer network structure containing a large amount of water is made by a homopolymer or a copolymer. The hydrogel becomes transparent as it swells through absorption of hydrophilic components, including water, in aqueous solution and also has adequate mechanical properties. Such swelling and mechanical properties of the polymer mainly depend on the properties of the polymer network structure. As a material for making such a hydrogel, a large number of polymers are mainly used. The polymer is divided into two kinds of natural polymer and synthetic polymer according to the origin of the material. Hydrogels made of natural polymers are made of polymers derived from natural materials such as agar, carrageenan, cellulose, and xanthan gum, which may give consumers a good impression of the origin of nature, but they are weak in mechanical properties. It is characteristic. Since most of these natural polymers are made by physical gelation reaction, hydrogels are easily dissolved and changed to a sol state at high temperature conditions, and at low temperature or room temperature conditions, the mechanical strength is weak so that they are broken or torn even in a small impact. Great care must be taken in the use of the product. In contrast, hydrogels made of synthetic polymers have strong binding properties such as chemical covalent bonds between molecules through crosslinking, and thus, unlike natural polymers, hydrogels have strong mechanical properties. Damaged Cases are relatively rare. In addition, due to the recent advances in technology, various polymers having biodegradable and biocompatible characteristics have been released, and thus, the recognition of synthetic polymers is also getting better. Hydrogel-related patents made by such synthetic polymers include a temperature sensitive state change hydrogel composition patent (Korean Patent No. 506543). According to this patent, the hydrogel state is changed to a fluid state by the body temperature when it comes into contact with the skin, and it has flowability. Through this, the beauty agent or drug contained in the hydrogel is uniformly coated on the skin and quickly penetrates. In this case, only a part of the hydrogel is changed to a fluid state through the reaction with the skin and has a limit.

In another patent (Korean Patent No. 848712), a double bond was introduced at both ends of the Pturonic and a polymer gel was prepared by polymerizing the polymer using a photoinitiator and ultraviolet light. However, this method is mainly aimed at raising the sol-gel transition temperature in combination with chitosan to avoid the drawback of Pluronic gelation at low temperatures when injecting gel into the body via injection. There is this. In addition, diethyl ether is used for precipitation during the synthesis of introducing double bonds at both ends of the pluronic polymer. Diethyl ether is not suitable for use in factories for mass production because of its high volatility and low boiling point. Known as

In the present invention, to provide a hydrogel production method by chemical crosslinking rather than physical gelling action to make a hydrogel having a strong resistance to temperature and external force. To this end, in the present invention, a pluronic polymer was used. Pluronic polymer is a trione block copolymer composed of PE0-PP0-PE0 (polyethyl eneox i de-po 1 ypr opy 1 eneox i de-po 1 ye t hy 1 eneox i de) ≤- biocompatible and physiological conditions It is widely known as a biodegradable polymer that decomposes in, and is known to be safe in the human body. Pluronic has a low critical solution temperature (LCST) characteristic of the hydrophobic group (PP0), which enables self-assembly above a certain temperature and thus temperature sensitivity. Most polymers, including the pluronic, are obtained through a polymerization process, the molecular weight of which is not always constant, but even distribution in various regions, Since it is obtained by averaging it, it is impossible to obtain a polymer of uniform quality. Therefore, hydrogels made with these polymers are not likely to have a constant sol-gel transition temperature obtained during the manufacturing process, and thus may not be uniform in the temperature conditions that change from the hydrogel to the flowable sol state. This is high.

[Detailed Description of the Invention]

[Technical problem]

The present invention, after introducing a double bond at both ends of the pluronic polymer, and chemically cross-linked through ultraviolet (UV) irradiation to produce a hydrogel having the desired physical properties. In this process, some water-soluble natural polymers are included for the superior feeling. In addition, the purpose of the present invention is to provide a cosmetic composition that gives the skin a refreshing and moisturizing feeling by using the hydrogel thus produced and the elasticity and adhesion to the skin by producing a hydrogel that shrinks in size by reacting to the skin temperature. .

Technical Solution

According to one aspect of the invention, the invention is reversible swelling in the skin temperature range, obtained by chemical crosslinking by ultraviolet (UV) in the presence or absence of a diacrylated pluronic polymer, a water soluble natural polymer, a photoinitiator or not. And it has a shrinking property, and provides a skin temperature-sensitive hydrogel cosmetic composition characterized in that it has a porous structure in its internal structure.

In the case of a hydrogel without a porous structure, only water-soluble agonists that are moistened on the surface can be delivered to the skin, but a pluronic hydrogel with a porous structure may contract the pluronic hydrogel in response to skin temperature. At this time, the porous structure serves as a way to allow the release of various water-soluble substances inside the skin.

In the present invention, the pluronic polymer is PE0-PP0-PE0 (poly ethyl eneoxide- o 1 ypr opy 1 eneox i de-po 1 yet hy 1 eneox i de) ≤. Any tri-block copolymer constructed may be used, but preferably has a molecular weight of about 8,700 Da's Pluronic F68 ((PE0) 75 (PP0) 30 (PE0) 75) or ^ Pluronic F127 ((PE0) 99 (PP0) 69 (PE0) 99) It provides a skin temperature sensitive hydrogel cosmetic composition.

Pluronic polymers include F38, F68, F77, F98, F108, F127 starting with F and L31, L42, L43, L44, L62, L72, Ll () l starting with L and P75, P103, starting with P, P104 and the like, the difference in brand name is due to the difference in composition ratio and form. Among them, F68 ((PE0) 75 (PP0) 30 (PE0) 75) with a molecular weight of about 8,700 Da and F127 ((PE0) 99 (PP0) 69 (PE0) with a molecular weight of about 12,600 Da are approved by the US Food and Drug Administration (FDA). 99) and the like are mainly used as biological materials. In the present invention, the diacrylated pluronic polymer provides a skin temperature sensitive hydrogel cosmetic composition, characterized in that the synthesis by adding a double bond acrylate at both ends of the pluronic polymer.

In the present invention, it provides a skin temperature sensitive hydrogel cosmetic composition characterized in that the nucleic acid is used as the precipitation solvent during the synthesis process. In the embodiment of the present invention, when the nucleic acid is used as the precipitation solvent, the synthesis reaction time of the polymer is drastically shortened and the double bond introduction rate is equal to or higher than that of diethyl ether as the conventional precipitation solvent. In the present invention, the water-soluble natural polymer may be used any water-soluble natural polymer capable of forming a hydrogel with the diacrylated pluronic polymer, preferably carrageenan, cellulose, agar, galactomannan, It provides a skin temperature sensitive hydrogel cosmetic composition, characterized in that at least one water-soluble natural polymer selected from the group consisting of glucomannan, guar gum, locust bean gum, alginic acid, carrageenan, xanthan gum and gellan. In the embodiment of the present invention it was confirmed that the additional use of the water-soluble natural polymer has a better feeling in ease of skin adhesion, degree of adhesion and moisturizing after use.

In the present invention, the skin temperature range is 0 ^° C-50 ^° C temperature range, preferably provides a skin temperature sensitivity hydrogel cosmetic composition, characterized in that 30 ^° C-40 ^° C. In the embodiment of the present invention, when applied to the actual skin swelling hydrogel swells at skin temperature over time It was confirmed to change to the contracted hydrogel.

In the present invention, the reversible swelling and shrinking properties in the skin degree range provides a skin temperature sensitive hydrogel cosmetic composition, characterized in that it changes from the swollen gel state to the contracted gel state in response to skin temperature. Conventional hydrogels have a reversible reaction from gel to sol in the skin temperature range, whereas the hydrogels of the present invention have a difference in reversible reaction from a swollen gel in the skin temperature range.

In the present invention, it provides a skin sensitizing hydrogel cosmetic composition characterized by imparting a feeling of cooling and moisturizing to the skin as well as imparting elasticity and fit to the skin. Hydrogel of the present invention by contracting by the skin temperature when attached to the skin to release the moisture and water-soluble potent substances can not only enjoy the refreshing and moisturizing feeling on the skin, but also gives the skin a feeling of elasticity and fit.

In the present invention, preferably 1-60% of diacrylated pluronic polymer, 0.1-30% of water-soluble natural polymer, 1-20% by weight of skin affinity enhancer, and natural organisms, based on the total weight of the composition. 1-20% by weight of material, 1-30% by weight of polyhydric alcohol, 0.01-10% by weight of functional additives and 20-90% by weight of water, with no or no small amount of photoinitiator added thereto. It provides a skin temperature-sensitive hydrogel cosmetic composition, which is obtained by chemically crosslinking by.

In the present invention, a hydrogel was prepared with or without a small amount of photoinitiator, and hydrogel production was possible regardless of the photoinitiator. The photoinitiator functions to promote the polymerization reaction by forming radicals well when irradiated with UV rays. However, since photoinitiators may remain on the surface or inside of the hydrogel after UV irradiation ends, use a small amount as much as possible in consideration of skin safety. It is preferable not to.

In the present invention, preferably the skin affinity enhancer is a skin temperature sensitive hydrogel cosmetic composition, characterized in that at least one polysaccharide or protein selected from the group consisting of chitosan, chitosan derivatives, elastin, collagen, hyaluronic acid to provide.

In the present invention, preferably the natural biomaterial is aloe, green tea, It provides a skin temperature sensitivity hydrogel cosmetic composition characterized in that the natural extract of plants, animals or minerals extracted from the gimgle, ginkgo leaves and the like.

In the present invention, the polyhydric alcohol preferably provides a skin temperature sensitive hydrogel cosmetic composition, characterized in that the water-soluble liquid butylene glycol, propylene glycol or glycerin.

In the present invention, preferably, the functional additive is methyl paraben, ethyl paraben, phenoxyethanol, alcohol, α-hydroxy as an additive that can impart cosmetic functionality through the addition of the stability and preservation of the hydrogel and the active ingredient. Provided is a skin temperature sensitive hydrogel cosmetic composition characterized by an acid, clofenesin, or kojic acid, titanium dioxide, aluminum oxide and the like.

According to another aspect of the present invention, the present invention provides a skin external cosmetics or medicines comprising the skin temperature sensitive hydrogel composition according to the present invention. The external skin cosmetics or medicines may be any external skin cosmetics or medicines that can use a conventional hydrogel as a medium.

Hereinafter, the present invention will be described in more detail.

When the Pluronic F-127 polymer is at a suitable concentration, a transition occurs between a fluid-free gel and a fluid sol at temperatures near body temperature (33-37 ^° C). At this time, the resulting gel is a physical gel that is weak in mechanical properties so that its shape can be collapsed by external temperature and force. Therefore, the inventors of the present invention by using the ultraviolet light (UV) to make a chemically cross-linked gel by using this simple transition phenomenon alone to make a hydrogel applicable to cosmetics.

The present inventors synthesized diacrylated pluronic by adding an acrylate having a double bond at both ends of the pluronic polymer. At this time, nucleic acid is used instead of the diethyl ether used in the previous paper (Lee et al., J. Biomater. Sci. Polymer Edn, Vol. 15, 1571-1583, 2004) for the safety of the workers in the synthesis process. It was. The vapor pressure of the nucleic acid (124 隱 Hg, 20 ^° C) is lower than the diethyl ether vapor pressure (440 薩 ¾, 20 ^° C), thus reducing the risk of solvent inhalation during the operation. The boiling point (about 69 ^° C) is higher than the boiling point of diethyl ether (about 35 ° C), so it is much more efficient in terms of evaporation of solvents that can be produced by exothermic reactions during the synthesis process. In addition, in the case of diethyl ether, dispersion similar to emulsion occurs during the precipitation process, which takes a long time to settle, whereas nucleic acid can be precipitated immediately, which is much superior to diethyl ether in terms of safety and process efficiency. Solvent.

In the present invention, the diacrylated pluronic acid made as described above alone and in combination with other water-soluble polymers to prepare a hydrogel through ultraviolet irradiation. Although diacrylated pluronic alone can produce hydrogels through UV irradiation, the present inventors invented water-soluble natural polymers such as cellulose and carrageenan gum to produce hydrogels with excellent feeling. Hydrogels were prepared. Existing hydrogels made of only water-soluble natural polymers did not have any specificities in their internal structure, but a clear porous structure was observed in hydrogels made by UV irradiation alone or in combination with other water-soluble polymers. .

In addition, the present invention also prepared hydrogels with little or no initiator. The hydrogel thus produced was swelled by the cosmetic composition in an aqueous solution at room temperature or refrigerated conditions and then reacted at 37 ° C, which is the skin temperature, to release the aqueous solution collected therein.

Advantageous Effects

The temperature sensitive hydrogel made by the present invention reacts to the skin temperature and releases moisturizing ingredients and various active ingredients, including water that was swelling inside the hydrogel while simultaneously shrinking the hydrogel itself. This gives the skin a refreshing and moisturizing feeling, and can supply various effective ingredients to the skin. In addition, due to the shrinking nature of the hydrogel gives a sense of elasticity to the skin, and also due to this shrinkage may help to attach the hydrogel more tightly to the skin. [Brief Description of Drawings]

1 is a graph measuring the swelling ratio (Swelling ratio) of the Pluronic hydrogel prepared according to an embodiment of the present invention.

Figure 2 is a graph measuring the contraction ratio (Contract ion ratio) of the Pluronic hydrogel prepared according to the embodiment of the present invention.

3 is a result of observing the hydrogel made of the internal structure of the Pluronic hydrogel prepared according to the embodiment of the present invention and the water-soluble polymer alone with a scanning electron microscope (SEM). [Form for implementation of invention]

Hereinafter, the present invention will be described in more detail based on the following examples. However, the following examples are only for illustrating the present invention, and the scope of the present invention is not limited thereto. Reagents and Samples

Pluronic F-127 ((PE0) 99 (PP0) 69 (PE0) 99) was purchased from BASF, Triethylamine was purchased from Sigma and Acryloyl chloride was purchased from Wako. In addition, methylene chloride, a solvent used in the synthesis reaction, was purchased from J & T Baker and nucleic acid (Hexane) used for precipitation was obtained from Daejeong (Korea). Example 1 Synthesis of Acrylated Pluronic

This step is to introduce double bonds at both ends of the Pluronic F127 polymer and to dry the Pluronic polymer by vacuum or hot air conditions for at least one day before synthesis. The dried fluorogenic F127 polymer (80 g, ca. 6.36 mmol) and triarylamine (2 mL, 14.48 mmol) are added to 200 mL of dichloromethane and dissolved. When all of the pluronic polymer was dissolved and transparent, acryloyl chloride (1 mL, 25.44 mmol) was slowly added dropwise to introduce double bonds at both ends of the pluronic polymer. This process is essential because of the specific odor of triethylamine and the hydrogen chloride (HC1) gas produced during the reaction. Proceed in the hood.

Prior papers (Lee et al., J. Biomater. Sci. Polymer Edn, Vol. 15, 1571-1583, 2004) and patent (Patent No. 848712) performed this synthesis reaction at 12 ^° C at 12 ^° C after 12 hours at 4 ° C. Although performed for a time, in the present invention, it was confirmed that similar results can be obtained by performing only 3 hours at room temperature.

In addition, conventional papers (Lee et al., J. Biomater. Sci. Polymer Edn, Vol. 15,

1571-1583, 2004) and patent (Patent No. 848712) precipitated the semicolumn with an excess amount of cold diethyl ether after the reaction and filtered, but in the present invention, nucleic acid was used instead of diethyl ether. In the configuration and operation of the present invention, diethyl ether has a boiling point of about 35 ^° C., a vapor pressure of 440 mmHg at 20 ^° C., whereas a nucleic acid has a boiling point of about 69 ^° C.,

The vapor pressure at 20 ° C. is 124 mmHg, which is relatively less volatile than diethyl ether. In addition, in the case of diethyl ether, it was better to use nucleic acid as a precipitation solution in terms of yield, such as rapid precipitation, in the case of nucleic acid, whereas the dispersion turned cloudy similarly to an emulsion upon excessive precipitation. That is, in the case of dietel ether, the yield of the finally obtained diacrylated pluronic polymer was about 60 to 70% by weight, whereas in the case of nucleic acid, the yield was about 80 to 90% or more. The polymer semi-aerated product (diacrylated pluronic) thus obtained was dried in a hood to the extent that the residual solvent was removed and then completely dried again in vacuo. The synthesized polymer was dissolved in CDC13 solvent and the 400MHZ 1H NMR spectrum was measured to calculate the double bond incorporation rate. The double bond incorporation rate of diacrylated pluronic F127 obtained by precipitation with nucleic acid after 3 hours reaction was about 74. It was about%. Also, as in the previous paper, the double bond introduction rate was about 72% when diethyl ether was used and the reaction time was increased to this level (Table 1). This was similar to about 72% of double bond incorporation of diacrylated Pluronic F127 obtained from a previous paper (Lee et al., J. Biomater. Sci. Polymer Edn, Vol. 15, 1571-1583, 2004). Table 1

Although the reaction time in Comparative Example 1 of Beating Table 1 was longer than that of Example 1 at 48 hours, the rate of double bond introduction was rather large in Example 1. This may be due to the difference in the environment of drying the initial Pluronic polymer and the solvent used in the precipitation process. Example 2 Preparation of Photopolymerized Polyuronic Hydrogel

In order to make a pluronic hydrogel, the polymer obtained in Example 1 was dissolved in water to make an aqueous solution. Specifically, the diacrylated pluronic polymer dissolves well after being put in water or left at room temperature for one day at room temperature. At this time, at least one of the water-soluble natural polymers composed of carrageenan and cellulose, agar, galactomannan, glucomannan, guar gum, locust bean gum, alginic acid, carrageenan, xanthan gum and gellan is dissolved together. This is to make the hydrogel with excellent usability. Also, among natural biological substances such as natural extracts of plants, animals or minerals extracted from at least one skin affinity enhancer composed of chitosan, chitosan derivatives, elastin, collagen, hyaluronic acid, aloe, green tea, citrus, ginkgo biloba, etc. At least one or more of polyhydric alcohols such as butylene glycol, propylene glycol, glycerin, methyl paraben, ethyl paraben, phenoxy ethane, alcohol, α-hydroxy acid, clophenesine, or kojic acid, titanium dioxide Use at least one of functional additives such as aluminum oxide. In the present invention, it is also possible to use a photoinitiator as needed to enhance the efficiency of photopolymerization. As a photoinitiator, a product of (4-Benzoylbenzyl) trimethylammonium chloride or Irgacure 1 Lease is used, and a maximum weight of 0.5% (w / vv) is used.

Specific ingredient table for preparing a hydrogel is shown in Table 2 below. [Table 2]

Since there is no significant difference in hydrogel manufacturing ability between the # 1 and # 2, Example 2 in the following experimental results will be described based on # 2 without the photoinitiator. When the polymer solution dissolved in the cold state is left at room temperature, the concentration of the aqueous solution may be changed to a physical gel state first. The physical gel was confirmed by inverting the plastic container and judging whether the gel was kept. After the physical gel is confirmed, ultraviolet rays are irradiated to prepare a chemical gel. At this time, ultraviolet rays were irradiated for 5 minutes, 10 minutes and 20 minutes. Di-acryloyl Pluronic F127, made by the reaction of acryloyl chloride and pluronic, introduces double bonds at both ends of the polymer, and the double bonds polymerize when irradiated with UV light. After UV irradiation, after washing with water in order to remove the unbanung polymer that may remain on the surface of the hydrogel, the hydrogel is removed using the desired shape. Hydrogel prepared in the present invention was designed to be a disk shape diameter of about 1.7 cm, the thickness is about 2.2 kPa. According to the concentration of the polymer and the preparation of the chemically cross-linked hydrogel according to the UV irradiation time is shown in Table 3 below.

Table 31

0: Form chemically crosslinked hydrogel

X: Chemically Crosslinked Hydrogel Not Forming Example 3 Swelling Ratio of Pluronic Hydrogel

Swelling properties of the hydrogel obtained in Example 2 were measured. The degree of swelling is 5 minutes, 10 minutes, 30 minutes at 4 ^° C, room temperature (23 ^° C) and 37 ^° C by adding a certain amount of water (10 mL) to the weight (Wo) of the hydrogel obtained immediately after the initial preparation. After 1 hour, the relative swelling degree was confirmed by changing the weight and diameter of the hydrogel. The degree of swelling was measured as a ratio of how much the weight of the hydrogel increased after a certain amount of time with respect to the weight of the hydrogel before adding water. 。 ^ 。Essential weight of hydrogel (g) -initial hydro weight (g)

^¾ ^ ^{(/ 0)} Initial Hydrogel Weight (g) ^{s ιυυ} The samples used in the swelling experiments were hydrogels polymerized by UV irradiation for 20 minutes at 25 and 30 weight ^ w / w). It was about cm. (Figure 1)

As shown in FIG. 1, the swelling degree increases as the polymer content decreases, and the swelling degree increases as the storage temperature is lowered. Example 4 Contraction Ratio of Pluronic Hydrogel 4 ° C. and room temperature for measuring the swelling degree of the hydrogel in Example 3

Samples stored at (23 ^° C.) are allowed to stand for one day at each condition and the hydrogel is fully swollen in water. Thereafter, the sample was taken out and applied to the skin, and then the hydrogel shrinkage was measured by measuring the weight of the hydrogel every predetermined time interval (5 minutes, 10 minutes and 30 minutes), which is shown in FIG. 2.

츠 八_。- Initial hydrogel weight (g) ^-hour ^/ hydrogel weight (g), _{Ί Λ} TT ^ no ( ^{/ 0} ) Initial hydrogel weight (g) ^{s ιυυ} Ask the surface to measure the hydrogel weight Since the measurement error may occur due to the water droplets present, the weight was measured after removing water on the surface of the hydrogel as much as possible. As shown in FIG. 2, the smaller the polymer content and the lower the initial temperature, the greater the shrinkage.

The shrinkage degree of the hydrogel may be measured by weight as shown in FIG. 2, but it is most effective to measure the change in the diameter of the hydrogel to enable consumers to know the immediate and visible effect. However, the hydrogel used in Figures 1 and 2 is not easy to check the change in diameter since the initial diameter itself is small as about 1.7 cm. Therefore, in the present invention, a relatively large hydrogel having a diameter of 5 cm was prepared and shrinkage was measured. At this time, the prepared hydrogel condition is that the content of the polymer The sample was irradiated with UV at 25 weight (\ ¥)% for 20 minutes. In addition, the initial thickness was designed to be 2 3 and 3 隱, respectively. Hydrogel swelled for one day in refrigerated conditions (4 ^° C) in order to measure the maximum shrinkage effect after the manufacture, the shrinkage experiment was carried out at 37 ^° C conditions. Hydrogels made up to an initial diameter of 5 cm increased in diameter to about 7.9 cm after swelling in refrigerated conditions for one day. In addition, the experiment was considered considering the shrinkage according to the initial thickness of the hydrogel. As a result, as shown in Table 4, the smaller the initial thickness of the hydrogel, the larger the shrinkage effect by the diameter. This is thought to be because shrinkage and swelling do not occur relatively easily because the thicker the thickness, the more crosslinks are present in the hydrogel.

Table 4

Example 5 Confirmation of Internal Structure of Hydrogel

Scanning electron microscopy (SEM) was observed for hydrogels prepared by heating water-soluble polymers such as Pluronic hydrogels made of only 15% (wAv) polymers of Example 2 and agar without UV irradiation. As a result, in the pluronic hydrogel, a porous structure having a size of 30 μm was observed as shown in FIG. 3, while the porous structure was not observed in a hydrogel made of only a water-soluble polymer. The porous structure in the hydrogel may be affected by the degree of crosslinking of the hydrogel. Example 6 improvement of feeling according to the presence or absence of water-soluble natural polymer

Composition # 3 of Table 2 was used as Comparative Example 2, and Composition # 2 of Example 2 of Table 2 was used in order to measure the degree of improvement in feeling of use. 10 female consumers in their 50s and 50s Table 5 shows the consumer quality evaluation. Consumer quality evaluation was performed based on the items on the ease of attachment of hydrogel, degree of adhesion and moisturizing after use. Table 5

-Quality Satisfaction Evaluation Criteria-

1 point: very bad, 2 points: bad, 3 points: normal 4 points: good, 5 points: very good As shown in Table 4, the quality satisfaction of Example 2 was found to be superior to Comparative Example 2. This suggests that the feeling of use of water-soluble natural polymer and that of diacrylated pluronic polymer showed synergistic effect. In addition, there was no significant difference between swelling and shrinkage between Example 2 and Comparative Example 2 to which the water-soluble natural polymer was added. This is a part of the diacrylated pluronic polymer, which mainly contributes to the swelling and shrinkage according to the temperature sensitization of the hydrogel, but it is judged to have a better feeling when additionally using a water-soluble natural polymer.

Industrial Applicability

As described above, according to the present invention, the water-soluble cosmetics contained in the hydrogel are more quickly and uniformly delivered into the skin through shrinkage according to the temperature of the hydrogel. It can be used as a skin temperature sensitive hydrogel cosmetic composition because it can be attached more tightly.

Claims

[Range of request]

[Claim 1]

Diacrylated pluronic polymers and water-soluble natural polymers have reversible swelling and shrinking properties over the skin temperature range, obtained by chemical crosslinking by ultraviolet (UV) with or without a photoinitiator and porous to its internal structure. Skin temperature sensitive hydrogel cosmetic composition characterized in that it has a structure.

[Claim 2]

The method of claim 1, wherein the pluronic polymer is Pluronic F68 ((PEO) 75 (PPO) 30 (PEO) 75) having a molecular weight of about 8,700 Da or Floronic F127 ((PE0) having a molecular weight of about 12,600 Da. ) 99 (PP0) 69 (PE0) 99) skin temperature sensitive hydrogel cosmetic composition, characterized in that.

[Claim 3]

The skin temperature sensitive hydrogel cosmetic composition according to claim 1, wherein the diacrylated pluronic polymer is synthesized by adding acrylates having double bonds to both ends of the pluronic polymer.

[Claim 4]

The skin temperature sensitive hydrogel cosmetic composition according to claim 3, wherein a nucleic acid is used as a precipitation solvent in the synthesis process.

[Claim 5]

The method of claim 1, wherein the water-soluble natural polymer is at least one water-soluble selected from the group consisting of carrageenan, salulose, agar, galactomannan, glucomannan, guar gum, locust bean gum, alginic acid, carrageenan, xanthan gum and gellan Skin temperature-sensitive hydrogel cosmetic composition, characterized in that the natural polymer.

[Claim 6]

According to claim 1, wherein the skin temperature range is a skin temperature sensitivity hydrogel cosmetic composition, characterized in that 0 ^° C-50 ^° C temperature range.

[Claim 7]

The skin temperature sensitive hydrogel cosmetic composition according to claim 1, wherein the reversible swelling and shrinking properties in the skin temperature range change from the swollen gel state to the shrunken gel state in response to the skin temperature.

[Claim 8]

The skin temperature-sensitive hydrogel cosmetic composition according to claim 1, which not only imparts a refreshing and moisturizing feeling to the skin but also imparts elasticity and adhesion to the skin.

[Claim 9]

The method of claim 1, based on the total weight of the composition 1-60% diacrylated polyuronic polymer, 0.1-30% by weight of water-soluble natural polymer, 1-20% by weight of skin affinity enhancer, natural biomaterial 1- 20 weight ¾>, 1-30 weight percent polyhydric alcohol, 0.01-10 weight ¾ weight functional additive, and 20-90 weight% water, which is added by ultraviolet (UV) with or without a small amount of photoinitiator. Skin temperature sensitive hadrogel cosmetic composition, characterized in that obtained by chemically crosslinking.

[Claim 10]

The skin temperature sensitive hydrogel cosmetic composition according to claim 9, wherein the skin affinity enhancer is at least one polysaccharide or protein selected from the group consisting of chitosan, chitosan derivative 1, elastin, collagen, hyaluronic acid.

[Claim 11]

10. The method of claim 9, wherein the natural biomass is aloe, green tea, citrus, Skin thermosensitizing hydrogel cosmetic composition, characterized in that the natural extract of plants, animals or minerals extracted from ginkgo leaves and the like.

[Claim 12]

The skin temperature-sensitive hydrogel cosmetic composition according to claim 9, wherein the polyhydric alcohol is a water-soluble liquid butylene glycol, propylene glycol or glycerin.

[Claim 13]

10. The method of claim 9, wherein the functional additive is a hydrogel stability and preservatives, through the addition of an active ingredient as a cosmetic functional additives that can be given to methyl parabens, ethyl parabens, phenoxyethanol, alcohols, α-hydroxy acids, A skin temperature sensitive hydrogel cosmetic composition characterized by clofenesin, kojic acid, titanium dioxide, aluminum oxide and the like.

[Claim 14]

The skin temperature-sensitive hydrogel cosmetic composition according to claim 9, wherein the photoinitiator is trimethylamonium chloride (4-benzoyl benzyl) or Irgacure series.

[Claim 15]

An external skin cosmetic or pharmaceutical product comprising the skin thermosensitizing hydrogel composition according to any one of claims 1 to 14.