WO2013178739A1 - Dispositif de dosage avec indication d'une quantité suffisante d'échantillon - Google Patents
Dispositif de dosage avec indication d'une quantité suffisante d'échantillon Download PDFInfo
- Publication number
- WO2013178739A1 WO2013178739A1 PCT/EP2013/061178 EP2013061178W WO2013178739A1 WO 2013178739 A1 WO2013178739 A1 WO 2013178739A1 EP 2013061178 W EP2013061178 W EP 2013061178W WO 2013178739 A1 WO2013178739 A1 WO 2013178739A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sample
- receiving member
- detection element
- assay
- assay device
- Prior art date
Links
- 238000003556 assay Methods 0.000 title claims abstract description 179
- 238000001514 detection method Methods 0.000 claims abstract description 196
- 239000012530 fluid Substances 0.000 claims abstract description 82
- 239000012491 analyte Substances 0.000 claims abstract description 48
- 239000000463 material Substances 0.000 claims description 59
- 239000003153 chemical reaction reagent Substances 0.000 claims description 55
- 238000012360 testing method Methods 0.000 claims description 47
- 210000002700 urine Anatomy 0.000 claims description 39
- 238000005070 sampling Methods 0.000 claims description 28
- 238000012546 transfer Methods 0.000 claims description 18
- 230000004888 barrier function Effects 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 15
- 239000011148 porous material Substances 0.000 claims description 13
- 238000011144 upstream manufacturing Methods 0.000 claims description 12
- 239000002250 absorbent Substances 0.000 claims description 6
- 230000002745 absorbent Effects 0.000 claims description 6
- 239000000017 hydrogel Substances 0.000 claims description 5
- 230000001419 dependent effect Effects 0.000 claims description 2
- 239000000523 sample Substances 0.000 description 505
- 239000007788 liquid Substances 0.000 description 32
- 239000000020 Nitrocellulose Substances 0.000 description 10
- 229920001220 nitrocellulos Polymers 0.000 description 10
- 238000009739 binding Methods 0.000 description 7
- 239000003365 glass fiber Substances 0.000 description 7
- 230000003287 optical effect Effects 0.000 description 7
- 210000001124 body fluid Anatomy 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000000835 fiber Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000009736 wetting Methods 0.000 description 5
- 102000011022 Chorionic Gonadotropin Human genes 0.000 description 4
- 108010062540 Chorionic Gonadotropin Proteins 0.000 description 4
- 239000004677 Nylon Substances 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 230000027455 binding Effects 0.000 description 4
- 229940084986 human chorionic gonadotropin Drugs 0.000 description 4
- 239000011133 lead Substances 0.000 description 4
- 230000005499 meniscus Effects 0.000 description 4
- 229920001778 nylon Polymers 0.000 description 4
- 229920000728 polyester Polymers 0.000 description 4
- 238000002203 pretreatment Methods 0.000 description 4
- 229920000742 Cotton Polymers 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 238000003776 cleavage reaction Methods 0.000 description 3
- 230000035935 pregnancy Effects 0.000 description 3
- 230000007017 scission Effects 0.000 description 3
- 230000009870 specific binding Effects 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000009151 Luteinizing Hormone Human genes 0.000 description 2
- 108010073521 Luteinizing Hormone Proteins 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000012876 carrier material Substances 0.000 description 2
- 238000007598 dipping method Methods 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- FJAZVHYPASAQKM-JBAURARKSA-N estrone 3-O-(beta-D-glucuronide) Chemical compound C([C@@H]1[C@@H](C2=CC=3)CC[C@]4([C@H]1CCC4=O)C)CC2=CC=3O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O FJAZVHYPASAQKM-JBAURARKSA-N 0.000 description 2
- 230000035558 fertility Effects 0.000 description 2
- 239000002657 fibrous material Substances 0.000 description 2
- 238000005755 formation reaction Methods 0.000 description 2
- 229940040129 luteinizing hormone Drugs 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000000123 paper Substances 0.000 description 2
- 239000007793 ph indicator Substances 0.000 description 2
- 238000009597 pregnancy test Methods 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 229920001059 synthetic polymer Polymers 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010003445 Ascites Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229910021580 Cobalt(II) chloride Inorganic materials 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 239000004128 Copper(II) sulphate Substances 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 206010072369 Pharyngeal exudate Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000002820 assay format Methods 0.000 description 1
- 238000013096 assay test Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- GVPFVAHMJGGAJG-UHFFFAOYSA-L cobalt dichloride Chemical compound [Cl-].[Cl-].[Co+2] GVPFVAHMJGGAJG-UHFFFAOYSA-L 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000012502 diagnostic product Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000010137 moulding (plastic) Methods 0.000 description 1
- 229910052755 nonmetal Inorganic materials 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- ZRHANBBTXQZFSP-UHFFFAOYSA-M potassium;4-amino-3,5,6-trichloropyridine-2-carboxylate Chemical compound [K+].NC1=C(Cl)C(Cl)=NC(C([O-])=O)=C1Cl ZRHANBBTXQZFSP-UHFFFAOYSA-M 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000013102 re-test Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/525—Multi-layer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Cette invention concerne un dispositif de dosage pour détecter un analyte dans un échantillon liquide, ledit dispositif comprenant : un élément récepteur d'échantillon (1), qui est poreux et en communication fluidique avec un ou plusieurs composants (2, 3) définissant un trajet d'écoulement du dosage, un des composants au moins étant un élément de détection (3) comprenant une zone de détection d'analyte (31) ; et un élément détecteur d'échantillon (13), situé à l'extérieur du trajet d'écoulement du dosage et séparé de l'élément récepteur d'échantillon (1) par un espace (7), le dispositif étant conçu pour que l'élément récepteur d'échantillon (1) et l'élément détecteur d'échantillon (13) puissent être en communication fluidique quand l'espace (7) est comblé par l'échantillon liquide.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1209664.0 | 2012-05-30 | ||
| GBGB1209664.0A GB201209664D0 (en) | 2012-05-30 | 2012-05-30 | Assay device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2013178739A1 true WO2013178739A1 (fr) | 2013-12-05 |
Family
ID=46546236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2013/061178 WO2013178739A1 (fr) | 2012-05-30 | 2013-05-30 | Dispositif de dosage avec indication d'une quantité suffisante d'échantillon |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB201209664D0 (fr) |
| WO (1) | WO2013178739A1 (fr) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015082646A1 (fr) * | 2013-12-04 | 2015-06-11 | Spd Swiss Precision Diagnostics Gmbh | Dispositif de dosage |
| US9606116B2 (en) | 2014-05-11 | 2017-03-28 | Lia Diagnostics, Inc. | Flexible, integrated urine-based diagnostic service |
| US10228377B2 (en) | 2013-10-02 | 2019-03-12 | Spd Swiss Precision Diagnostics Gmbh | Pregnancy test device and method |
| US10794920B2 (en) | 2015-04-02 | 2020-10-06 | Spd Swiss Precision Diagnostics Gmbh | Pregnancy test device and method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030098233A1 (en) * | 2001-10-10 | 2003-05-29 | Kermani Mahyar Z. | Determination of sample volume adequacy in biosensor devices |
| US20040248322A1 (en) * | 2003-06-06 | 2004-12-09 | David Charlton | Diagnostic test for analytes in a sample |
| US20080124749A1 (en) * | 2006-09-14 | 2008-05-29 | Farnam W Edward | Device and method for measuring properties of a sample |
-
2012
- 2012-05-30 GB GBGB1209664.0A patent/GB201209664D0/en not_active Ceased
-
2013
- 2013-05-30 WO PCT/EP2013/061178 patent/WO2013178739A1/fr active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030098233A1 (en) * | 2001-10-10 | 2003-05-29 | Kermani Mahyar Z. | Determination of sample volume adequacy in biosensor devices |
| US20040248322A1 (en) * | 2003-06-06 | 2004-12-09 | David Charlton | Diagnostic test for analytes in a sample |
| US20080124749A1 (en) * | 2006-09-14 | 2008-05-29 | Farnam W Edward | Device and method for measuring properties of a sample |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10228377B2 (en) | 2013-10-02 | 2019-03-12 | Spd Swiss Precision Diagnostics Gmbh | Pregnancy test device and method |
| US11099199B2 (en) | 2013-10-02 | 2021-08-24 | Spd Swiss Precision Diagnostics Gmbh | Pregnancy test device and method |
| WO2015082646A1 (fr) * | 2013-12-04 | 2015-06-11 | Spd Swiss Precision Diagnostics Gmbh | Dispositif de dosage |
| AU2014359181B2 (en) * | 2013-12-04 | 2017-10-19 | Spd Swiss Precision Diagnostics Gmbh | Assay device |
| US10328427B2 (en) | 2013-12-04 | 2019-06-25 | Spd Swiss Precision Diagnostics Gmbh | Assay device |
| US9606116B2 (en) | 2014-05-11 | 2017-03-28 | Lia Diagnostics, Inc. | Flexible, integrated urine-based diagnostic service |
| US10045694B2 (en) | 2014-05-11 | 2018-08-14 | Lia Diagnostics, Inc. | Integrated diagnostic device |
| US10542886B2 (en) | 2014-05-11 | 2020-01-28 | Lia Diagnostics, Inc. | Integrated diagnostic device |
| US10794920B2 (en) | 2015-04-02 | 2020-10-06 | Spd Swiss Precision Diagnostics Gmbh | Pregnancy test device and method |
Also Published As
| Publication number | Publication date |
|---|---|
| GB201209664D0 (en) | 2012-07-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2930879C (fr) | Dispositif d'epreuve biologique et utilisation associee en vue d'indiquer le caractere suffisant d'un prelevement pendant un evenement de prelevement | |
| EP2643696B1 (fr) | Dispositif d'essai | |
| US8611992B2 (en) | Diagnostic device and method for sensing hydration state of a mammalian subject | |
| US8911988B2 (en) | Menstrual fluid analysis | |
| EP1604204B1 (fr) | Dispositif d'analyse d'echantillon base sur l'agglutination | |
| EP3029463A1 (fr) | Diagnostic de l'oeil sec | |
| EP2124053A1 (fr) | Procédé d'acquisition d'informations biologiques et instrument, et procédé de mesure de substance active physiologiquement et instrument | |
| AU2011307356A1 (en) | Improved electronic analyte assaying device | |
| CA2906302C (fr) | Dispositif de test de diagnostic a structure amelioree | |
| WO2021017417A1 (fr) | Papier réactif de détection semi-quantitative de gonadotrophine chorionique humaine et son procédé de préparation, coupelle de réactif de détection semi-quantitative de gonadotrophine chorionique humaine, et ses applications | |
| WO2013178739A1 (fr) | Dispositif de dosage avec indication d'une quantité suffisante d'échantillon | |
| RU2281165C2 (ru) | Устройство для отбора жидких проб | |
| US20220296221A1 (en) | Device and Method for Pre-Term Birth Risk Assessment | |
| US20120149093A1 (en) | Method and Apparatus for Automating Chemical and Biological Assays | |
| US9964550B2 (en) | At-home blood pregnancy test kit | |
| WO2010133997A1 (fr) | Dispositif de diagnostique à détecteur d'application d'échantillon | |
| JP2011095156A (ja) | 唾液検査器具 | |
| GB2622865A (en) | A housing for sample collection | |
| US20070249037A1 (en) | Monitoring of Vitamin K Nutritional Status | |
| JP2009145079A (ja) | クロマトグラフィー分析用ストリップ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 13725980 Country of ref document: EP Kind code of ref document: A1 |
|
| NENP | Non-entry into the national phase |
Ref country code: DE |
|
| 122 | Ep: pct application non-entry in european phase |
Ref document number: 13725980 Country of ref document: EP Kind code of ref document: A1 |