WO2013137500A1 - Système de stimulation nerveuse cérébrale optique sans fil - Google Patents

Système de stimulation nerveuse cérébrale optique sans fil Download PDF

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Publication number
WO2013137500A1
WO2013137500A1 PCT/KR2012/001870 KR2012001870W WO2013137500A1 WO 2013137500 A1 WO2013137500 A1 WO 2013137500A1 KR 2012001870 W KR2012001870 W KR 2012001870W WO 2013137500 A1 WO2013137500 A1 WO 2013137500A1
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WO
WIPO (PCT)
Prior art keywords
light
stimulation system
wireless
nerve stimulation
cranial nerve
Prior art date
Application number
PCT/KR2012/001870
Other languages
English (en)
Korean (ko)
Inventor
신희섭
최일환
김고근
조일주
윤의성
Original Assignee
한국과학기술연구원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한국과학기술연구원 filed Critical 한국과학기술연구원
Priority to PCT/KR2012/001870 priority Critical patent/WO2013137500A1/fr
Publication of WO2013137500A1 publication Critical patent/WO2013137500A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0622—Optical stimulation for exciting neural tissue

Definitions

  • Embodiments relate to a wireless cranial nerve stimulation system.
  • Electric or light brain stimulation technology is used to treat patients' diseases, and at the same time applied to animals other than humans to reveal the brain function.
  • the cranial nerve stimulation system that stimulates the cranial nerve using light expresses some channels and enzymes that are stimulated only by light of a specific wavelength in the nerve cell, and then illuminates the light of a specific wavelength without causing damage to the nerve cell. Only neurons of a kind are selectively stimulated / inhibited.
  • FIG. 1 is a view showing an embodiment of a conventional light stimulation system for brain stimulation.
  • a conventional optical fiber is inserted into an animal's brain and the optical fiber is connected to an external light source. Light emitted from the light source unit is transmitted to the cranial nerve through the optical fiber connected to the light source unit.
  • the photo-stimulated animal and the light source are physically connected through the optical fiber, so the optical fiber restricts the free movement of the photo-stimulated animal.
  • This may be a potential stressor for animals participating in behavioral experiments and may adversely affect the experimental results.
  • the behavior of an animal subjected to photostimulation may damage the optical fiber or the optical stimulation system may become unstable.
  • a wireless cranial nerve stimulation system that can ensure the free movement of the subject to be measured by implementing a cranial nerve stimulation system in a wireless manner.
  • the light source for irradiating light
  • a light receiving unit mounted on a living body to be measured to receive light emitted from the light source unit
  • an optical stimulator for stimulating the neural tissue by applying the light received from the light receiver to the neural tissue.
  • the wireless cranial nerve stimulation system since the measurement target living body and the light source are physically separated, it does not limit the movement of the measurement target living body.
  • FIG. 1 is a view showing an embodiment of a light stimulation system for brain stimulation used in the prior art.
  • FIG. 2 is a view schematically showing the configuration of a wireless cranial nerve stimulation system according to an embodiment.
  • FIG 3 is a schematic cross-sectional view of a light receiving unit according to an embodiment of the present invention.
  • FIG. 4 is a plan view of a light receiving unit according to an embodiment of the present invention.
  • FIG. 5 is a plan view of a light receiving unit according to another embodiment of the present invention.
  • Figure 6 is a schematic view showing the configuration of a wireless cranial nerve stimulation system according to another embodiment of the present invention.
  • Figure 7 is a schematic view showing the configuration of a wireless cranial nerve stimulation system according to another embodiment of the present invention.
  • FIG. 2 is a view schematically showing the configuration of a wireless cranial nerve stimulation system according to an embodiment.
  • the wireless cranial nerve stimulation system includes a light source unit 10, a light receiver 20, and a light stimulator 30.
  • the light source unit 10 irradiates light.
  • the light source unit 10 may be implemented as a light emitting diode (LED), a laser diode, or the like.
  • LED light emitting diode
  • laser diode or the like.
  • the light receiving unit 20 is mounted on the head of the living body (for example, the mouse) 1 to be measured to receive light emitted from the light source unit 10, and transmits the received light to the light stimulation unit 30.
  • the light receiving unit 20 includes at least one lens, and the lens is preferably made of any one of a convex lens, a concave lens, and a Fresnel lens.
  • the light receiving unit 20 may be formed in a tube shape, a part of which is inserted into the body of the living body 1.
  • this is merely exemplary, and the light receiving unit 20 applied to the present invention is not limited to having a specific shape or form.
  • the optical stimulation unit 30 is inserted into the brain of the living body (1) to be measured and connected to the cranial nerve tissue, and stimulates the cranial nerve tissue by applying the light received from the light receiving unit 20 to the cranial nerve tissue.
  • the optical stimulation unit 30 may be implemented with an optical fiber.
  • FIG 3 is a schematic cross-sectional view of a light receiving unit according to an embodiment of the present invention.
  • the light receiving unit 20 is installed under the primary lens 11 and the primary lens 11 to receive the light emitted from the light source unit 10, and is received by the primary lens 11. It comprises a secondary lens 12 that focuses a light.
  • the primary lens 11 and the secondary lens 12 implemented by the Fresnel lens is preferably installed to face in opposite directions to each other to change the path of the light.
  • the primary lens 11 passes the light incident at the focus of the Fresnel lens perpendicular to the lens,
  • the light incident perpendicularly to the secondary lens 12 by the primary lens 11 passes through the secondary lens 12 installed in the opposite direction to the primary lens 11 and is then focused at the focal point.
  • the light receiving unit 20 may further include a top plate 13 having a guide hole 13a for guiding light into the light receiving unit 20 at a focal position of the primary lens 11.
  • the upper plate 13 is installed on the primary lens 11, but is preferably installed at the focal length of the primary lens 11.
  • the light receiving unit 20 may further include a lower plate 14 having a hole 14a formed at a focal position of the secondary lens 12.
  • the lower plate 14 is installed below the secondary lens 12, but is preferably installed at the focal length of the secondary lens 12.
  • the light stimulator 30 is integrally connected to the hole 14a formed in the lower plate 14.
  • the light stimulation part 30 is connected to and installed in the hole 14a formed at the focal point of the secondary lens 12, the light that has focused on the light after passing through the secondary lens 12 passes through the light stimulus.
  • the optical fiber which is transmitted to the optical fiber, which is a part 30, receives the light, and the optical stimulation part 30 is applied to the nerve tissue to stimulate the brain tissue.
  • a guide line 15 is installed outside the primary lens 11 of the light receiving unit 20, and a reflector for inducing diffuse reflection may be applied to the guide line 15.
  • the light irradiated from the light source unit 10 passes through the guide hole 13a of the light receiving unit 20 and enters into the guide line 15 of the primary lens 11 to be incident vertically through the primary lens 11.
  • the light incident on the secondary lens 12 by the primary lens 11 passes through the secondary lens 12 and then collects in focus.
  • the light irradiated from the light source unit 10 does not enter the guide line 15 of the primary lens 11 despite passing through the guide hole 13a, it is notified to the outside and irradiated from the light source unit 10. Aim the light to enter the guide line (15) inside.
  • the light that does not enter into the guide line 15 of the primary lens 11 is reflected by a reflector applied to the outside of the guide line 15, the outside is irradiated from the light source unit 10 through the reflected light Although the light passes through the guide hole 13a, it can be seen that the light cannot enter the guide line 15 of the primary lens 11.
  • FIG 5 is a plan view of a light receiving unit according to another exemplary embodiment of the present invention.
  • the light receiving unit 20 is an embodiment except for the electrical signal generator 16, the RF transmitter 18, the driver 17, and the power supply unit 19 installed on the upper plate 13. Since the light receiving unit 20 is substantially the same, the same reference numerals are used for corresponding components, and a detailed description thereof will be omitted.
  • the guide line 15 installed at the outer side of the primary lens 11 may be omitted.
  • the light receiving unit 20 includes a plurality of electric signal generators 16, an RF transmitter 18, a driver 17, and a power supply 19.
  • the plurality of electrical signal generators 16 are installed around the guide hole 13a formed in the upper plate 13 to generate an electrical signal when the light emitted from the light source unit 10 is received.
  • the light irradiated from the light source unit 10 should be incident to the guide hole 13a formed in the upper plate 13.
  • the light irradiated from the light source unit 10 does not enter the guide hole 13a and the guide hole 13a does not enter the guide hole 13a.
  • the electrical signal generator 16 When incident to the electrical signal generator 16 installed in the periphery, the electrical signal generator 16 generates and outputs an electrical signal as it receives light.
  • the electrical signal generator 16 may be implemented with a photo diode, a photo transistor, or the like.
  • the RF transmitter 18 generates and transmits an RF signal.
  • the driver 17 When the driver 17 receives an electrical signal of a predetermined voltage or higher from any one of the electrical signal generators 16, the driver 17 outputs a driving signal to the RF transmitter 18 to drive the RF transmitter 18.
  • the driver 17 may be implemented as a microprocessor, a logic element (eg, a logic sum gate), or the like.
  • the power supply unit 19 supplies power to the plurality of electrical signal generators 16, the RF transmitter 18, and the driver 17.
  • the power supply unit 19 may be implemented as a rechargeable battery, or may be implemented such that the rechargeable battery is charged with the electric signal generated by the electric signal generator 16 when receiving the light.
  • FIG. 6 is a view schematically showing the configuration of a wireless cranial nerve stimulation system according to another embodiment of the present invention.
  • the wireless cranial nerve stimulation system according to another embodiment of the present invention is substantially the same as the wireless cranial nerve stimulation system according to an embodiment except for the camera 40, the reflection mirror 50, and the control unit 60, the corresponding configuration
  • the same reference numerals are used for the elements, and detailed description thereof will be omitted.
  • the light receiver 20 includes a guide line 15 as in the embodiment of FIG. 4.
  • the wireless cranial nerve stimulation system includes a camera 40, a reflection mirror 50, and a controller 60.
  • the living body 1 which is the measurement target on which the light receiving unit 20 is mounted, is located at the bottom of the experimental box, and the light source unit 10 and the camera 40 are provided.
  • the reflection mirror 50 and the like will be described taking an environment provided on the ceiling of an experimental box as an example. However, this is merely an example, and the installation positions of the light source unit 10, the camera 40, the reflective mirror 50, and the like applied to the present invention are not limited thereto.
  • the camera 40 photographs the living body 1 as a measurement target. Specifically, the upper plate plate 13 of the light receiving unit 20 mounted on the head of the living body 1 to be measured is photographed, and the captured image signal is transmitted to the controller 60.
  • the reflecting mirror 50 reflects the light emitted from the light source unit 10 and transmits the light reflected to the light receiving unit 20, and the angle is adjusted under the control of the controller 60.
  • the controller 60 processes the image signal received from the camera 40 and outputs the image signal to a monitor (not shown), and emits light to the light receiving unit 20 according to a user's manipulation of the image signal output to the monitor (not shown).
  • the light emitted from the light source unit 10 passes through the guide hole 13a of the light receiving unit 20 by controlling the direction of the light source unit 10 to be irradiated or by controlling the angle of the reflecting mirror 50. To enter into the guideline (15).
  • a user who watches the top plate 13 of the light receiving unit 20 photographed through the camera 40 with a monitor may guide light of the primary lens 11 to the light emitted from the light source unit 10. If it is confirmed that the light is not reflected inside the line 15 and is reflected by the reflector applied to the outside of the guide line 15, the light emitted from the light source 10 may be manipulated by manipulating the direction of the light source 10. It passes through the guide hole 13a of 20) to enter the guide line 15 of the primary lens 11. Alternatively, the light of the light source unit 10 reflected by the reflecting mirror 50 by controlling the angle of the reflecting mirror 50 passes through the guide hole 13a of the light receiving unit 20 to guide lines 15 of the primary lens 11. ) To enter inside.
  • the controller 60 analyzes the image signal received from the camera 40 in real time and the light irradiated from the light source unit 10 passes through the guide hole 13a of the light receiving unit 20 to guide the primary lens 11.
  • the direction of the light source unit 10 may be automatically controlled to enter the line 15, or the angle of the reflective mirror 50 may be automatically controlled.
  • the controller 60 analyzes the image signal received from the camera 40 in real time, and when the light reflected by the reflector applied outside the guide line 15 is confirmed, the light irradiated from the light source unit 10 The light emitted from the light source unit 10 passes through the guide hole 13a of the light receiving unit 20 and determines that the guide line 15 of the primary lens 11 has not entered the guide line 15. The direction of the light source unit 10 is precisely readjusted to enter the guide line 15, or the angle of the reflecting mirror 50 is precisely readjusted.
  • FIG. 7 is a view schematically showing the configuration of a wireless cranial nerve stimulation system according to another embodiment of the present invention.
  • the wireless cranial nerve stimulation system according to another embodiment of the present invention is substantially the same as the wireless cranial nerve stimulation system according to an embodiment except for the RF receiver 70, the reflection mirror 50, and the controller 60.
  • the same reference numerals are used for components to be described, and detailed description thereof will be omitted.
  • the light receiver 20 uses the electrical signal generator 16, the RF transmitter 18, the driver 17, etc. as in the other embodiment of FIG. 5. It is preferable to comprise.
  • the wireless cranial nerve stimulation system includes an RF receiver 70, a reflection mirror 50, and a controller 60.
  • the living body 1 which is the measurement target equipped with the light receiving unit 20, is located at the bottom of the experimental box, and the light source unit 10 and the RF receiver 70 ),
  • the reflection mirror 50 and the like will be described taking an environment provided on the ceiling of the experimental box as an example.
  • this is merely an example, and the installation positions of the light source unit 10, the RF receiver 70, the reflecting mirror 50, and the like applied to the present invention are not limited thereto.
  • the RF receiver 70 receives an RF signal output from the RF transmitter 18 of the light receiver 20 mounted on the head of the living body 1 to be measured.
  • the reflecting mirror 50 reflects the light emitted from the light source unit 10 and transmits the light reflected to the light receiving unit 20, and the angle is adjusted under the control of the controller 60.
  • the controller 60 processes the RF signal received from the RF receiver 70 in real time so that light emitted from the light source 10 passes through the guide hole 13a of the light receiver 20 to guide the primary lens 11. 15, the direction of the light source unit 10 may be automatically controlled to enter the inside, or the angle of the reflective mirror 50 may be automatically controlled.
  • the light irradiated from the light source unit 10 should be incident to the guide hole 13a formed in the upper plate 13, and the light irradiated from the light source unit 10 does not enter the guide hole 13a and is guided.
  • the electric signal generator 16 When incident on the electric signal generator 16 provided around the hole 13a, the electric signal generator 16 generates and outputs an electric signal as it receives light, and generates a driver according to the generation of the electric signal.
  • the RF receiver 70 receives the RF signal output from the RF transmitter 18.
  • the controller 60 determines that the light irradiated from the light source unit 10 does not enter the guide hole 13a and is irradiated from the light source unit 10.
  • the light source unit 10 is precisely reoriented so that light is incident on the guide hole 13a of the light receiving unit 20, or the angle of the reflecting mirror 50 is precisely readjusted.
  • the light source unit 10 is installed on the ceiling of the experimental box, and the light receiving unit 20 and the light stimulating unit 30 are attached to the living body 1. Therefore, the experiment or test can be performed without disturbing the movement of the living body 1.
  • Embodiments relate to a wireless cranial nerve stimulation system.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

La présente invention concerne un système de stimulation nerveuse cérébrale optique sans fil. Ledit système de stimulation nerveuse cérébrale optique sans fil comprend les éléments suivants : une unité de source lumineuse émettant de la lumière ; une unité de réception de lumière montée sur un corps vivant cible devant être mesuré pour recevoir la lumière émise depuis l'unité de source lumineuse ; et une unité de stimulation optique appliquant la lumière reçue de l'unité de réception de lumière au tissu nerveux pour stimuler le tissu nerveux. Selon le système de stimulation cérébrale nerveuse optique sans fil, étant donné que le corps vivant cible devant être mesuré et l'unité de source lumineuse sont séparés physiquement l'un de l'autre, le mouvement du corps vivant cible devant être mesuré ne peut pas être limité.
PCT/KR2012/001870 2012-03-15 2012-03-15 Système de stimulation nerveuse cérébrale optique sans fil WO2013137500A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/KR2012/001870 WO2013137500A1 (fr) 2012-03-15 2012-03-15 Système de stimulation nerveuse cérébrale optique sans fil

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/KR2012/001870 WO2013137500A1 (fr) 2012-03-15 2012-03-15 Système de stimulation nerveuse cérébrale optique sans fil

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WO2013137500A1 true WO2013137500A1 (fr) 2013-09-19

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109009549A (zh) * 2018-08-20 2018-12-18 中国人民解放军军事科学院军事医学研究院 记录动物药物成瘾行为及相关脑区神经活动规律的装置

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040070952A (ko) * 2003-02-05 2004-08-11 주식회사 헬스피아 경혈점 자극 치료 시스템
JP2006071612A (ja) * 2004-09-06 2006-03-16 Niigata Tlo:Kk 学習機能障害評価方法、及び学習機能障害評価用装置
US20060155348A1 (en) * 2004-11-15 2006-07-13 Decharms Richard C Applications of the stimulation of neural tissue using light
JP2008141526A (ja) * 2006-12-01 2008-06-19 Hakodateken Koritsu Daigaku Koiki Rengo 光信号受信装置及び光信号受信方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040070952A (ko) * 2003-02-05 2004-08-11 주식회사 헬스피아 경혈점 자극 치료 시스템
JP2006071612A (ja) * 2004-09-06 2006-03-16 Niigata Tlo:Kk 学習機能障害評価方法、及び学習機能障害評価用装置
US20060155348A1 (en) * 2004-11-15 2006-07-13 Decharms Richard C Applications of the stimulation of neural tissue using light
JP2008141526A (ja) * 2006-12-01 2008-06-19 Hakodateken Koritsu Daigaku Koiki Rengo 光信号受信装置及び光信号受信方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109009549A (zh) * 2018-08-20 2018-12-18 中国人民解放军军事科学院军事医学研究院 记录动物药物成瘾行为及相关脑区神经活动规律的装置

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