WO2013137496A1 - Appareil extracteur de larmes - Google Patents

Appareil extracteur de larmes Download PDF

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Publication number
WO2013137496A1
WO2013137496A1 PCT/KR2012/001849 KR2012001849W WO2013137496A1 WO 2013137496 A1 WO2013137496 A1 WO 2013137496A1 KR 2012001849 W KR2012001849 W KR 2012001849W WO 2013137496 A1 WO2013137496 A1 WO 2013137496A1
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WO
WIPO (PCT)
Prior art keywords
tear
tears
unit
extraction device
storage unit
Prior art date
Application number
PCT/KR2012/001849
Other languages
English (en)
Korean (ko)
Inventor
김무섭
양용주
송승연
구윤희
Original Assignee
엘지전자 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 엘지전자 주식회사 filed Critical 엘지전자 주식회사
Priority to PCT/KR2012/001849 priority Critical patent/WO2013137496A1/fr
Publication of WO2013137496A1 publication Critical patent/WO2013137496A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/0067—Tear or lachrymal fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A61N2007/0026—Stimulation of nerve tissue

Definitions

  • the present invention relates to a tear extraction apparatus, and more particularly, to a tear extraction apparatus that can effectively collect tears used for medical examination.
  • Tears and fluids in the tears can be used not only as a means of identifying diseases related to the eyes but also for the analysis of biomarkers of diseases.
  • tears always wet the cornea and conjunctiva to wash away foreign material, supply glucose and oxygen to the corneal epithelium, collect waste products, and prevent infection. Tears are formed in the lacrimal glands soaking eyes and passing through the tear canal to the nose through the tear bag.
  • the daily secretion of tears is 1 ⁇ 1.2ml and is not secreted during sleep. Tears are slightly alkaline and have an osmotic pressure like plasma. The lacrimal glands are tripled and dominated by nerves, but no detailed mechanisms have been identified. For example, the reason why a lot of tears come out when sad is not known.
  • tears have the main function of protecting the eyes, but analyzing the tears and fluids in the tears can be used for analyzing biomarkers for diseases related to the eyes.
  • tears In order to analyze tears and body fluids in the tears, tears must be collected effectively, but since tears flow out along the skin, it is not easy to collect them. In addition, in order to collect tears, tears must be shed radically, but it is difficult to artificially make tears. Even if you open your eyes for a long time, the tears produced are very small and are not suitable for analysis. There is also a way to shed sadness and tears, but this is not a good way because it is not only individual but also not easy to cause emotional changes.
  • the present invention has been made in view of the above problems, and an object of the present invention is to provide a tear extraction apparatus that can artificially induce the generation of tears and effectively collect the tears produced.
  • a tear extracting device for achieving the above object is a stimulator for promoting tear generation; A collecting unit for collecting the generated tears; A storage unit for storing the tears collected by the collection unit; And a mask unit for fixing the components to closely contact the face to the user.
  • the stimulator may be configured as an ultrasonic stimulator.
  • the apparatus may further include a transducer configured to receive ultrasonic waves reflected from the ultrasonic stimulator.
  • the transducer may extract image information about the shape of the lacrimal gland based on the received ultrasound.
  • the apparatus may further include a transmission unit for transmitting the image information to the outside.
  • the transmitter may transmit the image information to the outside using wireless or wired communication.
  • the magnetic pole portion may be configured as a cold air injector for injecting cold air.
  • the cold air injector may inject cold air of 5 ⁇ 15 °C to the eye of the user.
  • the stimulation unit may be configured as a low frequency stimulator.
  • the low frequency stimulator may generate low frequency using alternating current or intermittent flat current of 10,000 Hz or less.
  • the collection unit which is composed of a flow path device may be fixed to the mask so that one end is located at the tear point of the user.
  • the other end of the collection unit may be connected to the storage unit to move the tears generated at the tear point of the user to the storage unit.
  • the storage unit the filtration membrane for removing the waste of tears moved through the collection unit; And a reservoir for storing the tears passing through the filtration membrane.
  • the tear extraction device can artificially induce the generation of tears, can effectively collect the generated tears to help analyze the tears.
  • FIG. 1 is a view illustrating a general mechanism in which tears are generated and flow
  • FIG. 2 is a view showing the configuration of a tear extracting apparatus according to an embodiment of the present invention
  • FIG. 3 is a view showing the configuration of a tear extracting apparatus according to another embodiment of the present invention.
  • FIG. 4 is a view showing the configuration of a tear extracting apparatus according to another embodiment of the present invention.
  • FIG. 5 is a view showing the configuration of the collecting portion of the tear extracting apparatus according to an embodiment of the present invention.
  • FIG. 6 is a view showing the configuration of a storage unit of the tear extraction apparatus according to an embodiment of the present invention.
  • FIG. 1 is a diagram illustrating a general mechanism in which tears are generated and flow. Tears are formed in the lacrimal glands (1) to wet the eyes, and pass through the tear canal (4) through the tear canal (4) through the upper and lower tear points (2,3) to the nose (6).
  • tears can not only protect the eyes but also identify various diseases through the components contained in the tears. It is an indicator of various diseases, such as retinopathy caused by diabetes as well as dryness according to the amount of tears.
  • the tear extracting apparatus includes a mask unit 100, a low frequency stimulator 110, a collector 140, and a storage 150.
  • the mask unit 100 has a function of fixing the low frequency stimulator 110, the collector 140, and the storage 150.
  • the low frequency stimulator 110, the collecting unit 140, and the storage unit 150 to which the storage unit 150 is fixed are manufactured to be in close contact with the user's face.
  • Figure 2 as a method of stimulating the tear gland (1), it includes a low-frequency stimulator 110 for stimulating the nerve.
  • a constant low-frequency electrical stimulation is applied to the nerves of the tear gland (1), tears are produced in the tear glands (1), and the resulting tears move to the tear point (2) after wetting the eyes.
  • Tears moved to the tear point 2 are collected through the collecting unit 140.
  • the structure and function of the collection unit 140 will be described in detail below.
  • Tears collected through the collecting unit 140 are stored in the storage unit 150 installed at the bottom of the collecting unit 140, the storage unit 150 is separated and used to move to the equipment for analysis. Specific configuration of the storage unit 150 will also be described in detail below.
  • alternating current or intermittent flat current below 10,000 Hz is used.
  • the current flow refers to a direct current in which a current flowing through a circuit always has a constant direction and magnitude, and is mainly used for electrotherapy for treating nerve and vascular disorders.
  • This flat current has an anode and a cathode, and in the present invention, cathode stimulation is used to stimulate nerves of the lacrimal glands 1.
  • the transducer 125 further includes a transducer 125 for receiving a signal from which ultrasonic waves generated by the ultrasonic stimulator 120 are reflected. Stimulation of the tear gland (1) through the generation of ultrasonic waves, the sound wave conveyed from the tear gland (1) is received by the transducer 125, to obtain image information about the shape of the tear gland (1), through which the tear gland (1 You can check the status of).
  • tears are produced in the tear gland (1), and the generated tears move to the tear point (2) after wetting the eyes.
  • the tears moved to the tear point 2 are collected through the collecting unit 140.
  • the collected tears are stored in the storage unit 150 installed at the bottom of the collecting unit 140 and the storage unit 150 is separated and used to move to the equipment for analysis.
  • Ultrasound means sound waves exceeding the audio frequency band of 16-20 Hz.
  • ultrasound is widely used as an imaging device, but ultrasound may be focused to selectively destroy only the target tissue, thereby obtaining the same effect as resection.
  • the present invention can confirm the state of the eye by using the technique of such an image, by controlling the output to stimulate the nerve around the tear gland (1) at an output of 1 ⁇ 2W per 1m2 to help the generation of tears.
  • Figure 4 as a method of stimulating the lacrimal gland (1), it includes a cold air injector 130 for injecting the cold air of 5 ⁇ 15 °C.
  • Tears of the tear gland (1) through the stimulation of the cold tears are produced in the tear glands (1), the resulting tears wet the eyes and move to the tear point (2).
  • the tears moved to the tear point 2 are collected through the collecting unit 140.
  • the collected tear is stored in the storage unit 150 installed at the bottom of the collecting unit 140, the storage unit 150 is separated and used to move to the equipment for analysis.
  • the tears collected by the embodiments of FIGS. 2 to 4 are administered to an analytical device and a lab-on-a-disc / lab-on-a-chip to analyze the eye. It is used to verify the condition, diabetes and retinopathy.
  • FIG. 5 is a view showing the configuration of the collecting unit 140 of the tear extracting apparatus according to an embodiment of the present invention.
  • the collecting unit 140 is configured as a flow path device, and an end thereof is positioned at the tear point 2.
  • the collection port 144 of the collecting unit 140 is fixed to the mask unit 100 so as to weakly press the tear point 140, the flow of tears through the pressure to press the tear point (2) the inner flow passage (146) Lead to the storage unit 150 is configured to smoothly gather tears.
  • the storage unit 150 is a space for storing tears flowing through the collecting unit 140, and removes wastes in the tears through the filtration membrane 154.
  • This can be a polymer membrane or other material.
  • the guide 152 may be made of a hydrophobic material so that tears can efficiently flow to the filtration membrane 154.
  • the tears passing through the filtration membrane 154 are collected in the detachable reservoir 156 and may be separated after extraction. That is, the reservoir 156 is detachable from the tear extracting device. After the extraction, the tears stored in the separated reservoir 156 may be efficiently used for long-term storage and movement of other analysis equipment.
  • the tear extraction device can artificially induce the generation of tears, can effectively collect the generated tears to help analyze the tears.

Abstract

Cette invention porte sur un appareil extracteur de larmes, ledit appareil extracteur de larmes comprenant : une unité de stimulation pour promouvoir la génération de larmes ; une unité de recueil pour recueillir les larmes générées ; une unité de stockage pour stocker les larmes recueillies par l'unité de recueil ; et une unité de masque pour fixer les composants de façon que lesdits composants soient en étroit contact avec le visage de l'utilisateur. Selon la présente invention, la génération des larmes est induite artificiellement, et les larmes générées peuvent être efficacement recueillies pour contribuer à l'analyse desdites larmes.
PCT/KR2012/001849 2012-03-14 2012-03-14 Appareil extracteur de larmes WO2013137496A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/KR2012/001849 WO2013137496A1 (fr) 2012-03-14 2012-03-14 Appareil extracteur de larmes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/KR2012/001849 WO2013137496A1 (fr) 2012-03-14 2012-03-14 Appareil extracteur de larmes

Publications (1)

Publication Number Publication Date
WO2013137496A1 true WO2013137496A1 (fr) 2013-09-19

Family

ID=49161376

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/001849 WO2013137496A1 (fr) 2012-03-14 2012-03-14 Appareil extracteur de larmes

Country Status (1)

Country Link
WO (1) WO2013137496A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1402859A1 (fr) * 2002-07-10 2004-03-31 Murube del Castillo, Juan Prothèse tubulaire pour drainer les larmes de l'oeil vers le nasal fossa
US20040181172A1 (en) * 2003-03-12 2004-09-16 Carney Fiona Patricia Devices for collecting analytes of interest in tears
US20070016074A1 (en) * 1996-09-04 2007-01-18 Abreu Marcio M Contact lens for collecting tears and detecting analytes for determining health status, ovulation detection, and diabetes screening

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070016074A1 (en) * 1996-09-04 2007-01-18 Abreu Marcio M Contact lens for collecting tears and detecting analytes for determining health status, ovulation detection, and diabetes screening
EP1402859A1 (fr) * 2002-07-10 2004-03-31 Murube del Castillo, Juan Prothèse tubulaire pour drainer les larmes de l'oeil vers le nasal fossa
US20040181172A1 (en) * 2003-03-12 2004-09-16 Carney Fiona Patricia Devices for collecting analytes of interest in tears
WO2004080297A1 (fr) * 2003-03-12 2004-09-23 Novartis Ag Dispositifs permettant de recueillir des analysats en rapport avec les larmes

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