WO2013107434A3 - Amorphous and solvated polymorphous forms of tiotropium iodide and a method their preparation - Google Patents

Amorphous and solvated polymorphous forms of tiotropium iodide and a method their preparation Download PDF

Info

Publication number
WO2013107434A3
WO2013107434A3 PCT/CZ2013/000003 CZ2013000003W WO2013107434A3 WO 2013107434 A3 WO2013107434 A3 WO 2013107434A3 CZ 2013000003 W CZ2013000003 W CZ 2013000003W WO 2013107434 A3 WO2013107434 A3 WO 2013107434A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
tiotropium iodide
amorphous
solvated
polymorphous forms
Prior art date
Application number
PCT/CZ2013/000003
Other languages
French (fr)
Other versions
WO2013107434A2 (en
Inventor
Igor CERNA
Vladimir Kral
Josef Hajicek
Ondrej Dammer
Original Assignee
Zentiva, K.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva, K.S. filed Critical Zentiva, K.S.
Publication of WO2013107434A2 publication Critical patent/WO2013107434A2/en
Publication of WO2013107434A3 publication Critical patent/WO2013107434A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Abstract

The invention relates to new polymorphous forms of tiotropium iodide of formula I and a method of their preparation, wherein a dichloromethane/acetonitrile solvate of tiotropium iodide of formula V is crystallized from water. The solution includes two new polymorphous forms of tiotropium iodide and an amorphous form of tiotropium iodide, including a method of their preparation.
PCT/CZ2013/000003 2012-01-20 2013-01-09 New polymorphous forms of tiotropium iodide and a method of their preparation WO2013107434A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZPV2012-41 2012-01-20
CZ20120041A CZ201241A3 (en) 2012-01-20 2012-01-20 Novel polymorphous forms of thiotropium iodide and process for preparing thereof

Publications (2)

Publication Number Publication Date
WO2013107434A2 WO2013107434A2 (en) 2013-07-25
WO2013107434A3 true WO2013107434A3 (en) 2013-09-19

Family

ID=47681474

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CZ2013/000003 WO2013107434A2 (en) 2012-01-20 2013-01-09 New polymorphous forms of tiotropium iodide and a method of their preparation

Country Status (2)

Country Link
CZ (1) CZ201241A3 (en)
WO (1) WO2013107434A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017138896A1 (en) 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005042526A1 (en) * 2003-11-03 2005-05-12 Boehringer Ingelheim International Gmbh Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same
WO2005042528A1 (en) * 2003-11-03 2005-05-12 Boehringer Ingelheim International Gmbh Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (en) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Esters of thienyl carboxylic acids with amino alcohols, their quaternization products, processes for their preparation and medicaments containing them
NZ583872A (en) 2005-06-15 2011-10-28 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
PL388070A1 (en) 2009-05-19 2010-11-22 Adamed Spółka Z Ograniczoną Odpowiedzialnością New thiotropium salts

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005042526A1 (en) * 2003-11-03 2005-05-12 Boehringer Ingelheim International Gmbh Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same
WO2005042528A1 (en) * 2003-11-03 2005-05-12 Boehringer Ingelheim International Gmbh Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GIRON D ET AL: "Solid-state of pharmaceutical compounds: Impact of the ICH Q6 guideline on industrial development", JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, KLUWER ACADEMIC PUBLISHERS, DORDRECHT, NL, vol. 77, no. 2, 1 August 2004 (2004-08-01), pages 709 - 747, XP019255140, ISSN: 1572-8943 *

Also Published As

Publication number Publication date
WO2013107434A2 (en) 2013-07-25
CZ201241A3 (en) 2013-07-31

Similar Documents

Publication Publication Date Title
ZA201405912B (en) Process for the production of acid anhydrides from epoxides
EP3006568A4 (en) Production method for tagatose
SG11201503362QA (en) Method for the production of oxazolidinone compounds
MX361653B (en) Process for preparing bile acid derivatives.
DK3210978T3 (en) Process for the production of acesulfame potassium
EP3008048A4 (en) Process for the preparation of 5-hydroxymethylfurfural (hmf)
IL238744A0 (en) Polymorphic forms of suvorexant, compositions comprisiing same methods of producing same
EP2797905A4 (en) Process for the production of furfural
PL3041801T3 (en) Method of making updoped cladding by using silicon tertrachloride as the dopant
EP2766379A4 (en) Small molecule compounds for the control of nematodes
SG11201504931SA (en) Novel methysergide derivatives
GB201115354D0 (en) Method of drilling through a wall of a hollow component
HK1204011A1 (en) Method for the production of furan derivatives from glucose d-
WO2015068159A3 (en) Process for the preparation of n-iodoamides
EP2909224A4 (en) An improved process for the preparation of fulvestrant
IN2014DN09451A (en)
HUP1300566A2 (en) Industrial process for producing steroid derivatives
GB2517094B (en) Receiving an update module by accessing a network site
WO2013107434A3 (en) Amorphous and solvated polymorphous forms of tiotropium iodide and a method their preparation
EP3007699A4 (en) Crystalline imatinib mesylate process
PT2964741T (en) A method of preparing anhydrous alkyl (ethoxy) sulphate compositions
EP2892886B8 (en) Process for the production of furan derivatives
PL2604592T3 (en) A process for the purification of aniracetam by crystallisation from aqueous solutions
HK1210617A1 (en) Process for the preparation of heterocyclic ester derivatives
EP3026047A4 (en) Method for producing heterocyclic compound

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13703313

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 13703313

Country of ref document: EP

Kind code of ref document: A2