WO2013107207A1 - Module de multi-mesure à auto-calibrage pour instrument de détection portable et procédé pour son utilisation - Google Patents

Module de multi-mesure à auto-calibrage pour instrument de détection portable et procédé pour son utilisation Download PDF

Info

Publication number
WO2013107207A1
WO2013107207A1 PCT/CN2012/084712 CN2012084712W WO2013107207A1 WO 2013107207 A1 WO2013107207 A1 WO 2013107207A1 CN 2012084712 W CN2012084712 W CN 2012084712W WO 2013107207 A1 WO2013107207 A1 WO 2013107207A1
Authority
WO
WIPO (PCT)
Prior art keywords
liquid
module
calibration
detected
capillary
Prior art date
Application number
PCT/CN2012/084712
Other languages
English (en)
Chinese (zh)
Inventor
张亚南
Original Assignee
湖州凯立特医疗器械有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 湖州凯立特医疗器械有限公司 filed Critical 湖州凯立特医疗器械有限公司
Publication of WO2013107207A1 publication Critical patent/WO2013107207A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48785—Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G01N35/00693—Calibration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/065—Valves, specific forms thereof with moving parts sliding valves

Definitions

  • the present invention relates to the field of liquid detection technology, and more particularly to a self-calibrating multi-measurement module for portable detection instruments and methods of use thereof.
  • the disadvantage is that it must be used in a stable indoor environment. AC power must be used.
  • the multi-sensor used in the configuration generally cannot provide the convenience of being ready to use. It takes a long time. The start-up and settling time, and more importantly, its relatively large size, even if one can move, it is very inconvenient to carry and transport. To sum up, it mainly applies the development of modern technology to system design and miniaturization, and miniaturizes and integrates traditional large-scale instruments, thereby pushing the use place from the central laboratory to the operating room and ward. , so that it can be directly measured at the sample collection site.
  • the second type is to separate the instrument itself from the measurement unit.
  • the instrument itself performs repeated measurements, but it is necessary to concentrate the reagents, calibration fluids, and detectors necessary to complete a test into one smaller unit to form a one-off
  • the chip used, each chip needs to be connected to the instrument, and the chip is discarded after completion (for example, patent number us
  • each measurement chip can only be used once, which has obvious disadvantages in the average single measurement cost, especially in the case of continuous measurement.
  • the cost disadvantage is more obvious, and the operation is very complicated and needs frequent The chip is replaced, so it is a user who tends to use it less frequently but does not need to have the former instrument.
  • the operation is very simple, the cost of a single measurement is low, and the measurement accuracy is high.
  • Another object of the present invention is to provide a portable detecting instrument which is simple in operation, including both the simplicity and miniaturization of a dry chip type instrument, and the high reliability and multiple measurement characteristics of the modular instrument. .
  • the technical solution of the present invention is as follows: a self-calibration multiple measurement module of a portable detection instrument,
  • a movement detecting module having a detecting sensor for detecting the calibration liquid and the liquid to be detected
  • a calibration bath capable of storing a sufficient volume of calibration liquid and in communication with the stationary module and capable of communicating with the motion detection module when the motion detection module is in a predetermined position;
  • the motion detecting module includes a moving block, and the measuring block is provided with a measuring pool, and a detecting sensor for detecting liquid in the measuring pool is disposed in the measuring pool, and the moving block is provided with a The liquid capillary guide tube and the calibration liquid capillary flow tube connected to the measuring cell are connected.
  • the fixing module is located in front of the movement detecting module, and comprises two liquid tube elastic sealing modules to be detected, when the free open end of the detected liquid capillary tube is inside one of the The liquid capillary guide tube is closed; the fixing module further includes a detected liquid connection port communicating with the detected liquid capillary draft tube and a calibration connection with the calibration liquid pool a liquid passage; a liquid passage communicating with the waste liquid pool between the two liquid pipe elastic sealing modules; the liquid connection port to be detected is located in the two closed liquid pipe elastic sealing modules In front of the front one; a calibration tube elastic sealing module is disposed in front of the calibration liquid channel, and the calibration liquid capillary tube is closed when the free opening end of the calibration liquid capillary tube is therein.
  • the detected liquid tube elastic sealing module comprises two elastic blocks made of an elastic material. Two adjacent side faces of the two elastic blocks are fitted to each other to form a fitting slit, and an intermediate position of the bonding slit is aligned with the capillary guiding tube for detecting the liquid.
  • the rear ends of the two elastic block bonding seams are provided with an introduction structure with a small front and a large front.
  • the fixing module further comprises two 0-rings that can be passed by the detected capillary capillary tube, the inner diameter of the two 0-rings being smaller than the capillary flow of the detected liquid
  • the outer diameter of the tube, the two 0-rings are respectively disposed behind and adhered to the two sealed liquid tube elastic sealing modules.
  • the inner diameter of the 0-ring is 0.75-0.95 times the outer diameter of the capillary capillary tube to be tested.
  • the elastic block is made of elastic rubber or elastic plastic or polyurethane.
  • the calibration tube elastic sealing module comprises two elastic bodies made of an elastic material, and two adjacent side faces of the two elastic bodies are fitted to form a fitting seam, and the sticker The intermediate position of the joint is aligned with the calibration liquid capillary tube, and the calibration liquid channel is provided with a 0-type sealing ring which can be penetrated by the calibration liquid capillary tube, and the calibration liquid channel An opening communicating with the calibration liquid pool is located between the 0-ring and the two elastomers.
  • the front end of the two elastic bodies is provided with a front 0-type sealing ring which is attached thereto and can be passed by the calibrating liquid capillary flow tube;
  • the inner diameter of the ring is 0.75-0.95 times the outer diameter of the capillary of the calibration liquid.
  • the rear end of the two elastomer-fitting seams is provided with an introduction structure that is small in front and small in size.
  • the inner diameter of the 0-type sealing ring is 0.75-0.95 times the outer diameter of the calibration liquid capillary draft tube.
  • the elastomer is made of elastic rubber or elastic plastic or polyurethane.
  • the detected liquid capillary flow tube and the calibration liquid capillary flow tube are made of stainless steel or plastic.
  • the motion detecting module includes a moving block, and the moving block is provided with a measuring pool, and the detecting sensor for detecting the liquid in the measuring pool is disposed in the measuring pool, and the moving block is A capillary draft tube is provided in communication with the measuring cell.
  • the fixing module is located in front of the movement detecting module, and comprises two elastic closing modules, the capillary diversion when the free open end of the capillary draft tube is inside one of the capillary guiding tubes The tube is closed; the fixing module further includes a detected liquid connection port communicating with the capillary draft tube and a channel communicating with the calibration liquid pool, wherein the channel is located at the two elastic Between the closed modules, the detected liquid connection port is located in front of the front of the two elastic closed modules.
  • the elastic sealing module comprises two elastic blocks made of an elastic material, and two adjacent side faces of the two elastic blocks are fitted to form a fitting seam, and the fitting The intermediate position of the slit is aligned with the capillary draft tube.
  • the rear ends of the two elastic block bonding seams are provided with an introduction structure that is small in front and small in the front.
  • the fixing module further comprises two 0-rings that can be passed by the capillary guiding tube, and the two 0-rings are respectively disposed behind the two elastic sealing modules.
  • the inner diameter of the two 0-rings is smaller than the outer diameter of the capillary draft tube.
  • the inner diameter of the 0-ring is 0.75-0.95 times the outer diameter of the capillary draft tube.
  • the elastic block is made of elastic rubber or elastic plastic or polyurethane.
  • the capillary draft tube is made of stainless steel or plastic.
  • the calibration liquid pool and the waste liquid pool are two chambers disposed at the bottom of the base or two containers disposed on the base.
  • the base is provided with a cover.
  • a portable detecting instrument comprising the self-calibrating multiple measuring module described above.
  • a method of using a self-calibrating multiple measurement module of a portable detection instrument comprising the steps of:
  • the movement detection module reaches a predetermined position to communicate with the calibration liquid pool, inhales the calibration liquid from the calibration liquid pool into the movement detection module, and then discharges the calibration liquid into the waste liquid pool, and the calibration liquid is discharged into the waste liquid
  • the calibration liquid is detected by the detection sensor, and the detection sensor sends the detection result to the signal processing unit of the portable detection instrument in the form of an electrical signal
  • the moving detecting module reaches the predetermined position and communicates with the detected liquid, and sucks the detected liquid into the movement detecting module.
  • the detecting sensor detects, the detecting sensor sends the detected result to the portable in the form of an electric signal.
  • the signal processing unit of the instrument is detected, and then the detected liquid to be detected is discharged into the waste liquid pool.
  • the flushing and the second calibration of the step c) are further included; the movement detecting module reaches the predetermined position in the step a) to communicate with the calibration liquid pool, and the calibration liquid is inhaled from the calibration liquid pool. The movement detection module then discharges the detected calibration liquid into the waste liquid tank to realize flushing of the movement detection module and secondary calibration of the detection sensor.
  • a method of using a self-calibrating multi-measurement module of a portable detection instrument comprising the steps of:
  • the movement detection module reaches a predetermined position and communicates with the calibration liquid pool, and the calibration liquid is sucked into the movement detection module from the calibration liquid pool.
  • the detection sensor detects, the detection sensor sends the detection result in the form of an electric signal. Giving a signal processing unit to the portable test instrument, and then discharging the detected calibration liquid into the waste liquid pool;
  • the moving detecting module reaches the predetermined position and communicates with the detected liquid, and sucks the detected liquid into the movement detecting module.
  • the detecting sensor detects, the detecting sensor sends the detected result to the portable in the form of an electric signal.
  • the signal processing unit of the instrument is detected, and then the detected liquid to be detected is discharged into the waste liquid pool.
  • the flushing and the second calibration of step c) are further included; the movement detecting module reaches the step a) The predetermined position is communicated with the calibration liquid pool, and the calibration liquid is sucked into the movement detection module from the calibration liquid pool, and then the detected calibration liquid is discharged into the waste liquid pool to realize flushing of the movement detection module and the detection sensor Secondary calibration.
  • the present invention has the following advantages:
  • the present invention provides a simple and effective method and measurement module, which enables a measurement module to be loaded into a portable detection instrument and can perform up to hundreds of sample measurements, the overall complexity.
  • Far less than the current modular instrument it includes both the simplicity and miniaturization of dry chip instruments, as well as the high reliability and multiple measurement characteristics of modular instruments. The cost of a single test is very low.
  • Figure 1 is a schematic view of the outline of the present invention
  • FIG. 2 is a schematic structural view of Embodiment 1 of the present invention; the liquid capillary tube for detecting is in a closed state;
  • FIG. 3 is a closed and detected calibrated liquid capillary tube after the moving detection module is moved in Embodiment 1 of the present invention;
  • FIG. 4 is a schematic view showing a state in which the caliper capillary guide tube is closed after the movement detecting module is advanced, and the liquid capillary tube and the detected liquid connection port are in communication with each other;
  • Figure 5 is a schematic view showing the structure of a second embodiment of the present invention, wherein the capillary draft tube is connected to the calibration liquid pool;
  • FIG. 6 is a schematic view showing the communication between the capillary draft tube and the liquid connection port to be detected according to the second embodiment of the present invention.
  • 201-moving block 202-measuring cell, 203-detected liquid capillary tube, 204-hose, 205-calibrating capillary tube, 206-capillary tube, 207-hose;
  • 6-micro pump 601-through cavity, 602-pump housing, 603-inlet, 604-piston, 605-linear conveying mechanism;
  • FIG. 2 is a schematic structural view of a measuring module in the embodiment, and when installed, it is installed in a portable testing instrument to form a complete portable detection.
  • the instrument can be used.
  • the measuring module includes a base 1.
  • the base 1 is mounted with a cover 9 for protecting the components mounted on the base.
  • the utility model further comprises a fixing module 4 disposed on the base.
  • a movement detecting module 2 having a detecting sensor 8 for detecting the calibration liquid and the detected liquid is provided on the base, and a sufficient volume of the calibration liquid can be stored and communicated with the fixed module 4 and the moving detecting module 2 is located at a predetermined position.
  • a calibration liquid cell 5 capable of communicating with the detection module 2, a waste liquid pool 7 for storing the detected calibration liquid and the liquid to be detected. Further, a portable pump is provided with a micropump 6 for transporting the calibration liquid and the liquid to be detected, and a linear conveying device 3 for enabling the movement detecting module 2 to linearly reciprocate on the base 1, for use in conjunction with the measuring module.
  • the calibration liquid pool 5 and the waste liquid pool 7 are two chambers disposed at the bottom of the base 1.
  • two containers may be provided to serve, and the two containers may be fixed or may be Disassembled, wherein the solvent of the waste liquid pool is larger than the calibration liquid pool, and the calibration liquid pool is provided with enough calibration liquid according to the number of uses and the amount of each use, and the general amount is enough to detect about 500 times.
  • the movement detecting module 2 is driven by the linear conveying device 3 to perform linear reciprocating motion on the base.
  • the linear conveying device is a linear motor, a micro cylinder, a micro electric push rod, or other well-known linear reciprocating motion.
  • the device or component is disposed in the portable detecting instrument, generally adopts a linear motor, and the moving detecting module 2 includes a moving block 201, and the moving block and the linear motor are fixedly connected, and the linear motor drives the linear reciprocating motion, and the moving block 201
  • a measuring cell 202 is provided therein, and a detecting sensor 8 for detecting liquid in the measuring cell 202 is disposed in the measuring cell 202.
  • the measuring cell 202 is a place for measuring the calibration liquid and the detected liquid, and the detecting sensor 8 is simultaneously connected with the portable detecting instrument.
  • the signal processing unit is connected, and the detected result can be sent to the signal processing unit of the portable detecting instrument in the form of an electrical signal, and is compared by the signal processing unit.
  • the moving block 201 is provided with the detected liquid capillary connected to the measuring pool 202.
  • the draft tube 203 and the calibrant capillary guide tube 205 are detected by the capillary flow of the liquid
  • the tube 203, the calibrating liquid capillary tube 205 are fixed in front of the moving block, and the micropump 6 inlet 603 is also in communication with the measuring cell 202, and the calibrating liquid capillary tube 205 and the detected liquid capillary tube 203 are parallel to each other.
  • the measuring cell has two openings, one is connected to the liquid capillary tube 203 to be detected, and the other is connected to the inlet 603 of the micropump 6 and the capillary tube of the calibration liquid, and the detecting sensor 8 is located at the two.
  • the detected liquid capillary tube 203 and the calibrant capillary tube 205 are hard capillary tubes made of stainless steel or plastic. Since the movement detecting module 2 is moving, the movement detecting module 2 and the micropump 6 inlet 603 are connected by a hose 207.
  • the micropump 6 disposed in the portable instrument is a plunger pump including a pump casing 602 having a through cavity 601, the pump casing is cylindrical, and the inlet 603 is disposed on the pump casing 602, and The through-cavity 601 is in communication with a piston 604.
  • the piston 604 is connected to a linear conveying mechanism 605 for driving the piston 604 to reciprocate linearly in the through-cavity 601.
  • the linear conveying mechanism 605 is a linear motor or a cylinder or an electric motor.
  • the push rod is generally a linear motor, and in order to facilitate the movement of the piston in the through cavity of the pump casing, lubricating grease can be disposed on the piston, which can also increase the sealing property, and the piston is retracted, so that the vacuum is generated in the through cavity, and the liquid can be adsorbed.
  • lubricating grease can be disposed on the piston, which can also increase the sealing property, and the piston is retracted, so that the vacuum is generated in the through cavity, and the liquid can be adsorbed.
  • it is of course another pump that can draw liquid into the pump and then discharge it.
  • the fixing module 4 is located in front of the movement detecting module 2, and when the movement detecting module 2 moves forward, the liquid capillary guide tube 203 and the calibration liquid capillary tube 205 can be inserted into the interior thereof, and the fixing module 4 is fixed.
  • the invention comprises two liquid tube elastic sealing modules 401, a detected liquid connection port 402 communicating with the liquid capillary tube 203 to be detected, and a calibration liquid channel 403 communicating with the calibration liquid pool 5, when When the free open end of the liquid capillary draft tube 203 is detected in one of the two sealed liquid tube elastic sealing modules, it is closed, and the two liquid tube elastic sealing modules are arranged one after the other, wherein
  • the liquid channel 404 is connected to the waste liquid pool 7 between the two liquid tube elastic sealing modules 401, because in the present embodiment, the calibration liquid pool 5,
  • the waste liquid pool 7 is two chambers disposed in the base, so the calibration liquid pool and the waste liquid pool can communicate with the calibration liquid passage and the liquid passage through the process hole or the pipeline, and are
  • the detection liquid connection port 402 is located in front of the front of the two liquid tube elastic sealing modules 401; in order to be connected with the externally-detected liquid container, the front end of the calibration liquid channel 403 is provided with a capillary flow of the calibration liquid.
  • the calibration tube elastic closure module 405 is closed when the tube 205 is in it.
  • the liquid tube elastic sealing module 401 to be tested comprises two elastic blocks 401a made of an elastic material, which may be elastic rubber or elastic plastic or polyurethane.
  • the two adjacent side faces of the two elastic blocks 401a are fitted to form a fitting seam, and the intermediate position of the bonding seam is aligned with the liquid capillary guide tube 203 to be tested, and the extending direction of the fitting seam
  • the advancing direction of the capillary capillary tube is the same, when the detected liquid capillary tube 203 is inserted between the two elastic blocks, two adjacent fitting sides of the two elastic blocks 401a
  • the portion in contact with the detected capillary capillary tube 203 is contracted and contracted.
  • the elastic block is made of an elastic material and the two elastic blocks are fixed, when the liquid capillary tube to be tested is inserted between the two elastic blocks, the sides of the two elastic blocks can be pressed to make itshrinking, while the side portion that is not in contact with the two elastic blocks continues to be fitted, so that the two elastic blocks are in a sealed state, and the liquid capillary guide tube is sealed, for better
  • the sealing effect can be provided with sealing oil or sealing grease on the side of the two elastic blocks to enhance the sealing effect, and both ends of the liquid passage 404 communicating with the waste liquid pool 7 are sealed by two elastic blocks, so that When the liquid capillary tube is not inserted, it is only in communication with the waste pool.
  • the inner diameters of the two 0-rings 406 are smaller than the outer diameter of the liquid capillary tube 203 to be detected, and the two 0-rings 406 are respectively disposed behind and matched with the two liquid tube elastic sealing modules 401 to be tested.
  • One of the 0-rings 406 is located in the liquid passage 404 and is fitted to the rear side of the two elastic blocks 401a constituting the liquid-tight sealing module 401 of the liquid to be tested to increase the sealing of the liquid passage, and the other two types
  • the ring can also wipe off the residual liquid on the outer wall of the capillary tube of the liquid to be detected to avoid cross-contamination.
  • the calibration tube elastic sealing module 405 comprises an elastic body 405a made of two elastic materials, generally elastic rubber or elastic plastic or polyurethane, the elastic body is fixed and cannot move, and the two elastic bodies 405a have two adjacent sides.
  • the extending direction of the fitting slit is the same as the advancing direction of the caliper capillary guide tube, and the intermediate position of the fitting slit is aligned with the calibration liquid capillary tube 205, when the calibration When the liquid capillary tube 205 is inserted between the two elastic bodies 405a, the portions of the two adjacent bonding sides of the two elastic bodies 405a that are in contact with the calibration liquid capillary tube 205 are squeezed.
  • the 0-type seal ring 407 the opening of the calibration liquid channel 403 communicating with the calibration liquid pool 5 is located between the 0-type seal ring 407 and the two elastic bodies 405a.
  • the 0-type seal ring Inner diameter of 407 The calibration liquid capillary tube is 0.75-0.95 times of the outer diameter, so that when the calibration liquid capillary tube passes through the 0-type sealing ring 407 into the calibration liquid channel 403, the entire calibration liquid channel 403 is sealed.
  • the 0-type sealing ring 407 can also wipe the liquid on the outer wall of the calibration liquid capillary tube 205 to avoid cross-contamination.
  • the rear ends of the two elastic bodies 405a are provided to be attached thereto and can be guided by the calibration liquid.
  • the front 0-ring seal 411 passes through the flow tube 205; the inner diameter of the front 0-type seal ring 411 is 0.75-0.95 times the outer diameter of the calibration liquid capillary guide tube 205, and the front 0-type seal ring 411 is also The liquid on the outer wall of the calibrant capillary tube 205 can be wiped off to avoid cross-contamination.
  • the rear end of the fitting seam of the two elastic bodies 405a is provided with a front small and large large introduction structure 405b.
  • the introduction structure 405b is an opening that gradually narrows from the rear end of the fitting slit.
  • the front end of the two elastic blocks 401a is provided with a front small and large introduction structure 401b, and the introduction structure 401b is from the rear of the seam. An opening that gradually narrows forward.
  • the method for detecting a plurality of measurement modules includes the following steps:
  • a) calibration liquid calibration using the linear transport device 3 in the portable test instrument to move forward on the base 1 with the movement detecting module 2, so that the movement detecting module 2 reaches a predetermined position and communicates with the calibration liquid pool 5 , using a micro pump 6 Aspirate the calibration liquid in the calibration liquid pool and enter the movement detection module 2, enter the micro pump 6, and then discharge the calibration liquid in the micro pump into the waste liquid pool.
  • the calibration is discharged from the micro pump.
  • the liquid fills the entire measuring cell and the liquid channel.
  • the detecting sensor 8 sends the detected result to the signal processing unit of the portable detecting device in the form of an electrical signal.
  • the mobile detecting module arrives at a predetermined schedule.
  • the position is the calibration liquid channel 403 communicating with the calibration liquid pool 5, and the free open end of the calibration liquid capillary tube of the movement detection module enters the calibration liquid channel, and communicates with the calibration liquid pool through the calibration liquid channel 403;
  • the liquid capillary guide tube 203 is located in the elastic sealing module of the liquid pipe to be tested, and is sealed. Because the micro pump used is a piston pump, the calibration liquid in the calibration liquid pool 5 is first sucked into the piston pump by the piston pump, and then the straight line The motor continues to move forward with the moving block of the movement detecting module, so that the detected liquid capillary tube 20 3 is connected with the waste liquid pool through the liquid passage 404.
  • the calibrated liquid capillary guide tube is sealed by the detection liquid tube elastic sealing module, the liquid cannot come out from the capillary draft tube, and then the piston pump starts to work, and the calibration liquid is started. Discharge from the pump into the waste pool and fill the measuring cell with the calibration solution;
  • the linear conveying device 3 continues to move forward with the movement detecting module 2, so that the movement detecting module 2 reaches a predetermined position and communicates with the detected liquid, in the process, the calibration liquid
  • the capillary draft tube is always sealed by the detecting liquid tube elastic sealing module, wherein the predetermined position is the position where the detected liquid capillary guiding tube 203 communicates with the detected liquid connecting port 402, and the movement detecting module 2 is The piston pump starts to work, and the detected liquid is extracted into the measuring pool of the movement detecting module 2.
  • step a) and step b) are completed, step c) is further included; flushing and secondary calibration; and the movement detecting module 2 is driven by the linear conveying device to reach the predetermined condition described in the step a) The position is in communication with the calibration liquid pool 5.
  • the liquid capillary tube of the detected liquid is closed, and the free open end of the capillary capillary tube enters the calibration liquid channel, and communicates with the calibration liquid pool through the calibration liquid channel 403;
  • the calibration solution is sucked into the liquid detection module 2, and then the detected calibration liquid is discharged into the waste liquid tank 7, the flushing of the movement detecting module 2 and the secondary calibration of the detecting sensor 8 are performed, and the micro pump is sucked from the calibration liquid pool.
  • the calibration solution passes through the measuring cell, and then the micropump discharges the calibration solution, passes through the measuring cell, and fills it.
  • the two actions enable the calibration solution to flush the measuring cell to prepare for the next measurement, and at the same time, the detecting sensor 8
  • the calibration solution can also be measured to obtain a calibration signal.
  • the measurement of the two detected liquids may be separated for a long time, during which the sensitivity of the detection sensor in the measurement pool may drift, so it may be set to perform a calibration operation within a fixed time,
  • the calibration solution in the measuring cell and channel is updated once to maintain the accuracy of the detection sensor.
  • step a This relationship satisfies that after each measurement, there is enough cleaning calibrant to clean the entire channel to the state to be tested, ready for the next measurement, and no waste of reagents; in step a, it can be repeated as many times as needed.
  • the calibration solution is used to wash away the residual liquid in the measuring cell and the liquid in the capillary tube of the detected liquid to ensure the accuracy of the measurement result.
  • the process of calibration for multiple detections can be realized by program setting, which can avoid interference. , to get the most accurate calibration results.
  • the portable detecting instrument compares the two test results in step a) and step b) to determine the liquid property index to be detected.
  • the so-called trait index refers to the result obtained after the comparison, and the result may be the result of the data comparison.
  • step a) is compared with the test value obtained in step b) to know whether the blood sugar is high or low, if it is detected whether a liquid is contaminated by heavy metals. Then, after step a) is compared with the detected value/curve obtained after the step b) is detected, it is known whether the heavy metals such as iron, chromium, etc. in the liquid exceed the national detection standard, if the turbidity of the tap water is detected. Then, after comparing step a) with the test result obtained after the step b) is completed, it is known whether the turbidity of the tap water exceeds the standard.
  • Embodiment 2 see FIGS. 5 and 6;
  • FIG. 5 is a schematic structural view of Embodiment 2 of the present invention, for the sake of clarity, the micropump and the linear transport device installed in the portable detecting instrument are connected, and implemented Example 1 provides a simple and effective method and measurement module and a portable test instrument equipped with such a measurement module. After a measurement module is installed in a portable test instrument, it can perform up to hundreds of sample measurements. The complexity is far lower than the current modular instrumentation.
  • the measurement module includes the simplicity and miniaturization of dry chip instruments, as well as the high reliability and multiple measurement characteristics of modular instruments. However, the structure is relatively complicated, not simple enough, and the method is relatively complicated.
  • the measurement module is used for measurement. For the detection of the calibration liquid and the detected liquid, both the inhalation and the discharge need two steps, and the time is relatively long; Therefore, we have improved it to make it simple in structure, cheaper in price, and shorter in detection time;
  • the movement detecting module 2 includes a moving block 201, and the moving block is connected to the linear conveying device 3.
  • the moving block 201 is provided with a measuring pool 202 for detecting the detection of the liquid in the measuring pool 202.
  • the sensor 8 is disposed in the measuring cell 202.
  • the moving block 201 is provided with a capillary guiding tube 206 communicating with the measuring cell 202.
  • the capillary guiding tube is a rigid capillary guiding tube, made of stainless steel or plastic. to make.
  • the waste liquid pool 7 is in communication with the outlet of the micropump 6, and the inlet of the micropump is in communication with the measuring cell 202.
  • the micropump is a plunger pump or a vane pump or a centrifugal pump or a peristaltic pump, and other well-known pumps having an inlet and an outlet.
  • a peristaltic pump is used, and the peristaltic pump inlet and the measuring tank 202 are connected through a hose 204, and the outlet is connected with The waste pool is connected by a hose, and the peristaltic pump is placed in a portable test instrument.
  • the fixing module 4 is located in front of the movement detecting module 2, and includes two elastic closing modules 408, when the free open end of the capillary guiding tube 206 is inside one of the The capillary guide tube 206 is closed; the fixed module 4 further includes a detected liquid connection port 402 communicating with the capillary draft tube 206 and a passage 409 communicating with the calibration liquid pool 5, the passage 409 Between the two elastic sealing modules 408, sealed by two elastic sealing modules, only communicating with the calibration liquid pool, the detected liquid connection opening 402 is located in the front of the two elastic sealing modules 408 The front of one.
  • the elastic sealing module 408 includes two elastic blocks 408a made of an elastic material, generally using elastic rubber or elastic plastic or polyurethane, and two adjacent sides of the two elastic blocks 408a are attached to each other to form a seam, the extending direction of the seam is the same as the direction of advancement of the capillary tube, and the intermediate position of the seam is aligned with the capillary tube 206 for facilitating the insertion of the capillary tube when the capillary flow is
  • portions of the two adjacent fitting sides of the two elastic blocks 408a that are in contact with the capillary guide tube 206 are squeezed and contracted, and this portion is contracted.
  • the fixing module 4 further includes two 0-rings 410 that can be passed through the capillary guide tube 206.
  • the two O-rings 410 are respectively disposed at the rear of the two elastic sealing modules 408 and are matched with the two elastic sealing modules, so as to better seal the passages, and the two 0
  • the ring can also wipe off the liquid on the outer wall of the capillary draft tube to avoid cross-contamination.
  • the inner diameter of the two O-rings 410 is smaller than the outer diameter of the capillary draft tube 206. Generally, the inner diameter of the O-ring 410 is 0.75-0.95 times the outer diameter of the capillary draft tube 206.
  • the rear ends of the two elastic blocks 408a are provided with a front small rear large introduction structure 408b, and the guiding structure is from the rear end of the fitting seam.
  • the opening that gradually narrows before.
  • the structure of the present embodiment is greatly simplified, the structure is simple, the structure is easy to manufacture, the volume is smaller, the carrying and mounting are more convenient, and the number of components used is also reduced. , lowering prices and increasing competitiveness.
  • a method of using the same is briefly described.
  • the linear conveying device 3 moves forward on the base 1 with the movement detecting module 2, so that the movement detecting module 2 reaches a predetermined position and communicates with the calibration liquid pool 5, and is sucked by the micro pump 6.
  • the calibration liquid in the calibration liquid pool enters the movement detection module 2.
  • the detection sensor 8 detects, the detection sensor 8 sends the detection result to the signal processing unit of the portable detection instrument in the form of an electrical signal, and the detected calibration liquid is discharged into the waste liquid.
  • the predetermined position that the movement detecting module reaches is the passage 409 that communicates with the calibration liquid pool 5, and the free open end of the capillary flow guiding tube of the movement detecting module communicates with the calibration liquid pool through the passage 409;
  • the micropump used in the embodiment is a peristaltic pump, and the outlet of the peristaltic pump is connected with the waste liquid pool, and when the linear motor moves forward with the moving block of the movement detecting module, When the free open end of the capillary draft tube is located at the channel 409, the peristaltic pump rotates, and the calibration liquid in the calibration liquid pool is sucked into the pump through the capillary draft tube.
  • the calibration liquid passes through the measuring pool and passes through the measuring pool.
  • the detection sensor detects and obtains the detection result, and then the detected calibration liquid enters the waste liquid pool through the outlet of the peristaltic pump, and the whole detection action is very simple and rapid; after the completion of the calibration liquid after the calibration is completed; the detection of the detected liquid is started;
  • the linear conveying device 3 continues to move forward with the movement detecting module 2, so that the movement detecting module 2 reaches a predetermined position to communicate with the detected liquid, and the micropump 6 starts to work to suck the detected liquid into
  • the detecting sensor 8 sends the detected result to the signal processing unit of the portable detecting device in the form of an electrical signal, and the detected liquid to be detected is discharged into the waste liquid pool 7;
  • the predetermined position is the position where the capillary draft tube communicates with the connected liquid connection port.
  • the peristaltic pump starts to work, sucking the detected liquid into the measuring pool of the movement detecting module 2, and after detecting by the detecting sensor 8, the detecting sensor 8
  • the detected result is sent to the signal processing unit of the portable detecting instrument in the form of an electric signal.
  • the detected liquid enters the waste liquid pool through the outlet of the peristaltic pump to complete the action of discharging the waste liquid.
  • step c) is further included; flushing and secondary calibration; and the movement detecting module 2 is driven by the linear conveying device to reach the step a)
  • the predetermined position is in communication with the calibration liquid pool 5.
  • the free open end of the capillary draft tube enters the channel, and communicates with the calibration liquid pool through the channel; the calibration liquid is sucked from the calibration liquid pool into the measuring cell of the movement detecting module 2 Flushing the measuring cell to remove residual liquid to be detected, and detecting the sensor to detect the calibration liquid, achieving flushing of the movement detecting module 2 and secondary calibration of the detecting sensor 8 to prepare for the next measurement.
  • the measurement of the two detected liquids may be separated for a long time, during which the sensitivity of the detection sensor in the measurement pool may drift, so it may be set to perform a calibration operation within a fixed time, The calibration solution in the measuring cell and channel is updated once to maintain the accuracy of the detection sensor.
  • the portable detecting instrument compares the two test results in step a) and step b) to determine the measured liquid property index; the so-called trait index refers to the result obtained after the comparison, and the result may be data comparison.
  • the result can also be the result of the curve comparison. If the blood glucose is detected, the step a) is compared with the detection value obtained in step b), and it is known whether the blood sugar is high or low, if it is detected whether a liquid is If the heavy metal is contaminated, then step a) is compared with the detected value/curve obtained after the step b) is detected. It is known whether the heavy metals such as iron and chromium in the liquid exceed the national testing standards. If the tap water is detected. The turbidity, after the comparison of the test results obtained in step a) and step b) after the test is completed, can all know whether the turbidity of the tap water exceeds the standard.
  • the detection method of the present embodiment is very rapid, and the actions during the detection process are less and faster.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Human Computer Interaction (AREA)
  • Quality & Reliability (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Measurement Of Levels Of Liquids Or Fluent Solid Materials (AREA)

Abstract

Un module de multi-mesure à auto-calibrage pour un instrument de détection portable et le procédé pour son utilisation. Le module de mesure comprend une base (1); un module de détection de mouvement (2) qui est utilisé pour détecter un liquide d'étalonnage et un liquide en cours de détection et il est pourvu d'un capteur de détection (8); un module fixe (4); un bassin de liquide d'étalonnage (5) qui est stocké avec un volume suffisant de liquide d'étalonnage et qui est en communication avec le module fixe (4), et peut être en communication avec le module de détection de mouvement (2) lorsque le module de détection de mouvement (2) est situé dans une position prédéfinie; et un bassin de liquide de déchets (7). Le procédé d'utilisation comporte les étapes suivantes : a) calibrer un liquide d'étalonnage; b) et détecter un liquide en cours de détection. La présente invention concerne un procédé et un module de mesures simples et efficaces, de sorte qu'un module de mesure peut accomplir des mesures d'échantillons multiples après avoir été placé dans un instrument de détection portable.
PCT/CN2012/084712 2012-01-19 2012-11-16 Module de multi-mesure à auto-calibrage pour instrument de détection portable et procédé pour son utilisation WO2013107207A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201210017394.2 2012-01-19
CN 201210017394 CN102565436B (zh) 2012-01-19 2012-01-19 便携式检测仪器的自校准多次测量模块及其使用方法

Publications (1)

Publication Number Publication Date
WO2013107207A1 true WO2013107207A1 (fr) 2013-07-25

Family

ID=46411389

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2012/084712 WO2013107207A1 (fr) 2012-01-19 2012-11-16 Module de multi-mesure à auto-calibrage pour instrument de détection portable et procédé pour son utilisation

Country Status (2)

Country Link
CN (1) CN102565436B (fr)
WO (1) WO2013107207A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102565436B (zh) * 2012-01-19 2013-09-18 湖州凯立特医疗器械有限公司 便携式检测仪器的自校准多次测量模块及其使用方法
CN103743917B (zh) * 2013-12-25 2015-09-16 浙江凯立特医疗器械有限公司 自校准测量装置及便携式检测仪器
DE202015101756U1 (de) * 2015-04-10 2016-07-13 Bürkert Werke GmbH Kalibriersystem
CN108226458A (zh) * 2018-02-02 2018-06-29 董寿岳 一种内分泌科用尿糖检测装置
CN115656188B (zh) * 2022-12-12 2023-04-11 北京国光领航科技有限公司 一种自校准激光治疗仪

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960497A (en) * 1975-08-19 1976-06-01 Beckman Instruments, Inc. Chemical analyzer with automatic calibration
EP2011438A2 (fr) * 2006-04-26 2009-01-07 Nikkiso Co., Ltd. Équipement de mesure de composant biologique et procede de calibrage d'equipement de mesure de composant biologique
CN101490561A (zh) * 2006-05-16 2009-07-22 奥里巴Abx公司 用于生物分析的成套装置
CN101505873A (zh) * 2005-08-24 2009-08-12 泰利化学公司 测试液体样品的方法、测试装置和多个测试装置的自动化系统
WO2011029698A1 (fr) * 2009-09-09 2011-03-17 Endress+Hauser Conducta Gesellschaft Für Mess- Und Regeltechnik Mbh+Co. Kg Appareil d'analyse pour la détermination automatisée d'une grandeur à mesurer d'un échantillon liquide
CN102187197A (zh) * 2008-10-16 2011-09-14 株式会社岛津制作所 试样注入口及具有该试样注入口的自动进样器
CN102192994A (zh) * 2010-03-18 2011-09-21 希森美康株式会社 生物体成分分析装置以及校正用盒
CN102435635A (zh) * 2011-11-30 2012-05-02 湖州凯立特医疗器械有限公司 一种液体检测芯片及检测方法
CN102565436A (zh) * 2012-01-19 2012-07-11 湖州凯立特医疗器械有限公司 便携式检测仪器的自校准多次测量模块及其使用方法
CN202404052U (zh) * 2011-11-30 2012-08-29 湖州凯立特医疗器械有限公司 一种液体检测芯片
CN202494684U (zh) * 2012-01-19 2012-10-17 湖州凯立特医疗器械有限公司 便携式检测仪器的自校准多次测量模块

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750881A (en) * 1995-07-13 1998-05-12 Chiron Diagnostics Corporation Method and apparatus for aspirating and dispensing sample fluids
DE20000122U1 (de) * 2000-01-05 2000-04-20 Abt Advanced Bioanalytical Tec Mobiles Handgerät mit wiederverwendbarem Biosensor
DE102005034574A1 (de) * 2005-01-07 2006-07-20 Merck Patent Gmbh Verfahren und Vorrichtung zur Entnahme und Analyse von Proben
CN101349672A (zh) * 2008-09-12 2009-01-21 福州大学 可精确控制电极距离的微流控芯片电化学检测装置

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960497A (en) * 1975-08-19 1976-06-01 Beckman Instruments, Inc. Chemical analyzer with automatic calibration
CN101505873A (zh) * 2005-08-24 2009-08-12 泰利化学公司 测试液体样品的方法、测试装置和多个测试装置的自动化系统
EP2011438A2 (fr) * 2006-04-26 2009-01-07 Nikkiso Co., Ltd. Équipement de mesure de composant biologique et procede de calibrage d'equipement de mesure de composant biologique
CN101490561A (zh) * 2006-05-16 2009-07-22 奥里巴Abx公司 用于生物分析的成套装置
CN102187197A (zh) * 2008-10-16 2011-09-14 株式会社岛津制作所 试样注入口及具有该试样注入口的自动进样器
WO2011029698A1 (fr) * 2009-09-09 2011-03-17 Endress+Hauser Conducta Gesellschaft Für Mess- Und Regeltechnik Mbh+Co. Kg Appareil d'analyse pour la détermination automatisée d'une grandeur à mesurer d'un échantillon liquide
CN102192994A (zh) * 2010-03-18 2011-09-21 希森美康株式会社 生物体成分分析装置以及校正用盒
CN102435635A (zh) * 2011-11-30 2012-05-02 湖州凯立特医疗器械有限公司 一种液体检测芯片及检测方法
CN202404052U (zh) * 2011-11-30 2012-08-29 湖州凯立特医疗器械有限公司 一种液体检测芯片
CN102565436A (zh) * 2012-01-19 2012-07-11 湖州凯立特医疗器械有限公司 便携式检测仪器的自校准多次测量模块及其使用方法
CN202494684U (zh) * 2012-01-19 2012-10-17 湖州凯立特医疗器械有限公司 便携式检测仪器的自校准多次测量模块

Also Published As

Publication number Publication date
CN102565436B (zh) 2013-09-18
CN102565436A (zh) 2012-07-11

Similar Documents

Publication Publication Date Title
CN105784571B (zh) 一种特定反应蛋白crp的双池子测量方法及装置
WO2013107207A1 (fr) Module de multi-mesure à auto-calibrage pour instrument de détection portable et procédé pour son utilisation
US20120101407A1 (en) Apparatus and method for preparation of small volume of samples
CN104135927A (zh) 具有集成的传感器装置的采血试管
CN104203412A (zh) 用于化学和/或生物物质的移动式多参数分析的集成式一次性芯片盒系统
CN109557295A (zh) 血气测试方法、血气测试主机、试剂包以及血气测试卡
TW201818076A (zh) 用於檢測樣本之分析裝置及方法
US11493474B2 (en) Mobile hand-held device with reusable biosensor cartridge
CN105319206B (zh) 水质提纯检测装置及水质提纯检测方法
CN202494684U (zh) 便携式检测仪器的自校准多次测量模块
CN107576809A (zh) 一种即时检验装置
WO2017194983A1 (fr) Dispositif et procédé d'échantillonnage de liquides avec une précision élevée dans un analyseur automatisé d'échantillons
CN110161257A (zh) 一种糖化血红蛋白分析仪
CN103743917B (zh) 自校准测量装置及便携式检测仪器
CN207281087U (zh) 一种微水测量进样装置
CN113278509B (zh) 用于核酸检测的芯片装置
CN114159101A (zh) 一种检验科用的尿液取样杯
CN216645976U (zh) 一种检验用标准计量取样装置
CN212134189U (zh) 一种环境污染源水质采样器
CN203551327U (zh) 一种医学检验取样装置
CN114441236A (zh) 一种采样装置以及样本分析仪
CN207351745U (zh) 一种预装式定量供给装置
CN206710309U (zh) 一种微量铀分析仪
CN212059468U (zh) 一种检验科尿液取样器
CN203658376U (zh) 自校准测量装置及便携式检测仪器

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12866314

Country of ref document: EP

Kind code of ref document: A1

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12866314

Country of ref document: EP

Kind code of ref document: A1