WO2013100732A1 - Procédé de préparation d'un fantôme humain semi-solide destiné à mesurer les caractéristiques rf et composition pour la préparation d'un fantôme humain - Google Patents

Procédé de préparation d'un fantôme humain semi-solide destiné à mesurer les caractéristiques rf et composition pour la préparation d'un fantôme humain Download PDF

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Publication number
WO2013100732A1
WO2013100732A1 PCT/KR2012/011798 KR2012011798W WO2013100732A1 WO 2013100732 A1 WO2013100732 A1 WO 2013100732A1 KR 2012011798 W KR2012011798 W KR 2012011798W WO 2013100732 A1 WO2013100732 A1 WO 2013100732A1
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WIPO (PCT)
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weight
phantom
composition
measuring
nacl
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PCT/KR2012/011798
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English (en)
Korean (ko)
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최재훈
이순용
권결
서원범
탁진필
송태호
주은만
백지수
박형상
김동탁
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한양대학교 산학협력단
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Publication of WO2013100732A1 publication Critical patent/WO2013100732A1/fr

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C70/00Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts
    • B29C70/88Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts characterised primarily by possessing specific properties, e.g. electrically conductive or locally reinforced
    • GPHYSICS
    • G09EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09BEDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
    • G09B23/286Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine for scanning or photography techniques, e.g. X-rays, ultrasonics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C70/00Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts
    • B29C70/02Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts comprising combinations of reinforcements, e.g. non-specified reinforcements, fibrous reinforcing inserts and fillers, e.g. particulate fillers, incorporated in matrix material, forming one or more layers and with or without non-reinforced or non-filled layers
    • GPHYSICS
    • G09EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09BEDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04BTRANSMISSION
    • H04B13/00Transmission systems characterised by the medium used for transmission, not provided for in groups H04B3/00 - H04B11/00
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04BTRANSMISSION
    • H04B13/00Transmission systems characterised by the medium used for transmission, not provided for in groups H04B3/00 - H04B11/00
    • H04B13/005Transmission systems in which the medium consists of the human body

Definitions

  • Embodiments of the present invention relate to a method of manufacturing a phantom, and more particularly, to a method of manufacturing a semi-solid phantom.
  • a radio transceiver including an antenna in order to wirelessly transmit and receive data of medical devices, a radio transceiver including an antenna must be manufactured according to the characteristics of the human body, and a human body phantom is required to experiment with it.
  • the human body phantom is used in various states such as liquid, semi-liquid, semi-solid, and solid, and is used for various purposes, such as a medical examination and a purpose of experimenting with a communication environment.
  • Bio data generated by medical equipment is mainly transmitted through the MICS band and the ISM band, and a human body phantom capable of experimenting whether medical equipment data is properly transmitted even in an environment having a dielectric constant and a conductivity of the human body is required.
  • the present invention proposes a human body phantom manufacturing method suitable for the test of wireless communication of medical equipment used in the human body.
  • the present invention proposes a human phantom manufacturing method that can be produced in a semi-solid form at a low cost.
  • dissolving NaCl and NaN 3 in distilled water (a); (B) mixing the agar powder with the solution of step (a); (C) mixing the compatibilizer into the solution of step (b);
  • a semi-solid human body phantom manufacturing method for measuring RF characteristics comprising the step (d) of preparing a composition for producing a phantom by mixing polyethylene powder in the solution of step (c).
  • step (b) the agar powder is dissolved in a low heat, but the viscosity is increased until the viscosity is lowered.
  • step (c) The dissolution step of step (c) is continued until the viscosity increases while the dissolving agent is lowered again.
  • the method further includes the step (e) of drying the phantom manufacturing composition.
  • the composition for preparing the phantom is 80 to 88% by weight of the distilled water, 0.01 to 0.08% by weight of NaN 3 , 1.9 to 2.3% by weight of the binder, 0.5 to 0.65% by weight of NaCl, 8.1 to 9.6% by weight of polyethylene powder, the agar powder It has a weight ratio of 2.3 to 2.8% by weight.
  • composition for preparing the phantom is 82 to 90% by weight of the distilled water, 0.01 to 0.08% by weight of the NaN 3 , 1.3 to 2.7% by weight of the binder, 0.46 to 0.63% by weight of the NaCl, 12.5 to 14.9% by weight of the polyethylene powder, Agar powder has a weight ratio of 2.3 to 3% by weight.
  • Step (a) dissolves NaCl and NaN 3 in distilled water at a temperature of about 40 ° C.
  • Step (b) mixes agar powder at a temperature of about 60 ° C.
  • the refining agent includes TX-151.
  • a composition for making a human phantom for measuring RF characteristics including ⁇ 2.8% by weight.
  • a composition for making a human phantom for measuring RF characteristics including ⁇ 3% by weight.
  • the present invention it can be suitably used for the test of the wireless communication of the medical equipment used for the human body, it is possible to provide a human phantom that can be manufactured in a semi-solid form at a low cost.
  • FIG. 1 is a flow chart showing the flow of the phantom manufacturing method according to a first embodiment of the present invention.
  • Figure 2 is a flow chart showing the flow of the human body phantom manufacturing method according to a second embodiment of the present invention.
  • Figure 3 is a graph showing the dielectric constant and conductivity characteristics in the MICS band of the phantom completed by the composition for manufacturing phantom prepared by the weight ratio as shown in Table 1.
  • Figure 4 is a graph showing the dielectric constant and conductivity characteristics in the ISM band of the phantom by the composition for manufacturing the phantom prepared by the weight ratio as shown in Table 2.
  • Figure 5 is a graph showing the dielectric constant and conductivity characteristics in the MICS band of the phantom by the composition for manufacturing the phantom prepared by the weight ratio as shown in Table 3.
  • Figure 6 is a graph showing the dielectric constant and conductivity characteristics in the ISM band of the phantom by the composition for producing phantom prepared by the weight ratio as shown in Table 4.
  • FIG. 7 is a diagram showing the change in permittivity when only the weight ratio of agar powder (Agar) is set as shown in Table 1;
  • FIG. 9 is a view showing the change in permittivity when setting the weight ratio and changing only the weight of the compensator (TX-151) as shown in Table 1.
  • 11 is a view showing the change in dielectric constant when setting the weight ratio and changing only the weight of the polyethylene powder, as shown in Table 2.
  • FIG. 12 is a view showing the change in permittivity when setting the weight ratio and changing only the weight of the compensator (TX-151) as shown in Table 2.
  • FIG. 12 is a view showing the change in permittivity when setting the weight ratio and changing only the weight of the compensator (TX-151) as shown in Table 2.
  • FIG. 13 is a view showing the change in conductivity when setting the weight ratio and changing only the weight of NaCl as shown in Table 2.
  • the phantom manufactured by the present invention is a phantom for testing radio transmission / reception characteristics when bio data is wirelessly transmitted through a human body from medical equipment measuring various bio data of the human body.
  • the phantom of the present invention may be used to check whether the bio data is accurately transmitted over the air when the bio data photographed by the capsule endoscope is transmitted, and is attached to the surface of the human body to measure blood pressure or electrocardiogram, etc. It may also be used to confirm whether the bio data of the medical equipment is transmitted correctly over the air.
  • the phantom manufactured by the present invention is manufactured in a semi-solid form because the radio transceiver should be usable while inserted in the phantom for the testing of equipment such as capsule endoscopes.
  • FIG. 1 is a flow chart showing the flow of the phantom manufacturing method according to a first embodiment of the present invention.
  • distilled water is heated. Distilled water heating is preferably performed until the temperature of the distilled water is 40 °C. When the temperature of the distilled water is 40 °C, NaCl and NaN 3 is added to perform the operation of dissolving NaCl and NaN 3 in distilled water (step 100).
  • NaCl is a substance for securing the necessary conductivity for the human body, and NaN 3 is used to prevent the phantom from being damaged when exposed to room temperature.
  • agar powder which is a coagulant
  • agar powder which is a coagulant
  • agar powder which is a coagulant
  • the operation after mixing the agar powder is preferably continued until the viscosity becomes high and then lowered while observing the viscosity of the solution.
  • the mixing operation of the agar powder is preferably between about 5 and 10 minutes.
  • NaCl and NaN 3 it is preferable to completely dissolve NaCl and NaN 3 in distilled water, and then mix the agar powder. If NaCl, NaN 3 and agar powder are mixed together, NaCl and NaN 3 will adhere to the agar powder, ensuring proper dissolution and viscosity. You won't lose.
  • Agar powder is to ensure the viscosity for producing a phantom semi-solid, the amount of agar powder is determined based on the required viscosity.
  • the binder is mixed and then dissolved (step 104).
  • the binder is preferably mixed and dissolved when the temperature of the distilled water reaches 70 ° C.
  • the agent is stirred by means of a device to dissolve it, and the agent is used to secure the viscosity of the phantom. Phantom viscosity is required for the radio to be tested and inserted into the phantom.
  • TX-151 which is commercially available from Oil Center Research (www.oilcenter.com).
  • TX-151 When dissolving TX-151, such as when dissolving agar powder, dissolve it until the viscosity increases and decreases.
  • polyethylene powder is added to the solution and mixed (step 106).
  • the mixing of the polyethylene powder is preferably done using a blender and the mixing operation is carried out until a uniform medium is obtained.
  • the polyethylene powder is a material for securing the same dielectric constant as the human body, and the amount of the polyethylene powder to be mixed may be determined according to the required dielectric constant.
  • the polyethylene powder is preferably mixed several times and mixed, for example, about three times.
  • the semi-solid phantom is completed by drying and solidifying the phantom preparation composition (step 108).
  • the polyethylene powder is mixed with a wrap and may be dried at room temperature for about one day.
  • the phantom manufacturing composition prepared according to the first embodiment of the present invention is made by mixing distilled water, NaN 3 , a compatibilizer (TX-151), NaCl, polyethylene powder and agar powder, which is prepared according to the first embodiment
  • the composition for making phantom is 80 to 88% by weight of distilled water, 0.01 to 0.08% by weight of NaN 3 , 1.9 to 2.3% by weight of a binder (TX-151), and 0.5 to 0.65% of NaCl.
  • Wt%, polyethylene powder 8.1-9.6% by weight and agar powder 2.3-2.8% by weight may be prepared by mixing.
  • the FCC has set a dielectric constant of 56.7 and a conductivity of 0.94 S / m for the phantom used in the MICS band, and the weight ratio is a weight ratio set to satisfy a tolerance of 5% for the dielectric constant and conductivity.
  • Figure 3 is a graph showing the dielectric constant and conductivity characteristics in the MICS band of the phantom completed by the composition for producing phantom prepared by the weight ratio as shown in Table 1.
  • the solid line is the dielectric constant in the MICS band and the dotted line is the conductivity in the MICS band.
  • the dielectric constant and the conductivity are close to the dielectric constant and the conductivity set by the FCC. Can be.
  • FIG. 7 is a diagram illustrating a change in permittivity when only the weight ratio is set as shown in Table 1 and only the weight of agar powder (Agar) is changed.
  • TX-151 satisfies the MICS band permittivity condition defined by the FCC within a range of 5% tolerance when 73.5g to 88.5g (1.9% to 2.3% by weight).
  • the composition for producing the phantom is 82 ⁇ 90% by weight of distilled water, 0.01 ⁇ 0.08% by weight of NaN 3 , bridge
  • the agent (TX-151) 1.3 ⁇ 2.7% by weight, NaCl 0.46 ⁇ 0.63% by weight, polyethylene powder 12.5 ⁇ 14.9% by weight and agar powder may be prepared by mixing 2.3% by weight.
  • NaCl and polyethylene powders are slightly less demanded than in the MICS zone and the specific gravity of distilled water and agar powder is high.
  • the FCC sets a dielectric constant of 52.7 and a conductivity of 1.95 S / m for the phantom used in the ISM band (center frequency 2.45 GHz), and the weight ratio satisfies 10% tolerance for the above dielectric constant and 5% tolerance for the conductivity. Weight ratio set to.
  • Figure 4 is a graph showing the dielectric constant and conductivity characteristics in the ISM band of the phantom by the composition for manufacturing the phantom prepared by the weight ratio as shown in Table 2.
  • the solid line is the dielectric constant in the ISM band and the dotted line is the conductivity in the ISM band.
  • the dielectric constant and the conductivity are close to the dielectric constant and the conductivity set by the FCC. can confirm.
  • the dielectric constant value is not changed so that the dielectric constant specified by the FCC is satisfied within the tolerance range of 10%, and the weight ratio is set to ensure the required viscosity. It is preferable to have a weight ratio of.
  • 11 is a diagram showing the change in dielectric constant when setting the weight ratio and changing only the weight of the polyethylene powder, as shown in Table 2.
  • the polyethylene powder in the total weight of 4139.5 g satisfies the ISM band dielectric constant condition specified by the FCC within the tolerance range of 10% when 514g to 629g (12.5% to 14.9% by weight).
  • FIG. 12 is a diagram showing the change in permittivity when setting the weight ratio and changing only the weight of the compensator (TX-151) as shown in Table 2.
  • the FCC meets the ISM band dielectric constant condition within the tolerance range of 10%. You can see that.
  • FIG. 13 is a diagram showing the change in conductivity when setting the weight ratio and changing only the weight of NaCl as shown in Table 2.
  • NaCl in the total weight of 4139.5 g satisfies the ISM band conductivity requirements defined by the FCC within a 5% tolerance range of 18.9 g to 26 g (0.46 wt% to 0.63 wt%).
  • Figure 2 is a flow chart showing the flow of the human body phantom manufacturing method according to a second embodiment of the present invention.
  • glycerin is dissolved in distilled water (step 200).
  • distilled water and glycerin are added to a pot and then dissolved using a device such as a foamer.
  • Glycerin is a substance for securing the same dielectric constant as the human body.
  • step 200 Dissolve until all NaCl grains are dissolved. It is preferable to dissolve glycerin and NaCl without dissolving them together.
  • agar powder (Agar) is added and heated (step 204).
  • Mixing and heating of the agar powder is preferably performed on a low heat and may not be viscous when heated at a high temperature.
  • the heating operation after mixing the agar powder is continued until the viscosity becomes higher and then lowered again while observing the viscosity of the solution.
  • a phantom preparation composition is prepared by mixing with agar powder, and the phantom is completed by applying a wrap to the composition for phantom preparation and drying at room temperature (step 206). The drying operation can take place for about a day.
  • composition for manufacturing a phantom prepared according to the second embodiment of the present invention is made by mixing distilled water, NaCl, glycerin and agar powder, and the phantom prepared according to the second embodiment is used for the experiment of human characteristics in the MICS band. 47 to 54% by weight of distilled water, 2 to 4% by weight of NaCl, 40 to 50% by weight of glycerin and 2 to 6% by weight of agar powder may be prepared.
  • Figure 5 is a graph showing the dielectric constant and conductivity characteristics in the MICS band of the phantom by the composition for manufacturing the phantom prepared by the weight ratio as shown in Table 3.
  • the solid line is the dielectric constant in the MICS band and the dotted line is the conductivity in the MICS band.
  • the dielectric constant and the conductivity are close to the dielectric constant and the conductivity set by the FCC. Can be.
  • the composition for producing the phantom is 61-69% by weight of distilled water, 1-2% by weight of NaCl, glycerin 22 31 wt% and 4-7 wt% of agar powder may be mixed.
  • the specific gravity of NaCl and glycerin is lower than that of the MICS band, and the specific gravity of distilled water and agar powder is increased.
  • Figure 6 is a graph showing the dielectric constant and conductivity characteristics in the ISM band of the phantom by the composition for manufacturing the phantom prepared by the weight ratio as shown in Table 4.
  • the solid line is the dielectric constant in the ISM band and the dotted line is the conductivity in the ISM band.
  • the dielectric constant and the conductivity are close to the dielectric constant and the conductivity set by the FCC. can confirm.
  • the phantom manufactured by the first embodiment can secure adhesiveness due to the use of TX-151, which can be usefully used for medical equipment inserted into the human body, such as a capsule endoscope, and the phantom manufactured by the second embodiment. Has more rigid characteristics than the first embodiment, and can be usefully used for experiments on the wireless transmission characteristics of On-Body type medical equipment such as electrocardiogram and blood pressure.
  • the method for manufacturing a human phantom and the composition for manufacturing a human phantom according to an embodiment of the present invention can satisfy the dielectric constant and conductivity conditions for the MICS band and the ISM band defined by the FCC. It can be used in the human phantom which must satisfy the permittivity and conductivity conditions for the MICS band and the ISM band.

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Abstract

L'invention concerne un procédé de préparation d'un fantôme humain semi-solide destiné à mesurer les caractéristiques RF et une composition permettant de préparer un fantôme humain. Le procédé décrit comprend les étapes consistant à : (a) dissoudre du NaCl et du NaN3 dans de l'eau distillée ; (b) mélanger une poudre d'agar-agar avec la solution de l'étape (a) ; (c) mélanger un agent gélifiant avec la solution de l'étape (b) ; et (d) mélanger une poudre de polyéthylène avec la solution de l'étape (c) pour préparer une composition de préparation d'un fantôme. Selon le procédé décrit, il est possible de fournir un fantôme humain qui peut être utilisé de façon appropriée dans un test de communication sans fil pour un équipement médical utilisé sur le corps humain, et qui peut être fabriqué sous une forme semi-solide à faible coût.
PCT/KR2012/011798 2011-12-28 2012-12-28 Procédé de préparation d'un fantôme humain semi-solide destiné à mesurer les caractéristiques rf et composition pour la préparation d'un fantôme humain WO2013100732A1 (fr)

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KR101665108B1 (ko) * 2015-02-24 2016-10-12 주식회사 덴티스 인체 유사 팬텀, 인체 유사 팬텀의 제조방법 및 이를 이용한 인체 삽입형 의료기기의 성능 평가 방법

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KR100623090B1 (ko) * 2006-03-07 2006-09-13 가톨릭대학교 산학협력단 자기공명영상 장비를 이용한 자기공명분광 성능 평가용팬텀
JP5051508B2 (ja) 2006-11-14 2012-10-17 学校法人東京理科大学 脂肪等価ファントム及びその作成方法、このファントムを用いた脂肪厚推定方法
JP5464397B2 (ja) * 2008-02-15 2014-04-09 国立大学法人 千葉大学 人体等価電磁ファントム
KR101016746B1 (ko) * 2008-12-11 2011-02-25 한국전자통신연구원 전자파를 이용한 유방암 진단장비 검사용 유방팬텀

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CHEA-OK, KO ET AL.: "Development of Local-Exposure Systems for In Vivo Studies at Mobile-Phone Frequency Bands.", THE JOURNAL OF KOREAN INSTITUTE OF ELECTROMAGNETIC ENGINEERING AND SCIENCE., vol. 17, no. 5, 2006, pages 451 - 460 *
PAOLO NPA.: "''Electromagnetic Radiations and Biological Interactions.'' ''Laurea Magistrale''", BIOMEDICAL ENGINEERING FIRST SEMESTER (6 CREDITS), ACADEMIC YEAR, 12 December 2011 (2011-12-12), pages 1 - 28, Retrieved from the Internet <URL:http://www.iet.unipi.it/p.nepa/Radiazionielettromagnetichebiomedica/13.%2xExperimental%20Dosimetry10.12.2011.pdf> *
RADIM ZAJI. CEK ET AL.: "Broadband Complex Permittivity Determination for Biomedical Applications.", ADVANCED MICROWAVE CIRCUITS AND SYSTEMS., 2010, pages 365 - 385 *

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