WO2013076440A1 - Sonde chirurgicale à radiofréquence - Google Patents

Sonde chirurgicale à radiofréquence Download PDF

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Publication number
WO2013076440A1
WO2013076440A1 PCT/GB2012/000845 GB2012000845W WO2013076440A1 WO 2013076440 A1 WO2013076440 A1 WO 2013076440A1 GB 2012000845 W GB2012000845 W GB 2012000845W WO 2013076440 A1 WO2013076440 A1 WO 2013076440A1
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WO
WIPO (PCT)
Prior art keywords
electrodes
electrode
peripheral
region
return path
Prior art date
Application number
PCT/GB2012/000845
Other languages
English (en)
Inventor
Zhigang Wang
Original Assignee
The University Of Dundee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The University Of Dundee filed Critical The University Of Dundee
Priority to GB1409118.5A priority Critical patent/GB2510309B8/en
Publication of WO2013076440A1 publication Critical patent/WO2013076440A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1482—Probes or electrodes therefor having a long rigid shaft for accessing the inner body transcutaneously in minimal invasive surgery, e.g. laparoscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00541—Lung or bronchi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00791—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00875—Resistance or impedance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1465—Deformable electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1475—Electrodes retractable in or deployable from a housing

Definitions

  • the present invention relates to an apparatus and method for destruction and separating/removing solid tumours and in particular to the application of
  • radiofrequency (RF) electromagnetic energy this purpose.
  • Cancer in solid organs can be destroyed by heat created by an alternating current or a direct current to weaken or kill cells.
  • This technique is generally known as thermal therapy and there are three commonly used techniques for destroying cells in this way.
  • Cell hyperthermia exposes the cancer cells to slightly higher temperatures of around 39 to 50°C to damage and kill cancer cells or to make cancer cells more sensitive to the effects of radiation and certain anti-cancer drugs. Hyperthermia is known to be useful for treatment of a small number of cancer types, is not in widespread use and is most effective when used alongside conventional therapies.
  • Electrosurgery is the application of a high-frequency electric current to biological tissue as a means to cut, coagulate or desiccate tissue. Its benefits include the ability to make precise cuts with limited blood loss. Electrosurgical devices are frequently used during surgical operations helping to prevent blood loss in hospital operating rooms or in outpatient procedures.
  • the tissue is heated by an electric current to
  • electrosurgery is usually used to refer to a quite different method than electrocautery.
  • the latter uses heat conduction from a probe heated to a glowing temperature by a direct current (much in the manner of a soldering iron).
  • Electrosurgery uses alternating current to directly heat the tissue itself.
  • Radio frequency ablation is a technique in which dysfunctional tissue is ablated using the heat generated from a high frequency alternating current to treat a medical disorder.
  • An important advantage of RF current is that it does not directly stimulate nerves or heart muscle and can therefore often be used without the need for general anaesthetic.
  • RFA is performed to treat tumours in lung, liver, kidney, bone and (rarely) in other body organs. Once a patient has been diagnosed as having a tumour is confirmed, the medical procedure involves the insertion of a needle-like RFA probe inside the tumour. The radiofrequency waves passing through the probe increase the temperature within tumour to above 50°C which results in the destruction of the tumour.
  • RFA is used to treat patients with small tumours that originated within the organ (primary tumours) or those tumours which have spread to the organ (metastasis).
  • An RF signal may be applied percutaneously with image guidance by CT, MR) or external ultrasound, or laparoscopically with visual guidance accompanied by contact ultrasound.
  • One of the challenges in thermal therapy is delivering the appropriate amount of heat to the correct part of the patient's body.
  • the temperatures must be high enough, and the temperatures must be sustained long enough, to damage or kill the cancer cells.
  • the temperatures are too high, or if they are kept elevated for too long, then serious side effects, including death can result.
  • RF probes and instruments come in various designs and configurations.
  • the 17-gauge needle electrode (Cool-tip RFA, Valleylab-Covidien, USA approved by the United States Food and Drug Administration (FDA)), can be configured as a cluster (3-needles) and may be used in treating non-resectable liver tumours,
  • This is a mono-polar RFA system which requires a skin pad-electrode to provide an electrode for the current return path to the RF generator.
  • Monopolar RFA systems such as that described in Zerfas et al, US patent 7458971 B2, Dec. 2008 can use a probe with an array of electrodes or expandable hooks.
  • Young & Zerfas (US patent 7524318, Apr 2009) discloses a system with various configured electrodes exemplified by the Christmas tree-like RITA needle (RITA Medical System, Inc., USA) or LeVeen electrode (umbrella-shaped array) from Boston Scientific (www.bostonscientific.com). Tissue impedance and/or in-situ temperature measurement are used as feedback to a control system which provides the appropriate level of RF energy output.
  • Bipolar RF probes can be created by closely arranging 2 electrodes at the tip of an RFA needle such as in CelonProSurge (www.celon.com) applicator [Anticancer Res 29:1309-1314 (2009)]. Bipolar and multipolar RFA electrode systems are shown in Lee, Jr. et al, US patent 7520877 B2, Apr 2009.
  • tumour cells have not been completely destroyed residual viable cancer cells will be present in the patient and will result in cancer recurrence after treatment.
  • existing RFA devices it is difficult to know where the RFA treatment margin is and it is difficult to deliver the RFA within the margin. It is also difficult to heat the tumour uniformly across the tumour to achieve RF ablation of the whole targeted tissues within the treatment margin.
  • Current RFA technology provides an RFA electrode (or multiple electrodes) which when inserted into the target tumour, heats the tumour tissue around the
  • an apparatus for treating a solid tumour to destroy tumour cells therein comprising: a radio frequency (RF) probe having a distal portion for treating said tumour cells and a proximal portion,
  • RF radio frequency
  • the distal portion comprises a plurality of substantially mechanically rigid electrodes which when deployed form an electrical bridge circuit with each electrode component being electrically insulated and which define a region within which a return path for a radio frequency current can be created such that the current is transmittable with more uniform distribution between a plurality of said electrodes via the return path and wherein the electrodes are provided with a switch to turn the electrodes on and off in order to determine the shape and position of the return path to provide a desired heating effect on the solid tumour when situated within the region.
  • the current is transmittable between a pair of said opposite and parallel located electrodes
  • the plurality of electrodes comprises a central elongate electrode having a longitudinal axis and a plurality of peripheral electrodes which are coupled to and radially extendable from a retracted position on the longitudinal axis of the elongate electrode to an extended position at a predetermined distance from the longitudinal electrode to define the region containing the return path.
  • the plurality of electrodes comprises an array of electrodes.
  • the plurality of electrodes are spaced apart along a longitudinal member or probe.
  • the peripheral electrode comprises at least two electrodes articulatably connected to move from the retracted position to the extended position.
  • the apparatus comprises first and second peripheral electrodes.
  • the first and second peripheral electrodes are arranged on opposing sides of the elongate electrode.
  • the first and second peripheral electrodes are arranged adjacent to one another on the elongate electrode.
  • the peripheral electrode comprises at least two rigid arms articulatably connected to move from the retracted position to the extended position.
  • the articulatable connection comprises a hinge.
  • the articulatable connection comprises a flexible mechanical structure or joint.
  • the peripheral electrode is fixedly connected to the elongate electrode at the distal end of the apparatus end remote and is slidably connected to the elongate electrode at the proximal end of the apparatus.
  • a third peripheral electrode can be arranged on the front side of the elongate electrode.
  • a fourth peripheral electrode can be arranged on the back side of the elongate electrode.
  • the peripheral electrode comprises a shape memory alloy.
  • the shape memory alloy can be changed in-situ to its previously heat- treated shape to optimally conform to any specific requirements of the volume where the tumour is to be destroyed.
  • the end of the elongate electrode which is remote from the handle comprises a cutting tip for easy insertion into a tumour.
  • the peripheral electrodes are further configured by external electrical connection in series to function as a single bipolar or monopolar electrode.
  • the bipolar electrode has an RF return path provided by a central elongate electrode.
  • the monopolar electrode has an RF return path provided by a skin mountable electrode.
  • the cutting tip is heated.
  • the cutting tip is heated electrically.
  • the proximal end of the apparatus comprises a handle.
  • the apparatus further comprises a temperature sensor for measuring temperature in the region.
  • the temperature sensor measures differences in temperature across the region.
  • the temperature sensor is located on the longitudinal electrode.
  • the temperature sensor comprises a plurality of sensors positioned on one or more of the electrodes.
  • a method for treating a solid tumour to destroy tumour cells therein comprising the steps of: positioning a plurality of electrodes to define a region around a target such that a current is transmittable between at least two of said electrodes via an electrical return path in the region;
  • the method further comprises the step of changing the desired current distribution and switching the electrodes to turn the electrodes on and off in order to obtain the desired shape and position of the return path in response to the change to the desired current distribution.
  • the step of changing the desired current distribution further comprises determining the temperature within the region to find areas which are too hot or too cold and switching the electrodes to change the position and shape of the return path to adjust the temperature across the region.
  • the plurality of electrodes comprises a central elongate electrode having a longitudinal axis and a plurality of peripheral electrodes which are coupled to and radially extendable from a retracted position on the longitudinal axis of the elongate electrode to an extended position at a predetermined distance from the longitudinal electrode to define the region containing the return path.
  • the plurality of electrodes comprises an array of electrodes.
  • the plurality of electrodes are spaced apart along a longitudinal member or probe.
  • the peripheral electrode comprises at least two electrodes articulatably connected to move from the retracted position to the extended position.
  • the peripheral electrodes are substantially rigid.
  • the first and second peripheral electrodes are arranged on opposing sides of the elongate electrode.
  • the first and second peripheral electrodes are arranged adjacent to one another on the elongate electrode.
  • the peripheral electrode comprises at least two rigid arms articulatably connected to move from the retracted position to the extended position.
  • the articulatable connection comprises a hinge.
  • the articulatable connection comprises a flexible mechanical structure or joint.
  • the peripheral electrode is fixedly connected to the elongate electrode at the distal end of the apparatus end remote and is slidably connected to the elongate electrode at the proximal end of the apparatus.
  • a third peripheral electrode can be arranged on the front side of the elongate electrode.
  • a fourth peripheral electrode can be arranged on the back side of the elongate electrode.
  • the peripheral electrode comprises a shape memory alloy.
  • the shape memory alloy can be changed in-situ to its previously heat- treated shape to optimally conform to any specific requirements of the volume where the tumour is to be destroyed.
  • the end of the elongate electrode which is remote from the handle comprises a cutting tip for easy insertion into a tumour.
  • the cutting tip is heated.
  • the cutting tip is heated electrically.
  • the proximal end of the apparatus comprises a handle.
  • the apparatus further comprises a temperature sensor for measuring temperature in the region.
  • the temperature sensor measures differences in temperature across the region.
  • the temperature sensor is located on the longitudinal electrode.
  • the temperature sensor comprises a plurality of sensors positioned on one or more of the electrodes.
  • Figure 1 shows a schematic diagram of a first embodiment of the present invention in the extended position
  • Figure 2 shows a schematic diagram of a second embodiment of the present invention in the extended position
  • Figures 3a and 3b show an embodiment of the present invention similar to that shown in figure 1 where the RF current is selectively switched on at a first combination of electrodes, figure 3c shows a calculated temperature iso-surface (>50°C) distribution within the region at 5 minutes;
  • Figure 4 shows an embodiment of the present invention similar to that shown in figure 1 where the RF current is selectively switched on at a second combination of electrodes;
  • Figure 5 shows an example of combined heating effect of the present invention after sequentially activated in figure 3b and figure 4.
  • Figures 6a and 6b show an embodiment of the present invention similar to that shown in figure 1 where the RF current is selectively switched on at a third
  • Figure 1 is a schematic drawing of a first embodiment of an RF probe 1 in
  • the probe 1 comprises a handle or proximal portion 3 and a distal portion 5 which comprises a plurality of electrodes.
  • a central electrode 15 extends from the top of the handle to the distal end of the device where it is connected to a joint 21.
  • the left hand side of the distal end 5 of the probe 1 comprises electrodes 9 and 13.
  • Electrode 9 is connected to electrode 13 by means of a joint 7 and to the proximal end of the probe by a joint 19.
  • the joints allow the angle between the electrodes 9 and 13 and the angle between electrode 9 and the central electrode to be varied.
  • Electrode 13 is connected to the distal end of the probe by joint 21 which allows the angle between the electrode 13 and the central shaft-electrode 15 to be varied.
  • Electrode 7 is connected to electrode 11 by means of a joint 23 and to the proximal end of the probe by a joint 19.
  • the joints allow the angle between the electrodes 11 and 7 and the angle between electrode 11 and the central electrode to be varied.
  • Electrode 7 is connected to the distal end of the probe by joint 21 which allows the angle between the electrode 7 and central shaft-electrode 15 to be varied.
  • the probe may be inserted into a patient with the electrodes in a retracted position whereby all of the electrodes are substantially coaxial with the central electrode 5 thereby minimising the cross sectional area of the probe during insertion.
  • FIG. 2 is a schematic drawing of a second embodiment of an RF probe 31 in accordance with the present invention.
  • the probe 31 comprises a handle or proximal portion 33 and a distal portion 35 which comprises a plurality of electrodes.
  • a central electrode 45 extends from the top of the handle to the distal end of the device where it is connected to a mounting 51
  • the left hand side of the distal end 35 of the probe 31 comprises electrodes 39 and 43.
  • Electrode 39 is connected to electrode 43 by means of a joint 47 and to the proximal end of the probe by a joint 49.
  • the joints allow the angle between the electrodes 39 and 43 and the angle between electrode 39 and the central electrode to be varied.
  • Electrode 43 is connected to the distal end of the probe by joint 51 which allows the angle between the electrode 43 and the distal end of the probe 31 to be varied.
  • the present invention provides a plurality of electrodes which are switchable on and off in order to change the position and shape of the electrical return path which is situated within a region, typically inside a patient undergoing treatment for the removal and/or destruction of a solid tumour.
  • One feature of the present invention is the ability to use changes in current distribution to produce controllable heat gradients within the region and to control temperature to a suitable level for cell necrosis. This is typically temperatures around or above 50° C:
  • Figures 3a, 3b and 3c show the use of the present invention to provide sequential heating with two parallel electrodes (7 and 9) which have been activated whilst the other electrodes remain switched off. In those circumstances, uniform RF current flows in the parallel electrode pair and the return path is concentrated in the region between electrodes 7 and 9.
  • Electrode 7 is connected to electrode 11 at the right hand side of the device. Electrode 9 is connected to array electrode 13 at the left hand side of the device.
  • the central shaft can be configured as array electrode 15.
  • a sliding actuator 30 (or other displacement mechanism) is reciprocally mounted on the handle and is coupled to electrodes 9 and 11. Movement of the sliding actuator 30 up the handle bends towards the distal end causes the joints 17, 21 located between respective electrodes to bend and to extend the electrodes 7, 9, 11 and 13 into a range of positions which extend radially outwards from the central electrode 15 thereby allowing different deployed shapes.
  • a locking mechanism is also provided to maintain the electrodes in their chosen position.
  • Figures 3a and 3b show a treatment sequence in accordance with the present invention in which array electrodes 7 and 9 are activated while other array electrodes are effectively switched off by being suspended in high impedance (high Z). This will result in RF current flow uniformly from electrodes 7 to 9 through the return path as illustrated by the lines 53 in figure 3b.
  • the parallel arrangement of the electrodes 7 and 9 produces a substantially even current distribution due to the parallel arrangement of the two activated electrodes which will generate a heated volume with a substantially even heat distribution.
  • Figure 3c shows a FE (finite element method) simulated RF ablated volume with a temperature iso-surface >50°C at 5 minutes treatment time.
  • a second example of a treatment sequence in accordance with the present invention is shown in figure 4.
  • electrodes 11 and 13 are activated while the other electrodes are suspended in high impedance (high Z). This will result in RF current flowing uniformly from electrodes 11 to 13 through the return path as illustrated by the lines 55 figure 4.
  • the parallel arrangement of the electrodes 1 and 13 produces a substantially even current distribution due to the parallel arrangement of the two activated electrodes which will generate a heated volume with a substantially even heat distribution. This will generate similar heated volume as shown in Figure 3c.
  • the switching sequences as described with respect to figures 3b and 4 are used in together but sequentially.
  • This combined treatment changes the shape and position of the return path and has a consequent effect upon the heat distribution within the region.
  • One example of the resultant combined treated volume (region) has temperature iso-surfaces which are illustrated in Figure 5.
  • This treatment sequences can be repeated many times automatically via computer control algorithm to obtain optimal RF ablation of tissue using lower RF dose (current/power) in each particular sequence.
  • FIG. 5 shows the apparatus of the invention 1 and the heated areas 63, 65, 67 and 69 as a white small area (hole) 61 which is not heated to a sufficiently high temperature for cell necrosis.
  • One of the advantages of the present invention is that where part of the region is not heated to a sufficient temperature,
  • the electrodes may be switched and a different RF heating sequence can be used which concentrates the return path (and therefore heating effect) upon the area which has been insufficiently heated.
  • all of the electrodes, 7, 9, 11, 13 and 15 are activated with the longitudinal electrode 15 as the positive electrode and electrodes, 7, 9, 11 and 13 as negative or ground electrodes, as shown in figure 6a.
  • the above sequence causes there to be a return path from each of the electrode 7, 9, 11 and 13 to the
  • Figure 6b shows an embodiment of the apparatus of the present invention 1 with lines showing F current flow 71 and shading 73 which depicts the region where high RF current density is to be found around electrode 15 and where a heated temperature iso-surface/volume will arise.
  • F current flow 71 and shading 73 depicts the region where high RF current density is to be found around electrode 15 and where a heated temperature iso-surface/volume will arise.
  • Figures 1 and 3 to 6 show embodiments of the present invention each of which have two limbs each comprising two electrodes and being arranged around a central shaft which also comprises an electrode.
  • Figure 2 shows a one limb structure which has one limb comprising two electrodes and being arranged around a central shaft which also comprises an electrode. It will be appreciated a device in accordance with the present invention can be provided with additional limbs, for example, two limbs could be added in the plane perpendicular to the plane in which the first two limbs are located and have a similar structure to that described above with the electrodes joint connected and a sliding/locking mechanism for conformal deployment.
  • the rigid electrode may be made of shape memory alloy (SMA) materials such as Nickel Titanium (NiTi or Nitinol) with any suitable pre-treated shapes.
  • SMA shape memory alloy
  • a straight rigid SMA wire or strip in Figs. 1-5 can be changed in-situ to its previously heat-treated shape such as a curved wire or strip when it is heated (by RF current) above its transformation temperature.
  • the transformation temperature of Nitinol material can be adjusted and may be set to that from body temperature up to 100 degree C, for example at 50 degree C.
  • the selection of pre-treated shapes for the rigid electrode is to optimally conform to any specific or irregular cancer geometry of individual patient, thus this will cause less damage to the surrounding healthy tissue beyond its margin clearance (e.g. 5mm):

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)

Abstract

La présente invention concerne un appareil pour traiter une tumeur solide pour détruire une tumeur. Celui-ci comprend une sonde à radiofréquence (RF) avec une partie distale qui comprend des électrodes mécaniquement rigides qui, lorsqu'elles sont déployées, forment un circuit de pont électrique, chaque composant d'électrode étant électriquement isolé. Les électrodes déployées définissent une région dans laquelle un trajet de retour pour un courant à radiofréquence peut être créé de sorte que le courant soit transmissible avec une distribution plus uniforme entre une paire d'électrodes opposées et parallèles via le trajet de retour. Les électrodes sont pourvues d'un commutateur pour activer et désactiver les électrodes afin de modifier la forme et la position du trajet de retour pour produire un effet de chauffage souhaité sur la tumeur solide lorsqu'elle est située dans la région.
PCT/GB2012/000845 2011-11-21 2012-11-20 Sonde chirurgicale à radiofréquence WO2013076440A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1409118.5A GB2510309B8 (en) 2011-11-21 2012-11-20 Radio frequency surgical probe

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1120023.5 2011-11-21
GB201120023A GB201120023D0 (en) 2011-11-21 2011-11-21 Radio frequency surgical probe

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WO2013076440A1 true WO2013076440A1 (fr) 2013-05-30

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11576716B2 (en) 2013-03-15 2023-02-14 Medtronic Holding Company Sàrl Electrosurgical mapping tools and methods

Citations (7)

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Publication number Priority date Publication date Assignee Title
US6267760B1 (en) * 1998-05-05 2001-07-31 Scimed Life Systems, Inc. Surgical method and apparatus for positioning a diagnostic or therapeutic element within the body and forming an incision in tissue with minimal blood loss
US20050143674A1 (en) * 1998-09-01 2005-06-30 Burbank Fred H. Methods and apparatus for securing medical instruments to desired locations in a patient's body
US20050288730A1 (en) * 2002-04-08 2005-12-29 Mark Deem Methods and apparatus for renal neuromodulation
US20080161801A1 (en) * 2003-09-12 2008-07-03 Minnow Medical, Inc. Selectable Eccentric Remodeling and/or Ablation of Atherosclerotic Material
US7458971B2 (en) 2004-09-24 2008-12-02 Boston Scientific Scimed, Inc. RF ablation probe with unibody electrode element
US7520877B2 (en) 2000-06-07 2009-04-21 Wisconsin Alumni Research Foundation Radiofrequency ablation system using multiple prong probes
US7524318B2 (en) 2004-10-28 2009-04-28 Boston Scientific Scimed, Inc. Ablation probe with flared electrodes

Patent Citations (7)

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Publication number Priority date Publication date Assignee Title
US6267760B1 (en) * 1998-05-05 2001-07-31 Scimed Life Systems, Inc. Surgical method and apparatus for positioning a diagnostic or therapeutic element within the body and forming an incision in tissue with minimal blood loss
US20050143674A1 (en) * 1998-09-01 2005-06-30 Burbank Fred H. Methods and apparatus for securing medical instruments to desired locations in a patient's body
US7520877B2 (en) 2000-06-07 2009-04-21 Wisconsin Alumni Research Foundation Radiofrequency ablation system using multiple prong probes
US20050288730A1 (en) * 2002-04-08 2005-12-29 Mark Deem Methods and apparatus for renal neuromodulation
US20080161801A1 (en) * 2003-09-12 2008-07-03 Minnow Medical, Inc. Selectable Eccentric Remodeling and/or Ablation of Atherosclerotic Material
US7458971B2 (en) 2004-09-24 2008-12-02 Boston Scientific Scimed, Inc. RF ablation probe with unibody electrode element
US7524318B2 (en) 2004-10-28 2009-04-28 Boston Scientific Scimed, Inc. Ablation probe with flared electrodes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANTICANCER RES, vol. 29, 2009, pages 1309 - 1314

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11576716B2 (en) 2013-03-15 2023-02-14 Medtronic Holding Company Sàrl Electrosurgical mapping tools and methods

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GB201120023D0 (en) 2012-01-04
GB2510309A (en) 2014-07-30
GB2510309B (en) 2015-05-20
GB2510309B8 (en) 2015-06-17
GB201409118D0 (en) 2014-07-09

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