WO2013075027A3 - Anti-sil6xr complex binding domains and methods of use - Google Patents

Anti-sil6xr complex binding domains and methods of use Download PDF

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Publication number
WO2013075027A3
WO2013075027A3 PCT/US2012/065679 US2012065679W WO2013075027A3 WO 2013075027 A3 WO2013075027 A3 WO 2013075027A3 US 2012065679 W US2012065679 W US 2012065679W WO 2013075027 A3 WO2013075027 A3 WO 2013075027A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
binding domains
complex binding
sil6xr
sil6xr complex
Prior art date
Application number
PCT/US2012/065679
Other languages
French (fr)
Other versions
WO2013075027A2 (en
Inventor
Alan K. LOFQUIST
Lynda Misher
Jeffrey B. ADAMO
Hang FANG
Padma RAVIKUMAR
Original Assignee
Emergent Product Development Seattle, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emergent Product Development Seattle, Llc filed Critical Emergent Product Development Seattle, Llc
Publication of WO2013075027A2 publication Critical patent/WO2013075027A2/en
Publication of WO2013075027A3 publication Critical patent/WO2013075027A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates generally to fusion proteins comprising anti-sIL6xR binding domains and methods of using same. Such proteins are useful, for example, in methods for treating any of a variety of inflammatory disorders including rheumatoid arthritis, psoriasis and ulcerative colitis.
PCT/US2012/065679 2011-11-17 2012-11-16 Anti-sil6xr complex binding domains and methods of use WO2013075027A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161561108P 2011-11-17 2011-11-17
US61/561,108 2011-11-17

Publications (2)

Publication Number Publication Date
WO2013075027A2 WO2013075027A2 (en) 2013-05-23
WO2013075027A3 true WO2013075027A3 (en) 2013-08-22

Family

ID=48430361

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/065679 WO2013075027A2 (en) 2011-11-17 2012-11-16 Anti-sil6xr complex binding domains and methods of use

Country Status (1)

Country Link
WO (1) WO2013075027A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016069889A1 (en) * 2014-10-31 2016-05-06 Resolve Therapeutics, Llc Therapeutic nuclease-transferrin fusions and methods
KR102497013B1 (en) * 2016-06-07 2023-02-20 맥스-델브뤼크-센트럼 퓌어 몰레쿨라레 메디친 Chimeric antigen receptors and CAR-T cells that bind BCMA
CN115066275A (en) * 2019-09-25 2022-09-16 斯图加特大学 Binding modules comprising modified EHD2 domains

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040259209A1 (en) * 2001-10-01 2004-12-23 Sun Lee-Hwei K. Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities
US20060084145A1 (en) * 2004-09-27 2006-04-20 Anderson Glenn M sRAGE mimetibody, compositions, methods and uses
WO2010003101A2 (en) * 2008-07-02 2010-01-07 Trubion Pharmaceuticals, Inc. Il6 immunotherapeutics
US20100098709A1 (en) * 2006-11-30 2010-04-22 Astrazeneca Ab Antibodies Specific For The Complex Of Interleukin-6 And The Interleukin-6 Receptor
US20110002936A1 (en) * 2008-05-13 2011-01-06 Walter Ferlin Anti-IL-6/IL-6R Antibodies and Methods of Use Thereof
US20110152173A1 (en) * 2008-07-02 2011-06-23 Emergent Product Development Seattle ,LLC TNF-a ANTAGONIST MULTI-TARGET BINDING PROTEINS
WO2011079308A2 (en) * 2009-12-23 2011-06-30 Emergent Product Development Seattle, Llc Compositions comprising tnf-alpha and il-6 antagonists and methods of use thereof
US20110177070A1 (en) * 2008-07-02 2011-07-21 Emergent Product Development Seatlle, LLC TGF-Beta Antagonist Multi-Target Binding Proteins

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040259209A1 (en) * 2001-10-01 2004-12-23 Sun Lee-Hwei K. Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities
US20060084145A1 (en) * 2004-09-27 2006-04-20 Anderson Glenn M sRAGE mimetibody, compositions, methods and uses
US20100098709A1 (en) * 2006-11-30 2010-04-22 Astrazeneca Ab Antibodies Specific For The Complex Of Interleukin-6 And The Interleukin-6 Receptor
US20110002936A1 (en) * 2008-05-13 2011-01-06 Walter Ferlin Anti-IL-6/IL-6R Antibodies and Methods of Use Thereof
US8034344B2 (en) * 2008-05-13 2011-10-11 Novimmune S.A. Anti-IL-6/IL-6R antibodies and methods of use thereof
WO2010003101A2 (en) * 2008-07-02 2010-01-07 Trubion Pharmaceuticals, Inc. Il6 immunotherapeutics
US20110142851A1 (en) * 2008-07-02 2011-06-16 Lynda Misher IL6 Immunotherapeutics
US20110152173A1 (en) * 2008-07-02 2011-06-23 Emergent Product Development Seattle ,LLC TNF-a ANTAGONIST MULTI-TARGET BINDING PROTEINS
US20110177070A1 (en) * 2008-07-02 2011-07-21 Emergent Product Development Seatlle, LLC TGF-Beta Antagonist Multi-Target Binding Proteins
WO2011079308A2 (en) * 2009-12-23 2011-06-30 Emergent Product Development Seattle, Llc Compositions comprising tnf-alpha and il-6 antagonists and methods of use thereof

Also Published As

Publication number Publication date
WO2013075027A2 (en) 2013-05-23

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