WO2013070079A3 - miRNA IN BLOOD BRAIN BARRIER OF MS PATIENTS - Google Patents

miRNA IN BLOOD BRAIN BARRIER OF MS PATIENTS Download PDF

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Publication number
WO2013070079A3
WO2013070079A3 PCT/NL2012/050793 NL2012050793W WO2013070079A3 WO 2013070079 A3 WO2013070079 A3 WO 2013070079A3 NL 2012050793 W NL2012050793 W NL 2012050793W WO 2013070079 A3 WO2013070079 A3 WO 2013070079A3
Authority
WO
WIPO (PCT)
Prior art keywords
brain barrier
blood
patients
mirna
blood brain
Prior art date
Application number
PCT/NL2012/050793
Other languages
French (fr)
Other versions
WO2013070079A8 (en
WO2013070079A2 (en
Inventor
Arie Reijerkerk
Helga Eveline DE VRIES
Original Assignee
Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk, Onderzoek En Patiëntenzorg
Stichting Vu-Vumc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk, Onderzoek En Patiëntenzorg, Stichting Vu-Vumc filed Critical Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk, Onderzoek En Patiëntenzorg
Publication of WO2013070079A2 publication Critical patent/WO2013070079A2/en
Publication of WO2013070079A3 publication Critical patent/WO2013070079A3/en
Publication of WO2013070079A8 publication Critical patent/WO2013070079A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Abstract

The blood-brain barrier (BBB) separates the blood and the central nervous system (CNS). Here it is disclosed that blood-brain barrier function can be increased with particular nucleic acid sequences, in particular in patients suffering from or diagnosed with Multiple Sclerosis. The use of compounds comprising such nucleic acid sequences for increasing blood-brain barrier function is described.
PCT/NL2012/050793 2011-11-10 2012-11-09 miRNA IN BLOOD BRAIN BARRIER OF MS PATIENTS WO2013070079A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL2007767 2011-11-10
NL2007767 2011-11-10

Publications (3)

Publication Number Publication Date
WO2013070079A2 WO2013070079A2 (en) 2013-05-16
WO2013070079A3 true WO2013070079A3 (en) 2013-07-11
WO2013070079A8 WO2013070079A8 (en) 2013-10-24

Family

ID=47278967

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL2012/050793 WO2013070079A2 (en) 2011-11-10 2012-11-09 miRNA IN BLOOD BRAIN BARRIER OF MS PATIENTS

Country Status (1)

Country Link
WO (1) WO2013070079A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018228875A1 (en) * 2017-06-15 2018-12-20 Nestec S.A. Micro-rna biomarkers of blood-brain barrier dysfunction
KR102177130B1 (en) 2017-08-18 2020-11-10 (주)큐라미스 Use of miR-18b for preventing, treating or diagnosing muscular disease and neuromuscular disease

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008140449A1 (en) * 2007-05-11 2008-11-20 Thomas Jefferson University Methods of treatment and prevention of neurodegenerative diseases and disorders
WO2008154644A1 (en) * 2007-06-12 2008-12-18 Case Western Reserve University Targeted cell death
WO2009047362A2 (en) * 2007-10-12 2009-04-16 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Method for opening tight junctions
WO2011149354A1 (en) * 2010-05-28 2011-12-01 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Mirnas involved in the blood brain barrier function

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100278810A1 (en) 2007-05-24 2010-11-04 Frank Kuhnert Methods of Modulating Angiogenesis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008140449A1 (en) * 2007-05-11 2008-11-20 Thomas Jefferson University Methods of treatment and prevention of neurodegenerative diseases and disorders
WO2008154644A1 (en) * 2007-06-12 2008-12-18 Case Western Reserve University Targeted cell death
WO2009047362A2 (en) * 2007-10-12 2009-04-16 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Method for opening tight junctions
WO2011149354A1 (en) * 2010-05-28 2011-12-01 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Mirnas involved in the blood brain barrier function

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ABBOTT N J ET AL: "Structure and function of the blood-brain barrier", NEUROBIOLOGY OF DISEASE, BLACKWELL SCIENTIFIC PUBLICATIONS, OXFORD, GB, vol. 37, no. 1, 1 January 2010 (2010-01-01), pages 13 - 25, XP026765781, ISSN: 0969-9961, [retrieved on 20090805], DOI: 10.1016/J.NBD.2009.07.030 *
JEYASEELAN K ET AL: "MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion", STROKE, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 39, 1 February 2008 (2008-02-01), pages 959 - 966, XP003027601, ISSN: 0039-2499, [retrieved on 20080207], DOI: 10.1161/STROKEAHA.107.500736 *
KE-JIE YIN ET AL: "Peroxisome Proliferator-Activated Receptor delta Regulation of miR-15a in Ischemia-Induced Cerebral Vascular Endothelial Injury", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 30, no. 18, 1 May 2010 (2010-05-01), pages 6398 - 6408, XP002637213, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.0780-10.2010 *
WEKSLER B B ET AL: "Blood-brain barrier-specific properties of a human adult brain endothelial cell line", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, US, vol. 19, no. 13, 1 November 2005 (2005-11-01), pages 1872 - 1874, XP002658008, ISSN: 0892-6638, [retrieved on 20050901], DOI: 10.1096/FJ.04-3458FJE *

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Publication number Publication date
WO2013070079A8 (en) 2013-10-24
WO2013070079A2 (en) 2013-05-16

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