WO2013064919A9 - Quinazoline derivatives with hsp90 inhibitory activity - Google Patents

Quinazoline derivatives with hsp90 inhibitory activity Download PDF

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Publication number
WO2013064919A9
WO2013064919A9 PCT/IB2012/054649 IB2012054649W WO2013064919A9 WO 2013064919 A9 WO2013064919 A9 WO 2013064919A9 IB 2012054649 W IB2012054649 W IB 2012054649W WO 2013064919 A9 WO2013064919 A9 WO 2013064919A9
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitory activity
quinazoline derivatives
hsp90 inhibitory
diseases
compounds
Prior art date
Application number
PCT/IB2012/054649
Other languages
French (fr)
Other versions
WO2013064919A1 (en
Inventor
Raffaella Amici
Andrea Colombo
Stephen Martin Courtney
Ciro Mercurio
Christian Aldo Georges Napoleon Montalbetti
Annalisa MORTONI
Mario Varasi
Original Assignee
Dac Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dac Srl filed Critical Dac Srl
Publication of WO2013064919A1 publication Critical patent/WO2013064919A1/en
Publication of WO2013064919A9 publication Critical patent/WO2013064919A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Abstract

Compounds of general formula (I): or a stereoisomer, tautomer, polymorph, hydrate, solvate, or a pharmaceutically acceptable salt thereof, wherein R is as defined herein, are useful for the treatment of diseases and conditions which are mediated by excessive or inappropriate Hsp90 activity such as proliferative diseases, e.g. cancers, viral and fungal infections, neurodegenerative or inflammatory diseases or conditions. The invention also relates to the preparation of these compounds as well as to pharmaceutical compositions comprising them.
PCT/IB2012/054649 2011-11-03 2012-09-07 Quinazoline derivatives with hsp90 inhibitory activity WO2013064919A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001013A ITTO20111013A1 (en) 2011-11-03 2011-11-03 PHARMACEUTICAL COMPOUNDS
ITTO2011A001013 2011-11-03

Publications (2)

Publication Number Publication Date
WO2013064919A1 WO2013064919A1 (en) 2013-05-10
WO2013064919A9 true WO2013064919A9 (en) 2013-06-27

Family

ID=45373781

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2012/054649 WO2013064919A1 (en) 2011-11-03 2012-09-07 Quinazoline derivatives with hsp90 inhibitory activity

Country Status (2)

Country Link
IT (1) ITTO20111013A1 (en)
WO (1) WO2013064919A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2952968A1 (en) 2014-07-01 2016-01-07 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US10654802B2 (en) 2016-07-08 2020-05-19 Arizona Board Of Regents On Behalf Of The Unversit Indoline derivatives and method for using and producing the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006236557A1 (en) 2005-04-14 2006-10-26 Novartis Vaccines And Diagnostics Inc. 2-amino-quinazolin-5-ones as HSP90 inhibitors useful in treating proliferation diseases
JO2783B1 (en) 2005-09-30 2014-03-15 نوفارتيس ايه جي 2-Amino-7,8-Dihidro-6H-Pyrido(4,3-D)Pyrimidin-5-ones
GB2449293A (en) * 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
JP5524084B2 (en) 2008-02-01 2014-06-18 武田薬品工業株式会社 Oxime derivatives as HSP90 inhibitors

Also Published As

Publication number Publication date
ITTO20111013A1 (en) 2013-05-04
WO2013064919A1 (en) 2013-05-10

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