WO2013058582A3 - 당전이 효소를 이용한 안사마이신 배당체의 제조방법 - Google Patents

당전이 효소를 이용한 안사마이신 배당체의 제조방법 Download PDF

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Publication number
WO2013058582A3
WO2013058582A3 PCT/KR2012/008560 KR2012008560W WO2013058582A3 WO 2013058582 A3 WO2013058582 A3 WO 2013058582A3 KR 2012008560 W KR2012008560 W KR 2012008560W WO 2013058582 A3 WO2013058582 A3 WO 2013058582A3
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WO
WIPO (PCT)
Prior art keywords
ansamycin
glycoside
backbone
glycosyltransferase
preparation
Prior art date
Application number
PCT/KR2012/008560
Other languages
English (en)
French (fr)
Other versions
WO2013058582A2 (ko
Inventor
김중수
홍영수
우미희
전효곤
오성주
Original Assignee
한국생명공학연구원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020110106457A external-priority patent/KR101456174B1/ko
Application filed by 한국생명공학연구원 filed Critical 한국생명공학연구원
Priority claimed from KR1020120115816A external-priority patent/KR101414724B1/ko
Publication of WO2013058582A2 publication Critical patent/WO2013058582A2/ko
Publication of WO2013058582A3 publication Critical patent/WO2013058582A3/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Abstract

본 발명은 당전이 효소를 이용한 안사마이신 배당체 또는 안사마이신 골격을 갖는 비-벤조퀴논 젤다나마이신 배당체의 제조방법, 비-벤조퀴논 젤다나마이신 배당체 및 이를 유효성분으로 함유하는 암 질환 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명은 안사마이신 또는 안사마이신 골격을 갖는 비-벤조퀴논 젤다나마이신 화합물에 글루코실기를 도입함으로써, 용해도가 상승하고, 생체 내 이용률을 높일 수 있으며, 안사마이신계 화합물의 활성을 유지하므로 항생제, 항진균제, 항바이러스제, 면역억제제, 퇴행성 신경질환제, 항염증제 또는 항암제로 유용하게 사용될 수 있다.
PCT/KR2012/008560 2011-10-18 2012-10-18 당전이 효소를 이용한 안사마이신 배당체의 제조방법 WO2013058582A2 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
KR10-2011-0106456 2011-10-18
KR20110106456 2011-10-18
KR10-2011-0106457 2011-10-18
KR1020110106457A KR101456174B1 (ko) 2011-10-18 2011-10-18 용해도가 증가된 비―퀴논 젤다나마이신 당전이 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이의 열충격 단백질(Ｈｓｐ90) 에이티피아제(ＡＴＰａｓｅ) 활성 저해용 약학적 조성물
KR1020120115816A KR101414724B1 (ko) 2011-10-18 2012-10-18 당전이 효소를 이용한 안사마이신 배당체의 제조방법
KR10-2012-0115816 2012-10-18

Publications (2)

Publication Number Publication Date
WO2013058582A2 WO2013058582A2 (ko) 2013-04-25
WO2013058582A3 true WO2013058582A3 (ko) 2013-07-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/008560 WO2013058582A2 (ko) 2011-10-18 2012-10-18 당전이 효소를 이용한 안사마이신 배당체의 제조방법

Country Status (1)

Country Link
WO (1) WO2013058582A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014185717A1 (ko) * 2013-05-15 2014-11-20 한국생명공학연구원 신규한 에포싸일론 유도체 및 그의 용도

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2292271A2 (en) * 2001-10-10 2011-03-09 BioGeneriX AG Remodelling and glycoconjugation of an antibody

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2292271A2 (en) * 2001-10-10 2011-03-09 BioGeneriX AG Remodelling and glycoconjugation of an antibody

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
WU, CHENG-ZHU ET AL.: "New non-quinone geldanamycin analogs from genetically engineered Streptomyces hygroscopicus", THE JOURNAL OF ANTIBIOTICS, vol. 64, March 2011 (2011-03-01), pages 461 - 463 *
WU, CHENG-ZHU: "Heat shock protein 90 inhibitors geldanamycin analogs from genetically engineered Streptomyces hygroscopicus", PH. D. THESIS, September 2011 (2011-09-01) *
ZHAO, P. ET AL.: "Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins", CHEMISTRY & BIOLOGY, vol. 15, 2008, pages 863 - 874, XP025533992, DOI: doi:10.1016/j.chembiol.2008.06.007 *

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Publication number Publication date
WO2013058582A2 (ko) 2013-04-25

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