WO2013058484A3 - 인제난 타입의 디테르펜 화합물 및 이를 포함하는 바이러스 감염 질환의 치료 또는 예방용 약학적 조성물 - Google Patents

인제난 타입의 디테르펜 화합물 및 이를 포함하는 바이러스 감염 질환의 치료 또는 예방용 약학적 조성물 Download PDF

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Publication number
WO2013058484A3
WO2013058484A3 PCT/KR2012/007897 KR2012007897W WO2013058484A3 WO 2013058484 A3 WO2013058484 A3 WO 2013058484A3 KR 2012007897 W KR2012007897 W KR 2012007897W WO 2013058484 A3 WO2013058484 A3 WO 2013058484A3
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WO
WIPO (PCT)
Prior art keywords
viral infectious
infectious diseases
treating
ingenane
pharmaceutical composition
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PCT/KR2012/007897
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English (en)
French (fr)
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WO2013058484A2 (ko
Inventor
오세량
김재화
이형규
키엡피셋
김두영
김정희
송재성
안경섭
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한국생명공학연구원
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Priority to CN201280062594.8A priority Critical patent/CN104024212B/zh
Priority to EP12841496.8A priority patent/EP2769973B1/en
Priority to US14/352,978 priority patent/US9481630B2/en
Publication of WO2013058484A2 publication Critical patent/WO2013058484A2/ko
Publication of WO2013058484A3 publication Critical patent/WO2013058484A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/93—Spiro compounds
    • C07C2603/95—Spiro compounds containing "not free" spiro atoms
    • C07C2603/98—Spiro compounds containing "not free" spiro atoms containing at least one ring with more than six ring members

Abstract

본 발명은 감수 유래 인제난 타입의 디테르펜 화합물 및 이를 포함하는, 바이러스 감염 질환의 치료 또는 예방용 약학적 조성물, 바이러스 감염 질환의 예방 또는 개선용 건강기능식품 및 인터페론 감마 생산 증강용 조성물에 관한 것이다. 또한, 본 발명은 상기 조성물을 치료 유효량으로 바이러스 감염질환의 발병 또는 발병가능성이 있는 개체에게 투여하는 단계를 포함하는, 바이러스 감염 질환의 예방 또는 치료 방법에 관한 것이다.
PCT/KR2012/007897 2011-10-19 2012-09-28 인제난 타입의 디테르펜 화합물 및 이를 포함하는 바이러스 감염 질환의 치료 또는 예방용 약학적 조성물 WO2013058484A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201280062594.8A CN104024212B (zh) 2011-10-19 2012-09-28 巨大戟烷型二萜化合物及含有它的用于治疗或预防病毒感染疾病的药物组合物
EP12841496.8A EP2769973B1 (en) 2011-10-19 2012-09-28 Ingenane-type diterpene compound, and pharmaceutical composition for treating or preventing viral infectious diseases
US14/352,978 US9481630B2 (en) 2011-10-19 2012-09-28 Ingenane-type diterpene compound, and pharmaceutical composition for treating or preventing viral infectious diseases containing same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2011-0107175 2011-10-19
KR1020110107175A KR101406201B1 (ko) 2011-10-19 2011-10-19 인제난 타입의 디테르펜 화합물 및 이를 포함하는 바이러스 감염 질환의 치료 또는 예방용 약학적 조성물

Publications (2)

Publication Number Publication Date
WO2013058484A2 WO2013058484A2 (ko) 2013-04-25
WO2013058484A3 true WO2013058484A3 (ko) 2013-07-04

Family

ID=48141508

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/007897 WO2013058484A2 (ko) 2011-10-19 2012-09-28 인제난 타입의 디테르펜 화합물 및 이를 포함하는 바이러스 감염 질환의 치료 또는 예방용 약학적 조성물

Country Status (5)

Country Link
US (1) US9481630B2 (ko)
EP (1) EP2769973B1 (ko)
KR (1) KR101406201B1 (ko)
CN (1) CN104024212B (ko)
WO (1) WO2013058484A2 (ko)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
CN104447633A (zh) * 2014-11-28 2015-03-25 天津耀宇生物技术有限公司 一种萜类化合物的制备方法
CN106928063B (zh) * 2015-12-31 2020-09-01 上海鑫昊生物科技有限公司 巨大戟二萜醇类化合物及其在抗hiv潜伏治疗上的应用
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
CN107653293B (zh) * 2016-07-24 2021-01-26 复旦大学 特异位点羟基化巨大戟烷型二萜衍生物的制备方法
US10982232B2 (en) 2016-07-27 2021-04-20 The Regents Of The University Of California Diterpene synthases and their use for production of diterpenes
CN108524448B (zh) * 2017-03-02 2019-10-18 新疆维吾尔自治区药物研究所 一种大戟二烯醇抗白内障眼用制剂及其制备方法和用途
CN110251495B (zh) * 2018-03-12 2022-05-31 重庆医科大学 20-脱氧巨大戟二萜醇在制备抑制hbv复制的药物中的应用
CN112107571A (zh) * 2019-06-20 2020-12-22 上海鑫昊生物科技有限公司 巨大戟二萜醇类化合物及其衍生物在抗hiv治疗上的应用
CN113968837B (zh) * 2021-11-12 2022-09-06 中国科学院兰州化学物理研究所 具有抗癫痫活性的化合物及其在制备抗癫痫药物中的应用

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Also Published As

Publication number Publication date
US20140371311A1 (en) 2014-12-18
US9481630B2 (en) 2016-11-01
EP2769973A4 (en) 2015-04-08
EP2769973A2 (en) 2014-08-27
CN104024212A (zh) 2014-09-03
WO2013058484A2 (ko) 2013-04-25
KR20130042990A (ko) 2013-04-29
CN104024212B (zh) 2016-01-20
EP2769973B1 (en) 2018-09-12
KR101406201B1 (ko) 2014-06-12

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