WO2013034594A1 - Récipient pharmaceutique, procédé de fabrication de ce récipient, et kit comportant ce récipient pharmaceutique - Google Patents

Récipient pharmaceutique, procédé de fabrication de ce récipient, et kit comportant ce récipient pharmaceutique Download PDF

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Publication number
WO2013034594A1
WO2013034594A1 PCT/EP2012/067315 EP2012067315W WO2013034594A1 WO 2013034594 A1 WO2013034594 A1 WO 2013034594A1 EP 2012067315 W EP2012067315 W EP 2012067315W WO 2013034594 A1 WO2013034594 A1 WO 2013034594A1
Authority
WO
WIPO (PCT)
Prior art keywords
seal
cap
container
relative
gripping member
Prior art date
Application number
PCT/EP2012/067315
Other languages
English (en)
Inventor
Leif Engmann Kristensen
Camilla DAMGAARD-SØRENSEN
Jens Peter Jensen
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of WO2013034594A1 publication Critical patent/WO2013034594A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/243—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes combined with an opening device
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/18—Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
    • B65D51/20—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing

Definitions

  • the present invention relates to a pharmaceutical container for holding a pharmaceutical product, a method of providing a pharmaceutical container, and a kit comprising a pharmaceutical container and a syringe. More specifically, the present invention relates to a pharmaceutical container having a container body, a plug seal for sealing off an opening of the container body, a seal cap for retaining the plug seal relative to the container body, an outer cap covering a portion of the seal cap and a gripping member for separating the outer cap from the seal cap.
  • Liquid pharmaceutical products for application to a patient by a syringe are typically packaged in containers which are sealed with a stopper inserted into a neck of the container.
  • Such containers may either be provided filled with the liquid medication or filled with a powdered drug that is to be reconstituted with a diluent prior to administration.
  • a metallic seal cap is typically applied over the exterior opening of the neck to cover the end of the rubber stopper. The seal cap is secured to the neck by crimping the cap seal around a shoulder of the neck.
  • the seal cap includes a small diameter hole at its centre, facilitating the insertion of a needle of the syringe into the container.
  • FIG. 1 a represents a prior art solution (disclosed in WO 2006/041965 A2) of a closure 10 for a pharmaceutical container wherein a removable outer cap 17 is attached over the seal cap 1 1 .
  • the mechanism for attaching the outer cap 17 to the seal cap 1 1 is expressly designed to be altered when the outer cap is removed from the seal cap, thus preventing replacement of the outer cap on the seal cap. Consequently, the absence of the outer cap 17 on a container is a positive indication that access to the medicament has been attempted or tampering of the container has been made.
  • Such an outer cap is.
  • the outer cap 17 is attached to the seal cap 1 1 and subsequently the seal cap/outer cap assembly is secured to the container body 12 by means of a crimping operation.
  • this type of outer cap is generally attractive. In addition it also provides a reliable and effective tamper evidence.
  • in pharmaceutical containers of the above kind due to the outer cap being somewhat diminutive, inexperienced users may by mistake attempt to penetrate the closure of the container with the needle while the outer cap is still being attached to the container. Such attempt may lead to the needle becoming bent and not suitable for the subsequent injection.
  • the diminutive nature of the outer cap does not offer an ergonomic grip. This may be a problem to some users.
  • Fig. 1 b represents another prior art solution originally disclosed in US 5,334,178 wherein a container closure includes an outer cap (seal 80) that is provided with a laterally extending tab portion 82 to facilitate removal of the outer cap 80.
  • a seal cap 30 is secured to the container body, but in this reference the outer cap 80 is attached to the seal cap 30 by means of a ridge 84 protruding radially inwards from a side wall of the outer cap that engages a groove 35 formed in a sidewall of the seal cap 30.
  • the outer cap 80 provides an improved grip, a similar or larger extending grip portion cannot be readily formed in the type of closure disclosed in fig. 1 a without interfering with the crimping operation for securing the seal cap to the container body.
  • the present invention relates to a pharmaceutical container for accommodating a pharmaceutical product.
  • the pharmaceutical container comprises: a container body having a wall section and a flange section defining an opening, a pierceable seal cooperating with the flange section of the container body to seal off the opening of the container body, the pierceable seal being adapted to be pierced by a needle cannula to gain access to the pharmaceutical product, a seal cap cooperating with the flange section of the container body and securing the pierceable seal relative to the flange section of the container body, the seal cap defining a seal cap opening through which access to the pierceable seal is enabled, an outer cap removably connected relative to the seal cap to seal the seal cap opening and enabling, upon removal of the outer cap relative to the seal cap, access to the pierceable seal through the seal cap opening, and a gripping member, the gripping member being formed separately from the outer cap but relatively connectable thereto, the gripping member defining first and second portions, the first portion being adapted for being mounted relative to the outer cap and the second portion being adapted to
  • a particular user- friendly and ergonomic solution is provided which at the same time visually indicates the need of operating the gripping member relative to the container body as an initial step. In this way, even first-time users of such pharmaceutical containers will be able to correctly gain access to the contents of the container. Hence, confusion and erroneous usage of the pharmaceutical container may be avoided.
  • the gripping member when specifying that the gripping member removes the outer cap relative to the seal cap, it implies that the outer cap is at least partially separated from the seal cap to enable needle access to the plug seal.
  • the outer cap may be removed from the seal cap even though the outer cap will still be loosely connected relative to the seal cap after operation of the gripping member but allowing a syringe needle to directly penetrate the pierceable seal.
  • the outer cap is fully separated from the cap seal.
  • the gripping member may be a member non-integrally formed relative to the outer cap but which is subsequently mounted onto or relative to the outer cap.
  • the pierceable seal may be provided as a plug having a section that enters into the opening of the flange section of the container body.
  • the pierceable seal may be generally disc shaped having a surface adapted to make sealing contact with the upper surface of the flange section of the container body.
  • the seal cap may be beaded onto the flange section of the container body to secure the pierceable seal relative to the flange section of the container body.
  • the seal cap is non-removably attached to the flange section.
  • the seal cap is beaded onto the flange section of the container body through 360 degrees of rotation to secure the pierceable seal relative to the flange section of the container body.
  • the outer cap may be fastened relative to the seal cap to thereby form an assembly that is subsequently secured relative to the flange section of the container.
  • the outer cap may be fastened relative to the seal cap by any suitable methods such as by a thermoforming process.
  • the means for fastening the outer cap relative to the seal cap may include retaining elements extending from the outer cap and engaging the seal cap and/or vice versa. Said retaining elements may be adapted to fracture during initial use of the container for preparing the container for needle penetration, i.e. during the initial procedure where the outer cap is removed from the seal cap, this procedure being carried out by operation of the gripping member.
  • the gripping member prior to being operated to remove the outer cap relative to the seal cap, is adapted to extend from the outer cap and at least partly along the container body towards an end of the container body distant from said opening of the container body.
  • the container may define a total height in the upright position, wherein the gripping member, prior to being operated to remove the outer cap relative to the seal cap, is adapted to extend from the outer cap and generally parallel with the container body along a substantial height of the container body, such as more than 25% of the height of the container, such as more than 40% of the height of the container, such as more than 50% of the height of the container, such as more than 75% of the height of the container and such as more than 90% of the total height of the container.
  • the container body may be of the kind having a main wall section and a reduced neck portion connecting the main wall section with the flange section.
  • the gripping member prior to being operated to remove the outer cap relative to the seal cap, may in some embodiments be adapted to extend from the outer cap and at least partly overlapping said reduced neck portion towards an end of the container body distant from said opening of the container body.
  • the gripping member In a storage state of the container, the gripping member may be arranged generally parallel to a central axis of the container body.
  • the second portion of the gripping member may define an open loop section adapted to receive a finger of a user.
  • Other embodiments may define a pull tab having serrated profile for increasing grip when grabbed between two fingers and pulled.
  • the first portion of the gripping member may be mounted relative to the outer cap by means of a mechanical engagement.
  • exemplary embodiments include a snap fit engagement, a friction fit engagement, a threaded engagement and a bayonet coupling engagement.
  • Alternative engagements between the first portion of the gripping member and the outer cap may be provided by the gripping member being adhered, glued or fused relative to the outer cap.
  • the present invention relates to a pharmaceutical kit comprising a pharmaceutical container according to the first aspect.
  • the base part of the container (a) may be arranged to form a first entity including the container body, the seal, the seal cap and the outer cap.
  • the gripping member (b) forms a second entity that may be arranged either pre-mounted relative to the outer cap or arranged separated therefrom.
  • the pharmaceutical kit further comprises a syringe (c) having a needle cannula attached at one end to cooperate with the pierceable seal of the pharmaceutical container, and d) a casing accommodating the pharmaceutical container and the syringe.
  • the syringe has a removable needle cap covering the needle cannula.
  • the gripping member of the container comprises a first indicia and the needle cap of the syringe comprises a second indicia wherein the first and second indicia indicates an operating sequence of firstly removal of the outer cap of the pharmaceutical container by means of operating the gripping member relative to the container body to enable access to the pierceable seal and subsequent removal of the needle cap from the syringe to expose the needle cannula.
  • the necessary steps for preparing the container and the needle may be safely performed enabling the penetration of the pierceable seal of the container by the needle cannula.
  • the syringe of the kit may be of the prefilled kind, such as being prefilled with a diluent or a pharmaceutical composition for mixing with the contents of the container.
  • the kit comprises first and second containers where each container is provided in accordance with the first aspect. Also, such kit may be provided with different indicia to indicate proper operating sequence.
  • the present invention relates to a method of manufacturing a pharmaceutical container according to the first aspect.
  • the method of providing a pharmaceutical container may comprise the steps of: a) providing a container body, the container body having a wall section and a flange section defining an opening, b) providing a pierceable seal and arranging the pierceable seal relative to the flange section of the container body, c) providing a seal cap for cooperating with the flange section of the container body and for securing the pierceable seal relative to the flange section of the container body, the seal cap defining a seal cap opening through which access to the pierceable seal is enabled, d) providing an outer cap and connecting the outer cap relative to the seal cap to seal the seal cap opening, e) securing the seal cap to the flange section to secure the pierceable seal relative to the flange section, and f) providing a gripping member, the gripping member and the outer cap being adapted to be relatively connected, the gripping member defining first and second portions, the first portion being adapted to be mounted relative to the outer cap, the second portion
  • step e) the step of securing the seal cap to the flange section includes the step of beading the outer cap onto the flange section of the container body.
  • the method step d) may be carried out prior to the method step e).
  • the method may further include the step of operating the second portion of the gripping member by manually operating the gripping member relative to the container body to thereby remove the outer cap relative to the seal cap to enable access to the pierceable seal.
  • Fig. 1 a and 1 b show two different prior art pharmaceutical containers
  • Fig. 2 is a cross sectional view of an embodiment of a pharmaceutical container in accordance with the present invention comprising a container assembly including an outer cap and a gripping member attached to the outer cap,
  • Fig. 3 is a perspective view of the pharmaceutical container shown in fig. 2, but prior to the subsequent assembling operation between the container assembly and the gripping member
  • Fig. 4a is a perspective view of the pharmaceutical container shown in fig. 3, after the assembling operation between the container assembly and the gripping member
  • Fig. 4b is a perspective view of the pharmaceutical container shown in fig. 4a, wherein the gripping member has been initially lifted for removing the outer cap of the container assembly,
  • Fig. 5 is a side view of a syringe adapted for cooperation with the pharmaceutical container shown in figs. 3, 4a and 4b, and
  • Fig. 6 is a side view of a pharmaceutical kit according to the second aspect of the invention comprising a pharmaceutical container as shown in figs. 3, 4a and 4b, a syringe as shown in fig. 5 and a casing holding the container and the syringe.
  • FIG. 2 shows a cross sectional view of an embodiment of a pharmaceutical container 100 in accordance with the present invention comprising a container assembly 200 including an outer cap 240 and a gripping member 300 attached to the outer cap 240.
  • the container body generally designated with reference numeral 210 has a longitudinally extending cylindrical wall integrally formed with a base portion to provide an internal volume for containing a liquid medication.
  • Wall structure and base may be fabricated from any suitable material, such as glass, polycarbonate plastic material or any other relatively inert material which is non-reactive with the medication to be contained.
  • a reduced diameter neck portion 212 connects the cylindrical wall with an outwardly extending flange section 21 1 .
  • the flange forms an opening leading into an interior cavity of the container body 210.
  • the flange section 21 1 provides a lower abutment edge for engagement with the lower inwardly extending edge portion 232 of a seal cap 230.
  • seal cap 230 is fabricated from soft aluminium that is beaded onto the flange section 21 1 all the way around the circumferential edge.
  • seal cap 230 has a central seal cap opening 231 that enable access to the container interior.
  • a pierceable seal 220 Positioned between the flange section 21 1 and the seal cap 230 is the top section of a pierceable seal 220.
  • the lower section of pierceable seal cap 220 forms a plug section that extends into the opening formed in flange section 21 1 .
  • Pierceable seal 220 may be fabricated by any suitable material capable of providing a tight fluid seal with the container body 210 while being penetrable by an injection needle or other fluid communication means such as a spike. Suitable materials for use in fabricating pierceable seal 220 are butyl rubber, latex and silicone, but other materials may be used as well. Also composite seal members may be used, for example provided as a layered product.
  • container assembly 200 comprises a cylindrical outer cap 240 which serves as a lid for sealing off the upper part of seal cap 230 until the container assembly 200 is put into initial use.
  • the outer cap 240 includes a round going external ridge 241 .
  • the outer cap 240 may be attached relative to the seal cap 230 so that removal of outer cap 240 from seal cap 230 prevents the outer cap 240 to be refitted relative to seal cap 230.
  • outer cap 240 serves additionally as a tamper indicating means. In the embodiment shown in fig.
  • the outer cap 240 includes a one or more retaining elements 242 each of which, in the storage state of the container, grips beneath the seal cap opening 231 so as to retain the outer cap 240 relative to the seal cap 230.
  • the one or more retaining elements may be provided by means of a disc shaped member that extends beneath the rim of seal cap opening 231 to thereby facilitate retaining of the outer cap 240 relative to the seal cap 230.
  • the retaining elements 242 may be designed to break off from outer cap 240. In other embodiments the retaining elements and the seal cap may be designed so that the retaining element(s) slips free from seal cap 230 once a predetermined force has been applied on the outer cap relative to the container body 210.
  • the container assembly 200 in the embodiment shown in fig. 2, generally corresponds to pharmaceutical containers that are commercially available.
  • the pharmaceutical container 100 further comprises a grip member 300 that is assembled relative to the outer cap 240 of container assembly 200 once the outer cap 240 and the seal cap 230 has been attached relative to the container body 210.
  • Fig. 3 shows the container assembly 200 and the gripping member 300 during the assembly process.
  • Gripping member 300 includes a first portion 310 defining a cylindrical opening that is adapted to receive the top portion of the outer cap 240.
  • the first portion 310 further comprises a first set of protrusions 312 and a second set of protrusions 31 1 both sets of protrusions extending radially inwards from the cylindrical opening of first portion 310.
  • the gripping member 300 at an end opposite to the first portion 310, includes a second portion 320 that is formed as a gripping tab that may easily be gripped and manipulated by the fingers of a user's hand.
  • the tab forms an open loop 321 which permits a finger of the user to be received into the loop 321.
  • the gripping member 300 When the outer cap 240 of the container assembly 200 is inserted into the cylindrical opening of the first portion 310 of the gripping member 300, the external ridge 241 of the outer cap 240 is snapped into engagement between the two sets of protrusions 31 1 and 312 (see fig. 2 and fig. 4a). Hence, the first portion 310 of the gripping member 300 is attached permanently to the outer cap 240, i.e. with a sufficient holding engagement that permits the movements of gripping member to be transferred to the outer cap 240. When the gripping member 300 has been attached to the container assembly 200, i.e.
  • the gripping member in the storage state of container 100, the gripping member extends from the outer cap 240 along the side of the container body 210 towards the bottom part along a substantial part of the total height of the container 100. Hence, an easily grabbed finger tab is formed which at the same time visually indicates that the gripping member 300 is to be operated before attempting to penetrate the liquid seal forming the top of the container 100.
  • Gripping member 300 may be made of a relatively soft plastic material or other material offering a suitable flexibility for the gripping member to bend as it is operated. In other embodiments, the gripping member may be made of a relatively stiff material offering only limited flexure.
  • the gripping member 300 includes a reduced width section 315 that bridges the first 310 and the second portion 320.
  • the reduced width section 315 enables the second portion 320 to be pulled sideways/upwards away from the sidewall of the container body 210 into the intermediate position shown in fig. 4b, while the outer cap 240 still remaining attached to the seal cap 230.
  • the outer cap 240 is pulled away from seal cap 230 upon fracturing of the retaining members 242 relative to the seal cap 230.
  • the pierceable seal 222 is exposed through the seal cap opening 231 enabling a needle of a syringe to penetrate through the pierceable seal.
  • the container 100 is made ready for use.
  • the process of preparing pharmaceutical containers accommodating a pharmaceutical product of the above described kind for shipment to a distributor may in some embodiments include the steps of: (1 ) sterilizing an empty container, (2) filling the container with a medicament, (3) placing the pierceable seal in or on the neck of the container, (4) attaching the outer cap to the seal cap, (5) sealing the end of the container with the seal cap/outer cap assembly, (6) sterilizing the sealed container, (7) labeling the container with the contents of the container and other information related to the manufacturing history and (8) attaching a gripping member relative to the outer cap.
  • a conventional syringe 400 which includes a barrel 410, a plunger 420 a needle connected to the barrel and a needle cap 440 sealing off and protecting the needle.
  • the syringe 400 and a pharmaceutical container 100 may be arranged as a kit including a casing 500 or other receptacle suitable for storing or carrying the kit.
  • a kit is shown in fig. 6 which shows a casing having a base and a lid and supporting members holding the syringe 400 separate but aligned relative to the container 100 so that the needle end of the syringe points towards the container closure.
  • the syringe 400 may be prefilled with a diluent while the container 100 may accommodate a lyophilized product.
  • the kit includes all the necessary elements for reconstituting a pharmaceutical product and subsequently injecting the reconstituted product into a patient.
  • the gripping member 300 may include an first indicia 316 such as the number “1 ", the letter “A”, Roman letter ⁇ ” or similar
  • the needle cap 440 may include a second indicia 446 such as the number "2", the letter “B”, roman letter “M” or similar.
  • the first indicia 316 and second indicia 446 indicates the proper sequence order for preparing the contents of the kit once the casing 500 has been opened. Hence the risk of human errors in preparing the injection or the risk of the user becoming confused will to a large degree be avoided.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention concerne un récipient pharmaceutique (100) comprenant un corps de récipient (210), un bouchon à percer (220), un anneau d'étanchéité de bouchon (230), une capsule arrachable (240), et un élément de préhension (300). L'élément de préhension (300) et la capsule arrachable (240) sont sensiblement solidaires l'un de l'autre, bien que formés indépendamment l'un de l'autre. L'élément de préhension (300) définit une première partie (310) montée sur la capsule arrachable (240) et une seconde partie (320) conçue pour être saisie manuellement par un utilisateur. La forme de l'élément de préhension (300) est conçue de façon que, lorsqu'un utilisateur déplace la seconde partie (320) de l'élément de préhension (300) par rapport au corps du récipient (210), l'élément de préhension (300) sépare de l'anneau d'étanchéité de bouchon (230) la capsule arrachable (240), donnant ainsi accès au bouchon à percer (220). L'invention concerne également un kit pharmaceutique et un procédé de réalisation d'un récipient pharmaceutique (100).
PCT/EP2012/067315 2011-09-06 2012-09-05 Récipient pharmaceutique, procédé de fabrication de ce récipient, et kit comportant ce récipient pharmaceutique WO2013034594A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP11180295 2011-09-06
EP11180295.5 2011-09-06
US201161533367P 2011-09-12 2011-09-12
US61/533,367 2011-09-12

Publications (1)

Publication Number Publication Date
WO2013034594A1 true WO2013034594A1 (fr) 2013-03-14

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015029580A1 (fr) * 2013-09-02 2015-03-05 大成化工株式会社 Capuchon pour flacon
CN113133939A (zh) * 2020-01-16 2021-07-20 A·雷蒙德公司 供具有颈部的容器用的具有带刻痕紧固凸耳的帽的锁定盖
WO2022231885A1 (fr) * 2021-04-26 2022-11-03 Corning Incorporated Système de fermeture de récipient et ensembles d'étanchéité pour maintenir l'intégrité du joint à basses températures de stockage
WO2023034088A1 (fr) * 2021-08-31 2023-03-09 Corning Incorporated Système de fermeture de récipient et ensembles de scellement pour maintenir l'intégrité du scellé aux basses températures de stockage
US11642280B2 (en) 2020-11-10 2023-05-09 Corning Incorporated Glass containers and sealing assemblies for maintaining seal integrity at low storage temperatures
WO2023091319A1 (fr) * 2021-11-22 2023-05-25 Corning Incorporated Conceptions de capuchon pour des systèmes de fermeture de récipient pharmaceutique
US11963928B2 (en) 2021-09-30 2024-04-23 Corning Incorporated Glass containers for storing pharmaceutical compositions

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LU88465A1 (fr) * 1994-03-14 1995-10-02 Fernando Borsano Décapsuleuse de bouchon pour bouteilles
WO2006041965A2 (fr) 2004-10-07 2006-04-20 West Pharmaceutical Services, Inc. Fermeture pour recipeint
US7296498B1 (en) * 2006-10-16 2007-11-20 Il Koo Kim Attached disposable bottle opener
US20100078404A1 (en) 2007-03-13 2010-04-01 Alcan Packaging Capsules Cap lifter for plugging cap, plugging assembly including a cap and said cap lifter

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FR1530677A (fr) * 1967-05-19 1968-06-28 Perfectionnement au bouchage des récipients
US3480172A (en) * 1968-04-09 1969-11-25 Baxter Laboratories Inc Reclosed package
DE2015629A1 (de) * 1970-04-02 1971-10-21 Feinermann, Roland, 2000 Hamburg Vorrichtung zum Offnen eines Kronen Verschlusses fur Flaschen
US4482071A (en) 1981-10-16 1984-11-13 Olympus Optical Co., Ltd. Sealing aid for fastening a resilient plug inserted into an opening of a container
US5447247A (en) 1991-10-04 1995-09-05 Firma Pohl Gmbh & Co. Kg Sealing cap
US5405031A (en) 1992-11-19 1995-04-11 Firma Pohl Gmbh & Co. Kg Closure for a medicine bottle
US5334178A (en) 1993-04-14 1994-08-02 Habley Medical Technology Corporation Pierceable pharmaceutical container closure with check valve
LU88465A1 (fr) * 1994-03-14 1995-10-02 Fernando Borsano Décapsuleuse de bouchon pour bouteilles
WO2006041965A2 (fr) 2004-10-07 2006-04-20 West Pharmaceutical Services, Inc. Fermeture pour recipeint
US7296498B1 (en) * 2006-10-16 2007-11-20 Il Koo Kim Attached disposable bottle opener
US20100078404A1 (en) 2007-03-13 2010-04-01 Alcan Packaging Capsules Cap lifter for plugging cap, plugging assembly including a cap and said cap lifter

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9555941B2 (en) 2013-09-02 2017-01-31 Taisei Kako Co., Ltd. Cap for vial
US9555940B2 (en) 2013-09-02 2017-01-31 Taisei Kako Co., Ltd. Cap for vial
JPWO2015029580A1 (ja) * 2013-09-02 2017-03-02 大成化工株式会社 バイアル用キャップ
WO2015029580A1 (fr) * 2013-09-02 2015-03-05 大成化工株式会社 Capuchon pour flacon
US12109172B2 (en) 2020-01-16 2024-10-08 A. Raymond Et Cie Locking cover for a container having a neck, with a cap having breakable securing tabs
CN113133939A (zh) * 2020-01-16 2021-07-20 A·雷蒙德公司 供具有颈部的容器用的具有带刻痕紧固凸耳的帽的锁定盖
WO2021144511A1 (fr) 2020-01-16 2021-07-22 A. Raymond Et Cie Coiffe de verrouillage pour recipient a col avec une capsule a pattes de fixation secables
FR3106339A1 (fr) * 2020-01-16 2021-07-23 A. Raymond Et Cie Coiffe de verrouillage pour recipient a col avec une capsule a pattes de fixation secables
US11642280B2 (en) 2020-11-10 2023-05-09 Corning Incorporated Glass containers and sealing assemblies for maintaining seal integrity at low storage temperatures
WO2022231885A1 (fr) * 2021-04-26 2022-11-03 Corning Incorporated Système de fermeture de récipient et ensembles d'étanchéité pour maintenir l'intégrité du joint à basses températures de stockage
WO2023034088A1 (fr) * 2021-08-31 2023-03-09 Corning Incorporated Système de fermeture de récipient et ensembles de scellement pour maintenir l'intégrité du scellé aux basses températures de stockage
US11963928B2 (en) 2021-09-30 2024-04-23 Corning Incorporated Glass containers for storing pharmaceutical compositions
US11963929B2 (en) 2021-09-30 2024-04-23 Corning Incorporated Glass containers for storing pharmaceutical compositions
US12076297B2 (en) 2021-09-30 2024-09-03 Corning Incorporated Glass containers for storing pharmaceutical compositions
US12076296B2 (en) 2021-09-30 2024-09-03 Corning Incorporated Glass containers for storing pharmaceutical compositions
US12090118B2 (en) 2021-11-22 2024-09-17 Corning Incorporated Cap design for pharmaceutical container closure systems
WO2023091319A1 (fr) * 2021-11-22 2023-05-25 Corning Incorporated Conceptions de capuchon pour des systèmes de fermeture de récipient pharmaceutique

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