WO2013032797A3 - Oxetane 3,3-dicarboxamide compounds and methods of making and using same - Google Patents

Oxetane 3,3-dicarboxamide compounds and methods of making and using same Download PDF

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Publication number
WO2013032797A3
WO2013032797A3 PCT/US2012/051790 US2012051790W WO2013032797A3 WO 2013032797 A3 WO2013032797 A3 WO 2013032797A3 US 2012051790 W US2012051790 W US 2012051790W WO 2013032797 A3 WO2013032797 A3 WO 2013032797A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxetane
compounds
dicarboxamide compounds
kdr
vegfr
Prior art date
Application number
PCT/US2012/051790
Other languages
French (fr)
Other versions
WO2013032797A2 (en
Inventor
Xiao-Tao Chen
Original Assignee
New Hope R & D Bioscience, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New Hope R & D Bioscience, Inc. filed Critical New Hope R & D Bioscience, Inc.
Publication of WO2013032797A2 publication Critical patent/WO2013032797A2/en
Publication of WO2013032797A3 publication Critical patent/WO2013032797A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

A novel series of oxetane 3,3-dicarboxamide compounds modulate protein kinase activity for modulating cellular activities such as proliferation, migration, differentiation, and programmed cell death. This novel series of oxetane 3,3-dicarboxamide compounds may inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDR (VEGFR-2) signal transduction pathways, thereby make them useful as anti-cancer agents. The pharmaceutical compositions that comprise these compounds are also useful in the treatment of diseases, other than cancers, which are associated with signal transduction pathways operating through growth factor and anti-angiogenesis receptors, such as c-Met, and KDR (VEGFR-2).
PCT/US2012/051790 2011-08-26 2012-08-22 Oxetane 3,3-dicarboxamide compounds and methods of making and using same WO2013032797A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161527870P 2011-08-26 2011-08-26
US61/527,870 2011-08-26

Publications (2)

Publication Number Publication Date
WO2013032797A2 WO2013032797A2 (en) 2013-03-07
WO2013032797A3 true WO2013032797A3 (en) 2014-05-22

Family

ID=47757123

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/051790 WO2013032797A2 (en) 2011-08-26 2012-08-22 Oxetane 3,3-dicarboxamide compounds and methods of making and using same

Country Status (1)

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WO (1) WO2013032797A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016004272A1 (en) 2014-07-02 2016-01-07 Pharmacyclics Llc Inhibitors of bruton's tyrosine kinase
CN105541798B (en) * 2016-02-03 2018-01-23 中国人民解放军第二军医大学 Quinolines Mutiple Targets kinase inhibitor with antitumor activity and preparation method thereof
CA3086522A1 (en) * 2017-12-20 2019-06-27 Angex Pharmaceutical, Inc. Carbamate and urea compounds as multikinase inhibitors
UY38349A (en) * 2018-08-30 2020-03-31 Array Biopharma Inc PYRAZOLO [3,4-B] PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES
CN110467616B (en) * 2019-07-01 2021-12-21 江西科技师范大学 Preparation and application of triazolopyrazine compound containing heteroaryl substituted pyridazinone structure
CN110407839B (en) * 2019-07-01 2022-01-04 江西科技师范大学 Preparation and application of triazole heterocyclic compound containing heteroaryl amide structure
WO2023227676A1 (en) 2022-05-25 2023-11-30 Basf Se Herbicidal malonic acid monoamides and malonamide esters

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080161305A1 (en) * 2005-04-06 2008-07-03 Exelixis, Inc. C-Met Modulators and Methods of Use
US20100093727A1 (en) * 2008-10-14 2010-04-15 Ning Xi Compounds and methods of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080161305A1 (en) * 2005-04-06 2008-07-03 Exelixis, Inc. C-Met Modulators and Methods of Use
US20100093727A1 (en) * 2008-10-14 2010-04-15 Ning Xi Compounds and methods of use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
SCHIERING ET AL.: "Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a", PNAS, vol. 100, no. 22, 28 October 2003 (2003-10-28), pages 12654 - 12659, XP002491742, Retrieved from the Internet <URL:http://www.pnas.org/content/100/22/12654.full.pdf+html> DOI: doi:10.1073/pnas.1734128100 *
TROST ET AL.: "Total Synthesis of (+)-Frondosin A. Application of the Ru-Catalyzed [5+2] Cycloaddition", JACS, vol. 129, 2007, pages 11781 - 11790 *
VALEUR ET AL.: "Amide bond formation: beyond the myth of coupling reagents", CHEM SOC REV, vol. 38, 2009, pages 606 - 631 *

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Publication number Publication date
WO2013032797A2 (en) 2013-03-07

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