WO2013013601A1 - 一种淡水鱼类抗病毒药 - Google Patents
一种淡水鱼类抗病毒药 Download PDFInfo
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- WO2013013601A1 WO2013013601A1 PCT/CN2012/078992 CN2012078992W WO2013013601A1 WO 2013013601 A1 WO2013013601 A1 WO 2013013601A1 CN 2012078992 W CN2012078992 W CN 2012078992W WO 2013013601 A1 WO2013013601 A1 WO 2013013601A1
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- freshwater fish
- chrysanthemum
- cork
- houttuynia
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- 241000251468 Actinopterygii Species 0.000 title claims abstract description 23
- 239000013505 freshwater Substances 0.000 title claims abstract description 23
- 230000000840 anti-viral effect Effects 0.000 title claims abstract description 7
- 239000003814 drug Substances 0.000 title abstract description 17
- 235000003130 Arctium lappa Nutrition 0.000 claims abstract description 9
- 241001529733 Nepeta Species 0.000 claims abstract description 7
- 240000005528 Arctium lappa Species 0.000 claims abstract 3
- 235000007516 Chrysanthemum Nutrition 0.000 claims description 11
- 239000007799 cork Substances 0.000 claims description 10
- 240000000691 Houttuynia cordata Species 0.000 claims description 9
- 235000013717 Houttuynia Nutrition 0.000 claims description 8
- 235000008078 Arctium minus Nutrition 0.000 claims description 7
- 241001061264 Astragalus Species 0.000 claims description 7
- 241001071795 Gentiana Species 0.000 claims description 7
- 240000002299 Symphytum officinale Species 0.000 claims description 7
- 235000005865 Symphytum officinale Nutrition 0.000 claims description 7
- 235000006533 astragalus Nutrition 0.000 claims description 7
- 210000004233 talus Anatomy 0.000 claims description 7
- 241000272814 Anser sp. Species 0.000 claims description 6
- 239000003443 antiviral agent Substances 0.000 claims description 5
- 244000025254 Cannabis sativa Species 0.000 claims description 4
- 244000227633 Ocotea pretiosa Species 0.000 claims description 2
- 235000004263 Ocotea pretiosa Nutrition 0.000 claims description 2
- 241000723353 Chrysanthemum Species 0.000 claims 3
- 241000272517 Anseriformes Species 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 abstract description 4
- 241000700605 Viruses Species 0.000 abstract description 3
- 241000928504 Centipeda minima Species 0.000 abstract 1
- 241001135871 Gentiana scabra Species 0.000 abstract 1
- 241000118844 Lithospermum purpurocaeruleum Species 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000252230 Ctenopharyngodon idella Species 0.000 description 3
- 229940125904 compound 1 Drugs 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 208000005374 Poisoning Diseases 0.000 description 2
- 241000207929 Scutellaria Species 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000009360 aquaculture Methods 0.000 description 2
- 244000144974 aquaculture Species 0.000 description 2
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- 239000000645 desinfectant Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
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- 229920000742 Cotton Polymers 0.000 description 1
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- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
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- 206010023126 Jaundice Diseases 0.000 description 1
- 241000239268 Leiurus quinquestriatus Species 0.000 description 1
- 241000218378 Magnolia Species 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
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- 229940126214 compound 3 Drugs 0.000 description 1
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- 239000000835 fiber Substances 0.000 description 1
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- 230000036541 health Effects 0.000 description 1
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- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910000069 nitrogen hydride Inorganic materials 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Definitions
- the invention belongs to the technical field of freshwater fish medicine, in particular to a freshwater fish antiviral medicine.
- the object of the present invention is to overcome the deficiencies of the prior art and to provide a freshwater fish antiviral drug which is safe and environmentally friendly.
- a freshwater fish antiviral drug characterized by: comprising the following components by weight: 35 to 45 parts of Daqingye, 25 to 35 parts of Nepeta, 25 to 35 parts of burdock, 15 of gentian ⁇ 25 servings, goose does not eat grass 15 ⁇ 25 parts and comfrey 15 ⁇ 25 parts.
- the component further includes any one of any of yellow scorpion, chrysanthemum, hunt, cork, and houttuynia, any two, any three, any four or five.
- the components further include 25 to 35 parts of astragalus, 15 to 25 parts of chrysanthemum, 15 to 25 parts of one hundred, 2 to 35 parts of cork, and 35 to 45 parts of houttuynia.
- the components are 40 parts of Folium Isatidis, 30 parts of Nepeta, 30 parts of burdock, 20 parts of gentian, and no goose 20 parts, 20 parts of comfrey, 30 parts of astragalus, 20 parts of chrysanthemum, 20 parts of 100 parts, 30 parts of cork and 40 parts of Houttuynia.
- the advantages and positive effects of the present invention are:
- the invention is based on the theory of traditional Chinese medicine, scientific compatibility, using modern scientific and technological means to quantitatively and semi-quantitatively test the active ingredients of most of the medicinal materials, and the finished product has a strong inhibitory effect on the poisoning of freshwater fish, and the synergy of each medicinal drug.
- the effect not only strengthens the inhibition of the virus, but also reduces the toxicity of the single-flavored drug, has a significant control effect on the viral disease, and is a traditional Chinese medicine with good curative effect, no pollution, no residue and convenient use, and is particularly suitable for use. For large-scale freshwater fish farms.
- a freshwater fish antiviral drug characterized by: comprising the following components by weight: Daqingye 35 ⁇
- Nepeta 25 ⁇ 35 parts 45 parts, Nepeta 25 ⁇ 35 parts, burdock 25 ⁇ 35 parts, gentian 15 ⁇ 25 parts, goose no herb 15 ⁇ 25 parts and comfrey 15 ⁇ 25 parts.
- Any one, any two, any three, any four or five kinds of jaundice, chrysanthemum, hunt, cork, and houttuy may be added to the above components.
- the most preferred components are 40 parts of Folium Isatidis, 30 parts of Nepeta, 30 parts of burdock, 20 parts of gentian, 20 parts of goose, 20 parts of comfrey, 30 parts of scutellaria, 20 parts of sassafras, 20 parts of chrysanthemum, and 100 parts. 20 servings, 30 servings of Cork and 40 copies of Houttuynia.
- the preparation method of the drug is:
- Each component is pulverized, and the pulverized particle size can all pass through a 40 mesh screen.
- the mixed semi-finished products are placed in an aluminum foil bag, and the finished product is obtained by weighing and sealing.
- the test process is as follows: 1.Comparative formula compound 1: 40 kg of Daqingye; 40 kg of Leiwan, 50 kg of crane, 20 kg of chrysanthemum, 40 kg of ⁇ 40 kg, 20 kg of 100 parts, 4 Q kg of angelica, stellar star 2 Q kg, 30 kg of cork, tamping 2 Q kg.
- Compound 2 Astragalus 4 Q kg, Codonopsis 4 Q kg, Magnolia 4 Q kg, Dilated 3 Q kg, Perrin 20 kg, 100 kg 30 kg, Gentleman 30 kg, Betel nut 20 kg, Astragalus 30 kg , 30 grams of burdock.
- the composition of the feed is composed of crude protein, carbohydrate, crude fat and crude fiber. It is divided into three parts and added to the above three kinds of compounds. The amount added is 0.5 g per company feed, and the drug is added.
- the material is processed into a hard particle having a diameter of 3.5 mm by a processing machine, and dried for use.
- the most preferred components have the best effect, can effectively prevent and treat bleeding diseases, and reduce the mortality of grass carp.
- the present invention is based on the theory of traditional Chinese medicine, scientific compatibility, using modern scientific and technological means to quantitatively and semi-quantitatively determine the active ingredients of most of the medicinal materials, and the finished product has a strong inhibitory effect on freshwater fish poisoning infection.
- Synergistic action of various herbs not only strengthens the inhibitory effect on the virus, but also reduces the toxicity of the single-flavored drug, has a significant control effect on the viral disease, is a good curative effect, no pollution, no residue, and is convenient to use.
- Chinese medicine especially suitable for large-scale freshwater fish farms.
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- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Alternative & Traditional Medicine (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
一种淡水鱼抗病毒药，包括按重量分数配比的以下成分：大青叶（35-45），荆芥（25-35），牛蒡子（25-35），龙胆草（15-25），鹅不食草（15-25）和紫草（15-25）。所述抗病毒药对淡水鱼类病毒有较强的抑制作用，适用于大规模淡水鱼类养殖场。
Description
一种淡水鱼类抗病毒药 技术领域
本发明属于淡水鱼药物技术领域， 尤其是一种淡水鱼类抗病毒药。
背景技术在农业产业调整过程中， 淡水养殖比重逐渐增大， 而水产类疫病成为制约淡 水养殖发展的重要因素。 在淡水鱼类养殖业中， 病毒性疾病以预防为主， 治疗也主要是应 用广谱消毒剂预防水质污染为主， 随之养殖规模的扩大， 疾病的发展及变异也越来越多， 采用现有消毒剂过多时会造成淡水鱼体内过量的药物残留， 对人们的身体健康造成了威 胁。
人们通过研究， 正逐渐采用中药来进行淡水鱼的防治工作， 但未取得较大的进展， 所 以急需一种疗效好、 无公害、 无残留、 使用方便的药物。
发明内容
本发明的目的在于克服现有技术的不足之处， 提供使用安全、 绿色环保的一种淡水鱼 类抗病毒药。
本发明采用的技术方案是：
一种淡水鱼类抗病毒药， 其特征在于： 包括按重量分数配比的以下组分： 大青叶 35〜 45份， 荆芥 25〜35份， 牛蒡子 25〜35份， 龙胆草 15〜25份， 鹅不食草 15〜25份和紫草 15〜25份。
而且， 所述组分还包括黄芩、 菊花、 百部、 黄柏、 鱼腥草之中的任意一种、 任意两种、 任意三种、 任意四种或五种。
而且， 所述组分还包括黄芩 25〜35份、 菊花 15〜25份、 百部 15〜25份、 黄柏 2〜35 份和鱼腥草 35〜45份。
而且， 所述组分为大青叶 40份、 荆芥 30份、 牛蒡子 30份、 龙胆草 20份、 鹅不食草
20份、 紫草 20份、 黄芩 30份、 菊花 20份、 百部 20份、 黄柏 30份和鱼腥草 40份。 本发明的优点和积极效果是：
本发明依据中药理论， 科学配伍， 运用现代科技手段对其中大部分药材的有效成分进 行定量、 半定量检测， 制得的成品对淡水鱼类毒毒感染有较强的抑制作用， 各味药协同作 用， 不仅加强了对病毒的抑制作用， 而且减少了单味药的毒性， 对病毒性疾病有显著的防 治效果， 是一种疗效好、 无公害、 无残留、 使用方便的中药， 特别适用于对大规模淡水鱼 类养殖场。
具体实》式
下面结合实施例， 对本发明进一步说明， 下述实施例是说明性的， 不是限定性的， 不 能以下述实施例来限定本发明的保护范围。
一种淡水鱼类抗病毒药， 其特征在于： 包括按重量分数配比的以下组分： 大青叶 35〜
45份， 荆芥 25〜35份， 牛蒡子 25〜35份， 龙胆草 15〜25份， 鹅不食草 15〜25份和紫草 15〜25份。
还可以在上述组分中加入黄芩、 菊花、 百部、 黄柏、 鱼腥草之中的任意一种、 任意两 种、 任意三种、 任意四种或五种。 其中黄芩 25〜35份、 菊花 15〜25份、 百部 15〜25份、 黄柏 2〜35份、 鱼腥草 35〜45份。
最优选的组分为大青叶 40份、 荆芥 30份、 牛蒡子 30份、 龙胆草 20份、 鹅不食草 20 份、 紫草 20份、 黄芩 30份、 菊花 20份、 百部 20份、 黄柏 30份和鱼腥草 40份。
该药物的制备方法是：
1.将各组分各自粉碎， 粉碎的粒度能全部通过 40目筛网即可。
2.将粉碎后的各组分依次称量、 复核。
3.将各组分加入 SBH-600高效混合机中， 混合时间为 25分钟。
4.将混合好的半成品装入铝箔袋中， 称量、 封口即制得成品。
试验过程为： 1.对比配方 复方 1 : 大青叶 40公斤； 雷丸 4 0公斤、 鹤虱 5 0公斤、 菊花 20公斤、 茯苓 4 0公 斤、 百部 20公斤、 当归 4 Q公斤、 胆星 2 Q公斤、 黄柏 30公斤、 枳实 2 Q公斤。 复方 2 : 黄芪 4 Q公斤、 党参 4 Q公斤、 厚朴 4 Q公斤、 续断 3 Q公斤、 佩兰 2 0公 斤、 百部 3 0公斤、 使君子 3 0公斤、 槟榔 2 0公斤， 黄芩 30公斤， 牛蒡子 30公斤。 最优选组份： 大青叶 40公斤； 荆芥 30公斤； 牛蒡子 30公斤； 龙胆草 20公斤； 鹅不 食草 20公斤； 紫草 20公斤； 黄芩 30公斤； 菊花 20公斤； 百部 20公斤； 黄柏 30公斤； 鱼腥草 40公斤。 2.伺料的成分 伺料由粗蛋白质、 碳水化合物、 粗脂肪和粗纤维构成， 分为三份， 分别加入上述三种 复方， 加入量为每公司伺料中加入 0.5克， 加入药物的伺料经伺料加工机制成直径 3.5毫 米的硬颗粒， 干燥后备用。
3.试验条件及管理 患草鱼出血病鱼种， 实验鱼共 80尾， 随机分养于 4个水族箱 (130 cmxlOO cmx80 cm) 中， 分别是复方 1、 2、 3组和对照组， 每组 20尾。 实验组投喂相应的伺料， 对照组投喂基础伺料， 投饵率均为 3%， 伺养 15天。 实验期间的水温在 19.4〜26.8°C ,有循环滤泵和充气泵， 定期换水和清洗滤棉， 维持溶 解氧在 5.7〜7.9 mg/L, pH值在 6.1〜8.0， 控制氨 (NH3)的浓度小于 0.02 mg/L,控制亚硝酸 盐 (N02-)的含量小于 0.20 mg/L。
4.试验结果如表 1所示 天数 0 3 5 7 1 5 对照 0 6 1 5 2 0
复方 1 0 5 1 2 2 0
表 1 : 草鱼的死亡统计
最优选的组份的效果最好， 能有效的防治出血病， 降低草鱼的死亡率。
综上所述， 本发明依据中药理论， 科学配伍， 运用现代科技手段对其中大部分药材的 有效成分进行定量、 半定量检测， 制得的成品对淡水鱼类毒毒感染有较强的抑制作用， 各 味药协同作用， 不仅加强了对病毒的抑制作用， 而且减少了单味药的毒性， 对病毒性疾病 有显著的防治效果， 是一种疗效好、 无公害、 无残留、 使用方便的中药， 特别适用于对大 规模淡水鱼类养殖场。
Claims
1、一种淡水鱼类抗病毒药，其特征在于：包括按重量分数配比的以下组分：大青叶 35〜 45份， 荆芥 25〜35份， 牛蒡子 25〜35份， 龙胆草 15〜25份， 鹅不食草 15〜25份和紫草 15〜25份。
2、根据权利要求 1所述的一种淡水鱼类抗病毒药， 其特征在于： 所述组分还包括黄芩、 菊花、 百部、 黄柏、 鱼腥草之中的任意一种、 任意两种、 任意三种、 任意四种或五种。
3、 根据权利要求 2所述的一种淡水鱼类抗病毒药， 其特征在于： 所述组分还包括黄芩 25〜35份、 菊花 15〜25份、 百部 15〜25份、 黄柏 2〜35份和鱼腥草 35〜45份。
4、 根据权利要求 2或 3所述的一种淡水鱼类抗病毒药， 其特征在于： 所述组分为大青 叶 40份、 荆芥 30份、 牛蒡子 30份、 龙胆草 20份、 鹅不食草 20份、 紫草 20份、 黄芩 30 份、 菊花 20份、 百部 20份、 黄柏 30份和鱼腥草 40份。
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| CN107155969A (zh) * | 2017-06-15 | 2017-09-15 | 合肥慧明瀚生态农业科技有限公司 | 一种鲤鱼的混养养殖方法 |
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| CN101417009A (zh) * | 2008-10-31 | 2009-04-29 | 天津必佳药业集团有限公司 | 一种抗禽流感中药组合物 |
| CN101757149A (zh) * | 2008-10-30 | 2010-06-30 | 天津生机集团股份有限公司 | 一种防治鱼类出血病的纯中药复方药物 |
| CN102266438A (zh) * | 2011-07-25 | 2011-12-07 | 鼎正动物药业（天津）有限公司 | 一种淡水鱼类抗病毒药 |
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| CN101757149A (zh) * | 2008-10-30 | 2010-06-30 | 天津生机集团股份有限公司 | 一种防治鱼类出血病的纯中药复方药物 |
| CN101417009A (zh) * | 2008-10-31 | 2009-04-29 | 天津必佳药业集团有限公司 | 一种抗禽流感中药组合物 |
| CN102266438A (zh) * | 2011-07-25 | 2011-12-07 | 鼎正动物药业（天津）有限公司 | 一种淡水鱼类抗病毒药 |
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| YUN, YUQIN ET AL.: "Development and application of Anti-bacteria and Anti-virus Chinese Herbal Medicine", SHANDONG JOURNAL OF ANIMAL HUSBANDRY AND VETERINARY SCIENCE, October 2002 (2002-10-01), pages 19 - 21 * |
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