CN105708960B - 治疗羊口疮的中药组合物 - Google Patents
治疗羊口疮的中药组合物 Download PDFInfo
- Publication number
- CN105708960B CN105708960B CN201610200026.XA CN201610200026A CN105708960B CN 105708960 B CN105708960 B CN 105708960B CN 201610200026 A CN201610200026 A CN 201610200026A CN 105708960 B CN105708960 B CN 105708960B
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- medicine composition
- mouth virus
- sheep
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 73
- 239000000203 mixture Substances 0.000 title claims abstract description 72
- 241000700605 Viruses Species 0.000 title claims abstract description 37
- 206010031009 Oral pain Diseases 0.000 title claims abstract description 30
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 13
- 241000208671 Campanulaceae Species 0.000 claims abstract description 13
- 244000247747 Coptis groenlandica Species 0.000 claims abstract description 13
- 235000002991 Coptis groenlandica Nutrition 0.000 claims abstract description 13
- 244000183914 Dianthus superbus Species 0.000 claims abstract description 12
- 235000013535 Dianthus superbus Nutrition 0.000 claims abstract description 12
- 244000111489 Gardenia augusta Species 0.000 claims abstract description 12
- 235000018958 Gardenia augusta Nutrition 0.000 claims abstract description 12
- 241000737253 Lygodium japonicum Species 0.000 claims abstract description 10
- 235000003805 Musa ABB Group Nutrition 0.000 claims abstract description 9
- 240000008790 Musa x paradisiaca Species 0.000 claims abstract description 9
- 235000015266 Plantago major Nutrition 0.000 claims abstract description 9
- 229940079593 drug Drugs 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 7
- 241000411851 herbal medicine Species 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 10
- 241001465754 Metazoa Species 0.000 abstract description 5
- 230000001225 therapeutic effect Effects 0.000 abstract description 5
- 230000002265 prevention Effects 0.000 abstract description 4
- 239000000463 material Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 241001494479 Pecora Species 0.000 description 55
- 239000000843 powder Substances 0.000 description 12
- 210000002966 serum Anatomy 0.000 description 8
- 235000010676 Ocimum basilicum Nutrition 0.000 description 7
- 240000007926 Ocimum gratissimum Species 0.000 description 7
- 239000000654 additive Substances 0.000 description 7
- 230000000996 additive effect Effects 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 241000596154 Belamcanda Species 0.000 description 6
- 240000008488 Thlaspi arvense Species 0.000 description 6
- 235000008214 Thlaspi arvense Nutrition 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000000706 filtrate Substances 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 206010037888 Rash pustular Diseases 0.000 description 5
- 230000001524 infective effect Effects 0.000 description 5
- 208000029561 pustule Diseases 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 3
- 241000283707 Capra Species 0.000 description 3
- 101710088194 Dehydrogenase Proteins 0.000 description 3
- 235000019687 Lamb Nutrition 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 241000736299 Adiantum Species 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 101150114503 F1L gene Proteins 0.000 description 2
- 244000143590 Salvia chinensis Species 0.000 description 2
- 235000007154 Salvia chinensis Nutrition 0.000 description 2
- 235000005794 Salvia japonica Nutrition 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 208000002399 aphthous stomatitis Diseases 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 description 1
- 244000080767 Areca catechu Species 0.000 description 1
- 235000006226 Areca catechu Nutrition 0.000 description 1
- 206010004542 Bezoar Diseases 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 240000001238 Gaultheria procumbens Species 0.000 description 1
- 235000007297 Gaultheria procumbens Nutrition 0.000 description 1
- 239000009636 Huang Qi Substances 0.000 description 1
- 241000122518 Hypericum beanii Species 0.000 description 1
- 235000003340 Ilex viridis Nutrition 0.000 description 1
- 241001100987 Ilex viridis Species 0.000 description 1
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 241000700625 Poxviridae Species 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010039424 Salivary hypersecretion Diseases 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 244000089698 Zanthoxylum simulans Species 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000000729 antidote Substances 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 229940116229 borneol Drugs 0.000 description 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000002279 cholagogic effect Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- -1 filter Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 244000144992 flock Species 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229910052602 gypsum Inorganic materials 0.000 description 1
- 239000010440 gypsum Substances 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000009318 large scale farming Methods 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 208000026451 salivation Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
本发明属于畜牧业养殖技术领域，尤其涉及一种治疗羊口疮的中药组合物。所述的治疗羊口疮的中药组合物，按重量份计由以下组分组成：水牛角40‑100份，生地90‑150份，扁蓄30‑80份，黄连50‑120份，黄芩40‑110份，车前子50‑120份，栀子50‑120份，海金沙5‑20份，连翘50‑120份，桔梗40‑110份，金银花50‑120份，瞿麦30‑80份。该中药组合物对羊口疮的治疗效果优于现有技术，为羊口疮的进一步防治奠定理论基础。该中药组合物没有任何毒副作用，药材易获得，成本低。
Description
技术领域
本发明属于畜牧业养殖技术领域，尤其涉及一种治疗羊口疮的中药组合物。
背景技术
羊传染性脓疱俗称羊口疮,是羊传染性脓疱病毒引起的羊发生的一种传染病。临床可分为唇型、蹄型、外阴型，山羊口疮病属于痘病毒科中的一种，在负染标本中，病毒粒子具有线团状的特征。本病多发于3-6个月的羔羊，常程群发性，而成龄羊具有一定的抗病能力。病羊以口唇部感染为主要症状。首先在口角、上唇或鼻镜上发生散在的小红斑点，以后逐渐变为丘疹、结节，继而形成水疱或脓疱，蔓延至整个口唇周围及颜面、眼睑和耳廓等部。病羊由于疼痛而不愿采食，表现流涎，精神委顿，食欲减退或废绝，反刍减少，被毛粗乱无光，日渐消瘦。哺乳母羊的乳房也可能同样患病，主要是由于小羊咬伤而感染。近年来，该病在国内多个地区均有爆发。目前，用于治疗羊口疮的药物相对较少，给该病的防治带来巨大困难，给养羊业带来较大的经济损失。
目前，抗病毒天然药物的研究已成为热点。多种生物学技术被用于大规模筛选抗病毒中药，主要通过对机体抗体水平、血液生化指标、激素水平、分子生物学指标进行检测分析中药对动物机体免疫系统、消化代谢系统的影响。如申请号为201310486476.6的发明专利公开了一种预防山羊口疮的中草药配方，该配方按重量百分比由以下成分组成：苔参4％、龙胞5％、白剑5％、花椒6％、黄花香4％、冰片5％、硼砂30％、芒硝5％、人中白4％、人工牛黄6％、青黛4％、石膏5％、黄柏4％、黄连2％、桔梗2％、儿茶2％、余量水至100％。经实践发现该配方防治可达到95％以上，特别是对从羔羊就开始进行防治的羊群中，基本预防效果可以达到100％，且不出现任何副作用，适于大规模养殖。又如申请号为201510533885.6的发明专利公开了一种治疗羊口疮的药物，该药物是由以下重 量份的原料制成的：亮叶冬青1-2重量份，猪鬃草1-2重量份，鼠尾草0.5-1重量份，罗勒0.5-1重量份。该药物制备成外用给药制剂，其制法为：干燥的亮叶冬青、猪鬃草、鼠尾草、罗勒，第一次加11倍量水浸泡1小时，煎煮1小时，第二次加4倍量水煎煮1小时，合并水煎液，滤过，滤液加50％乙醇，制成药物搽剂。
大多数中草药成分都具有较好的抗病毒效果，如金银花在抗消化道病毒感染和呼吸道病毒感染时具有较好的疗效，黄芪对流感病毒等具有一定的抑制效果。目前，关于清热解毒药物的研究相对较多，但真正用于治疗羊口疮的中药相对较少。本申请的发明人基于其早期的研究发表了一篇文章《三种中药复方对羊口疮作用效果的初步研究》，该文章中记载了以消炎镇痛、清热解毒、保肝利胆、增强免疫和增强食欲为目的筛选出的三种中药复方，选用三种中药复方对羊口疮病例进行处理，并对处理后的羊只血清生化指标、相关激素指标和体重进行统计分析，结果表明，三种中药复方均有控制该病的效果，且以中药复方Ⅱ对羊口疮的治疗效果最优。本申请的发明人通过试验研究和临床观察对复方Ⅱ进一步深入研究，探索其对羊口疮的治疗效果，并对复方配方进行了改进，发现了一种治疗羊口疮更有效的中药组合物，为羊口疮的进一步防治奠定理论基础。
发明内容
有鉴于此，本发明的目的在于提供一种治疗羊口疮效果更优的中药组合物，该中药组合物是在已有研究的基础上进一步改进所得，治疗效果优于现有技术。
为实现上述目的，本发明的技术方案为：
治疗羊口疮的中药组合物，按重量份计由以下组分组成：
水牛角40-100份，生地90-150份，扁蓄30-80份，黄连50-120份，黄芩40-110份，车前子50-120份，栀子50-120份，海金沙5-20份，连翘50-120份，桔梗40-110份，金银花50-120份，瞿麦30-80份。
进一步，所述的中药组合物，按重量份计由以下组分组成：
水牛角50-80份，生地100-130份，扁蓄40-60份，黄连70-110份，黄芩60-100份，车前子70-110份，栀子70-110份，海金沙10-15份，连翘70-110份，桔梗50-80份，金银花70-100份，瞿麦40-70份。
更进一步，所述的中药组合物，按重量份计由以下组分组成：
水牛角60份，生地120份，扁蓄50份，黄连80份，黄芩70份，车前子90份，栀子80份，海金沙10份，连翘80份，桔梗70份，金银花80份，瞿麦50份。
本发明还保护所述的中药组合物在制备治疗羊口疮药物中的应用，本发明的中药组合物对羊口疮具有较好的疗效。
本发明还保护由本发明的中药组合物制备的任何治疗羊口疮的药物制剂，所述制剂为本领域可实现的任何制剂形式，如散剂、颗粒剂、水剂等等。
在本发明的一个具体实施例中，具体公开了一种散剂，其制备方法为：中药组合物的所有药物经中草药粉碎机粉碎后过40-120目筛，拌匀得中药组合物散剂。该散剂的使用方法是将其添加于羊饲料中进行饲喂，一般按照0.5％的添加量进行饲喂，但是散剂的添加量可由饲喂人员根据羊只大小、病情情况及饲喂时间酌情添加或减少，直至完全康复。
本申请的发明人还发现，当所述的中药组合物与另一种组合物配合使用时效果更佳，两者存在协同作用。
因此，进一步，所述的治疗羊口疮的中药组合物，所述中药组合物与协同组合物B配合使用，所述协同组合物B按重量份计由以下组分组成：灯心草80-150份、败酱草50-90份、罗勒30-80份和射干10-30份。
优选的，所述协同组合物B按重量份计由以下组分组成：灯心草100-130份、败酱草60-80份，罗勒40-60份，射干20-30。
更优选的，所述协同组合物B按重量份计由以下组分组成：灯心草120份、败酱草70份，罗勒50份，射干25。
由于所述的中药组合物与协同组合物B有协同作用，因此，本发明还保护所述的中药组合物与协同组合物B配合使用在制备治疗羊口疮药物中的应用，两者配合使用对羊口疮治疗效果更佳，所述协同组合物B按重量份计由以下组分组成：灯心草80-150份、败酱草50-90份、罗勒30-80份和射干10-30份。
进一步，本发明还提供了所述的中药组合物与协同组合物B配合使用的方法，所述协同组合物B按重量份计由以下组分组成：灯心草80-150份、败酱草50-90份、罗勒30-80份和射干10-30份；所述的方法为：
(1)中药组合物的所有药物经中草药粉碎机粉碎后过40-120目筛，拌匀得中药组合物散剂；
(2)协同组合物B按上述重量份进行混合，加入1-3倍重量的水后煮沸20-60分钟，过滤得滤液；
(3)在羊饲料中添加步骤(1)所得的中药组合物散剂进行饲喂，于每次饲喂后灌服步骤(2)所得的滤液。
其中散剂的添加量一般按照0.5％的添加量进行饲喂，但是散剂的添加量可由饲喂人员根据羊只大小、病情情况及饲喂时间酌情添加或减少，直至完全康复。同理，灌服滤液一般按照每次20-30ml的量进行，但是也可由饲喂人员根据羊只大小、病情情况及饲喂时间酌情添加或减少，直至完全康复。
进一步，所述的方法，中药组合物的所有药物经中草药粉碎机粉碎后过60-80目筛。
进一步，为了使药物溶出更充分，所述的方法中，其步骤(2)中，协同组 合物B可进行提前浸泡，也可多次加水煮沸，然后合并滤液。
具体实施方式
为了使本发明的目的、技术方案和优点更加清楚，以下对本发明的优选实施例进行详细的描述。
以下实施例中涉及的动物羊只为波尔山羊，均选自重庆荣昌某羊场。
试验羊只的选择：
参照NCBI中公布的羊口疮病毒膜蛋白F1L基因序列设计特异性引物，将来自同一羊场相同品种的疑似羊传染性脓疱病毒感染的大小相近的羊只，采集口唇部痂皮进行病原PCR分子鉴定，并将PCR产物送往生工生物工程(上海)股份有限公司进行测序。试验羊只在约1000bp位置处均出现预期的阳性条带，测序后发现大小为1023bp，在NCBI中经BLAST比对发现，其与羊口疮病毒F1L基因序列相似度为100％，进而确定随选的试验羊只均为羊传染性脓疱病毒感染的患病羊只。
实施例1治疗羊口疮的中药组合物配方
配方A:
按重量份计由以下组分组成：
水牛角50份，生地90份，扁蓄40份，黄连70份，黄芩60份，车前子70份，栀子110份，海金沙15份，连翘120份，桔梗80份，金银花100份，瞿麦70份。
配方B:
按重量份计由以下组分组成：
水牛角80份，生地130份，扁蓄60份，黄连110份，黄芩100份，车前子110份，栀子70份，海金沙10份，连翘70份，桔梗50份，金银花70份，瞿麦40份。
配方C:
按重量份计由以下组分组成：
水牛角60份，生地120份，扁蓄50份，黄连80份，黄芩70份，车前子90份，栀子80份，海金沙10份，连翘80份，桔梗70份，金银花80份，瞿麦50份。
配方D:
按重量份计由以下组分组成：
水牛角60份，生地120份，黄连80份，黄芩70份，栀子80份，连翘80份，桔梗70份，金银花80份，瞿麦50份。
实施例2羊口疮治疗疗效研究
(1)药物的制备
将所有药物经中草药粉碎机粉碎后过40目筛，分别按照实施例1中的配方A、B、C、D进行配制，拌匀，备用。
(2)将来自同一羊场相同品种的已确定感染羊传染性脓疱病毒且大小相近的试验羊只平均分为四组，每组10只，另选10只健康羊作为正常对照组。在试验羊饲料中分别添加配方A、B、C、D的药物，按照0.5％的添加量饲喂，20d后停止添加中药，与正常对照组保持一致的饲喂方式，观察并记录羊只的康复情况。
运用配方A、B、C、D的药物对羊只进行治疗后，其结果为：
A、B、C组羊只全部康复，羊只全部康复时间在10-12天，而D组康复羊只为6只，康复时间为16-18天。
另外，参照《三种中药复方对羊口疮作用效果的初步研究》[黑龙江畜牧兽医科技版，动物保健品，2015第10月(上)208-210页]中的方法，在饲喂20天后，采集试验羊只及对照组血清，送往重庆永荣矿业有限公司总医院进行相关指标(血清中酶)的检测分析，通过对血清生化指标检测分析发现，A、B、C组处理的羊只血清中乳酸脱氢酶、碱性磷酸酶、白蛋白、谷丙转氨酶水平显著高于空白对照组健康羊只，而D组处理的羊只血清中乳酸脱氢酶、碱性磷酸酶、白蛋白、谷丙转氨酶水平与空白对照组健康羊只相比差异不显著。
实施例3中药组合物与协同组合物B配合使用
(1)中药组合物按重量份计由以下组分组成：
水牛角60份，生地120份，扁蓄50份，黄连80份，黄芩70份，车前子90份，栀子80份，海金沙10份，连翘80份，桔梗70份，金银花80份，瞿麦50份；将中药组合物的所有药物经中草药粉碎机粉碎后过60目筛，拌匀得中药组合物散剂；
(2)所述协同组合物B按重量份计由以下组分组成：灯心草120份，败酱草70份，罗勒50份，射干25份；协同组合物B按上述重量份进行混合，加入1-3倍重量的水后煮沸20-60分钟，过滤得滤液；
(3)将来自同一羊场相同品种的已确定感染羊传染性脓疱病毒且大小相近的试验羊只平均分为E、F两组，每组10只，另选10只健康羊作为正常对照组。E组试验羊饲料中添加中药组合物散剂，按照0.5％的添加量饲喂，F组试验羊饲料中添加中药组合物散剂，按照0.5％的添加量饲喂，并且于每次饲喂后灌服20ml步骤(2)所得的滤液。20d后停止添加中药组合物并停止灌服药液，与正常对照组保持一致的饲喂方式，观察并记录羊只的康复情况。结果表明，E组羊只全部康复，羊只全部康复时间为10天，F组羊只全部康复，羊只全部康复时间为5天。并且，通过对血清生化指标检测分析发现，F组处理的羊只血清中乳酸脱氢酶、碱性磷酸酶、白蛋白、谷丙转氨酶水平显著高于E组。
本实施例中，中药组合物配比与协同组合物B配比均为最佳配比，本申请的发明人还将中药组合物与协同组合物B的其他配比进行了试验，结果表明，试验羊只均全部康复，羊只全部康复时间为5-7天。
最后说明的是，以上实施例仅用以说明本发明的技术方案而非限制，尽管参照较佳实施例对本发明进行了详细说明，本领域的普通技术人员应当理解，可以对本发明的技术方案进行修改或者等同替换，而不脱离本发明技术方案的宗旨和范围，其均应涵盖在本发明的权利要求范围当中。
Claims (6)
1.治疗羊口疮的中药组合物，其特征在于，按重量份计由以下组分组成：
水牛角40-100份，生地90-150份，扁蓄30-80份，黄连50-120份，黄芩40-110份，车前子50-120份，栀子50-120份，海金沙5-20份，连翘50-120份，桔梗40-110份，金银花50-120份，瞿麦30-80份。
2.根据权利要求1所述的中药组合物，其特征在于，按重量份计由以下组分组成：
水牛角50-80份，生地100-130份，扁蓄40-60份，黄连70-110份，黄芩60-100份，车前子70-110份，栀子70-110份，海金沙10-15份，连翘70-110份，桔梗50-80份，金银花70-100份，瞿麦40-70份。
3.根据权利要求2所述的中药组合物，其特征在于，按重量份计由以下组分组成：
水牛角60份，生地120份，扁蓄50份，黄连80份，黄芩70份，车前子90份，栀子80份，海金沙10份，连翘80份，桔梗70份，金银花80份，瞿麦50份。
4.权利要求1-3任一项所述的中药组合物在制备治疗羊口疮药物中的应用。
5.由权利要求1-3任一项所述的中药组合物制备的治疗羊口疮的药物制剂。
6.权利要求1-3任一项所述的中药组合物的制备方法，其特征在于，所述的制备方法为：
中药组合物的所有药物经中草药粉碎机粉碎后过40-120目筛，拌匀得中药组合物散剂。
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810609117.8A CN108567864B (zh) | 2016-04-01 | 2016-04-01 | 用于治疗羊口疮的中药配方 |
| CN201610200026.XA CN105708960B (zh) | 2016-04-01 | 2016-04-01 | 治疗羊口疮的中药组合物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610200026.XA CN105708960B (zh) | 2016-04-01 | 2016-04-01 | 治疗羊口疮的中药组合物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810609117.8A Division CN108567864B (zh) | 2016-04-01 | 2016-04-01 | 用于治疗羊口疮的中药配方 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105708960A CN105708960A (zh) | 2016-06-29 |
| CN105708960B true CN105708960B (zh) | 2018-07-03 |
Family
ID=56159506
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810609117.8A Active CN108567864B (zh) | 2016-04-01 | 2016-04-01 | 用于治疗羊口疮的中药配方 |
| CN201610200026.XA Active CN105708960B (zh) | 2016-04-01 | 2016-04-01 | 治疗羊口疮的中药组合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810609117.8A Active CN108567864B (zh) | 2016-04-01 | 2016-04-01 | 用于治疗羊口疮的中药配方 |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN108567864B (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998942A (zh) * | 2016-07-03 | 2016-10-12 | 张俊清 | 一种治疗羊传染性脓疱病的中药组合物 |
| CN106138247A (zh) * | 2016-08-08 | 2016-11-23 | 覃先皓 | 一种治疗羊口疮的中药组合物 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100749A (zh) * | 2009-12-18 | 2011-06-22 | 董礼德 | 一种治疗家畜皮肤病变的中药膏及其制备方法 |
| CN105106654A (zh) * | 2015-09-25 | 2015-12-02 | 全椒县大地种植专业合作社 | 一种预防和治疗羊群羊口疮的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101361846A (zh) * | 2008-08-08 | 2009-02-11 | 西安自力中药集团有限公司 | 一种用于治疗内科实火证类的解毒清热中药及制作方法 |
| CN104208468A (zh) * | 2014-08-22 | 2014-12-17 | 严中明 | 用于马口疮治疗的中药组合物 |
| CN104784311B (zh) * | 2015-03-23 | 2018-01-02 | 四川成康动物药业有限公司 | 用于防治动物口疮蹄癀的组合药物及其制备方法 |
-
2016
- 2016-04-01 CN CN201810609117.8A patent/CN108567864B/zh active Active
- 2016-04-01 CN CN201610200026.XA patent/CN105708960B/zh active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100749A (zh) * | 2009-12-18 | 2011-06-22 | 董礼德 | 一种治疗家畜皮肤病变的中药膏及其制备方法 |
| CN105106654A (zh) * | 2015-09-25 | 2015-12-02 | 全椒县大地种植专业合作社 | 一种预防和治疗羊群羊口疮的方法 |
Non-Patent Citations (2)
| Title |
|---|
| 三种中药复方对羊口疮作用效果的初步研究;张素辉等;《黑龙江畜牧兽医》;20151031(第10期);第208-210页 * |
| 中西医结合治疗羔羊口疮;李志杰等;《中兽医医药杂志》;19991231(第6期);第29-30页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105708960A (zh) | 2016-06-29 |
| CN108567864A (zh) | 2018-09-25 |
| CN108567864B (zh) | 2021-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105663532A (zh) | 一种治疗鸡痘的中药组合物 | |
| CN104784618A (zh) | 一种用于治疗头痛的中药组合物 | |
| CN102038100A (zh) | 用于预防和治疗猪瘟的饲料添加剂 | |
| CN105708960B (zh) | 治疗羊口疮的中药组合物 | |
| CN103432339B (zh) | 一种中药组合物和中药制剂及其用途 | |
| US20180099021A1 (en) | Topical drug for treating breast cancer and preparation method thereof | |
| CN101194995B (zh) | 治疗动物病毒、细菌及其混合感染的中成药 | |
| CN103041251B (zh) | 一种治疗慢性支气管炎的中药组合物 | |
| CN1960743A (zh) | 草药组合物 | |
| CN105106524A (zh) | 一种治疗奶牛乳房炎的中药及其制备方法 | |
| CN103656077A (zh) | 一种具有治疗慢性肾脏病的中药复方组合物 | |
| CN101683429A (zh) | 防治禽传染性法氏囊病的中兽药颗粒剂及其制备方法 | |
| CN108245654A (zh) | 一种防治鸡球虫病的口服液 | |
| CN104888137B (zh) | 一种治疗多囊卵巢综合症的药物制剂 | |
| CN101732534A (zh) | 一种补肾生精益气养血的中药 | |
| CN108852994A (zh) | 一种中药美白面膜 | |
| CN107183397A (zh) | 提高鹌鹑免疫功能的饲料添加剂的制备方法 | |
| CN107496485A (zh) | 毛大丁草的益肝作用及应用技术 | |
| CN105194216A (zh) | 一种去脚气精华液及其制备方法 | |
| CN104398893B (zh) | 一种治疗急性湿疹的复合中药软膏及其制备方法 | |
| CN105343816A (zh) | 一种孕妇用口腔溃疡喷剂及其制备方法 | |
| CN1528418A (zh) | 治疗肾盂肾炎肾损伤的中药及其制备方法 | |
| CN104001031A (zh) | 一种治疗哮喘的药物 | |
| CN105106261A (zh) | 一种用于治疗淋巴癌的中药组合物 | |
| CN103877481B (zh) | 一种治疗顽固性口腔溃疡的药物组合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |